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Programmable process parameters guarantee high

reproducibility.

High efficient processing for significantly reduced batch

time (approximately 60%) & operating cost.

End products are stable, air free, glossy with consistent

specific weight for improved filling performance

downstream.

Rapid dosing of large quantities of try materials.

Shear energy optimization by means of stator

adjustment.

High transfer performance.

Highest flexibility for product & process requirement.

Aseptic design for fast and efficient cleaning.

Batch to batch consistency & high reproducibility.

Economic operation & handling.

Range tools ensure maximum process versatility.

KEY BENEFITS

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O Lotion, Gel

Sterile eye drop

Inhalation liquid

Toothpaste

Hair care products

Mascara

Mayonnaise

Body care products

Colour pastes

Cosmetic creams

intments, Cream,

APPLICATIONS

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Hemispherical or conical vessel with slow speed agitator

with inline or bottom entry HSE for production scale unit.

Top entry homogenizer for pilot unit.

Wax phase vessel.

Water phase vessel.

Internal and external homogenization.

Heating and cooling system with temperature control

and safety equipment.

Vacuum system.

Working platform above 300kg plant.

Hydraulic lid lifting system.

Control panel.

STANDARD VERSION

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User-friendly interface \ with

PLC.

Choice o f automat ion

package.

Load cell and dosing unit.

Available Capacities from 25

lit. to 2000 lit.

OPTIONS

OINTMENT/CREAM MANUFACTURINGFACILITY

INLINE HOMIGENIZER:- Recirculation of product together

with action of the advanced scraper agitator system & vortex

breaker ensure through macro mixing in vessel, by means

of horizontal & vertical movement of the product.

Repeatedly passing of the product through the

homogenizer combined with vacuum action also ensures

removal of entrained air. The end result is high quality

deaerated product.

Real heart of the process equipment is the inline

incorporated homogenizer. Which homogenizes complete

mass in circulation. Small quantity of ingredient inline feed

guaranteed by mix throughout the mass.

Integrated vacuum system with its water ring vacuum pump

pulls both liquid & powders directly in to the HSE.

Innovative process technology offers consistently high

product quality, shorter batch time, minimum operating

costs, low space requirement and user friendly operation.

“Paan Pharmatech” Processing unit is used for

production of pharmaceuticals emulsions, suspension,

ointment and creams & premium cosmetics, requires

highest standards of mixer, the control system and the

recipe management.

Validatable production and cleaning process unit with FDA-

approved materials. Varying products and product qualities

for the international market need flexible and universally

applicable process units.

Vast experience combined with extensive R&D has

produced the best combination of mixing & homogenizing

tool in system. Offering high productivity, quality and yield.

Flexibility in system allows minimum batch sizes to be

produced.

DESCRIPTION

LIQUID MANUFACTURING FACILITY

“A systematic approach to identifying and eliminating waste

through continuous improvement, flowing the product at the

pull of the customer in pursuit of perfection.”

Single pass incorporation of powder capitalizes on the

benefits of in-line Processing. It is the controlled

introduction of the powder phase into the liquid phase.

In-line mixing can be achieved by various methods:

i. A device located online between two vessels.

ii. In the water fill line leading to a batch tank.

iii. In a re-circulation loop.

It is part of continuous process,Here many of the issues

raised with in-tank mixing can effectively be prevented.

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Direct addition of powder to a process line has tangible

advantages over traditional in-tank mixing.

A single-pass, in-line approach allows not only the controlled

introduction of powders but also the controlled application of the

shear necessary for specific behavior characteristics of the

powders.

The Inline introduction of the powder completely eliminates the

lump formation, this benefit is especially valuable when dealing

with heat or shear sensitive products.

Reduces batch times. -Powders can be introduced and

dispersed into the liquid during the filling operation of the vessel.

-Single pass, in-line processing eliminates build-up on the tank

wall, mixer shaft, and baffles.

-Reduces tank-cleaning time, lowers the chance for cross

contamination, and virtually eliminates ingredient waste.

Reduces equipment requirements in many ways.

-A single in-line device can be used to feed a number of storage

(batch) tanks.

-No need to install expensive de-aerating devices, no tank

vortexing occurs.

Less space requirement- minimized, resulting into cost saving.

Reduces utility requirements –

No steam required, Water required for washing is reduced by

80%. Power consumption is reduced by more than 75%.

The energy used is focused.No energy is wasted on trying to re-

circulate multiple passes.

Consistent product- Repeatable product quality.

Elimination of over processing to remove lumps- when

dealing with heat or shear sensitive products.

THE BETTER WAY TO MIX SOLIDS INTO LIQUIDS

Off.: Plot-36, Shramsafalya, RSC -11, Veer Savarkar Nagar, Thane (W) – 400606 Maharashtra (INDIA).

Tel.: 91- 22 – 2582 8524, 0250-6454728/29 Telefax: 91 – 22 -2583 3896

Website: Email: paanfabriworkengineers@yahoo.inwww.paanpharmatech.com

Pharmatech Engineers Pvt. Ltd.PAAN

Pharmatech Engineers Pvt. Ltd.PAAN

Multichamber homogenizing, dispersion machine. A new machine and

system concept in answer to increasing pressure in the areas of qualities

and cost for stirring, mixing and dispersion applications.

it has been growing in the manufacturing world and some solutions

that are readily available to help manufacturers to achieve the

benefits of this concept.

THE CONCEPT OF INLINE MANUFACTURING

'THE INSTINCTIVE CHOICE IS IN-TANK MIXING,BUT WITH

PROBLEM POWDERS,IN-LINE MIXING GIVES FAR

BETTER RESULTS'

Process Engineers are often challenged with proper selection

of mixing technology for given operation. They are more likely to

confronted with difficult solids. Like High molecular

hydrocolloids, cellulose, gums, starches, carboxy methyl

cellulose & proteins.

When trying to mix difficult solids in liquids two problems

are particularly common:

The powder floats resisting all efforts to “wet” them out. OR

They lumps together forming impenetrable sticky mass or

fisheyes (Lump of product with hydrated skin & non hydrated

dry core.)

Powder floats because of surface tension effects. As a mass of

powder is introduced into liquid, surface tension forces doesn't

allow liquid to enter into mass. Floating mass OR raft forms

leading to build up layer on shaft & vessel wall. These powders

are hydrophobic. (fumed silica, carbon black, coca powder &

organic pigments.)

CHALLENGES TO OVERCOME

PAAN Pharmatech can help manufacturers, to understand the

benefits of Inline technology concept.

Understanding Customer Value- Only what your customers

perceive as value is important.

Value Stream Analysis- Once you understand the value that you

deliver to your customers, you need to analyze all the steps in your

business processes to determine which ones actually add value.

Flow- Instead of moving the product from one place to the

next in large batches, production should flow continuously from raw

materials to finished goods in dedicated production cells.

Pull- Rather than building goods to stock, customer demand Pulls

Finished goods through the system. Work is not performed unless

the part is required downstream.

Perfection- Completely remove waste from the process and flow

product continuously according to the demands of your customer

reduces time.

FIVE BASIC PRINCIPLES OF THE INLINE LIQUIDMANUFACTURING PROCESS

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Dust free handling.

CIP cleaning possible.

Processing at high viscosity.

Compact design.

Almost maintenance free.

Uniform, reproducible product quality.

Output Performance up to 20,000 lit. /hr.

CHARACTERISTIC FEATURES OFPROCESS SYSTEM

Pharmaceutical, food, cosmetics etc.

Applications

When an agglomerate of hydrophllic powder comes into

contact with water, the particles on the surface of agglomerates

gets hydrated & swell quickly & form gel layer. Inner core of the

particle cannot be hydrated because they are well shielded by

the water.These are gums obtained from the plants (locust

beans, guar, Synthetic in nature carboxy methyl cellulose &

carbomer) difficult to wet & mix.

Some Processors run the in-tank high shear mixer till they

satisfy with dispersion or have eliminated most of the lumps.

This is time consuming, Overall this overprocessing can

potentially damages the end product, if it is either shear or heat

sensitive. At the end of batch a significant amount of dry

material must be removed by filtration & thus wasted.

By one traditional method fisheyes formation can be

prevented by pre-wetting the powder in non-aqueous

solution such as glycol , Once dispersed the solution is

then blended in aqueous phase to complete hydration.

This can effective approach but it needs to follow an

additional step , extra equipment & added material cost

I) Air entrainment is virtually eliminated without using baffles.

ii) Strong Axial flow pattern, uniform velocity profile.

iii) By pass tube gives single pass powder dispersion directly

to rotor stator

iv) Top entry, variable speed.

PAAN IN-TANK JET MIXER

We encourage “hands on” experience on all equipment. On going evaluations can be undertaken as special additional

service either on site or in our unit.

If you would like to know more about syrup making process (Integrated cold process) and its benefits, contact us and

ask for more details. We will give you and your associate team the basic tools that you can see the area in your plant where

and how syrup manufacturing now inline process system could enhance a product quality, quantity and safety. It also

increases your profit and save tremendous utility by using new concept in pharma industry in India.

SEMINAR AND CUSTOMER TRAINING

TECHNICAL SPECIFICATION

MODEL Capacity (lit./hr) Powerconsumptions(HP)

Solid feed inletNB

Liquid feed inletNB

HMD -1000 1000 5 40

HMD -2500 2500 10 50

HMD -3000 3000 12.5 65

HMD -5000 5000 15 75

HMD -7500 7500 20 75

HMD -10000 10000 25 100

25

32

40

50

50

75

Productdischarge NB

32

40

50

65

65

65