Dr Katarzyna Pokajewicz

HONEYWELL RESEARCH CHEMICALSOctober 2016Karl Fischer titration

seminar

© 2016 by Honeywell International Inc. All rights reserved.

Who is Honeywell?3

$38.6Bin sales for 2015

53%Of sales outside U.S.

• ~1300 sites

• 70 countries

• 129.000 employees

• Morris Plains, NJ headquarter

• Fortune 100

• NYSE: HON

AerospaceAutomation and Control Solutions

Performance Materials and Technologies

3

Performance materials and technologies

Catalysts, adsorbents and chemicals for processing crude oil

Refrigerants

Electronic materials

Intermediates for paint, varnish and glue

4

Performance materials and technologies

Substrates for plastics

Nylon resins

Nylon foils

Disinfectants

5

Performance materials and technologies

Fertilizer Sulf-N®

ammonium sulphate

Polymer films for drug packaging

Fine chemicals

Luminescent dyes

HONEYWELL RESEARCH CHEMICALS

© 2016 by Honeywell International Inc. All rights reserved.

New Research Chemicals Business7

Q4 2015Q3 2015Q2 2015Q4 2014Q3 2014

Merck announces that it will acquire Sigma-Aldrich

September 2014

Deal is accepted globally by governments & institutions

Fall/Winter 2014

The European Commission rules the acquisition could lead to unfair competition in certain areas.

Sigma-Aldrich has to sell part of its portfolio to proceed with the merger.

June 2015

Honeywell announces its intention to buy divested business from Sigma-Aldrich

October 2015

Honeywell acquires selected product lines from Sigma-Aldrich portfolio

December 2015

Background Timeline

Transition agreement

Till 15th Dec 2016 agreement with Merck

Merck's customer service,

distribution, logistics

Since mid-Nov 2016 Honeywell

RC starts operating independly

16th Dec 2016 Honeywell RC

works completely on it’s own

8

Merck S

igma-A

ldrich

Hon

eyw

ell

16 Dec

16 Nov

Honeywell porfolio

Legacy Sigma-Aldrich

• Brands: Fluka, Chromasolv, Hydranal, TraceSELECT, Fixanal• Products: Solvents, inorganics, titration productsMostly produced by Honeywell as subcontractor!

Legacy Honeywell• Brand: Burdick&Jackson, Riedel de Haën

• Solvents (general, analytical and biosynthesis grades, anhydrous), inorganics

9

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After acquisition: Fluka branded products and S-A with suffix „-D”

Present: All Honeywell, Fluka, Riedel de Haën, Burdick&Jackson branded products

Honeywell porfolio

Our website

In preparation – functional in November

11

www.lab-honeywell.com

Branding

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Fluka

High purity analytical reagentsRiedel de Haën

High purity solvents

Burdick& Jackson

High purity solvents for synthesis

Sub-brands:- Hydranal ®

- TraceSELECT ®

- Fixanal ®

Sub-brands:- Chromasolv ®

- TraceSELECT ®

General grade reagents

Sub-brands:- BioSyn®

© 2016 by Honeywell International Inc. All rights reserved.

Honeywell Research Chemicals13

Portfolio Brands

PortfolioOverview

SOLVENTSHigh-purity solvents and reagents for synthesis

SOLVENTSHigh-purity solvents for dedicated applications

ANALYTICAL REAGENTS

Karl Fischer titration, standards, acids, bases, salts,

and pH buffers

PERFORMANCE GRADE

Solvents and inorganics for general laboratory use

Product Lines

• BioSyn™ - DNA, RNA and peptide synthesis

• Anhydrous - Moisture-sensitive organic synthesis, organometallic, combinatorial chemistry, and related applications

• Chromasolv™ -Chromatography techniques including LC-MS, UHPLC, Headspace, and GC

• Spectroscopy - IR and UV-Vis applications

• ACS and Pharmacopoeia Grade - Industrial and pharmaceutical applications

• TraceSELECT™ Solvents -Trace and low-metal content analysis

• Analytical Inorganics• Standard Solutions -

Buffers and concentrated solutions

• Hydranal™ - Karl Fischer titration for measuring water content

• TraceSELECT™ Inorganics - Trace and low-metal content analysis

• Solvents - ACS specific use (HPLC), ACS general use, solvents for histology, and reagent grade for chemical synthesis and other industrial applications

• Inorganics - Chemical synthesis and inorganic chemistry including essential acids and bases, salts, metals and elements, and reagents for chemical reactions

Services & Technology

Returnable/Re-usable Container Program for BioSyn™ Solvents and Blends reduces carbon footprint while saving time and money

Returnable/Re-usable Container Program reduces carbon footprint while saving time and money

Honeywell LabReady™ for customer-specific blends using proprietary, closed-loop blending technology

Special Packaging Technology for guaranteed, free flowing powder in hygroscopic inorganics

Dedicated Packaging for Volumetric Solutions

Supply in Larger Quantity

Scalable to Production Requirements

1 2 3 4

Synthesis solvents

• Anhydrous solvents

• Biosyn®

DNA/RNA and peptide synthesis reagents designed for scientists and manufacturers performing automated oligonucleotide/peptide synthesis

Anhydrous solvents, deblocking, activator, capping andoxidation reagents

Available next year

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1 2 3 4

High purity solvents

• ACS and Pharmacopeia grade

• Spectroscopy solventsfor UV-VIS and IR

• TraceSELECT® solventsFor inorganic trace analysis, metal speciation analysis by LC-ICP-MS

• Chromasolv ®

for LC and GC

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Chromasolv® solvents17

For LC

Grade HPLC Gradient Plus LC-MS LC-MS Ultra

Purity Medium High High Higher Higher Highest

Water Low Lower Lower Lower Lower

UV Low Lower Lower Lower Lowest

HPLC UV Gradient

─ Low Lower Lower Lowest

Fluorescence Low Lower Lower Lower Lowest

Metal Testing ─ ─ ─ ppb Level ppb Level

Non-Volatile Residue

Lower Lower Lowest Lowest Lowest

SummaryLimited Gradient

Gradient Analysis

Lowest UV and Gradient Analysis

Suitability for LC-MS

Suitability for UHPLC-MS

LC-MS Ultra Chromasolv®

LC-MS Chromasolv®

Chromasolv® Plus

Chromasolv® gradient grade

Chromasolv®

Grades for HPLC

Chromasolv® solventsFor GC

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Grade Pesticide Residue Analysis GC-Headspace

Applications Low boiling solvents for direct GC injectionHigh boiling solvents for Headspace/OVI

analysis

Organic Purity Very High Very High

Trace Metal Testing ─ ─

Non-Volatile Residue/Microfiltration

≤0.0005% 0.2 micron filtered

SpecialSuitability tested for residue analysis, ≤5 ng/L

compared to Lindane

GC-Headspace tested for OVIs (organic volatile impurities) acc. to Ph.Eur.,

USP and ICH

Typical solventsAcetone, Hexane,

Ethyl acetateDMSO, DMA, DMF, Water

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1 2 3 4

Titration

Hydranal® lineFor water determination by Karl-Fischer methodTitration solutions, solvents, water standards, auxiliary reagents

Other titration methods

• Ready to use titrant solutions/buffers:- bottled- VOLPAC® (5 or 10L)

• Concentrates- Fixanal®

• Indicators

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TraceSELECT

Digestion reagents (acids, bases, salts)• trace analysis

(TraceSELECT®) • ultratrace analysis

(TraceSELECT® Ultra)

• Purified by sub-boiling distillation

• Packed in high-quality HDPE orfluoropolymer bottles

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reagents for metal trace analysis (AAS and ICP)

Free flowing powders

Innovative, proprietary packaging solution that addresses the common issue of clumping that occurs with many hygroscopic salts and buffers by preventing the absorption of water from the surrounding environment.

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Anhydrous salts, acids and bases

Features:

1. Technology eliminates the lengthy process of breaking up solids before use and reduces waste.

2. Technology allows users to work safer by eliminating the need to break up solids.

3. Packaging sizes range from 100 g to 12 kg to support customer’s needs.

4. We offer the broadest selection of products in a format that prevents moisture absorption.

Others analytical

• Standards

• Adsorbents

• High purity acids, bases, salts (ACS, Pharmacopeia)

• Analytical consumables

• Different analytical reagents: derivatisation, mobile phaseadditives…

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1 2 3 4

For each and every lab day to day use

Lab essentials

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• Reagent grade• Purum p.a.• Laboratory reagent• Industrial application grades • Histological grade

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Industrial fine chemicals

Key Markets Served:

• Sealants & Adhesives• Catalysts & Catalytic Precursors• Metal Treatment• Electroplating• Oral Care• Pharma• Food, Beverage and Nutrition

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• ISO 9001 Certification

Seelze plant, Germany

• Production site for lab and fine chemicals

• Hydranal™ Production

• Center of Excellence for Karl Fischer titration

• Center of Excellence for Packaging Engineering

• High Volume Production and Packing

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• ISO 9001 Certification

Muskegon Plant, Michigan, USA

© 2016 by Honeywell International Inc. All rights reserved.

Honeywell Research Chemicals30

• Leader in high-purity solvents and Karl Fischer titration

• Best quality material on the market

• Competitively priced

• Exceptional lot-to-lot consistency

• Production and QC in Germany and US

• Broad offer of different grades

• Bulk availability

• Flexibility in custom packaging and blending

• Highly developed returnable containers program

Our Strengths

© 2016 by Honeywell International Inc. All rights reserved.

Honeywell Research Chemicals31

We aim to become your supplier of high quality lab reagents and chemicals for analytical and chemistry laboratories

Thank You