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1Leny Budhi Harti -Metabolic Syndrome

Leny Budhi HartiLeny Budhi Harti

Program Studi Ilmu GiziProgram Studi Ilmu Gizi

Fakultas Kedokteran Universitas BrawijayaFakultas Kedokteran Universitas Brawijaya

Malang, 1 Nopember 2011Malang, 1 Nopember 2011

Obesity & Reproductive Disorders

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Obesity & Male Reproductive Disorders

Obese males usually express a characteristic hormonal profile

described as hyperestrogenic hypogonadotropic

hypogonadism.

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It is associated with a

decrease in circulating

androgen levels.

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Obesity & Male Reproductive Disorders

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Obesity & Male Reproductive Disorders

Obesity and Erectile Dysfunction

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ObesityObesity 1

ProinflamatoryProinflamatorycytokinescytokines

Endothelial dysfunctionEndothelial dysfunction

Erectile dysfunctionErectile dysfunction

CVDCVD

ErectileErectile

dysfunctiondysfunction

2

NONO

pathwaypathway

hypoandrogenismhypoandrogenism

3

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Obesity & Female ReproductiveObesity & Female ReproductiveDisordersDisorders

Insulin resistance and

compensatory

hyperinsulinemia

PCOS (polycystic

ovarian syndrome)

Anovulation,hyperandrogenismsuch as

hirsutism, acne, and male-pattern hair loss

Obesity & Female ReproductiveObesity & Female ReproductiveDisordersDisorders

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In insulin resistance syndrome, excess insulin

is capable of stimulating steroidogenesis,

excessive androgen production from the

theca cells and excessive oestrogen

production from the granulosa cells of the

ovaries.

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Obesity & Female ReproductiveObesity & Female Reproductive

DisordersDisorders

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The ovary is a target organ for insulin.

Insulin stimulates ovarian steroidogenesis intheca and granulosa cells, and enhances thestimulatory effect of LH through LH receptorupregulation

Insulin also acts at the level of the pituitary,where it may enhance the sensitivity of thegonadotroph cells to the action of GNRH, furtherenhancing the stimulation of ovariansteroidogenesis

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Adipokines

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Summary

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References

Dokras, Anuja. 2007. Plycystic Ovary Syndrome and the Impact ofObesity on Fertility.

Hammoud, Ahmad O, et al. Obesity and Male ReproductivePotential. Journal of Andrology, Vol. 27, No. 5, September/October2006. Copyright E American Society of Andrology

Ramsay, Jane E., Greer ,Ian., Sattar, Naveed. Obesity andReproduction. BMJ volume 333, December 2006

Brewer, Christopher J., and Adam H Balen. The Adverse Effect ofObesity on Conceprion and Implantation. Reproduction (2010) 140347364

Kyrou, Ioannis., and Tsigos, Constantin. Chronic Stress, VisceralObesity and Gonadal Dysfuntion. HORMONES 2008, 7(4):287-293

Ogbuji, C. Queen. Oesity and Reproductive Performance in Woman.African Journal of Reproductive Health Sept. 2010 (Regular Issue);14(3)

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