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Nutritional Testing Effective tools for complex chronic illnesses
personalized patient recommendations with Genova Diagnostics’ innovative line of nutritional tests
Target
Anti-Oxidants prevent cellular damage. Necessary anti-oxidants that are not produced by the body and must be obtained from the diet include Vitamins C and E. Other anti-oxidants (such as glutathione, lipoic acid and CoQ-10) are formed endogenously, but have declining levels with age and may warrant replacement.
• Vitamin A / Carotenoids• Vitamin C • Vitamin E / Tocopherols• Lipoic Acid• CoQ-10• Glutathione• Plant-Based Anti-Oxidants
1
B-Vitamins are cofactors for enzymes and are essential to fundamental metabolic processes. Dietary sources are essential for the body to manufacture B-vitamins.
• B-1 Thiamin• B-2 Riboflavin• B-3 Niacin• B-6 Pyridoxine• B-7 Biotin• B-9 Folic Acid• B-12 Cobalamin
2Minerals play a vital role as cofactors for a wide variety of enzymatic processes. Functional levels for four minerals are provided.
• Manganese• Molybdenum• Magnesium• Zinc
3
Essential Fatty Acids are not made by the body but are required for optimal functioning of a variety of physiologic processes. They must be obtained through diet to preclude deficiencies from occurring.
• Recommendations for supplementation of Omega 3 fatty acids are provided.
• The Omega 3 Index – an indicator of cardiovascular risk – is highlighted as well.
4
Digestive Support needs are assessed and recommendations are made in two categories to optimize digestion and absorption of macronutrients and micronutrients.
• Pancreatic enzyme support • Probiotic supplementation
5
21 3
5 4
Our most comprehensive nutritional diagnostics provide a framework of core nutrients in 5 key areas:
NHANES 1999-2002 Advance Data from vital and healthy statistics; no 395. National Center for Healthy Statistics 2008
*
NutrEval is Genova’s most comprehensive nutritional evaluation to identify specific imbalances of vitamins, nutrients, and essential co-factors. It achieves this by combining analysis of organic acids, amino acids, essential fatty acids, oxidative stress and elemental markers.
ONE is a nutritional evaluation that includes key organic acids and amino acids to evaluate the functional need for antioxidants, B-vitamins, minerals, digestive support, and amino acids.
ION (Individual•Optimal•Nutrition) provides a combination of analyses that measures levels of organic acids, fatty acids, amino acids, vitamins, minerals, and antioxidants, offering a complete evaluation of functions that impact patients’ mental and physical well-being. The ION Profile is available in New York State.
Genova Diagnostics’ line of nutritional tests provide insight through comprehensive panels and concise profiles for accessing one specific area of concern.
IINDIVIDUAL • OPTIMAL • NUTRITIONAL
Biomarkers Reported NE PLS*3001 NE FMV* ONE*
3200ION
3100
ION AA403102
C/ION3104 Biomarkers Reported NE PLS*
3001 NE FMV* ONE*3200
ION3100
ION AA403102
C/ION3104
Amino Acids Organic Acids
1-Methylhistidine • • • • Nutrient Cellular and Mitochondrial Markers
3-Methylhistidine • • • • Fatty Acid Metabolism
α-Aminoadipic Acid • • • • Adipate • • • • • •
α-Amino-N-Butyric Acid • • • • Suberate • • • • • •
ß-Alanine • • • • Ethylmalonate • • •
ß-Aminoisobutyric Acid • • • • Carbohydrate Metabolism
Alanine • • • • Pyruvate • • • • • •
Anserine • • • Lactic Acid • • •
Arginine • • • • • • L-Lactate • • •
Asparagine • • • • • • ß-Hydroxybutyrate • • •
Aspartic Acid • • • • • • β-OH-β-Methylglutaric Acid •
Carnosine • • • β-OH-Butyric Acid (BHBA) • •
Citrulline • • • • • • Energy Production (Citric Acid Cycle)
Cystathionine • • • • Citrate • • • • • •
Cysteine • • • cis-Aconitate • • • • • •
Cystine • • • Isocitrate • • • • • •
Ethanolamine • • • • a-Ketoglutarate • • • • • •
Gamma-Aminobutyric Acid • • • • Succinate • • • • • •
Glutamic Acid • • • • • • Fumarate • • •
Glutamine • • • • • • Malate • • • • • •
Glycine • • • • • • Hydroxymethylglutarate • • • • • •
Histidine • • • • • • Vitamin Markers
Homocysteine • • • B-Complex Vitamin Markers
Homocystine • a-Ketoadipic Acid • • •
Hydroxylysine • a-Ketoisovalerate • • • • • •
Hydroxyproline • a-Ketoisocaproate • • • • • •
Isoleucine • • • • • • a-Keto-ß-Methylvalerate • • • • • •
Leucine • • • • • • Xanthurenate • • • • • •
Lysine • • • • • • ß-Hydroxyisovalerate • • •
Methionine • • • • • • Glutaric Acid • • •
Ornithine • • • • • • 3-Hydroxypropionic Acid • • •
Phenylalanine • • • • • • Isovalerylglycine • • •
Phosphoethanolamine • • • • 3-Hydroxyisovaleric Acid • • • •
Phosphoserine • • • Methylation Cofactor Markers
Proline • • • • Methylmalonate • • • • •
Sarcosine • • • • Formiminoglutamate • • • • •
Serine • • • • • • Cell Regulation Markers
Taurine • • • • • • Neurotransmitter Metabolism Markers
Threonine • • • • • • Vanilmandelate • • • • • •
Tryptophan • • • • • • Homovanillate • • • • • •
Tyrosine • • • • • • 5-Hydroxyindoleacetate • • • • • •
Valine • • • • • • Kynurenate • • • • • •
Urea • • • Quinolinate • • • • • •
Amino Acid Ratios Kynurenic / Quinolinic Ratio • • •
Arginine/Ornithine • 3-Methyl-4-OH-phenylglycol • • •
Asparagine/Aspartate • Picolinate • • •
Glutamine/Glutamate • • • • • Oxidative Damage and Antioxidant Markers
Phenylalanine/Tyrosine • • • p-Hydroxyphenyllactate • • •
Hydroxyproline/Proline • Lipid Peroxides • • •
α-ANB/Leucine •
Tryptophan/LNAA • • •
IND
IVID
UA
L C
OM
PO
NE
NT
S
Biomarkers Reported NE PLS*3001 NE FMV* ONE*
3200ION
3100
ION AA403102
C/ION3104 Biomarkers Reported NE PLS*
3001 NE FMV* ONE*3200
ION3100
ION AA403102
C/ION3104
Organic Acids Fatty Acids
Toxicants and Detoxification Polyunsaturated Omega-3
a-Ketophenylacetic Acid • • • Alpha-Linolenic Acid (ALA) • • • • •
a-Hydroxyisobutyric Acid • • • Docosahexaenoic Acid (DHA) • • • • •
2-Methylhippurate • • • Docosapentaenoic Acid • • • • •
Orotate • • • • • • Eicosapentaenoic Acid (EPA) • • • • •
Glucarate • • • % Omega-3s • •
a-Hydroxybutyrate • • • Polyunsaturated Omega-6
Pyroglutamate • • • • • • Arachidonic Acid • • • • •
Sulfate • • • Dihomogamma Linolenic Acid • • • • •
Tyrosine Metabolism Docasadienoic Acid • • •
2-Hydroxyphenylacetic Acid • • • Docosatetraenoic Acid • • • • •
Homogentisic Acid • • • Eicosadienoic Acid • • • • •
Malabsorption and Dysbiosis Markers Gamma Linolenic Acid (GLA) • • • • •
Malabsorption Markers Linoleic Acid (LA) • • • • •
Indoleacetic Acid • • • % Omega-6s • •
Bacterial /Yeast Dysbiosis Markers Polyunsaturated Omega-9
Bacterial - general Mead Acid • • •
Benzoate • • • • • • % Omega-9s • •
Hippurate • • • • • • Monounsaturated Omega-7
Benzoic/Hippuric Acids Ratio 11-Eicosenoic Acid • • •
Dihydroxyphenylpropionic Acid • • • Myristoleic Acid • • •
3-Hyroxyproprionic Acid • • • Nervonic Acid • • • • •
4-Hydroxyphenylpyruvic Acid • • • Oleic Acid • • • • •
Phenylpropionate • • • Palmitoleic Acid • • • • •
Phenylacetate • • • • • • Vaccenic Acid • • • • •
p-Hydroxybenzoate • • • Saturated
p-Hydroxyphenylacetate • • • Arachidic Acid • • • • •
Indican • • • Behenic Acid • • • • •
Tricarballylate • • • Capric Acid • • •
L. acidophilus/general bacterial Hexacosanoic Acid • • •
D-Lactate • • • Lauric Acid • • •
Clostridial species Lignoceric Acid • • • • •
3,4 Dihydroxyphenylpropionate • • • Margaric Acid • •
Yeast/Fungal Myristic Acid • • •
D-Arabinitol • • • Palmitic Acid • • • • •
Arabinose • • • Stearic Acid • • • • •
Citramalic Acid • • • % Saturated Fats • •
Tartaric Acid • • • Saturated
Oxidative Stress Arachidic Acid • • • • •
Coenzyme Q10 • • • • • Behenic Acid • • • • •
Alpha tocopherol • • • • • Capric Acid • • •
Gamma tocopherol • • • Hexacosanoic Acid • • •
Vitamin A • • • • Lauric Acid • • •
ß-Carotene • • • • Lignoceric Acid • • • • •
Lipid Peroxides • • • • • • Margaric Acid • •
Vitamin D • • • Myristic Acid • • •
Glutathione • • Palmitic Acid • • • • •
8-Hydroxy-2’-deoxyguanosine • • • • • • Stearic Acid • • • • •
% Saturated Fats • •
Biomarkers Reported NE PLS*3001 NE FMV* ONE*
3200ION
3100
ION AA403102
C/ION3104 Biomarkers Reported NE PLS*
3001 NE FMV* ONE*3200
ION3100
ION AA403102
C/ION3104
Organic Acids Fatty Acids
Toxicants and Detoxification Polyunsaturated Omega-3
a-Ketophenylacetic Acid • • • Alpha-Linolenic Acid (ALA) • • • • •
a-Hydroxyisobutyric Acid • • • Docosahexaenoic Acid (DHA) • • • • •
2-Methylhippurate • • • Docosapentaenoic Acid • • • • •
Orotate • • • • • • Eicosapentaenoic Acid (EPA) • • • • •
Glucarate • • • % Omega-3s • •
a-Hydroxybutyrate • • • Polyunsaturated Omega-6
Pyroglutamate • • • • • • Arachidonic Acid • • • • •
Sulfate • • • Dihomogamma Linolenic Acid • • • • •
Tyrosine Metabolism Docasadienoic Acid • • •
2-Hydroxyphenylacetic Acid • • • Docosatetraenoic Acid • • • • •
Homogentisic Acid • • • Eicosadienoic Acid • • • • •
Malabsorption and Dysbiosis Markers Gamma Linolenic Acid (GLA) • • • • •
Malabsorption Markers Linoleic Acid (LA) • • • • •
Indoleacetic Acid • • • % Omega-6s • •
Bacterial /Yeast Dysbiosis Markers Polyunsaturated Omega-9
Bacterial - general Mead Acid • • •
Benzoate • • • • • • % Omega-9s • •
Hippurate • • • • • • Monounsaturated Omega-7
Benzoic/Hippuric Acids Ratio 11-Eicosenoic Acid • • •
Dihydroxyphenylpropionic Acid • • • Myristoleic Acid • • •
3-Hyroxyproprionic Acid • • • Nervonic Acid • • • • •
4-Hydroxyphenylpyruvic Acid • • • Oleic Acid • • • • •
Phenylpropionate • • • Palmitoleic Acid • • • • •
Phenylacetate • • • • • • Vaccenic Acid • • • • •
p-Hydroxybenzoate • • • Saturated
p-Hydroxyphenylacetate • • • Arachidic Acid • • • • •
Indican • • • Behenic Acid • • • • •
Tricarballylate • • • Capric Acid • • •
L. acidophilus/general bacterial Hexacosanoic Acid • • •
D-Lactate • • • Lauric Acid • • •
Clostridial species Lignoceric Acid • • • • •
3,4 Dihydroxyphenylpropionate • • • Margaric Acid • •
Yeast/Fungal Myristic Acid • • •
D-Arabinitol • • • Palmitic Acid • • • • •
Arabinose • • • Stearic Acid • • • • •
Citramalic Acid • • • % Saturated Fats • •
Tartaric Acid • • • Saturated
Oxidative Stress Arachidic Acid • • • • •
Coenzyme Q10 • • • • • Behenic Acid • • • • •
Alpha tocopherol • • • • • Capric Acid • • •
Gamma tocopherol • • • Hexacosanoic Acid • • •
Vitamin A • • • • Lauric Acid • • •
ß-Carotene • • • • Lignoceric Acid • • • • •
Lipid Peroxides • • • • • • Margaric Acid • •
Vitamin D • • • Myristic Acid • • •
Glutathione • • Palmitic Acid • • • • •
8-Hydroxy-2’-deoxyguanosine • • • • • • Stearic Acid • • • • •
% Saturated Fats • •
Biomarkers Reported NE PLS*3001 NE FMV* ONE*
3200ION
3100
ION AA403102
C/ION3104 Biomarkers Reported NE PLS*
3001 NE FMV* ONE*3200
ION3100
ION AA403102
C/ION3104
Fatty Acids Cardiovascular Health
Odd Chain Lipoprotein Factors
Heneicosanoic Acid • • • Total Cholesterol •
Heptadecanoic Acid • • • HDL Cholesterol •
Nonadecanoic Acid • • • Direct LDL •
Pentadecanoic Acid • • • • • Triglycerides •
Tricosanoic Acid • • • • • Lipoprotein (a) •
Trans Lipoprotein Ratios •
Elaidic Acid • • LDL/HDL •
Palmitelaidic Acid • • • Total/HDL •
Total C:18 Trans • • • Glucose
Ratios (calculated)/Various Insulin •
LA/GLA Chronic Inflammatory Markers
LA/DGLA • • • • • C-Reactive Protein (HS) •
EPA/DGLA • • • Ferritin •
AA/EPA • • • • • Fibrinogen •
Triene/Tetraene • • • Oxidant Stress Factors
Stearic/Oleic Coenzyme Q10 •
Omega-6s/ Omega-3s • • Vitamin E
Index of Omega-3 • Lipid Peroxides •
Nutrient and Toxic Elements Add-ons
Nutrient Elements Vitamin D + + +
Calcium • • • SNP - APO E (C112R + R158C) + +
Copper • • • • • SNP - MTHFR Combined (A1298C + + +
Magnesium • • • • • SNP - TNFA + +
Manganese • • SNP - COMT (V158M) + +
Potassium • • • • • CoQ10 +
Selenium • • • • • Vitamin K Assay + + +
Zinc • • • • • Serum Chemistries + + +
Toxic Elements Neopterin/Biopterin Profile + + +
Aluminum • • •
Arsenic • • • • • *NOT AVAILABLE IN NEW YORK
Cadmium • • • • •
Lead* • • • • •
Mercury • • • • •
Tin • •
A F E W O F T H E C O M M O N U S E S O F N U T R I T I O N A L T E S T I N G I N C L U D E :
• Mood disorder - Depression - Anxiety - Sleep disturbance• Fibromyalgia or Fatigue• Optimized health and sports fitness
Genova Diagnostics, Inc.63 Zillicoa Street
Asheville, NC 28801Phone: 800.522.4762
Fax: 828.252.9303
w w w . g d x . n e t
Genova Diagnostics, Europe46-50 Coombe Road
New MaldenSurrey, KT3 4QF
Phone: 020.8336.7750Fax: 020.8336.7751
www.gdx.net/UK
GDX-7-146
Genova’s standard-setting report designsynthesizes complex biochemistry into actionable treatment options. Our rigorous testing analyzes a wide array of biomarkers and combines those results using an algorithm that considers the complex interrelation of a patient’s individual chemistry.
The report combines the results into specific recommendations personalized for each patient.
Our nutrition reports feature:• Synthesized and actionable areas of
high need for supplementation
• Color-metric reports that signal key areas of concern
• Suggested personalized supplement schedule which provides personalized recommendations for antioxidants, B-vitamins, minerals, essential fatty acids, digestive support, and amino acids is available upon request
• Easy-to-use “Interpretation At-A-Glance” that provides patients valuable information about the function of individual nutrients, causes and complications of their deficiencies, and their dietary sources
© 2 0 1 9 G e n o v a D i a g n o s t i c se,mp,nutr i t ion_tr i fo ld ,103019
