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NUTRIOSE®
A source of long lasting
energy
Sophie Chesnoy
February 2013
2
Agenda
Diabetes education & prevention
Carbohydrates & glycaemia
NUTRIOSE®, a soluble dietary fiber
NUTRIOSE®, a soluble dietary fiber, which has low
glycaemic and insulinaemic responses
NUTRIOSE® is slowly fermented in the colon and
produces SCFA contributing to the daily energy supply
How to empower the general public on better
awareness?
3
Agenda
Diabetes education & prevention
Carbohydrates & glycaemia
NUTRIOSE®, a soluble dietary fiber
NUTRIOSE®, a soluble dietary fiber, which has low
glycaemic and insulinaemic responses
NUTRIOSE® is slowly fermented in the colon and
produces SCFA contributing to the daily energy supply
How to empower the general public on better
awareness?
4
World diabetes day 2012
Type 2 diabetes is a common and serious global health
problem, which, for most countries, has developed
together with rapid cultural and social changes, ageing
populations, increasing urbanisation, dietary changes,
reduced physical activity, and other unhealthy
behaviours.
There is conclusive evidence that type 2 diabetes can be
prevented through nutrition counselling, increasing
physical activity and modest weight reduction.
5
Doak et al. Obes Rev 2012
Obesity in European women, self-reported 2001-2005.
Obesity in Europe
6
Glycaemic Response: a market demand
1. N
utr
aceutical W
orld, o
cto
bre
2012 -
2. In
tern
ational D
iabete
s F
oundation
The market for the glycaemic response represents an opportunity
� 180 000 studies in 2012
Diabetic people
�366 millions of people worldwide2
A lot of people are not aware of risk associated
�Overweight & metabolic syndrome
�116 milliards dollars = USA annual cost for
patients care
« TREATMENT »« TREATMENT » « PREVENTION »« PREVENTION »
The glycaemic Response emerges as a solution:
7
Lifestyle prevention
- RCT
- 523 subjects with impaired glucose levels
- Mean duration of follow-up: 3.2 years
Goals:
- Weight reduction
- Total fat intake
- Saturated fat
- Fiber
- Moderate exercise
Tuomilehto, NEJM 2001
8
58% reduction in diabetes
3 kg weight loss
Tuomilehto, NEJM 2001
Prevention of type 2 diabetes by
lifestyle prevention
9
Agenda
Diabetes education & prevention
Carbohydrates & glycaemia
NUTRIOSE®, a soluble dietary fiber
NUTRIOSE®, a soluble dietary fiber, which has low
glycaemic and insulinaemic responses
NUTRIOSE® is slowly fermented in the colon and
produces SCFA contributing to the daily energy supply
How to empower the general public on better
awareness?
10
How to take advantage of these benefits?
Glycaemic index
Carbs
(Starch,Sugars,Fibers)
Variation of blood glycaemia &
energy supply
Management of
daily intake &
satiety
Long term consequences
(metabolic
syndrome)
The glycaemic response Energy balanceImpact on health
costs
11
Carbohydrates & glycaemia
A number of factors influence glycaemic responses to food :
� Amount of carbs
� Type of sugar (glucose, fructose, sucrose lactose)
� Cooking & food processing
12
Types of carbohydrates and energy
Complex fermentable carbohydrates are sometimes described as potentially good sources of long-lasting energybecause of a low GR, and because of providing "prolonged energy release".
A high and fast energy supply is often needed at the beginning of physical effort or for a short task.
A prolonged supply of energy over time is required, for example, during prolonged, endurance tasks, providing energy for brain (concentration, learning) and muscular effort:
- in the upper intestinal tract under a glucose form
- in the lower tract under SCFAs form
� Interest of NUTRIOSE® for prolonged energy release : a tool for reformulation
13
Agenda
Diabetes education & prevention
Carbohydrates & glycaemia
NUTRIOSE®, a soluble dietary fiber
NUTRIOSE®, a soluble dietary fiber, which has low
glycaemic and insulinaemic responses
NUTRIOSE® is slowly fermented in the colon and
produces SCFA contributing to the daily energy supply
How to empower the general public on better
awareness?
14
NUTRIOSE®
Provide some rapidly available energy for brain and
effort in the upper intestinal tract under a glucose form
(NUTRIOSE® 06 has a not nil energetical value ), while
inducing low glycaemic (GR = 25) and insulinaemic
responses (IR = 13)
Provide late energy converted from SCFAs, during further
digestion in the lower intestinal tract, to ketone bodies or
glucose, or directly used by muscles, due to bacterial
fermentations (prebiotic effect)
Maintain well-being during digestion (high digestive
tolerance threshold)
15
Agenda
Diabetes education & prevention
Carbohydrates & glycaemia
NUTRIOSE®, a soluble dietary fiber
NUTRIOSE®, a soluble dietary fiber, which has low
glycaemic and insulinaemic responses
NUTRIOSE® is slowly fermented in the colon and
produces SCFA contributing to the daily energy supply
How to empower the general public on better
awareness?
16
NUTRIOSE® 06
10 %
excreted
75 %
progressively
fermented
15 %
absorbed
Small intestine
Colon
Short chain
fatty acids
Biomass
Energy CO2
CH4/H2
Faeces
GlucoseUp
pe
r tr
act
Low
er
tra
ctWhat is Nutriose® ? Metabolic fate
17
NUTRIOSE® : focus on glycaemic response -
the small intestine stage
Glycaemic and insulinaemic
responses after ingestion of
NUTRIOSE® compared to
dextrose : NUTRIOSE® has a low
GR and a low IR
low GR 25
low IR 13
Donazzolo et al., Dietary Fiber, 2003
18
Agenda
Diabetes education & prevention
Carbohydrates & glycaemia
NUTRIOSE®, a soluble dietary fiber
NUTRIOSE®, a soluble dietary fiber, which has low
glycaemic and insulinaemic responses
NUTRIOSE® is slowly fermented in the colon and
produces SCFA contributing to the daily energy supply
How to empower the general public on better
awareness?
19
NUTRIOSE® : focus on delayed energy
release – the large intestine stage
According to the definition of Woods and Gorbach (2001),
NUTRIOSE® 06 acts as a prebiotic fiber from 8 g/day:
� beneficial bacteria (glucidolytic flora ) and/or � in harmful bacteria
(proteolytic flora)
� intestinal pH
bacterial enzymes concentrations : � fecal α- and β-glucosidases
Slow and long-lasting colonic fermentations : SCFAs production, breath
hydrogen excretionLefranc-Millot C et al., chapters in books 2010, 2009
Lefranc-Millot C et al., Nutrition Bulletin, 2008
Van den Heuvel EGHM et al., Eur.J. Nutr., 2005
Van den Heuvel et al., Eur.J. Clin. Nutr., 2004
20
Butyrate in particular, and other SCFAs, may promote satiety
Butyrate increases expression of gene encoding for PYY and GLP1
The pattern of fermentation (mostly the ratio acetate : propionate),
may impact the potential lipid lowering properties of non digestible
carbohydrates: colonic propionate is a gluconeogenic substrate in
humans and inhibits the use of acetate for cholesterol synthesis.
Partially
hydrolysed
guar gum
NUTRIOSE®
Inulin
Role of SCFAs
Stewart ML et al. Gastroenterology, 2007
Hamer, H. M et al. Aliment Pharmacol Ther, 2008
Zhou J et al.Obesity 2006
Hijova E et al. Bratisl Lek Listy, 2007
Wolever TMSet al. Am J Clin Nutr 199l
21
TimeSmall Intestine Colon
Energy
GLUCOSE
(low GR)
SHORT CHAIN
FATTY ACIDS
+
= 2 kcal/g
NUTRIOSE® is a source of long-lasting energy
glucose
NUTRIOSE®
What is NUTRIOSE® ?
Metabolic fate
Livesey G, Nutrition Research Review, 1992
European Commission (2008) Commission Directive
2008/100/EC of 28 October 2008 amending Council Directive
90/496/EEC on nutrition labelling for foodstuffs as regards
recommended daily allowances, energy conversion factors and
definitions. Official Journal of the European Union L 285/9.
22
Agenda
Diabetes education & prevention
Carbohydrates & glycaemia
NUTRIOSE®, a soluble dietary fiber
NUTRIOSE®, a soluble dietary fiber, which has low
glycaemic and insulinaemic responses
NUTRIOSE® is slowly fermented in the colon and
produces SCFA contributing to the daily energy supply
How to empower the general public on better
awareness?
23
How to educate ?
Glycaemic indexCarbohydrates
Blood variation of glycaemia
impacting the
energy supply
Management of
daily caloric intake
Long term consequences,
metabolic syndrome
Glycaemic response
To increase people awareness about
this connection
Long terms consequences
New product positioning New promotion tools
24
Age makes a difference
Younger
people
Younger
people
They find it harder to manage food habits,
especially female students and young people starting their career, who tend to
snack.
They realise how important
healthy food is when they have children.
They exercise more often to
manage their weight better.
Their nutritional knowledge is under average.
Not very interested in managing daily
caloric intake
25
Age makes a difference
Older
people
Older
people
They are more concerned about food because they have more knowledge on the subject thank to their
experience.
Their lifestyle is more tranquil, they are more
serene
They are generally more concerned with their
weight / figure.
They are more concerned with food quality.
More concerned about finding
healthy food
26
Conclusion
� NUTRIOSE® can be used at
the recommended dosage
for :
� fiber fortification
� prebiotic effects
� satiety and weight
management
A source of carbohydrate� decreased glycaemic response
� Prolonged energy supply
� …
CARBOHYDRATESFIBER
+
Healthy food choice for prediabetes people
NUTRIOSE® may be used in accordance with many of the WHO/FAO nutritional
recommendations (less sugars, more fibres, etc)
27
THANK YOU