Nuclear Medicine division status

Jean-Michel Poutissou7th April 2011

Response to last year’s report• Formal screening of new projects• MHESA project status• CCM status• Expansion of wet laboratory space• New recruitment• Graduate students• Solid target• New imaging detectors• MDS Nordion collaboration

November 29th retreat• 15 months NRCan NISP grant for cyclotron

production of 99mTc received : Tight delivery deadlines. (March 2012)

• NSERC/CIHR grant ongoing (LS96) linked to the above.

• MHESA new radiochemistry laboratory ( Joint project with Nordion) finally on track to be done soon ( TRIUMF`s share in the NRC budget to be expended by March 2011)

• GMP lab to be operational in December• Radiochemistry research projects

NUMED FY 2011-12 Goals

• 1) deliver on the NRCan project milestones• 2) Deliver Tracers to our best partners like

PPRC,PET centre, BCCA, UBC faculties ,Nordion, GE,..

We need:• MHESA laboratory completion and operation• GMP lab Operation

Other goals

• Centre Comparative Medicine– New MicroPet /Spec scanner (CFI-Vesna)– Design of new pipeline connection to CCM

• Detector development:– New MicroPet/MRI scanner F.Retiere

CFI proposal ( U.Manitoba/UBC/TRIUMF)– New “low” cost PET scanner development

( TRIUMF/BCCA) by Fabrice Retiere

Other projects under consideration

• Second CDR grant with Nordion• Grant application with Genome BC• Canadian Molecular Imaging Network centre

of excellence proposal to be submit by August

AJJOA J

2010

JOA J

2011

JOA J

2012

A J O

2013

November 29, 2010

Major TasksJ A J O

2014

NU-MED Plan (2010-2015)

Tender & award contract

Funding approved

Target development and testing

Team organized

Detailled design

Report to NRCan

Install

Cyclotron proposal

Commissioning

.New building/TR19 relocation

GMP lab 005 operation

MH

ES

LA

B

2011

2012

2013

2014

Construction

An

imal

GMP lab 005

Hot cells delivery

GMP lab 007 upgrade ??

• Icfi PROPOSAL (MULTI MODAL FACILITY)

• CFI proposal ( MPET/SPEct/ct

• piPELINE

JMP

201520

10

99m

Tc

pro

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ctio

n

Milestones NRU restart ommissioningl )

Legend:

Research

Infrastructure construction

Science

Deputy Division HeadNew Programs

P.Schaffer

New Infrastructure (P&S)

New Tracers Radiochemistry – Lead Scientist (BAE)

Targets/Medical Isotope Production – Lead Scientist (BAE)

SeniorTarget Scientist

Target EngineerTarget Chemist

Electro-mechanical

Engineer

Cyclotron-Ops

Nuclear MedicineNuclear MedicineJ.M. PoutissouJ.M. Poutissou

Deputy Division HeadCore Programs

M. Adam

Special AdvisorT. Ruth

NRCan

SeniorTarget Scientist

Target Engineer

Electro-mechanical

Engineer

Target Chemist

Project ManagerNSERC/CIHR

Principal Investigator

NRCan Partners

NRCan NISP project

New infrastructure

• GMP laboratory RCA005 upgrade:– 3 new hot cells ( Comecer)– 3 new chemistry boxes– New ventilation strategy– Clean room environment

GMP lab/personnel

MHESA laboratory

Centre for Comparative Medicine

• Construction on going• Occupancy ( early 2012)• CFI proposal for a Spect/Pet micro scannerby V.Sossi and P.Schaffer.Major concern with PETA activist groupNew policy on disclosure of our LSPEC proposals

and reports

Hiring plan

• One extra Scientist ( radiochemist)• One professional ( MHESA lab manager)• Mike Adam will be replaced when he retires.• Several additions to the target group will be

absorbed when the NRCan project terminates ( new soft funding or NRC bridge funding)

Students/ Postdocs

• • NRCan NISP project:• TOM MORLEY, PDF

• • PPRC/UBC PET Centre collaboration and the Good Manufacturing Practice Laboratory (GMP) upgrade:• G. TOPPING, PHD STUDENT (LS 94)• 1 MSc STUDENT (VESNA)• 3 PHD STUDENTS ( VESNA)• • NORDION/TRIUMF collaboration:• ESTER BOROS, PHD STUDENT• ERIC PRICE, PHD STUDENT• CATERINA RAMOGIDA, PHD STUDENT• JAQUELINE CAWTHRAY, PDF• LISA MURPHY, PDF• •

Students/Postdocs• • BCCA-TRIUMF collaboration:• NONE AT THIS TIME• • GE Healthcare Collaboration:• HUA YANG, PDF• • CIHR/GENOME BC proposal (OLIGONUCLEOTIDES, MICRO-FLUIDICS):• JAMES INKSTER, PHD STUDENT• KATE LIU, CO-OP STUDENT• SAMAR HAROUN, PHD STUDENT • ZARA SANAI, PHD STUDENT• YING LI, PHD STUDENT• M. POURSHIASIAN, PHD STUDENT• • • Collaboration with UBC’s Centre for Comparative Medicine (CCM):• TBA• MINet collaboration:• TBA

Policy for the SAP-EEC,MMS-EEC and LSPEC

• In order to align TRIUMF policies on openness with other laboratories around the world, this document outlines in broad terms our new policies. Below EEC refers to all three committees.

• 1) All proposals submitted to TRIUMF will be available for view on the TRIUMF internal WEB in their entirety after review and if approved by the EEC.

– a. Only the title, author list, status, and short abstract (< 300 words) will be displayed on the public web pages.

– b. The EEC reports (and comments) are internal TRIUMF documents and will only be displayed on the internal TRIUMF web site. The full EEC report will be made available to the appropriate external funding committees.

– c. Proposals with private sector partners should follow Non Disclosure Agreements.(NDA)

• 2) Presentations to the EECs are open to everyone. Slides are available to the committee only. • 3) Review committee members will treat the content of proposals as confidential. • 4) Requests for information on proposals from outside the TRIUMF community will be granted only

by the authors in consultation with TRIUMF communications. • 5) Within 60 days of receiving beam time the spokesperson will provide to the Science Division for

posting, on the public WEB pages, a short summary (< 300 words) of the experiment results. The summary of results will be used in the annual report. Details are disclosed at the discretion of the spokesperson.

• 6) The interpretation and application of this policy is the responsibility of the respective Division Head.