Nuclear Envelope Lamin-A Couples Actin Dynamics with Immunological Synapse Architecture and T Cell Activation

by José M. González-Granado, Carlos Silvestre-Roig, Vera Rocha-Perugini, Laia Trigueros-Motos, Danay Cibrián, Giulia Morlino, Marta Blanco-Berrocal, Fernando G.

Osorio, José M. P. Freije, Carlos López-Otín, Francisco Sánchez-Madrid, and Vicente Andrés

Sci. Signal.Volume 7(322):ra37-ra37

April 22, 2014

©2014 by American Association for the Advancement of Science

A-type lamins are increased in abundance upon T cell activation.

José M. González-Granado et al., Sci. Signal. 2014;7:ra37

©2014 by American Association for the Advancement of Science

Loss of A-type lamins impairs T cell activation in vitro and in vivo.

José M. González-Granado et al., Sci. Signal. 2014;7:ra37

©2014 by American Association for the Advancement of Science

Lamin-A enhances the activation of human J77 cells.

José M. González-Granado et al., Sci. Signal. 2014;7:ra37

©2014 by American Association for the Advancement of Science

Lamin-A modulates the dynamics of human J77 cell–Raji cell interactions.

José M. González-Granado et al., Sci. Signal. 2014;7:ra37

©2014 by American Association for the Advancement of Science

Lamin-A is required for optimal movement of TCR-CD3 complexes within the plasma membrane and TCR-dependent signaling.

José M. González-Granado et al., Sci. Signal. 2014;7:ra37

©2014 by American Association for the Advancement of Science

A-type lamins promote MTOC translocation and F-actin polymerization in activated T cells.

José M. González-Granado et al., Sci. Signal. 2014;7:ra37

©2014 by American Association for the Advancement of Science

The lamin-A–mediated increase in the extent of T cell activation requires a physical connection between the nucleus and the cytoskeleton through the LINC complex.

José M. González-Granado et al., Sci. Signal. 2014;7:ra37

©2014 by American Association for the Advancement of Science