NSF-NSEC for Integrated Nanopatterning and Detection Technologies

(NSEC Grant Number EEC – 0647560)

Chad Mirkin (PI), Michael Bedzyk, Vinayak Dravid, Horacio Espinosa, Franz Geiger, Mark Hersam, Joseph Hupp, SonBinh Nguyen,

Monica Olvera de la Cruz, George Schatz, Richard Van Duyne, William Klein, Chang Liu, Milan Mrksich, Steve Sligar, Teri Odom,

Steve Wolinsky, Laurie Zoloth, Mercouri Kanatzidis, Jiaxing Huang, C. Shad Thaxton

Northwestern University, University of Chicago, University of Illinois at Urbana-Champaign

SRG 1: Nanopatterning

2 nm

Dip-Pen Nanolithography Feedback Controlled Lithography Heteromolecular

10 million Pen Array Intermolecular spacing with atomic precision Nanostructures

SRG 3:Integrated Biodetection ChipSRG 2: Signal Transduction & Receptor Design

Flow cellLamp Spectrometer

Flo

w

Aperture

250 nm

Drug Binding to Membrane Proteins

Alkanethiolate

Alkyldisulfide

m/z

Detector

MS

Detection Strategies Enabled by NanoMaterialsNew Receptor Chemistries

Measuring Telomerase Activity Profiling HDAC Activity

Ac-GXKAcZGC-NH2

D N E Q K R H S T M W F Y V I L A G PDNEQKRHSTMWFYVILAGP

Z P

osi

tio

n

X Position

0 1

Polymer Pen Lithography 2-D Active Probe Arrays Parallel Inking Wells

Education and Outreach

Research Experience for Undergraduates Research Experience for Teachers

Nanoscape: The Journal of Undergraduate

Research in Nanoscience

103 articles published to date

Undergraduate authors from institutions across the

country

Volume VIII released Summer 2011

On-line and print version

Print version mailed to >1,000 college and university

departments and libraries

255 REU participants

67% of participants women and underrepresented

minorities

Hands-on research plus professional development

activities– Technical writing course

– Public Speaking workshop

– Tour of Argonne National Laboratory

– Final symposium and written paper

– Over 100 published papers

Program includes hands-on research and

curriculum development for their classrooms

88 pre-college teachers have participated to-date

> 11,000 pre-college students impacted to-date

Partnership with the Museum of Science

and Industry, Chicago

Resulting in 2,400 square ft permanent exhibit

on nanotechnology

Opening Spring 2013

Potential to reach over 2 million visitors per year

DiscoverNano Website(www.discovernano.northwestern.edu)

~1,000,000 visitors a year

Includes:

– Introduction to nanotechnology

– Historical timeline

– Nano Art gallery

– Curriculum projects

– Meet the Researchers section

Nanotechnology Town Hall Meetings

Introduces nanotechnology to the public

Addresses societal/ethical concerns

7 meetings held, > 600 attendees to date

Nanoscience Pre-college Module Inquiry-based, links to real-world applications,

extensively field-tested

Includes student & teacher manuals

Being disseminated world-wide by NCLT

Knowledge Transfer (to-date)

> 850 publications

151 invention disclosures and 75 patent filings

1,607 domestic and international seminars & colloquia

104 Frontiers in Nanotechnology Seminars

8 International Institute for Nanotechnology Symposiums

17 start-up companies launched through Small Business

Evaluation & Entrepreneur’s (SBEE) Program with over

$600M in VC invested

20 companies enlisted in Nanotechnology Corporate

Partners (NCP) program

70 Industrial partnerships

55 International partnerships

Integrated chip-based detection system

Improved bio-barcode assay

Protein biomarker identification

Surface immobilized bio-barcode assay

The authors thank the

National Science Foundation

for support of this work.

MOSFET-embedded

microcantilever development

Integration of novel receptors with nanomechanical detection platform