NSF-NSEC for Integrated Nanopatterning and Detection TechnologiesNSF-NSEC for Integrated Nanopatterning and Detection Technologies(NSEC Grant Number EEC – 0647560)(NSEC Grant Number EEC – 0647560)

Chad Mirkin (PI), Michael Bedzyk, Vinayak Dravid, Horacio Espinosa, Franz Geiger, Mark Hersam, Joseph Hupp, SonBinh Nguyen, Monica Olvera de la Cruz, George Schatz, Richard Van Duyne, William Klein, Chang Liu, Milan Mrksich, Steve Sligar, Teri Odom,

Steve Wolinsky, Laurie Zoloth, Mercouri Kanatzidis, Jiaxing Huang, C. Shad Thaxton

Northwestern University, University of Chicago, University of Illinois at Urbana-Champaign

SRG 1: Nanopatterning

2 nm

Dip-Pen Nanolithography Feedback Controlled Lithography Heteromolecular 10 million Pen Array Intermolecular spacing with atomic precision Nanostructures

SRG 3:Integrated Biodetection ChipSRG 2: Signal Transduction & Receptor Design

Flow cellLamp Spectrometer

Flo

w

Aperture

250 nm

Drug Binding to Membrane Proteins

Alkanethiolate

Alkyldisulfide

m/z

Detector

MS

Detection Strategies Enabled by NanoMaterialsNew Receptor Chemistries

Measuring Telomerase Activity Profiling HDAC ActivityAc-GXKAcZGC-NH2

D N E Q K R H S T M W F Y V I L A G PDNEQKRHSTMWFYVILAGP

Z Po

sitio

n

X Position

0 1

Polymer Pen Lithography 2-D Active Probe Arrays Parallel Inking Wells

Education and Outreach

Research Experience for Undergraduates Research Experience for Teachers

Nanoscape: The Journal of Undergraduate Research in Nanoscience

93 articles published to date

Undergraduate authors from institutions across the country

Volume VIII to be released Summer 2011

On-line and print version

Print version mailed to >1,000 college and university departments and libraries

208 REU participants to date

50% of participants women and underrepresented minorities

Hands-on research plus professional development activities– Technical writing course– Public Speaking workshop– Tour of Argonne National Laboratory– Final symposium and written paper– Over 90 published papers

Program includes hands-on research and curriculum development for their classrooms

81 pre-college teachers have participated to-date

~9000 pre-college students impacted to-date

Partnership with the Museum of Science and Industry, Chicago

Resulting in 2,400 square ft permanent exhibit on nanotechnology

Opening 2011 Potential to reach over 2 million visitors per year

DiscoverNano Website (www.discovernano.northwestern.edu)

>900,000 visitors a year Includes:

– Introduction to nanotechnology– Historical timeline– Nano Art gallery– Curriculum projects– Meet the Researchers section

Nanotechnology Town Hall Meetings Introduces nanotechnology to the public Addresses societal/ethical concerns 7 meetings held, ~600 attendees to date

Nanoscience Pre-college Module Inquiry-based, links to real-world applications,

extensively field-tested Includes student & teacher manuals Being disseminated world-wide by NCLT

Knowledge Transfer (to-date)

726 publications

193 provisional patents

1,444 domestic and international seminars & colloquia

97 Frontiers in Nanotechnology Seminars

7 International Institute for Nanotechnology Symposiums

16 start-up companies launched through Small Business Evaluation & Entrepreneur’s (SBEE) Program (>$500M in VC invested)

20 companies enlisted in Nanotechnology Corporate Partners (NCP) program

70 Industrial partnerships

47 International partnerships

Integrated chip-based detection systemIntegrated chip-based detection system

Improved bio-barcode assay

Protein biomarker identification

Surface immobilized bio-barcode assay

The authors thank the National Science Foundation

for support of this work.

MOSFET-embedded microcantilever development

Integration of novel receptors with nanomechanical detection platform