[1] Steed, Lisa L. et al. Reduction of nasal Staphylococcus aureus carriage in health care professionals by treatment with a nonantibiotic, alcohol-based nasal antiseptic. American Journal of Infection Control , Volume 42 Issue 8 841 - 846

[2] Coates, T et al. Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects. J Antimicrob Chemother 2009; 64,9-15

[3] Wertheim HFL, et al. Risk and outcome of nosocomial Staphylococcus aureus bacteremia in nasal carriers versus non-carriers. Lancet 2004; 364:703-705

[4] Kalmeijer MD et al. Nasal carriage of SA is a major risk factor for surgical site infections in orthopedic surgery. Infect Control Hosp Epidemiol 2000; 21:319-323

[5] Anderson DJ et al. Strategies to prevent surgical site infections in Acute Care Hospitals. SHEA/IDSA Practice recommendations. Infect Control Hosp Epidemiol 2014; 35(6):605-627

[6] Anderson DJ et al. Strategies to prevent surgical site infections in Acute Care Hospitals. SHEA/IDSA Practice recommendations. Infect Control Hosp Epidemiol 2014; 35(6):605-627

[7] Bratzler DW, Hunt DR. The Surgical Infection Prevention and Surgical Care Improvement projects: national initiatives to improve outcomes for patients having surgery. Clin Infect Dis. 2006; 43(3):322-330

[8] Davis KA et al. Methicillin-resistant Staphylococcus aureus (MRSA) nares colonization at hospital admission and its effect on subsequent MRSA infection Clin Infect Dis. 2004 Sep 15; 39(6):776-82

[9] Lemon KP et al. Comparative analysis of the bacterial microbiota of the human nostril and oropharynx. Mbio 1(3):1-9, 2012

[10] Kaye, KS et al. The deathly toll of invasive MRSA infection in community hospitals. CID 2008:46 (15 May)

[11] Anderson DJ, Kaye KS et al. Clinical and financial outcomes due to MRSA SSI: a multi-center matched outcomes study. 2009 PLos ONE 4(12);e8305

[12] Anderson DJ et al. Strategies to prevent surgical site infections in Acute Care Hospitals. SHEA/IDSA Practice recommendations. Infect Control Hosp Epidemiol 2014; 35(6):605-627

ENDNOTES

Evidence shows nasal bacteria are a primary contributorto the spread of infection. Nozin® Nasal Sanitizer® antiseptic

can help reduce the risk WITHOUT ANTIBIOTICS.

GO

AL Make another step toward zero infections by achieving

Staphylococcus aureus, including MRSA, nasal decolonization of surgical patient AND healthcare workers/caregivers in contact with patient.

ST

RAT

EG

Y

•Perioperative care: Reduce nasal carriage in the patient and everyone around the patient before, during and after surgery

•Reduce Staphylococcus aureus nasal carriage in the patient prior to surgery

•Reduce Staphylococcus aureus nasal carriage of everyone who comes in contact with the patient before, during and after surgery

•Maintain decolonization of the patient and caregivers during post-operative period to help reduce complications that often lead to readmission

IND

ICAT

ION

Patient•Day of Surgery

•3 Nozin swabs within 1 hr. prior to surgery•Next 5-8 days

•3 Nozin swabs /day

Staff•All OR staff

•2 Nozin swabs /shift•Recovery/Post op

•2 Nozin swabs/shift

Visitors•Nozin swab before entering patient room•Additional Nozin swab every 8 hrs

Caregivers at home•2 Nozin swabs/day for 5-8 days

Nozin® Nasal Sanitizer® antiseptic

360° NaSal DecoloNizatioN ProgramSurgery Protocol

4608 North Park Avenue, Suite 200 - Chevy Chase, MD 20815NoziN.com 877-669-4648

the most comprehensive program for nasal decolonization for surgical patients

Nozin® Nasal Sanitizer® antiseptic

Surgery 360° Decolonization Program

reduceStaphylococcus aureus

Nasal carriage

a safe, effective, non-antibiotic method for nasal carriage reductionNozin® Nasal Sanitizer® Advanced Antiseptic is a non-prescription ethanol-based product with a demonstrated microbial killing activity that is topically applied with a swab to the nares.[1]

CliNiCally ShOwN TO rEDuCE NaSal CarriagE, wiThOuT aNTibiOTiCS

FaST aCTiNg

lONg laSTiNg

brOaD SPECTrum EFFiCaCy

PrOVEN SaFE aND EFFECTiVE

EaSy & PlEaSaNT TO uSE

lOw COST

Perioperative Care

Same Day Decolonization

long lasting Effect

Supports antibiotic Stewardship

NaSal DecoloNizatioN ProDUctS comPariSoN

Nozin® Nasal Sanitizer®

antiseptic

antibiotic prophylactic (mupirocin)

5% povidone-iodine

effective ✔ ✔ ✔

Non-antibiotic ✔ ✘ ✔

Same day use ✔ ✘ ✔compliance assurance ✔ ✘ ✔

easy to use / Pleasant ✔ ✘ ✘

Sustained decolonization ✔ ✘ ✘

all-inclusive: HcW/caregiver use ✔ ✘ ✘

low cost ✔ ✔ ✘

the NoziN aDVaNtage

WHeN USeD iN SUrgery ProtocolS, NoziN caN acHieVe effectiVe DecoloNizatioN with the added advantage of addressing existing concerns over current preventive protocols.

Studies have shown nasal carriage of Staphylococcus aureus to be the most important risk factor for developing surgical site infection (SSi) [4]

of Staphylococcus aureus / MRSA* infections are caused by the patient’s own flora.[2] [3]

%

Nozin® Popswab® applicator is applied topically to the nares

*Methicillin-resistant Staphylococcus aureus (MRSA)

the Nozin role in SSi Prevention

Nozin Nasal Sanitizer antiseptic can help protect patients against the spread of infection, improve the quality of care and reduce facility costs.

99% (median) effectiveness

Does NOT contribute to antibiotic resistance

Follows antibiotic stewardship guidelines

Compliance made easy: pleasant and easy to use

CAN be used in unplanned/emergency surgeries

CAN be used post-op to help prevent infections

CAN be used by healthcare workers and caregivers

Cost-effective – low cost ensures sustainability

NOZIN 360: THE MOST COMPREHENSIVE NASAL DECOLONIZATION PROGRAMHelp prevent infections by safely reducing Staphylococcus aureus nasal carriage in patients and everyone in contact with them: healthcare workers, visitors and at home caregivers.

Remove ampule fromits cardboard sleeve.

Remove1

Swab around nostril 2rim 6X in each direction.

Apply to nostril 2 8

® ®

HOW TO USE POPSWAB® AMPULE

USE ONLY WITH SLEEVE ON AMPULE.Shake well.

Shake4

Crush at dot to pop.Squeeze to wet swab.

Pop, Squeeze5

®

Reinsert ampule intosleeve, swab exposed.

Reinsert3

Squeeze ampule toresaturate swab.

Resaturate7

®

Flip ampule around to expose swab tip.

Flip2

swab tip

sleeve

Swab around nostril 1 rim 6X in each direction.

Apply to nostril 1 6

® ®

Preventing a SINGLE CASEof SSI due to MRSA

can save hospitals aS mUcH aS $60,000 [11]

201in

SSIs are the most common adverse event for surgical patients:

1 in 20 patients undergoing surgery will have an SSI [7]

30%

30% of population carry Staphylococcus aureus

in the nose” [9]

22%

The 1-year mortality rate among patients with MRSA SSI is 22%. [10]

iS tHe leaDiNg caUSe of SUrgical Site iNfectioNS (SSis) [5]

StaPHylococcUS aUreUS /mrSa

Patients carrying MRSA bacteria have an 1 in 5 chance of developing a life-threatening MRSA infection. [8]

51in

Quality of Care

up

Patient Satisfaction

up

infection Control

Costs Down

Surgical site infections are the most common and costly healthcare-associated infections (HAIs) [6]

Clinical practice guidelines recommend intranasal

Staphylococcus aureus decolonization for high-risk procedures,

including orthopedic and cardiothoracic procedures as part

of an effective strategy to prevent SSis (ShEa/iDSa).[12]

Nozin® Nasal Sanitizer®