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NoxiFerm™
NoxiFerm™ -‐ new feed ingredient with interes4ng proper4es in feed for
broilers and pigs By Development Manager Karsten C. Kjeldsen and Product Development Consultant Brian Eskildsen
E-‐mail: [email protected] or [email protected]
Content
1. NoxiFerm™ -‐ a combina4on product – Sodium gluconate and natural flavoring compounds of botanical origin with high content of polyphenols
2. Importance of an4oxidants 3. Trials with NoxiFerm™ 4. Product informa4on and recommended inclusion 5. Conclusion 6. Cost – Benefit analisys of NoxiFerm
NoxiFerm™ – new potent feed ingredient for broilers and pigs
• NoxiFerm™: Natural blends of an4-‐oxidants and sodium gluconate • Together gives interes4ng proper4es in feed for broilers and
other animals • Prebio4c effects: Promotes the produc4on of short chain faVy
acids in broilers and pigs intes4nal tract and increase villus height
• Trial results with broilers show synergis4c effect with significant improved weight gain and FCR. A farm test with pigs indicate a similar effects on produc4on results.
NoxiFerm™ -‐ feed ingredient with interes4ng proper4es
Natural blends of an/-‐oxidants -‐ NoxiGuard™ as part of NoxiFerm™
• NoxiGuard™ is a unique mixture of natural flavoring compounds of botanical origin with high content of polyphenols
• The polyphenols have a very high an4oxidant ac4vity • The ac4ve polyphenols in NoxiGuard™ are more than 3 4mes as potent
an4oxidant as pure synthe4c vitamin E • Introduces a unique combina4on of water and fat soluble an/oxidants
• Important for a broad an4oxidant effect in the animal body • An4oxidant ac4vity is controlled and standardized by analysis
• All-‐round effects due to synergies between the ac4ve elements • NoxiGuard polyphenols are important parts of our NoxiFerm product
NoxiGuard™ -‐ main effects in animals
• The an4oxida4ve effect will be seen by • Immune s4mula4on • Improved health condi4ons • Improved produc4on results • Reduced use of an4oxidant, e.g. Vitamin E and C • Reduced heat stress
• Supports high feed intake during hot environment
§ An4oxidants are natural substances which protect the cells of the body from unstable molecules known as free radicals
§ Free radicals are by-‐products from normal cellular processes
§ An4oxidants interact and stabillize these free radicals
§ The an4oxidants and free radicals must be in balance to avoid oxida4ve stress
What are an4oxidants?
§ An4oxidants neutralize free radicals
§ Elektron dona4on by the an4oxidant
§ Forma4on of complex between oxidizing element
and the an4oxidant
§ Regenerates other an4oxidants
An4oxidants – Modes of ac4on
§ Endogenous § Superoxide dismutase § catalase § glutathionine peroxidase
§ Natural § Vitamin E § Vitamin C § Selenium (not an4oxidant, but co-‐factor to glutathionine peroxidase) § Polyphenols (from herbs, fruit, vegetables)
§ Synthe4c – works in the feed § Ethoxyquin § BHT § BHA
Types of an4oxidants
Nagluferm® -‐ feed material with interes4ng proper4es • Nagluferm® -‐ Sodium gluconate
• Sodium gluconate, sodium salt of d-‐gluconic acids • Gluconic acid is obtained from glucose by fermenta4on
• Gluconate is poorly digested and absorbed in small intes4ne, but fermented subsequently and works as a prebio4c (bypass the small intes4ne) • 70% Gluconic Acid reaches the large intes4ne (Asano et al., 1997)
• Promotes the produc4on of short chain faVy acids which are used as energy source for the animal
• Increases intes4nal villous height and crypt depth • Nagluferm® can accomplish improved produc4on results with
broilers and pigs
Effect of different products on piglet produc4on performance
Control Na-‐gluconate 0.25% MOS 0.3% Formi LHS,
(PDF) 0.8%
Start body weight, kg 11.83 11.97 11.37 11.61
Final body weight, kg 36.72c 38.36a 37.35b 37.53b
Feed intake, kg/day 1.03 1.04 1.03 1.03
Daily weight gain, g/day 590b 630a 620ab 620ab
Feed : Gain, kg/kg 1.75b 1.65a 1.66a 1.67
a b c, significant difference , p>0.05 Source: Poeikhampha et al., 2011 Asian-‐Aust. J. Anim. Science.
Intes4nal villous height and crypt depth
Source: Poeikhampha et al., 2011 Asian-‐Aust. J. Anim. Science. a b, significant difference, P<0.02
0 50
100 150 200 250 300 350 400
Control Na-‐Gluconate 0.25%
MOS 0.3% Formi LHS 0,8%
Measured in jejunum, µm
Villous height Crypt depth
a
a
b b
a a
b
b
Effect on produc4on of ammonia and short chain faVy acids in the caecum of piglets
Control Na-‐gluconate 0.25% MOS 0.3% Formi LHS,
(PDF) 0.8%
Ammonia 2.62a 2.11b 2.27a 2.64a
Lac/c acid 0.51 0.57 0.59 0.52
Ace/c acid 11.43 13.04 11.65 12.57
Propionic acid 15.30 20.96 20.84 20.51
Butyric acid 6.09 9.58 9.18 8.47
Total SCFA 32.82 43.57 * 41.68* 41.55*
Measured in mmol/L a b, significant difference, P<0,05 *) Tending difference, p = 0,09
Source: Poeikhampha et al., 2011 Asian-‐Aust. J. Anim. Science.
Nagluferm® increases SCFA in broilers
Nagluferm®, %
Control 0
0.1
0.2
0.3
0.4
P
Total SCFA, mg/g
9.69b 12.43ab 13.69a 15.40a 15.21a 0.01
Ace/c acid, mg/g
4.80 5.39 5.56 5.78 6.78 0.52
Propionic acid, mg/g
0.53 1.28 1.46 1.46 1.57 0.46
Butyric acid, mg/g
2.57 3.17 3.45 3.66 3.94 0.57
Adapted from a trial at customer from Poland
Different leVers within the same row means significant results at P<0.05
Short-chain fatty acids concentration in broilers caecum (mg/g).
Trial 1: Effect of Nagluferm®, NoxiGuard™ and NoxiFerm™
• Design: 4 treatments with 5 replicates of 12 broilers (total 240 Ross 308 broilers), March 2014 • T1: Control diet • T2: 2500 ppm Nagluferm® • T3: NoxiGuard™ • T4: NoxiFerm™(2500 ppm Nagluferm® + NoxiGuard™)
Trial 1: Effect of Nagluferm®, NoxiGuard™ and Noxiferm™ in feed for broilers (day 21)
Control Nagluferm®
2500 ppm
NoxiGuard™
NoxiFerm™
2500 ppm (Combina4on)
P-‐value
Weight day 21, g 910a 937b 963c 997d <0.001
Average daily weight gain (ADG), g
41.2a 42.8b 43.9c 45.4d <0.001
Index, ADG 100 103.9 106.6 110.2 -‐ Feed : Gain, kg/kg 1.39a 1.36ab 1.31bc 1.27c <0.001
Index, FCR 100 97.8 94.2 91.4 -‐ Values within the same column with no common superscript are significantly different (P≤0,05)
Trial 2: Effect of NoxiFerm™
• Design: 2 treatments with 5 replicates of 12 birds (total 120 broilers), June 2014 • T1: Control diet • T2: T1 + NoxiFerm™ (2000 ppm Nagluferm® + NoxiGuard™)
Trial 2 broilers: Effect of 2000 ppm NoxiFerm™
Day 10 Day 21 Day 35
Control NoxiFerm™ Control NoxiFerm™ Control NoxiFerm™
Weight, g 284 312 912 973 2.113 2.240
ADG, g 24.2 27.0*** 41.2 44.2*** 59.0 63.2***
Index, ADG 100 111.9 100 107.3 100 106.6
Feed : Gain, kg/kg
1.28 1.13*** 1.40 1.30*** 1.64 1.53***
Index, FCR 100 88.4 100 92.9 100 93.3
Level of significance: NS (not significant), * (P≤0,05), ** (P≤0,01), *** (P≤0,001)
NoxiFerm™, farm trial piglets, Denmark
Control NoxiFerm™ 0.25%
Index: NoxiFerm™ /Control
Number of piglets 52 52 -‐
Av. start weight, kg 6.40 6.45 100.7
Av. weight day 21, kg 11.50 12.40 107.8
Av. daily gain, g 241 281 116.7
Av. Daily feed intake, g 285 344 120.7
FU/kg weight gain 1.18 1.22 103.4
Medica/on, no of piglets treated
9 4 44.4
Trial setup: • Control • C+ 0.25% NoxiFerm™ All pigs received feed with 2.500 ppm Zinc Oxide from day 0-‐14
NoxiFerm™ product informa4on
• NoxiFerm™ (patent pending) • Complementary feed • Easy to handle when kept in dry condi4on • No risk of corrosion • Shelf life: 2 years from date of produc4on, when stored in original bags in dry condi4on
• Product available in 1000 kg big bags and in small bags
Recommended inclusion
• Recommended inclusion in feed for broilers • 2 kg per ton of complete feed un4l day 21 • 1-‐2 kg per ton from day 21 un4l slaughter
• Recommended inclusion in feed for pigs: • Piglets <25 kg: 2.5 kg per ton of complete feed • Growers and Finishers: 2.0-‐2.5 kg per ton of complete feed
Conclusion
• Synergies between the ac4ve components in NoxiFerm™ • Polyphenols (NoxiGuard™) • Sodium Gluconate (Nagluferm®)
• Promotes the produc4on of short chain faVy acids which are used as energy source for the animal
• Increases intes4nal villous height and crypt depth • Improved produc4on results on growth rate and FCR
Cost-‐benefit NoxiFerm™
Units
Cost saving: 0.01 improvement in FCR 6.70 EUR/1000 broilers
Price
NoxiFerm™ in feed: 2000 ppm 3.50 EUR/1000 kg. Feed
Recommended inclusion
NoxiFerm™: 2000 ppm, day 0-‐36 12.30 EUR/1000 broilers
NoxiFerm™: 2000 ppm, day 0-‐21 + 1000 ppm day 22-‐36 8.20 EUR/1000 broilers
Price pr. kg. Price pr. kg. (EUR)
Feed* 0.3512
NoxiFerm™ 1.75
* Danish average feed price for broilers, July 2014
Cost-‐benefit NoxiFerm™
Benefit calcula/ons for trial Units
Cost saving: 0.01 improvement in FCR * 6.70 EUR/1000 broilers
FCR R2 Trial results: FCR: 1.64 – 1.53 0.11 FCR improvement
FCR Benefit:
NoxiFerm™: 11 * 6.70 EUR/1000 broiler 73.70 EUR/1000 broilers
Cost NoxiFerm™: 2000 ppm, day 0-‐36 12.30 EUR/1000 broilers
Benefit NoxiFerm – R2 Trial results: 61.40 EUR/1000 broilers
Es4m. benefit NoxiFerm: 0.06 FCR impr. 40.20-‐12.30 27.30 EUR/1000 broiler
Price pr. kg. Price pr. kg. (EUR)
Feed* 0.3512
NoxiFerm™ 1.75
* Danish average feed price for broilers, July 2014
Thank You
