Now available by MAZOR ROBOTICS · Market opportunity: Over 2,500 hospitals in the US alone Business model: Capital ($750K) + disposable ($1,200) + service Sales team: Blue chip sales,

of 281www.MazorRobotics.com

Robotic Spine Surgery?

Ori Hadomi, CEOSeptember 2011

MZOR:TA

Now available byMAZOR ROBOTICS


Forward Looking Statement

Any forecast and/or forecasting statement, included in this presentation, is based on the Management's assessment at its discretion. However, these forecasts and/or statements are based on the Company's expectations at the time of this Presentation and do hold in store a number of uncertainties and risk to consider.

It is important to emphasize that actual results may differ substantially from expectations in these forecasts and/ or forecasting statements, resulting from various factors. The Company does not make any representations regarding the accuracy and achievement of the forecasts and/or forecasting statements.

In addition, forecasts and/or forecasting statements relate to the date of this Presentation only and the Company is not under any obligation to update or correct any of the forecasts and/or forecasting statements to reflect events or circumstances after the date of this Presentation.


Robotic Spine Surgery: Enabling MISThe Renaissance – latest technology generation launched Q3/11

Regulatory status: FDA & CE cleared

User base: Over 30 units in leading clinical sites; over 2,000 live cases

Market opportunity: Over 2,500 hospitals in the US alone

Business model: Capital ($750K) + disposable ($1,200) + service

Sales team: Blue chip sales, Ex ISRG team

Competition: The only FDA cleared robotics technology for spine surgery

ROI for customers: Strategic investment – differentiator10 -15 months (subject to incremental volume)


Mazor Robotics• Corporate Structure

• Global company - 50 employees world wide• Offices: US, Germany & Israel• US team expansion (12 and growing)• YTD financing: $49M; Cash balance : $20M• Publicly traded at TASE (MZOR)

• Mature Technology• Clinical effectiveness proven (>2,000 cases)• 7 CE & FDA cleared products• Strong IP • Over 20 systems in Europe & 6 in USA

• Global Business Plan • Expansion in Europe, Asia and USA• Capital + recurrent revenues business model


Spine (Multi Level) Fixation with Pedicle Screws

The Need For Robotics In Spine Surgery

Misplaced Pedicle screw

Revision

Pedicle Screws Inserted Free-Hand Are Misplaced in 10% of Cases

Pedicle Screw Placement Accuracy: a Meta-AnalysisKosmopoulos V, Schizas C.; Spine 2007 Feb 1;32(3):E111-20


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Misplaced Pedicle screw

Revision


Major medical complications were reported in 5.2% of complex fusion procedures.

Trends, Major Medical Complications, and Charges Associated With Surgery for Lumbar Spinal Stenosis in Older Adults. JAMA April 2010


CT-based 3D Planning Software

• CT-based 3D planning

• Guided instrumentation

• 1 mm accuracy

Computing Workstation

Robotic Guidance Unit


Step 1:Plan

Step 4:Operate

Step 2:Mount

Step 3:3D Sync

Preoperative blueprint of the ideal surgeryis created in a virtual 3D environment

Spine Surgery with


Step 1:Plan

Step 4:Operate

Step 2:Mount

Step 3:3D Sync

Rigid attachment to the patient assures maximum surgical accuracy throughout the procedure

Spine Surgery with


Step 1:Plan

Step 4:Operate

Step 2:Mount

Step 3:3D Sync

Two fluoroscopy images are automatically synchronized with the CT based surgical blueprint (independent of anatomy)

Spine Surgery with


Step 1:Plan

Step 4:Operate

Step 2:Mount

Step 3:3D Sync

Tools and implants are guided to theplanned trajectory with 1 mm accuracy

Spine Surgery with


Clinically validated by surgeons’ experience:• Over 2,000 procedures worldwide• Over 12,000 implants• No cases of permanent

nerve damage

Powered by Mazor Robotics Technology


Complete Solution to the Spine Surgery Market

Procedures• Pedicle screws (Cervical to Sacrum)• Obese patients• Revisions and Osteoporotic bones• Scoliosis & Deformities • Variety of Trajectories:

• Transfacet and translaminar-facet screws

• Sacroiliac screws• Tumor evacuation and removal• Percutaneous Spine stabilization (GO-LIF)

Surgical Approaches• Posterior:

• Open• MIS• Percutaneous


Soon to come to the US: Brain ApplicationApplications• Brain biopsies• DBS placements• Shunt placements

Advantages• Accuracy• Frameless• Surgical speed

Regulatory Status: • CE cleared• Expect FDA clearance by

Q1/12


Mazor Robotics Clinically Validated Technology:Clinical Evidence

98.3% Accuracy of 3,271 implants in 635 cases in 14 medical centerswith 49% of implants placed percutaneousely(typically 10%-20% of spine surgeries are MIS)Devito DP, Kaplan L, Dietl R, et al. Clinical acceptance and accuracy assessment of spinal implants guided with SpineAssist surgical robot: retrospective study. Spine. 2010;35(24):2109-2115.

Compared to freehand surgery, in 112 cases Mazor Robotics-guided surgery significantly:• Improved implant accuracy• Reduced X-ray dosage• Reduced complication rates, re-operations,• and postop opoids• Reduced average length of stayKantelhardt SR, Martinez R, Baerwinkel S, Burger R, GieseA, Rohde V. Perioperative course and accuracy of screwpositioning in conventional, open robotic-guided andpercutaneous robotic-guided, pedicle screw placement.Eur Spine J. 2011;20(6):860-868.


Mazor Robotics Clinically Validated Technology:Clinical Evidence

98.9% Accuracy of 365 implants in 7 medical centersHardenbrook M, Knoller N, Barzilay Y, Zilberstein B,et al. Clinical experience with miniature robot for spinalsurgery: 89 clinical cases. E-Poster presented at 14thInternational Meeting on Advanced Spine Techniques(IMAST); July 2007; Paradise Island, Bahamas.

“…a reliable tool for exact pedicle screw placement”Pechlivanis I, Kiriyanthan G, Engelhardt M, et al.Percutaneous placement of pedicle screws in the lumbar spine using a bone mounted miniature robotic system, first experiences and accuracy of screw placement. Spine. 2009;34(4):392–398.

99.6% Accuracy of 1,815 implants in 120 scoliotic adolescentsDevito DP, Gaskill T, Erikson M, Fernandez M. Robotic based guidance for pedicle screw instrumentation of the scolioticspine. Presented at Pediatric Society of North America (POSNA); May 2011; Montreal, Canada.


Mazor Robotics Systems in Daily Clinical Use Worldwide


Revenue Model

4OperateRenaissance™

Surgical System$759K

Robot disposable$1.2K per procedure

Service agreement$76K per year

Implantable devices$6-8K per procedure


Mazor Robotics Value Proposition Equation

Patient• Safety• Speed of rehabilitation• Risk of complications• Aesthetics• Radiation

PV = Precision Invasiveness

• Surgeon• Patient Value (PV) +

• Ease of use• Prestige• Marketing tool• Cutting edge

technology

= Surgeon Value (SV)

• Hospital Admin• (PV) + (SV) +

• Revenues • Differentiation• Market share• Reputation

= Hospital Value (HV)

MAZOR ROBOTICS OFFERS VALUE TO ALL THE PLAYERS IN THE HEALTHCARE SPECTRUM

PrecisionInvasivenessPatient Value (PV) =


Mazor Robotics Clinically Validated Technology:Surgeon Testimonials

“If you do spine surgery for a living,this will come naturally to you...This is the future of spinal surgery.”--Isador H. Lieberman, MD, MBA, FRCSC, Plano, Texas, USA

“Once I tell my patients about this technology, they all want me to use it in their operations.”--Dale S. Horne, MD, PhD, Cincinnati, Ohio, USA

“The value of preoperative evaluation of the vertebral anatomy in these [scoliotic] pediatric patients cannot be over emphasized and has been an unexpected and enlightening outcome of the detailed analysis provided by the planning software.”--Dennis P. Devito, MD, Atlanta, Georgia, USA

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Hospital Marketing Kit

Adverts PostersBillboards

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In the PipelineProduct Renaissance Brain Surgery Implantable Devices

Intended USE • Advanced platform + 3D Imaging

• Cervical application

• Precise positioning for brain surgery (DBS,biopsy, shunt placement)

• Robotic enabled MIS spine stabilization procedures

Regulatory Status (Forecast)

FDACE

Q2/2011Q2/2011

2012Q1/2011

Emerald: Q2/2011GO-LIF: CE cleared

Launch Plan H2/2011 2012 2012


Mazor On The Runway: Sales Channels

USA– Introduction - H2 2010

– Ramping up sales with clear and validated business plan

– Direct sale headed by Mr. Chris Sells, Ex VP Sales, Intuitive Surgical

– CEO relocated to the USA to support activities


Mazor On The Runway: Sales Channels

• Europe:• Direct Sale:

• Germany, Austria, Switzerland• Started sales in 2008• Over 15 active systems installed• > 800 clinical cases

• Active Distributors since H2/2011• Holland• Russia• Czech Republic• Targeting: Spain, Portugal, GB & France

• Asia:• Korea – Distributor • Targeting: Taiwan, India, Singapore, China,


Summary

• Mature technology with promising new products pipeline

• Proven business model and aggressive sales strategy

• Global company - experienced management team

• Expanding sales in Europe, Asia and the US

• Mazor Robotics Ticker in TASE: MZOR


Thank YouYour questions are welcome

www.MazorRobotics.com

Documents

Now available by MAZOR ROBOTICS · Market opportunity: Over 2,500 hospitals in the US alone Business model: Capital ($750K) + disposable ($1,200) + service Sales team: Blue chip sales,