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November 11, 2015
Moving from the defense industry to the medical instruments industry
Gavriel J. Iddan, D.SC.
FROM THE NOTEBOOKS OF A TROUBLED INVENTOR
EX 2015
&
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I REMEMBER AS A CHILD, THE DOCTOR CARRIED ALL THE INSTRUMENTS IN
A BLACK CASE..……
FEW URINE AND BLOOD TESTS
IMAGING MENT X-RAY
SURGERY WAS RARE AND COMPLICATED
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MEDICAL KNOWHOW AND SURGERY PROGRESED BY MILITARY MEDICINE……
FEW DEVICES AND INSTRUMENTS
LAB TEST BASED ON CHEMISTRY AND SIMPLE MICROSCOPY
MEDICATION WAS LIMITED AND INCLUDED ASPIRIN, SULFA…..
NO REGULATION……
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ENTERS WW 2 AND THE COLD WAR
MILITARY RESEARCH AND SPENDING WENT WILD…….(FEAR, BIG SPENDING, NO ATTENTION TO COST…)
NEW TECHNOLOGIES INVENTED INCLUDING: SEMICONDUCTORS AND ELEC. INSTRIMENTS POLYMERS CERAMICS, METALS….
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COMPLEX MACHINARY - JETS, ROCKETS, SUBMARINES, SATELITES,
COMMUNICATIONS…
ADVANCED MANUFACTURING CNC AND LATELY 3D PRINING
NEW SYSTEMATIC APPROACH TO MANEGEMENT
WORK BY CODES AND REGULATIONS.……
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DEFENSE TECHNOLOGY OF YESTERDAY: MECHANICS, BINOCULAR OPTICS, RADIO AND RADAR ELECTRONICS, CHEMISTRY OF EXPLOSIVES,
THE MAGNIFICENT 7 THAT EVOLVED FROM THEMILITARY/SPACE ACTIVITY:
1. MINIATURIZATION, of electronic circuits and other components
2. MATERIALS, polymers, ceramics and high quality steels titanium and other metals that are bio compatible!
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3. System - interdisciplinary engineering
4. Regulation and standards
5. Computer assisted design and manufacturing
6. Computer assisted management.
7. Robotics
THESE MAGNIFICENT 7 SHAPED OUR MODERN MEDICAL INSTRUMENTS INDUSTRY
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IN ADDITION:
LIFE SCIENCE AND MEDICINE ARE CHANGING FROM EXPERIMENTAL DISCIPLINE INTO A QUANTITATIVE EXACT SCIENCE
IT LEADS TO OUR ABILITY TO USE ENGINEERING APPROACH IN THE DESIGN OF MEDICAL INSRUMENTS.
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SOME EXAMPLES:
1.MEDICAL IMAGING INCORPORATING IMAGE PROCESSING CT, MRI, ULS, OCT – my new initiative….
2. BIOCHEMISTRY (MINIATURE INSULIN PUMPS ) 3. MINIATURIZATION (LAPARASCOPY, PCR, DEFIBRILATION) 4. MATERIALS (TOTAL HIP REPLACEMENT…..)
5. ROBOTICS (DA VINCHI…..)
6. TISSUE ENGINEERING
THE LIST GROWS DAILY…..
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SO, YOU HAVE DECIDED TO BECOME AN INNOVATOR……… TO HAVE A STARTUP………
GOOD LUCK ! YOU ARE GOING TO NEED IT !
Here are some helpful advises
A PHYSICIAN IDENTIFIED A NEED AND THE ENGINEER PROPOSED A SOLUTION
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OR, AS L. PASTEUR SAID:“LUCK FAVERS THE PREPERED MIND”
1 .ALWAYS, but ALWAYS START WITH TRUE MARKET NEED
2 .EXAMINE MANY OPTIONS AND AVOID NIH
3 .CHECK CAREFULEY THE IP SCENE
4 .PREPARE A CONSERVATIVE WORK PLAN BUT, DO NOT OVER DO IT
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1st year 2nd year 3rd yearProject time
launchReady for manufacturing
Current technology (limited knowhow)
Required spec’s
Technology
Tech. Slope, true TEAM knowhow
R/D cost
Tech. gap
competitive edge & strong IP
* Iddan G. J. ・ From the note books of a troubled inventor ・ SPIE Vol. 6083 608301-1 2006
TRUE KNOWHOW REQUIRES INFORMATION ON WHAT’S COOKING IN LAB’S AND OTHER COMPANIES
R/D TRIANGLE
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Always be on watch for a
DISRUPTIVE TECHNOLOGY: *
IF YOU DON’T YOU MAY BE SURPRIZED AND LOSE YOUR PROJECT
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EVOLUTION
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REVOLUTION
HYBRID CARS
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SMART PHONE REVOLUTION
IC CELLULAR
TRANSISTOR
EVOLUTION
REVOLUTION
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MY EXAMPLES
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3DV SYSTEMS
GREAT IDEA.……
GENERATE 3D IMAGES BY SENDING A SHORT LASER LIGHT PULSE “LIGHT WALL” . THE REFLECTED WALL HAS IMPRINT OF THE 3D SCENE.REFLECTD WALL IS CAPTURED BY A CAMERA . BY CHOPING THE WALL, A BW IMAGE IS CREATED WITH THE GRAY LEVEL BEING AN INDICATION OF EACH PIXEL RANGE.
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Laser pulsed illuminator
Light wall
object
Reflected imprinted wall
imager
gate
Gated wall
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BUT……..
NO SPECIFIC MARKETING GOAL EXISTED, AND WE WERE SURE THAT EVERYBODY WILL RCOGNIZE THE BENEFITS……………
OUR FIRT GOAL WAS TO OFFER IT TO TV STUDIOS AS A SMART REPLACEMENT TO CHROMA - KEY
IT WAS NICE BUT THE IMAGES WERE NOT PERFECT NOT GOOD ENOUGH FOR STUDIO
MONEY WAS RUNNING OUT
WE DECIDED TO GO FOR VIDEO GAME……….TOO LATE
THE COMPANY WAS SOLD TO MICROSOFT WITH MINIMAL RETURN TO THE INVESTORS.
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ENDOSCOPIC VIDEO PILL
WHILE TALKING WITH A GASTROENTEROLOGIST
FRIEND I WAS TOLD OF SOME SHORT COMINGS OF
THE ENDOSCOPES AND WAS ENTICED TO FIND A
SOLUTION. THE MARKET NEEDED IT………
R.D.C. HAS BEEN ESTABLISHED BY RUVEN KRUPIK FOR THE PURPOSE OF INVESTING IN “RAFAEL” TECHNOLOGIES.G. MERON WAS HIRED AS THE CEO AND FOUNDED “GIVEN IMAGING”
We transformed the world of GI from science fiction to reality
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November 11, 2015
1st GI Diagnostic Breakthrough in 25 Years
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RigidEndoscopy
1960 1970 1990 20001980
Flexible endoscopy
Capsule endoscopy
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1. Optical dome
2. Lens holder
3. Lens
4. Illuminating LEDs (light emitting diodes)
5. CMOS (Complementary Metal Oxide Semiconductor) imager
6. Batteries
7. ASIC (Application Specific Integrated Circuit) transmitter
8. Antenna
First Generation PillCam SB
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The Given® Diagnostic System
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Ambulatory DataRecorder™ on a belt
RAPID® application for image processing and viewing
M2A® Capsule
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Mouth to Cecum
TeethTeeth EpiglottisEpiglottis
Small IntestineSmall Intestine
Barret’s EsophagusBarret’s Esophagus
Wall of right colonWall of right colonMultiple telangiectasia on a gastric fold
Multiple telangiectasia on a gastric fold
November 11, 2015
Time Line
1981: Gabi Iddan meets Eitan Skapa M.D. and learns about the need to examine the small intestine.
1986: small CCD are available.
1990: small transmitters are available.
1992: The capsule conceptual design born.
1993: experiments begin, CMOS imager appears.
1994: patent application.
1995: ASIC transmitter appears.
1997: Given Imaging incorporated
2001: FDA granted
Technology not available!
20 Ye
ars
10 Ye
ars
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CHANGES ……..
1981 2002 2011
Dr. Gabi Iddan
Prof. Eitan Skapa
First Thoughts on capsule
Enjoying Grandchildren
Working on Solutions
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WHAT SHALL WE DO IN THE AGE OF GLOBALIZATION ?????
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ECONOMY AND INDUSTRY WERE BASED ON ADAM SMITH AND HIS UNSEEN HAND AND THE DEVISION OF LABOR
FOLOWWING WW I JOHN MAYNARD KEYNES INDICATED THE NEED FOR GOVERNMENT INTERVENSION AND REGULATION
TODAY THAT IS NOT ENOUGH ENVIRONMENT, FAR EAST AND REGULATIONS ARE GAME CHANGERS WHICH SHOULD BE DELT WITH WHEN CONCIDERING A NEW PROJECT.
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TRADITIONAL INDUSTRIES HAD TO CLOSE:
IN ISRAEL…ATA TEXTILE, ONE OF THE FLAG SHIPS CLOSED ITS GATES FOLLOWING MORE THAN 50 YEARS OF ACTIVITY
BRITISH HIGH COMMISIONER OF
PALESTINE VISITS “ATA” 1937
BUT, OSEM, ISCAR SUCCEDED BY HAVING FINE INNOVATIVE MANEGEMENTS
SIR ARTHUR WAUCHOPE
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OTHER PLAYERS SUCH ASRAFAEL, ELBIT , AIA AND NETFIM SUCCEDED BY MANEGEMENT SENSING THE CHANGES AND ENTERED NEW FIELDS
THE HIGH TECH REVOLUTION SAVED OUR ECONOMY (AND THE NEW IMMIGRANTS FROM RUSSIA…….)
CHECKPOINT, INTEL AND GIVEN IMAGING TO NAME A FEW, CHANGED THE NATURE OF OUR INDUSTRY
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FACTORS EFFECTING THE NEW DESIGNS(MEDICAL INDUSTRY)
1.TOUGH SAFETY REGULATIONS (FDA…..)
2.HIGH COST OF MEDICAL CARE
3.LOW COST MANUFACTURING IN CHINA, INDIA ETC. EFFECTS THE PRODUCT DESIGN.
4.TOUGH ENVIRONMENTAL LOWS
5.INVESTORS ARE MIXEDUP IN THE COMPANY OPERATION
6.PATENTS ARE CONSUMING FUNDS
7.FUELS ARE EXPENSIVE
8.TERROR IS EFFECTING THE WAY WE WORK
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HOW SHOULD WE SECURE OUR ECONOMICAL FUTURE UNDER THE CHANGING RULES ???
INNOVATION AND QUALITY
HOW CAN WE DO IT???
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HARD WORK……INTERDISSPLINARY EDUCATIONDO NOT BE AFRAID IN CASE OF FAILUREMIND THE ALTERNATIVESBE RESPONSIBLE WITH EXPENSES.
DO NOT GIVE UP WHEN IN TRUBLE
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SOME POSITIVE INDICATIONS:
CSO FUND ARE GREAT FOR STARTUPS
DEMAND FOR NEW TECHNIQUES AND HIGH TECH PRODUCTS IS ON THE RISE
RAPID TECHNOLOGICAL PROGRESS IS PROVIDING NEW POSSIBILITIES
November 11, 2015 38
THANK YOU
