Novel Drug Delivery in Pediatric Medulloblastoma

Group 37 – Arvin Soepriatna (Presenter), Chris Peng, Blessan Sebastian

Client: Mr. Mike Sabo, Pulse Therapeutics, Inc.BME 401, Prof. Anastasio

10/28/2013

NeedMore efficient treatment process regarding

drug delivery with chemotherapeutic agentsCurrently no method to exclusively target

tumorsChemotherapy side effects are serious

Increased drug dosage without side-effectsShorter and more effective treatment time

Specific Design RequirementsParameters Specifications

Imaging Phantom Size < 3x3 ft

Imaging Phantom Weight ≤ 30 lbs

Magnet Device Controller < 3x3 ft

Magnetic Field Strength < 1 T

Localization Duration < 5 min

Imaging Depth < 10 cm

Standard Operation Time < 4 hrs

System Power Inlet Standard 110V

Phantom Designs• Box Obstacle

Course• 3D Styrofoam

Brain Phantom• Blood Vessel

Phantom

Magnetic Control DeviceCartesia

n

Conical Spherical

Advantages and Disadvantages

Imaging Technology AlternativesPositron Emission Tomography (PET)

Measures γ-rays emission from radioactive tracer[1]

Half-life of tracers[2]

13N ~ 20 min. 18F ~ 110 min.

Recent discoveries 64Cu ~ 12.7 hours [3]

Nanoparticle conjugation[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.[2] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.[3] Anderson, Carolyn J., Farrokh Dehdashti, P. Cutler, Sally Schwarz, Richard Laforest. "64Cu-TETA-Octreotide as a Pet Imaging Agent for Patients with Neuroendocrine Tumors." The Journal of Nuclear Medicine 42.2 (2001): 213-21. Print.

Imaging Technology AlternativesSingle Photon Emission Computed

Tomography (SPECT)Similar to PET

γ-rays emission Radioactive tracer

Average half-lives ~6 hours[1]

Difference from PET[2]

Lower resolution High Noise

[1] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.[2] Rahmim, Arman, and Habib Zaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.

Imaging Technology AlternativesDoppler Ultrasound

Measures the time it takes for pulse signals to be returned to the receiver from its generation.[1]

High resolution imagesProblem:

Distortion through thick bones[2]

High signal to noise ratioTranscranial Ultrasound

Suboccipital Window [3][1] Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.[2] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.[3] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.

Imaging Technology AlternativesSpectral Computed Tomography (CT)

Measures X-ray attenuation coefficient Utilizes photon counting detectors [1]

Broad spectrum info from X-ray Lower dosage of X-ray

High Resolution

[1] Persson, Mats. "Reconstruction of Spectral CT Images." Thesis. Royal Institute of Technology, 2011. Reconstruction of Spectral CT Images. 2011. Web. 26 Oct. 2013.

Advantages and Disadvantages

[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.[2] Rahmim, Arman, and Habib Zaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.

Chosen DesignMagnetic Control Device: Conical Movement

Imaging Technology: Transcranial Doppler Ultrasound

PhantomStyrofoam thickness: 3cm

Model skull + brain IV tubing Diameter: 0.5 cm

CSF = 0.7 – 1.0 mPa*s @37o C[1]

Saline = 0.72 mPa*s[2]

Pathway fixturesPlastic hooksThin plastic cable wires

[1] Roselli, Robert J., and Kenneth R. Diller . Biotransport: Principles and Applications. 1st ed. New York: Springer Science Business Media, 2011. p. 139. eBook. [2] Kestin, Joseph, H. Ezzat Khalifa, et al, et al. "Tables of the Dynamic and Kinematic Viscosity of NaCl Solutions." J. Phys. Chem. Ref. Data. 10.1 (1981): 71-89. Web. 27 Oct. 2013.

Conical Magnetic Control DeviceJoint modification of the machine made by

Pulse TherapeuticsMotor specs for joints

300 WattsMotor specs for rotating magnet

Up to 300 RPM

Peak Voltage Output of MagnetVoltage measured using 3D magnetic

transducer probe

Doppler UltrasoundLocation of transducer

Angle of incidenceProperties of transducer

For adults[1]

3-MHz transducersFor pediatric

5-MHz transducers

[1] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.Image source: Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.

Project Timeline

Team OrganizationTeam Member Responsibilities

Chris Peng Webpage, CAD Specialist, MATLAB specialist

Arvin Soepriatna Progress PresentationImaging Research, Experimental

Analysis

Blessan Sebastian Final PresentationDesign Parameters and Safety,

Phantom Development

Thank you for listening!