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University of Hawailsquoi Board of Regents 2444 Dole Street Bachman 209 Honolulu HI 96822 Telephone No (808) 956-8213 Fax No (808) 956-5156
Accommodation required by law for Persons with Disabilities requires at least (5) five days prior notice to the board office at 956-8213 or borhawaiiedu
Notice of Meeting
UNIVERSITY OF HAWAIlsquoI
BOARD OF REGENTS COMMITTEE ON RESEARCH AND INNOVATION Members Regent Eugene Bal (Chair) Regent Stanford Yuen (Vice Chair) and Regents Higa Putnam Shinsato Tagorda and Wilson
Date Wednesday November 1 2017
Time 1230 pm
Place University of Hawaiʻi at Mānoa Information Technology Building 1st Floor Conference Room 105AB 2520 Correa Road Honolulu Hawailsquoi 96822
AGENDA
I Call Meeting to Order
II Approval of Minutes of the September 7 2017 Meeting
III Public Comment Period for Agenda Items All written testimony on agenda itemsreceived after posting of this agenda and up to 24 hours in advance of the meeting willbe distributed to the board Late testimony on agenda items will be distributed to theboard within 24 hours of receipt Written testimony may be submitted via US mailemail at borhawaiiedu or facsimile at 956-5156 Individuals submitting writtentestimony are not automatically signed up for oral testimony Registration for oraltestimony on agenda items will be provided at the meeting location 15 minutes prior tothe meeting and closed once the meeting begins Oral testimony is limited to three (3)minutes All written testimony submitted are public documents Therefore anytestimony that is submitted verbally or in writing electronically or in person for use inthe public meeting process is public information
IV Agenda ItemsA For Information
1 FY18 Q1 Extramural Awards Report2 Update on UH Cancer Center P30 Proposal and Status3 Update on Act 38 (2017) and Act 39 (2017) and proposed
commercialization structure4 Life Cycle of Proposals and Awards
V Adjournment
Office of the Vice President for Research and Innovation
UNIVERSITYof HAWAIrsquoF UN VEtHY
SYSTEM
lsquo17 OCT 24 P2 26 ET 26 11 42
October 25 2017UNIVERSITY OF HNIiPRESIDENTrsquoS OFFICE
MEMORANDUM
TO Eugene Bal III ChairpersonBOR Committee on Research and Innovation
VIA David Lassner
FROM Vassilis L SyrmoVice President for esearch and In nova ion
SUBJECT BOR COMMITTEE ON RESEARCH AND INNOVATION AGENDAMATERIALS FOR NOVEMBER 2017 MEETING
Please find attached the following materials that will be discussed at the November 12017 BOR Committee on Research and Innovation meeting
A For Information
1 FY18 Qi Extramural Awards Analysis (VPRI presentation)
a FY18 QJ Research and Innovation Metrics Summary
b FY18 Monthly Report of Extramural Awards (as of September 30 2017)
c FY17 Q4 Extramural Awards Analysis Report
2 UH Cancer Center Annual Report to the BOR mdash Update on UH Cancer CenterP30 Proposal amp Status (UH Cancer Center Director presentation)
3 Update on Act 38 and Act 39 proposed commercialization structure (VPRIpresentation)
4 Life Cycle of Proposals amp Awards (VPRI presentation)
Attachments
2444 Dole Street Bachman HallHonolulu Hawairsquoi 96822
Telephone (808) 956-5006 bull Fax (808) 956-5286
An Equal OpportunityAffirmative Action Institution
FY18 Q1 Extramural Awards Analysis
BOR Research amp Innovation Committee Meeting November 1 2017
Overview
bull FY18 Q1 Recap bull Significant Awards by Campus bull Award Amounts by Location bull Q1 Analysis
2
FY18 Q1 Recap
bull FY18 Q1 total is $164 million 96 less than FY17 Q1 ($182 million)
bull 2nd underperforming quarter in a row might be a cause for
concern
3
4
Quarterly Extramural Awards $ millions
2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
FY18 Q1 Significant Awards by Campus
5
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-
Based Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
FY18 Q1 Award Amounts by Location ($ millions)
6
Campus
2015
2016
2017
2018
2018-17 Change
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Q115 Q116 Q117 Q118 2018-17 Change
Award Count 621 600 657 682 38
Major Changes by Location
bull Maui College (+$58m) ndash Two new awards from National Science Foundation (NSF) totaling
$17 million ndash Incremental funding for NSF award totaling $2 million (no increment
in FY 17) ndash Supplemental funding for Hawailsquoi Department of Human Services
totaling $18 million (Received in Q2 as opposed to Q1 in FY 17 ndash timing)
7
Major Changes by Location (cont)
bull UH System (-$31m) ndash Office of the VP for Academic Planning amp Policy FY17 Q1 ndash $5 million
Kamehameha Schools award FY18 Q1 ndash No award of comparable size ndash Applied Research Laboratory FY18 Q1 ndash Two new Department of
Defense awards totaling $19 million
8
Major Changes by Location (cont)
bull UH Mānoa (-$171m) ndash Federal award decreases in
bull HHS - Department of Health and Human Services (-$128m) ndash Primarily affecting School of Medicine and UH Cancer Center
bull ED - Department of Education (-$28m) ndash Primarily affecting College of Education
bull NSF - National Science Foundation (-$29m) ndash Various units
9
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Office of the Vice President for Research and Innovation
UNIVERSITYof HAWAIrsquoF UN VEtHY
SYSTEM
lsquo17 OCT 24 P2 26 ET 26 11 42
October 25 2017UNIVERSITY OF HNIiPRESIDENTrsquoS OFFICE
MEMORANDUM
TO Eugene Bal III ChairpersonBOR Committee on Research and Innovation
VIA David Lassner
FROM Vassilis L SyrmoVice President for esearch and In nova ion
SUBJECT BOR COMMITTEE ON RESEARCH AND INNOVATION AGENDAMATERIALS FOR NOVEMBER 2017 MEETING
Please find attached the following materials that will be discussed at the November 12017 BOR Committee on Research and Innovation meeting
A For Information
1 FY18 Qi Extramural Awards Analysis (VPRI presentation)
a FY18 QJ Research and Innovation Metrics Summary
b FY18 Monthly Report of Extramural Awards (as of September 30 2017)
c FY17 Q4 Extramural Awards Analysis Report
2 UH Cancer Center Annual Report to the BOR mdash Update on UH Cancer CenterP30 Proposal amp Status (UH Cancer Center Director presentation)
3 Update on Act 38 and Act 39 proposed commercialization structure (VPRIpresentation)
4 Life Cycle of Proposals amp Awards (VPRI presentation)
Attachments
2444 Dole Street Bachman HallHonolulu Hawairsquoi 96822
Telephone (808) 956-5006 bull Fax (808) 956-5286
An Equal OpportunityAffirmative Action Institution
FY18 Q1 Extramural Awards Analysis
BOR Research amp Innovation Committee Meeting November 1 2017
Overview
bull FY18 Q1 Recap bull Significant Awards by Campus bull Award Amounts by Location bull Q1 Analysis
2
FY18 Q1 Recap
bull FY18 Q1 total is $164 million 96 less than FY17 Q1 ($182 million)
bull 2nd underperforming quarter in a row might be a cause for
concern
3
4
Quarterly Extramural Awards $ millions
2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
FY18 Q1 Significant Awards by Campus
5
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-
Based Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
FY18 Q1 Award Amounts by Location ($ millions)
6
Campus
2015
2016
2017
2018
2018-17 Change
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Q115 Q116 Q117 Q118 2018-17 Change
Award Count 621 600 657 682 38
Major Changes by Location
bull Maui College (+$58m) ndash Two new awards from National Science Foundation (NSF) totaling
$17 million ndash Incremental funding for NSF award totaling $2 million (no increment
in FY 17) ndash Supplemental funding for Hawailsquoi Department of Human Services
totaling $18 million (Received in Q2 as opposed to Q1 in FY 17 ndash timing)
7
Major Changes by Location (cont)
bull UH System (-$31m) ndash Office of the VP for Academic Planning amp Policy FY17 Q1 ndash $5 million
Kamehameha Schools award FY18 Q1 ndash No award of comparable size ndash Applied Research Laboratory FY18 Q1 ndash Two new Department of
Defense awards totaling $19 million
8
Major Changes by Location (cont)
bull UH Mānoa (-$171m) ndash Federal award decreases in
bull HHS - Department of Health and Human Services (-$128m) ndash Primarily affecting School of Medicine and UH Cancer Center
bull ED - Department of Education (-$28m) ndash Primarily affecting College of Education
bull NSF - National Science Foundation (-$29m) ndash Various units
9
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
FY18 Q1 Extramural Awards Analysis
BOR Research amp Innovation Committee Meeting November 1 2017
Overview
bull FY18 Q1 Recap bull Significant Awards by Campus bull Award Amounts by Location bull Q1 Analysis
2
FY18 Q1 Recap
bull FY18 Q1 total is $164 million 96 less than FY17 Q1 ($182 million)
bull 2nd underperforming quarter in a row might be a cause for
concern
3
4
Quarterly Extramural Awards $ millions
2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
FY18 Q1 Significant Awards by Campus
5
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-
Based Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
FY18 Q1 Award Amounts by Location ($ millions)
6
Campus
2015
2016
2017
2018
2018-17 Change
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Q115 Q116 Q117 Q118 2018-17 Change
Award Count 621 600 657 682 38
Major Changes by Location
bull Maui College (+$58m) ndash Two new awards from National Science Foundation (NSF) totaling
$17 million ndash Incremental funding for NSF award totaling $2 million (no increment
in FY 17) ndash Supplemental funding for Hawailsquoi Department of Human Services
totaling $18 million (Received in Q2 as opposed to Q1 in FY 17 ndash timing)
7
Major Changes by Location (cont)
bull UH System (-$31m) ndash Office of the VP for Academic Planning amp Policy FY17 Q1 ndash $5 million
Kamehameha Schools award FY18 Q1 ndash No award of comparable size ndash Applied Research Laboratory FY18 Q1 ndash Two new Department of
Defense awards totaling $19 million
8
Major Changes by Location (cont)
bull UH Mānoa (-$171m) ndash Federal award decreases in
bull HHS - Department of Health and Human Services (-$128m) ndash Primarily affecting School of Medicine and UH Cancer Center
bull ED - Department of Education (-$28m) ndash Primarily affecting College of Education
bull NSF - National Science Foundation (-$29m) ndash Various units
9
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Overview
bull FY18 Q1 Recap bull Significant Awards by Campus bull Award Amounts by Location bull Q1 Analysis
2
FY18 Q1 Recap
bull FY18 Q1 total is $164 million 96 less than FY17 Q1 ($182 million)
bull 2nd underperforming quarter in a row might be a cause for
concern
3
4
Quarterly Extramural Awards $ millions
2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
FY18 Q1 Significant Awards by Campus
5
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-
Based Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
FY18 Q1 Award Amounts by Location ($ millions)
6
Campus
2015
2016
2017
2018
2018-17 Change
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Q115 Q116 Q117 Q118 2018-17 Change
Award Count 621 600 657 682 38
Major Changes by Location
bull Maui College (+$58m) ndash Two new awards from National Science Foundation (NSF) totaling
$17 million ndash Incremental funding for NSF award totaling $2 million (no increment
in FY 17) ndash Supplemental funding for Hawailsquoi Department of Human Services
totaling $18 million (Received in Q2 as opposed to Q1 in FY 17 ndash timing)
7
Major Changes by Location (cont)
bull UH System (-$31m) ndash Office of the VP for Academic Planning amp Policy FY17 Q1 ndash $5 million
Kamehameha Schools award FY18 Q1 ndash No award of comparable size ndash Applied Research Laboratory FY18 Q1 ndash Two new Department of
Defense awards totaling $19 million
8
Major Changes by Location (cont)
bull UH Mānoa (-$171m) ndash Federal award decreases in
bull HHS - Department of Health and Human Services (-$128m) ndash Primarily affecting School of Medicine and UH Cancer Center
bull ED - Department of Education (-$28m) ndash Primarily affecting College of Education
bull NSF - National Science Foundation (-$29m) ndash Various units
9
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
FY18 Q1 Recap
bull FY18 Q1 total is $164 million 96 less than FY17 Q1 ($182 million)
bull 2nd underperforming quarter in a row might be a cause for
concern
3
4
Quarterly Extramural Awards $ millions
2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
FY18 Q1 Significant Awards by Campus
5
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-
Based Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
FY18 Q1 Award Amounts by Location ($ millions)
6
Campus
2015
2016
2017
2018
2018-17 Change
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Q115 Q116 Q117 Q118 2018-17 Change
Award Count 621 600 657 682 38
Major Changes by Location
bull Maui College (+$58m) ndash Two new awards from National Science Foundation (NSF) totaling
$17 million ndash Incremental funding for NSF award totaling $2 million (no increment
in FY 17) ndash Supplemental funding for Hawailsquoi Department of Human Services
totaling $18 million (Received in Q2 as opposed to Q1 in FY 17 ndash timing)
7
Major Changes by Location (cont)
bull UH System (-$31m) ndash Office of the VP for Academic Planning amp Policy FY17 Q1 ndash $5 million
Kamehameha Schools award FY18 Q1 ndash No award of comparable size ndash Applied Research Laboratory FY18 Q1 ndash Two new Department of
Defense awards totaling $19 million
8
Major Changes by Location (cont)
bull UH Mānoa (-$171m) ndash Federal award decreases in
bull HHS - Department of Health and Human Services (-$128m) ndash Primarily affecting School of Medicine and UH Cancer Center
bull ED - Department of Education (-$28m) ndash Primarily affecting College of Education
bull NSF - National Science Foundation (-$29m) ndash Various units
9
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
4
Quarterly Extramural Awards $ millions
2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
FY18 Q1 Significant Awards by Campus
5
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-
Based Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
FY18 Q1 Award Amounts by Location ($ millions)
6
Campus
2015
2016
2017
2018
2018-17 Change
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Q115 Q116 Q117 Q118 2018-17 Change
Award Count 621 600 657 682 38
Major Changes by Location
bull Maui College (+$58m) ndash Two new awards from National Science Foundation (NSF) totaling
$17 million ndash Incremental funding for NSF award totaling $2 million (no increment
in FY 17) ndash Supplemental funding for Hawailsquoi Department of Human Services
totaling $18 million (Received in Q2 as opposed to Q1 in FY 17 ndash timing)
7
Major Changes by Location (cont)
bull UH System (-$31m) ndash Office of the VP for Academic Planning amp Policy FY17 Q1 ndash $5 million
Kamehameha Schools award FY18 Q1 ndash No award of comparable size ndash Applied Research Laboratory FY18 Q1 ndash Two new Department of
Defense awards totaling $19 million
8
Major Changes by Location (cont)
bull UH Mānoa (-$171m) ndash Federal award decreases in
bull HHS - Department of Health and Human Services (-$128m) ndash Primarily affecting School of Medicine and UH Cancer Center
bull ED - Department of Education (-$28m) ndash Primarily affecting College of Education
bull NSF - National Science Foundation (-$29m) ndash Various units
9
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
FY18 Q1 Significant Awards by Campus
5
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-
Based Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
FY18 Q1 Award Amounts by Location ($ millions)
6
Campus
2015
2016
2017
2018
2018-17 Change
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Q115 Q116 Q117 Q118 2018-17 Change
Award Count 621 600 657 682 38
Major Changes by Location
bull Maui College (+$58m) ndash Two new awards from National Science Foundation (NSF) totaling
$17 million ndash Incremental funding for NSF award totaling $2 million (no increment
in FY 17) ndash Supplemental funding for Hawailsquoi Department of Human Services
totaling $18 million (Received in Q2 as opposed to Q1 in FY 17 ndash timing)
7
Major Changes by Location (cont)
bull UH System (-$31m) ndash Office of the VP for Academic Planning amp Policy FY17 Q1 ndash $5 million
Kamehameha Schools award FY18 Q1 ndash No award of comparable size ndash Applied Research Laboratory FY18 Q1 ndash Two new Department of
Defense awards totaling $19 million
8
Major Changes by Location (cont)
bull UH Mānoa (-$171m) ndash Federal award decreases in
bull HHS - Department of Health and Human Services (-$128m) ndash Primarily affecting School of Medicine and UH Cancer Center
bull ED - Department of Education (-$28m) ndash Primarily affecting College of Education
bull NSF - National Science Foundation (-$29m) ndash Various units
9
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
FY18 Q1 Award Amounts by Location ($ millions)
6
Campus
2015
2016
2017
2018
2018-17 Change
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Q115 Q116 Q117 Q118 2018-17 Change
Award Count 621 600 657 682 38
Major Changes by Location
bull Maui College (+$58m) ndash Two new awards from National Science Foundation (NSF) totaling
$17 million ndash Incremental funding for NSF award totaling $2 million (no increment
in FY 17) ndash Supplemental funding for Hawailsquoi Department of Human Services
totaling $18 million (Received in Q2 as opposed to Q1 in FY 17 ndash timing)
7
Major Changes by Location (cont)
bull UH System (-$31m) ndash Office of the VP for Academic Planning amp Policy FY17 Q1 ndash $5 million
Kamehameha Schools award FY18 Q1 ndash No award of comparable size ndash Applied Research Laboratory FY18 Q1 ndash Two new Department of
Defense awards totaling $19 million
8
Major Changes by Location (cont)
bull UH Mānoa (-$171m) ndash Federal award decreases in
bull HHS - Department of Health and Human Services (-$128m) ndash Primarily affecting School of Medicine and UH Cancer Center
bull ED - Department of Education (-$28m) ndash Primarily affecting College of Education
bull NSF - National Science Foundation (-$29m) ndash Various units
9
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Major Changes by Location
bull Maui College (+$58m) ndash Two new awards from National Science Foundation (NSF) totaling
$17 million ndash Incremental funding for NSF award totaling $2 million (no increment
in FY 17) ndash Supplemental funding for Hawailsquoi Department of Human Services
totaling $18 million (Received in Q2 as opposed to Q1 in FY 17 ndash timing)
7
Major Changes by Location (cont)
bull UH System (-$31m) ndash Office of the VP for Academic Planning amp Policy FY17 Q1 ndash $5 million
Kamehameha Schools award FY18 Q1 ndash No award of comparable size ndash Applied Research Laboratory FY18 Q1 ndash Two new Department of
Defense awards totaling $19 million
8
Major Changes by Location (cont)
bull UH Mānoa (-$171m) ndash Federal award decreases in
bull HHS - Department of Health and Human Services (-$128m) ndash Primarily affecting School of Medicine and UH Cancer Center
bull ED - Department of Education (-$28m) ndash Primarily affecting College of Education
bull NSF - National Science Foundation (-$29m) ndash Various units
9
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Major Changes by Location (cont)
bull UH System (-$31m) ndash Office of the VP for Academic Planning amp Policy FY17 Q1 ndash $5 million
Kamehameha Schools award FY18 Q1 ndash No award of comparable size ndash Applied Research Laboratory FY18 Q1 ndash Two new Department of
Defense awards totaling $19 million
8
Major Changes by Location (cont)
bull UH Mānoa (-$171m) ndash Federal award decreases in
bull HHS - Department of Health and Human Services (-$128m) ndash Primarily affecting School of Medicine and UH Cancer Center
bull ED - Department of Education (-$28m) ndash Primarily affecting College of Education
bull NSF - National Science Foundation (-$29m) ndash Various units
9
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Major Changes by Location (cont)
bull UH Mānoa (-$171m) ndash Federal award decreases in
bull HHS - Department of Health and Human Services (-$128m) ndash Primarily affecting School of Medicine and UH Cancer Center
bull ED - Department of Education (-$28m) ndash Primarily affecting College of Education
bull NSF - National Science Foundation (-$29m) ndash Various units
9
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Major Changes by Location (cont)
bull UH Mānoa ndash Non-federal award decreases
bull Hawailsquoi ndash Health Organizations (-$116m) ndash Primarily affecting School of Medicine (usually receive majority of these awards in Q1 -
timing)
10
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
FY Q1 Analysis
bull Expected seasonal increase in FY18 Q1 federal awards did not occur ndash For example UH Mānoa had declines in three of top five federal
sponsors (HHS ED and NSF)
bull In some cases possible that timing of incremental funding is
affecting comparability on a quarter-by-quarter basis ndash Whether overall FY 18 results will improve remains to be seen
11
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Extramural Sponsor Awards Quarterly Summary
Jul 1 - Sep 30 2017 Jul 1 - Sep 30 2016
Program Type Count Amount Count Amount
Research 383 $ 82212163 372 $ 84332181
Non-Research 299 $ 84469597 285 $ 97312322
Total 682 $166681760 657 $181644503
Note The detailed award listing is available at
httpwwworshawaiieduindexphpbor-reports
The FY 2017 year-to-date total was $181805711 The unofficial FY 2018 year-to-date total is 682 awards totaling $164493372
1
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Contracts and Grants Awards As of Quarter One ndash FY 2018
Qua
rter
ly
Cum
ulat
ive
2
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Contracts and Grants Expenditures As of Quarter One ndash FY 2018
3
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Contracts and Grants FampA Recovery As of Quarter One ndash FY 2018
4
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
OTT Research amp Innovation Metrics FY 2018 ndash First Quarter Summary
FY 2018 FY 2017
Metric 7117 ndash 93017 7116 ndash 93016
Invention Disclosures 8 10
US Provisional Patents Filed 6 6
US Non-Provisional Patents Filed 8 5
US Non-Provisional Patents Issued 0 1
License Agreements 3 2
Royalty Revenue $724682 1324007
5
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Invention Disclosures As of Quarter One ndash FY 2018
10
8
52
0
10
20
30
40
50
60
Q1 Q2 Q3 Q40
2
4
6
8
10
12
14
16
18
Qua
rterly
Inventions Disclosed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
6
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
US Provisional Patents Filed As of Quarter One ndash FY 2018
6 6
35
0
5
10
15
20
25
30
35
40
0
2
4
6
8
10
12
14
Q1 Q2 Q3 Q4
Qua
rterly
US Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
7
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
US Non-Provisional Patents Filed As of Quarter One ndash FY 2018
5
816
0
2
4
6
8
10
12
14
16
18
0
1
2
3
4
5
6
7
8
9
Q1 Q2 Q3 Q4
Axi
s Ti
tle
US Non-Provisional Patents Filed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
8
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
US Non-Provisional Patents Issued As of Quarter One ndash FY 2018
1
8
0
1
2
3
4
5
6
7
8
9
0
05
1
15
2
25
3
35
Q1 Q2 Q3 Q4
Qu
arte
rly
US Non-Provisional Patents Issued
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
9
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
LicenseOption Agreements As of Quarter One ndash FY 2018
2
3
12
0
2
4
6
8
10
12
14
0
1
2
3
4
5
6
Q1 Q2 Q3 Q4
Qua
rterly
LicenseOption Agreements Executed
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
10
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Royalty RevenueAs of Quarter One ndash FY 2018
1324007 724682
28875204
-
50000
100000
150000
200000
250000
300000
350000
-
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Q1 Q2 Q3 Q4
Qu
arte
rly
Royalty Revenue
FY 2017 Quarterly FY 2018 Quarterly FY 2017 Cumulative
11
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
FY 2018 Monthly Report of Awards to Date as of September 30 2017Summary By Campus
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708Honolulu Community College 5 2167392 4 951167 (1216225) -561Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Windward Community College 16 6543739 12 5866248 (677491) -104Subtotal Community Colleges and UH Maui College 54 22940943 54 24574030 1633087 71University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44University of Hawaii System 26 16859149 24 15627721 (1231428) -73Grand Total 657 181644503 682 166681760 (14962743) -82
FY 2018 Monthly Report of Awards to Date as of September 30 2017Campus Details
Campus Award Count Award Amount Award Count Award Amount $ Change ChangeHawaii Community College 1 44800 3 434919 390119 8708
Chancellor Hawaii Community College 1 44800 3 434919 390119 8708 Academic Affairs (Hawaii CC) - - 2 384919 384919 1000
Office of Continuing Education amp Training - - 1 50000 50000 1000UH Center at West Hawaii 1 44800 - - (44800) -1000
Honolulu Community College 5 2167392 4 951167 (1216225) -561Chancellor Honolulu Community College 5 2167392 4 951167 (1216225) -561
Academic Affairs (Honolulu CC) 1 486303 1 576039 89736 185Chancellor Honolulu Community College 1 237198 2 325128 87930 371Natural Sciences 2 1318891 - - (1318891) -1000Pacific Center for Advanced Technology Training 1 125000 - - (125000) -1000University College - - 1 50000 50000 1000
Kapiolani Community College 9 4715884 9 3705770 (1010114) -214Chancellor Kapiolani Community College 9 4715884 9 3705770 (1010114) -214
Academic Affairs (KCC) 1 494973 - - (494973) -1000Arts and Sciences Academic Program 1 999997 - - (999997) -1000Chancellor Kapiolani Community College 2 2716971 3 2841211 124240 46Continuing Education Non-Credit Program 1 64749 - - (64749) -1000Culinary Arts (KCC) 1 14994 2 132756 117762 7854Emergency Medical Services 1 149480 1 149480 - 00Emergency Medical Technician - - 1 240000 240000 1000Office for Institutional Effectiveness - - 1 2000 2000 1000Office of International Affairs 1 1037 - - (1037) -1000Student Support Services 1 273683 1 340323 66640 243
Kauai Community College 6 1976851 3 877867 (1098984) -556Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556
Chancellor Kauai Community College 6 1976851 3 877867 (1098984) -556Leeward Community College 6 3612346 4 3007777 (604569) -167
Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167Chancellor Leeward Community College 6 3612346 4 3007777 (604569) -167
University of Hawaii at Hilo 45 6089502 65 7486410 1396908 229Chancellor UH Hilo 2 851640 4 1683215 831575 976
Chancellor UH Hilo 2 851640 4 1683215 831575 976College of Agriculture Forestry and Natural Resource Mgt 6 875262 7 526513 (348749) -398
College of Agriculture Forestry and Natural Resource Mgt 4 831057 4 255454 (575603) -693Pacific Aquaculture and Coastal Resources Ctr 2 44205 3 271059 226854 5132
College of Arts and Sciences 10 1735713 12 1214878 (520835) -300Anthropology (UH Hilo) 1 3260 - - (3260) -1000Biology (UH Hilo) 2 150000 3 240527 90527 604College of Arts and Sciences 1 275000 1 300000 25000 91Geography (UH Hilo) 1 12534 1 165000 152466 12164Marine Science - - 1 24373 24373 1000Mathematics (UH Hilo) - - 1 7000 7000 1000Natural Sciences Division 5 1294919 3 282466 (1012453) -782Physics and Astronomy - - 1 95512 95512 1000Social Sciences Division - - 1 100000 100000 1000
College of Continuing Education and Community Svc - - 1 7750 7750 1000College of Continuing Education and Community Svc - - 1 7750 7750 1000
College of Pharmacy 5 437217 5 123660 (313557) -717College of Pharmacy 2 34770 2 36260 1490 43Pharmaceutical Sciences 2 387922 2 47400 (340522) -878Pharmacy Practice 1 14525 1 40000 25475 1754
Hawaii Small Business Development Center 2 87050 - - (87050) -1000Hawaii Small Business Development Center 2 87050 - - (87050) -1000
Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473Imiloa Astronomy Center Of Hawaii 2 118553 4 174645 56092 473
Ka HakaUla O KeElikolani-UHH 2 364140 3 1574437 1210297 3324Hale Kuamoo Center - - 1 634437 634437 1000Ka HakaUla O KeElikolani-UHH 2 364140 2 940000 575860 1581
Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000Vice Chancellor for Administrative Affairs - - 1 2250 2250 1000
Vice Chancellor for Research 11 544944 19 1131322 586378 1076
FY 2017 FY 2018
FY 2017 FY 2018
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Vice Chancellor for Research 11 544944 19 1131322 586378 1076Vice Chancellor for Student Affairs 5 1074983 9 1047740 (27243) -25
Center For Gifted And Talented Native Hawaiian Children - - 1 44800 44800 1000Upward Bound 3 772500 - - (772500) -1000Vice Chancellor for Student Affairs 2 302483 8 1002940 700457 2316
University of Hawaii at Manoa 522 130373737 528 113846555 (16527182) -127College of Arts and Humanities 4 286063 8 330325 44262 155 American Studies - - 2 104618 104618 1000
History (UH Manoa) - - 1 52777 52777 1000Music (UH Manoa) - - 1 5930 5930 1000Philosophy (UH Manoa) 1 255818 1 150000 (105818) -414Theatre and Dance 2 8245 - - (8245) -1000UHM Uehiro Academy for Philosophy and Ethics in Education 1 22000 3 17000 (5000) -227
College of Education 23 7102610 18 4240380 (2862230) -403Center on Disability StudiesUniversity Affiliated Pgms 15 5085052 9 2506372 (2578680) -507College of Education 1 68134 2 265000 196866 2889Curriculum Research and Development Group 4 1410818 2 330103 (1080715) -766Department of Kinesiology and Rehabilitation Science 2 305510 2 230500 (75010) -246Department of Special Education 1 233096 2 498074 264978 1137Institute for Teacher Education - - 1 410331 410331 1000
College of Engineering 14 1524463 12 1882869 358406 235Civil and Environmental Engineering 3 102239 7 1000709 898470 8788College of Engineering 1 494802 2 749160 254358 514Electrical Engineering 7 608373 - - (608373) -1000Mechanical Engineering 3 319049 3 133000 (186049) -583
College of Language Linguistics and Literature 12 1246133 16 1361084 114951 92Center for Language and Technology 2 4170 2 16339 12169 2918College of Language Linguistics and Literature 1 174700 1 174700 - 00Department of East Asian Languages and Literature 3 888392 3 917073 28681 32Department of English - - 3 6200 6200 1000Department of Linguistics 6 178871 6 246260 67389 377Dept of Languages and Literatures of Europe and the Americas - - 1 512 512 1000
College of Natural Sciences 79 7191634 73 7062436 (129198) -18Department of Biology (Biology Program) 5 110476 5 739495 629019 5694Department of Botany 54 4951402 50 5090767 139365 28Department of Chemistry 2 236505 4 260028 23523 99Department of Mathematics 3 565355 3 286345 (279010) -494Department of Microbiology - - 1 540 540 1000Department of Physics and Astronomy 10 875899 7 494915 (380984) -435Information and Computer Sciences 5 451997 3 190346 (261651) -579
College of Social Sciences 23 7576977 30 8770104 1193127 157Department of Anthropology 2 71949 1 226267 154318 2145Economics (UH Manoa) 1 46072 5 242905 196833 4272Geography (UH Manoa) 2 142178 4 247210 105032 739Psychology (UH Manoa) 4 827582 3 1082845 255263 308School of Communications 2 36167 1 5000 (31167) -862Social Science Research Institute 10 1450529 13 1803877 353348 244Social Sciences Public Policy Center 1 2500 - - (2500) -1000Urban and Regional Planning 1 5000000 3 5162000 162000 32
College of Tropical Agriculture and Human Resources 40 4474105 49 5711889 1237784 277Center on the Family 3 329750 2 230000 (99750) -303College of Tropical Agriculture and Human Resources 2 66907 6 703867 636960 9520Cooperative Extension - - 3 716464 716464 1000Family and Consumer Sciences 3 212122 2 130647 (81475) -384Hawaii County 2 31140 3 471608 440468 14145Human Nutrition Food and Animal Sciences 4 267797 3 87439 (180358) -673Maui County 2 83347 2 153197 69850 838Molecular Biosciences and Bioengineering - - 1 75000 75000 1000Natural Resources and Environmental Mgt 7 437752 4 176275 (261477) -597Oahu County 1 100000 1 23496 (76504) -765Office of The Assoc Dean for Academic and Student Affairs - - 1 124630 124630 1000Plant and Environmental Protection Sciences 13 2782526 18 2729091 (53435) -19Tropical Plant and Soil Science 3 162764 3 90175 (72589) -446
Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141Hawaiinuiakea School of Hawaiian Knowledge 4 1905279 3 2173074 267795 141
Institute for Astronomy 18 6394192 14 7256200 862008 135Institute for Astronomy 18 6394192 14 7256200 862008 135
John A Burns School of Medicine 80 33578908 58 13792197 (19786711) -589Department of Anatomy Biochemistry and Physiology 1 319398 1 77000 (242398) -759Department of Cell and Molecular Biology 3 3208889 2 2350280 (858609) -268Department of Complementary and Alternative Medicine 5 2257892 8 2419581 161689 72Department of Family Medicine and Community Health 3 1090000 3 2050100 960100 881Department of Geriatric Medicine 4 1884265 1 38275 (1845990) -980Department of Medicine 18 4288337 9 720025 (3568312) -832Department of Native Hawaiian Health 4 430445 3 376312 (54133) -126Department of Obstetrics Gynecology and Womens Health 9 4589243 6 578374 (4010869) -874Department of Pediatrics 9 4255760 4 780989 (3474771) -816Department of Psychiatry 3 3220006 1 56331 (3163675) -983Department of Surgery 9 1940386 - - (1940386) -1000Department of Tropical Medicine Medical Micro and Pharm 8 3194603 13 1955921 (1238682) -388Institute for Biogenesis Research 2 2197975 - - (2197975) -1000John A Burns School of Medicine 1 19204 6 1710009 1690805 88044Native Hawaiian Center of Excellence 1 682505 1 679000 (3505) -05
Lyon Arboretum 3 154194 1 13000 (141194) -916
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Lyon Arboretum 3 154194 1 13000 (141194) -916Office of Research Compliance - - 1 49900 49900 1000
Animal and Veterinary Services Program - - 1 49900 49900 1000Outreach College 2 3700 4 35750 32050 8662
Community Programs 2 3700 3 7750 4050 1095Outreach College - - 1 28000 28000 1000
School of Architecture 1 146146 1 150175 4029 28School of Architecture 1 146146 1 150175 4029 28
School of Nursing and Dental Hygiene 2 931975 7 1411017 479042 514Department of Nursing 2 931975 5 1324566 392591 421School of Nursing and Dental Hygiene - - 2 86451 86451 1000
School of Ocean and Earth Science and Technology 156 33831515 161 42728583 8897068 263Center for Microbial Oceanography Research and Edu (C-MORE) 2 1229934 7 3831803 2601869 2115Department of Atmospheric Sciences 4 2961949 1 75174 (2886775) -975Department of Geology and Geophysics 8 1096473 6 490472 (606001) -553Department of Ocean and Resources Engineering 1 493000 4 466280 (26720) -54Department of Oceanography 18 5241733 19 3200810 (2040923) -389Hawaii Institute of Geophysics and Planetology (HIGP) 35 3699777 32 4146370 446593 121Hawaii Institute of Marine Biology (HIMB) 12 933030 15 2045252 1112222 1192Hawaii Natural Energy Institute (HNEI) 2 343792 5 2438997 2095205 6094International Pacific Research Center (IPRC) 4 499639 5 1338162 838523 1678Joint Institute for Marine and Atmospheric Research (JIMAR) 50 14321426 46 19167255 4845829 338Pacific Biosciences Research Center 5 357273 5 287414 (69859) -196School of Ocean and Earth Science and Technology 4 1322000 4 3219375 1897375 1435Sea Grant College Program 11 1331489 12 2021219 689730 518
School of Pacific and Asian Studies 3 687250 7 1576250 889000 1294Center for Japanese Studies 1 219850 2 571350 351500 1599Center for Korean Studies - - 1 20000 20000 1000Center for Pacific Islands Studies 1 228000 2 405000 177000 776Center for Southeast Asian Studies 1 239400 2 579900 340500 1422
School of Social Work 9 1049935 10 1916044 866109 825Center on Aging 1 14983 1 86231 71248 4755Dept of Public Health Sciences and Epidemiology 2 44488 2 144018 99530 2237Office of Public Health Studies 3 934820 6 1619765 684945 733School of Social Work 3 55644 1 66030 10386 187
Shidler College of Business 1 210000 - - (210000) 1000Department of Management and Industrial Relations 1 210000 - - (210000) -1000
University of Hawaii Cancer Center 26 17463289 26 6259247 (11204042) -642Cancer Etiology 13 8707637 9 1281094 (7426543) -853Clinical Sciences 5 6583740 9 1704424 (4879316) -741Natural Products 4 428402 2 316921 (111481) -260University of Hawaii Cancer Center 4 1743510 6 2956808 1213298 696
Vice Chancellor Academic Affairs 1 47419 7 1173822 1126403 23754Graduate Education - - 1 695000 695000 1000Library (UH Manoa) 1 47419 4 52081 4662 98Service Learning - - 1 22886 22886 1000Undergraduate Education - - 1 403855 403855 1000
Vice Chancellor Admin Finance and Operations 1 4807 - - (4807) -1000Buildings amp Grounds Management 1 4807 - - (4807) -1000
Vice Chancellor Students 10 4215318 7 1506192 (2709126) -643Health amp Wellness - - 1 25000 25000 1000Student Equity Excel amp Diversity 9 4140318 6 1481192 (2659126) -642Womens Center 1 75000 - - (75000) -1000
Water Resources Research Center 3 99302 5 3451718 3352416 33760Water Resources Research Center 3 99302 5 3451718 3352416 33760
William S Richardson School of Law 7 248523 10 994299 745776 3001William S Richardson School of Law 7 248523 10 994299 745776 3001
University of Hawaii at West Oahu 10 5381172 11 5147044 (234128) -44Chancellor UH West Oahu 10 5381172 11 5147044 (234128) -44
Chancellor UH West Oahu 3 2119104 3 2059769 (59335) -28Division of Social Sciences 2 231326 4 714553 483227 2089General Business Administration 1 424088 - - (424088) -1000General Public Administration 1 328000 - - (328000) -1000Vice Chancellor for Student Affairs 3 2278654 4 2372722 94068 41
University of Hawaii Maui College 11 3879931 19 9730282 5850351 1508Chancellor UH Maui College 11 3879931 19 9730282 5850351 1508
Academic Affairs (UH Maui College) - - 1 2000000 2000000 1000Allied Health Department - - 1 1100 1100 1000Chancellor UH Maui College 2 1139764 13 4285067 3145303 2760Culinary Arts (UH Maui College) 1 45000 - - (45000) -1000General Education 1 800000 1 800000 - 00Human Services (UH Maui College) - - 1 1883888 1883888 1000Music (UH Maui College) 1 500000 1 500000 - 00Non-Credit Programs (UH Maui College) 1 20000 - - (20000) -1000Student Affairs (UH Maui College) 4 1341034 1 260227 (1080807) -806University of Hawaii Center Maui 1 34133 - - (34133) -1000
University of Hawaii System 26 16859149 24 15627721 (1231428) -73Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699
Office of the Vice President for Community Colleges 1 182847 2 1224959 1042112 5699Office of the Vice President for Research and Innovation 8 796326 7 2854065 2057739 2584
Applied Research Laboratory 7 776326 7 2854065 2077739 2676Office of the Vice President for Research and Innovation 1 20000 - - (20000) -1000
Office of the VP for Academic Planning and Policy 5 7232728 7 3336450 (3896278) -539Hawaii P-20 Partnerships for Education Office 1 23750 6 3236450 3212700 135272
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Office of the VP for Academic Planning and Policy 4 7208978 1 100000 (7108978) -986Office of the VP for Information TechChief Info Officer 11 8642248 8 8212247 (430001) -50
Maui High Performance Computing Center (MHPCC) 4 2700991 - - (2700991) -1000Office of the VP for Information TechChief Info Officer 2 157459 3 1955560 1798101 11419Pacific Disaster Center 5 5783798 5 6256687 472889 82
VP For Administration 1 5000 - - (5000) -1000VP For Administration 1 5000 - - (5000) -1000
Windward Community College 16 6543739 12 5866248 (677491) -104Chancellor Windward Community College 16 6543739 12 5866248 (677491) -104
Academic Affairs (Windward CC) 1 49975 - - (49975) -1000Chancellor Windward Community College 15 6493764 12 5866248 (627516) -97
Grand Total 657 181644503 682 166681760 (14962743) -82
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
1
FY18 Q1 Extramural Awards Report
I Summary The University of Hawailsquoi (UH) extramural awards for the first quarter of FY 18 amounted to $164 million which was short of FY17 Q1 by around $18 million (96) and short of the FY18 Q1 forecast by around $11 million (63) A second underperforming quarter in a row gives one pause as the University enters Q2 which is historically one of its slower growth quarters
II Quarterly Performance Metrics
Awards for FY18 Q1 were short around $18 million (96) of FY17 Q1 The performance was on par with FY14 Q1 and FY16 Q1 in which both fiscal years ended better than FY 17 despite FY 17rsquos promising start As the second underperforming quarter in a row this is a solemn reminder that Q2 is usually one of the Universityrsquos slower growth quarters which brings about uncertainties Hopefully resolution of possible timing issues with some larger awards will lead to a rally similar to FY14 Q2
Quarterly Extramural Awards
$ millions 2011 2012 2013 2014 2015 2016 2017 2018
Q1 252 203 178 167 191 166 182 164 Q2 79 48 75 75 77 57 59 -- Q3 69 45 57 56 53 66 67 -- Q4 90 140 100 96 105 102 79 -- FY 489 436 410 393 426 391 387 164
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
2
III Significant Awards by Campus
During FY18 Q1 UH received 682 awards from 217 different sponsors The following table reports the largest awards received this quarter by campus
Campus Sponsor Type Sponsor Project Title Amount
Mānoa
Federal
Department of Homeland
Security National Disaster Preparedness
Training Center 5000000
Hilo Federal Department of
Education UH Hilo and HawCC Cooperative
Arrangement Development Grant 830715
West Olsquoahu Federal Department of
Education UH West Oahu PIKO Po o Ike Kino
and Ohana Project 2000000
Hawailsquoi CC Business and
Other Kamehameha
Schools UH West Hawaii Kulike Success
Through College Readiness 229878
Honolulu CC Federal Department of
Education
Hoala hou - Renewing a Pathway to Student Success Through Culture-Based
Learning 576039
Kapilsquoolani CC Federal Department of
Education
Strengthening Kapiolanirsquos Campus and Culture for Student Success Kauhale Ke Kuleana the Responsibility of the
Whole Village 1970810
Kaualsquoi CC Federal Department of
Education Crossing Cultures 831167
Leeward CC Federal Department of
Education Paa Ke Kahua Strengthening Our
Foundation 1998368
Maui College Federal National Science
Foundation
Akeakamai I Ka La Hiki Ola Scientific Exploration Beneath The Life-Bringing
Sun (NSF ATST Mitigation Plan) 2000000
Windward CC Federal Department of
Education
Hanaiaulu Feed and Grow Nurturing Student Parents and STEM at
Windward Community College through Renovation 1989018
UH System1 Federal Department of
Defense Managing Partner of Pacific Disaster
Center 3621979
These projects were also identified as UH Mānoa UH West Olsquoahu Kapilsquoolani Community College Kaualsquoi Community College Leeward Community College and Windward Community Collegersquos largest awards in FY17 Q1 as well In fact the vast majority of the projects on this table are continuations of prior awards While this reflects steady revenue the lack of large new projects continues to affect overall results
IV Award Trends by Campus
The gains and losses for non-UH Mānoa campuses generally offset each other Thus the award trend analysis will be limited to the large dollar increases or decreases on the UH Mānoa and UH Maui College campuses and at the UH System level
1 UH System represents units under Vice Presidents that receive extramural funding Examples include the P20 and Gear Up grants under the VP for Academic Affairs Maui High Performance Computing Center and Pacific Disaster Center contracts under the VP for Information Technology Applied Research Laboratory task orders under the VP for Research and Innovation and the Pacific Business Center Program under the VP for Community Colleges
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
3
Q1 Award Amounts by Location $ millions
Campus
2015
2016
2017
2018
2018-17 Change2
Mānoa 138 122 130 112 -132 Hilo 11 7 6 7 250 West Olsquoahu 3 5 5 5 -52 Hawailsquoi CC 2 0 0 0 8708 Honolulu CC 0 2 2 1 -558 Kapilsquoolani CC 3 3 5 4 214 Kaualsquoi CC 1 1 2 1 -556 Leeward CC 3 3 4 3 -167 Maui College 6 7 4 10 1495 Windward CC 4 4 6 6 -104 UH System 21 10 18 15 -173 TOTAL 191 166 182 164 -96
Major dollar increases and decreases are attributed as follows UH Mānoa ndash Federal Awards Of the Universityrsquos top five (5) federal agencies UH Mānoa had FY18 Q1 decreases in 1) the Department of Health and Human Services (HHS) which includes the National Institutes of Health (NIH) and National Cancer Institute (NCI) 2) the Department of Education (ED) and 3) the National Science Foundation (NSF)
Agency
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
HHS 397m 303m 301m 173m -128m-424 ED 81m 112m 104m 75m -28m-272 NSF 150m 162m 119m 89m -29m-248
Department of Health and Human Services (HHS) The majority of the FY18 Q1 decrease in HHS awards is attributable to the John A Burns School
of Medicine and the UH Cancer Center
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
School of Medicine 186m 145m 180m 89m -83m-482 UH Cancer Center 151m 127m 107m 49m -58m-543
bull John A Burns School of Medicine Unlike FY17 Q1 which had twelve (12) awards over
$500000 (total $142 million) FY18 Q1 had seven (7) awards over $500000 (total $67 million) Eight (8) of the twelve (12) awards in FY17 Q1 (totaling $85 million) were incremental funding
2 The percent change over the prior year is calculated using the actual figures not the rounded figures
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
4
bull UH Cancer Center Unlike FY17 Q1 which had five (5) awards over $500000 (total $91 million) FY18 Q1 had three (3) awards over $500000 (total $36 million) Four (4) of the five (5) awards in FY17 Q1 (totaling $85 million) were incremental funding
bull In our FY17 Q4 report we noted that the School of Medicine and UH Cancer Center actually experienced increases across FY 15 to FY 17 There is a possibility that timing of incremental funding will affect their overall FY 18 results
Department of Education (ED) The majority of the FY18 Q1 decrease in ED awards is attributable to the College of Education
Unit
Q115
Q116
Q117
Q118
Q117 to Q118 Decrease
College of Education 36m 33m 40m 17m -24m-588
Compared to FY17 Q1 which had seven (7) awards over $500000 (totaling $59 million) FY18 Q1 had one (1) award for $547000 Three (3) of the seven (7) awards in FY17 Q1 (totaling $26 million) were increments Timing issues may also affect FY 18 results
UH Mānoa ndash Non-Federal Awards Compared to FY16 Q1 and FY17 Q1 the School of Medicine received a significant amount less in salary and fringe (SampF) reimbursement agreements from Hawailsquoi health organizations There are approximately $5 million in pending agreements in Q2 which means that timing issues are affecting quarterly results
SampF Reimb Agreements Q116 Q117 Q118 Dollar amount $109m $131m $824K of fiscal year total 932 996 TBD
UH Maui College Four (4) awards accounted for the nearly $6 million increase in FY18 Q1 compared to FY17 Q1
bull $2 million in incremental funding for the NSF ldquoATST Mitigation Planrdquo Note that no increments were received in FY 17 but two (2) increments totaling $4 million were received in FY 16
bull $18 million in supplemental funding for the Hawailsquoi Department of Human Services ldquoHawailsquoi Child Welfare Continuous Quality Improvement Projectrdquo Note that in FY 17 the supplement was received in Q2 as opposed to Q1 Thus the increase is due to timing of the award in FY 18
bull Two (2) new awards from the NSF 1) ldquoCSP4Hawaii Deployment of Computer Science Principles Courses within Secondary
Schools in Hawailsquoirdquo totaling $999239
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
5
2) and ldquoCollaborative Research Examining the Impact of an Industry-aligned STEM Problem Based Learning Curriculum on Native Hawaiian and Underrepresented Youth Workforce Developmentrdquo totaling $720763
UH System
bull Unlike FY17 Q1 where the Office of the Vice President for Academic Planning and Policy benefited from the $5 million Kamehameha Schools award there was no award of comparable size in FY18 Q1
bull Two (2) new awards at the Applied Research Laboratory (ARL) offset UH System level decreases 1) ldquoInfraRed Celestial Reference Frame Observations Using the United Kingdom
InfraRed Telescope (UKIRT)rdquo totaling $700000 2) and ldquoResearch and Development for DoD Vanguard Center of High Performance
Computingrdquo for $12 million
V Forecast vs Actuals
The FY18 Q1 results were approximately $11 million short (63) of the forecasted amount Like FY17 Q4 where the seasonal state and local government increases did not occur the seasonal federal government increase failed to materialize in FY18 Q1 (federal FY17 Q4) which affected results Continued uncertainty in the federal budget may mean that federal sponsors have remained cautious in granting awards even though the amounts available on paper have increased over the past two (2) federal fiscal years Nevertheless the FY 18 forecast will remain at $408 million
FY 2018 Forecast Actual Variance Q1 175 164 -63 Q2 74 mdash TBD Q3 57 mdash TBD Q4 102 mdash TBD
Total 408 164
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
UNIVERSITY OF HAWAIlsquoI CANCER CENTER ANNUAL REPORT FOR THE BOR
Randall F Holcombe MD MBA November 1 2017
Accelerating cures through cancer research in Hawailsquoi
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
The mission of the University of Hawailsquoi Cancer Center is to reduce the burden of cancer through research education patient care and community outreach with an emphasis on the unique ethnic cultural and environmental characteristics of Hawailsquoi and the Pacific
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Grant funding by UH Cancer Center members
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Funding success rate
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
UH Cancer Center and Education bull Summer Internship
program bull Graduate student
education bull Educating local science
teachers bull SOCRA training for CRAs bull Training grants
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
UH Cancer Center and Community Outreach
bull Community events ndash 14 over past year focused specifically on the community
bull Seminars ndash Over 160 this past year many open to the public
bull State Cancer Plan ndash Involvement with development of plan in conjunction with the
DOH
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Partnerships and Collaborations Hawailsquoi Cancer Consortium Trans-Pacific Partnership for
Cancer Prevention
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Public Relations bull 100 news articles in print broadcast or
electronic media over this past year
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Faculty recognitions
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Faculty | Recognition | Year | |||
Gertraud Maskarinec | Fulbright Global Awardee | 2017-2018 | |||
Jeffrey Berenberg | Mastership for Extraordinary Service from the American College of Physicians and election to the Alliance for Clinical Trials Oncology Board of Directors | 2017 | |||
Carl-Wilhelm Vogel | Overseas fellow of the Royal Society of Medicine London | 2016 | |||
Jeffrey Berenberg | NCORP Health Care Disparities Working Group | 2016-present | |||
Jared Acoba | NCI Gastrointestinal Cancer Steering Committee | 2016-present | |||
Randall Holcombe | Chair Physicianrsquos Clinical Leadership Initiative Association of American Cancer Institutes | 2015-2018 | |||
Loiumlc Le Marchand | Thomson Reuters ldquoWorldrsquos Most Influential Scientific Mindsrdquo | 2015 2016 |
Clinical trials for patients with cancer or at risk for cancer bull 2336 patients enrolled onto trials in 2016
ndash 354 treatment trials ndash 177 other interventional trials ndash 1805 observational trials
bull High proportion of racial and ethnic minority accrual ndash Includes specific studies focused on Native Hawaiians who
experience significant cancer health disparities
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Operating budget projected to balance in FY2018
(800000000)
(700000000)
(600000000)
(500000000)
(400000000)
(300000000)
(200000000)
(100000000)
-
100000000
UH Cancer Center Operating Margin
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Future opportunities bull Retain NCI designation bull Clinical trials initiatives bull Build out of UH Cancer Center Annex bull Institute for Ethnic Diversity and Cancer Health Disparities bull Faculty recruitment
ndash Microbiome and cancer ndash Cancer Imaging ndash Cancer prevention ndash Cancer Immunology
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
UniversityofHawailsquoiCancerCenter
AnnualReport
BoardofRegentsResearchampInnovationCommitteeRandallFHolcombeMDMBA
November12017
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
EXECUTIVESUMMARYThisreportsummarizessomeofthemostimportantactivitiesinitiativesandaccomplishmentsoftheUHCancerCenterfromOctober12016throughOctober12017
bull UHCancerCenterfocusesonitsmissiono CancerCenterfacultyhaveworkedcollaborativelyoverthepastyeartoachieveitsmission
toreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreach
bull SuccessofUHCancerCentermembersinobtainingextramuralfundingo ThegrantsportfolioofUHCancerCentermembershasincreasedoverthepast5yearswith
$41millionintotalextramuralfundsin2016Theamountgrantfundingforproposalssubmittedin2017isa20increaseover2016ThesuccessrateforgrantfundingbyUHCancerCentermembersisnearlydoublethenationalaverage
bull CancerCenterinvolvementineducationo UHCancerCentercontinuestobeinvolvedingraduatestudenteducationsummerresearch
internshipsandamyriadofotherinstructionalandtrainingactivitiesbull Communityoutreachandengagement
o UHCancerCentermembersarecommittedtocommunityeducationaboutcancerandoutreachactivitiesfocusedoncancerpreventionscreeningdetectionandtreatment
bull Partnershipso WithreengagementofHawailsquoiCancerConsortium(HCC)partnersandeffortstofocusHCC
activitiesontheclinicalresearchinfrastructuretheHCChasagreedtoextendthetermoftheaffiliationanadditionalyearto2019UHCancerCenterhasalsoestablishedanewTrans-PacificPartnershipforCancerPreventiontopromotecancerpreventionandcontrolresearchacrossthePacific
bull Publicrelationso Extensivelocalprintbroadcastandon-linemediacoverageofUHCancerCenteroverthe
pastyearhasbeen100positivebull Facultyrecognitions
o NumerousUHCancerCenterfacultyhavereceivednationalandinternationalrecognitionsoverthepastyear
bull Clinicaltrialsforcancerpatientso UHCancerCenterprovidesaclinicaltrialsinfrastructurefacilitatingaccessforover23ofthe
cancerpatientsintheStatewithoversightoftrialsatQueensMedicalSystemHPHhospitalsKuakiniHealthSystemandnumerousprivatepracticesitesonOlsquoahuUHCancerCenterhasaspecificfocustoprovidetrialsrelevanttoNativeHawaiiansandotherracialandethnicgroupswithcancerhealthdisparities
bull Facultyrecruitmentso SeveralnewfacultyhavebeenrecruitedoverthepastyearinsupportoftheCancerCenter
missionsincludingtwoacademiccliniciansbull UHCancerCenterwillhaveabalancedoperatingbudgetin2018
o TheCancerCenterisveryappreciativeofthecurrentUHMānoaleadershipthathasrecognizedan8yearhistoryofinsufficientgeneralfundssupporttotheCancerCenterincomparisontootherresearchandacademicunitsandhasprovidedresourcestopartiallycorrectthisinequityThisincombinationwithsupportfromtheGovernorwhorecognizedthesubstantialreductionofStatefundingthathasarisenbecauseofreducedcigarettetaxrevenuesandwithimprovedinternalfiscalmanagementUHCancerCenterhaserasedanoperatingdeficitthatwasover$7millioninFY2016
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
UHCancerCenterFocusesonitsMissionThemissionoftheUniversityofHawailsquoiCancerCenteristoreducetheburdenofcancerthroughresearcheducationpatientcareandcommunityoutreachwithanemphasisontheuniqueethnicculturalandenvironmentalcharacteristicsofHawailsquoiandthePacificThepastyearhasbeenexemplifiedbytheCancerCenterfacultyworkingcollaborativelytowardachievingthismissionthroughthefollowinggoals
1 Supportbasicandtranslationalcancer-focusedresearchthatcontributestoabiologicalunderstandingofcanceramongdiverseracialandethnicgroupsharnessestheopportunitiesfordiscoveryfromnaturalproductspresentwithintheuniqueenvironmentofourcatchmentareaandtranslateinnovationstothebenefitofindividualswithorathighriskforcancer
2 Supportpopulation-basedresearchthatenhancesanunderstandingoftheoccurrenceandoutcomesofcanceramongdiverseracialandethnicgroupsidentifiesapproachestomeaningfullyintervenetoreducetheburdenofcancerwithinthecatchmentareaaddresscancerhealthdisparitiessuchasthosefoundamongNativeHawaiiansandinformsthepublicandpolicymakersregardingcancerriskandprevention
3 Supportaninfrastructuretotranslatediscoverytoclinicalandpublichealthpracticefacilitateaccesstonovelcancerclinicalpreventionandcommunitytrialsandengagethemedicalcommunityandthecommunityatlargeinordertoadvancethescienceandpracticeofcancerriskassessmentcancerpreventioncancertreatmentandcancerhealthcaredelivery
ExtraordinaryprogresstowardachievingthesegoalshasbeenmadeoverthepastyearThisprogresswasdocumentedintheCancerCenterSupportGrant(P30)applicationtotheNationalCancerInstitutesubmittedSeptember252017
SeminalAdvancesinCancerResearchNumerousseminaladvancesweremadethispastyearbyCancerCenterinvestigatorsManyreceivednationalrecognitionTheseinclude
bull CarboneYangndashUnusuallyhighMesotheliomarateinyoungwomeninChina(JAMAOncology)bull CarboneYangndashBAP1asmechanismforasbestosandsunexposure(UV)relatedcancers(Nature)bull CasselndashNoKeOlaPonoaNāKāneprojectforcoloncancerscreeningamongHawaiianmenbull GarmirendashSinglecellcancerbioinformatics(FrontiersinGenetics)bull HernandezPaulinondashBetelnutandoralmicrobiomeinPacificIslanders(PLOSOne)bull JiandashMetabolomicsandfructoseutilizationinAML(CancerCell)bull MatterShvetsovMaskarinecndashNativeHawaiianshavetwo-foldhighermortalityfromcancer
associatedsepsis(PLOSOne)bull ParkBousheyWilkensLeMarchandndashhighqualitydietandcolorectalcanceracrossethnically
diversepopulations(Gastroenterology)bull RamosndashRSKinhibitorforbraintumortreatment(Oncotarget)bull RosserndashNovelbladdercancerassay(JTranslationalMedicine)bull TurksonndashStat3inhibitorforcancertreatment(LeukemiaLymphoma)[compoundderivedfrom
ironweedfoundonHawailsquoiIsland]bull WilkensLeMarchandndashCYP2A6polymorphismsandlungcancer(CancerResearch)bull WillsndasheCigarettespromotelateruseofcombustiblecigarettes(JAMAPediatrics)
EstablishmentofNewCapabilitiesinGenomicSequencingAcollaborationwithJABSOMwasformalizedcreatingaKakalsquoakocampusGenomicsandBioinformaticsSharedResource(GBSR)TheGBSRoffersstate-of-the-artgenomicsequencingwiththeadditionofanIllumina500NextGenSequencerSystemThenewstructurewillimproveefficienciesandprovideenhancedsupportforresearchersacrosstheUHsystem
NewCapabilitiesinMetabolomicsOverthepastseveralyearsUHCancerCenterinvestedindevelopmentofaMetabolomicsSharedResource(MeSR)whichisnowestablishedasoneofthepremierfacilitiesintheUSforthistypeofresearchLedbyDr
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
WeiJiathisfacilityoffersuniquesupportforinvestigatorsinvolvedinresearchonmetabolicconditionsnutritionobesityandcancerThisprovidesresearchersacrossUHaccesstocuttingedgecapabilitiesinthisburgeoningfield
Peer-ReviewedResearchPublicationsOverthepastyearthe69UHCancerCentermemberspublished242peer-reviewedmanuscriptsAveryselectedlistingofsomeofthemostimportantpaperspublishedoverthepastyearisincluded(AppendixI)CancerCenterGrantsPortfolioUHCancerCentermembersgenerateasubstantialamountofextramuralfundingandthetotalfundingreceivedhasbeenincreasingIn2012totalextramuralfundingforCancerCentermemberswasslightlyover$27millionIn2016thishadincreasedto$41million2017hasseenanearly20increaseinthenumberofgrantssubmittedforfundingconsiderationAsofOctober62017totalfundingsubmittedin2017is$175millionwith$36millionalreadyawardedand$135millionpendingadecisionfromthefundingagencyGrantsubmissionandfundinginformationisshownintheFigurebelow
ThesuccessrateforfundingbyUHCancerCentermembershassubstantiallyexceededthesuccessrateforallgrantssubmittedtotheNationalCancerInstitutenationallyforeveryyearsince2012ThisdemonstratesthehighqualityofproposalsbeingsubmittedbyCancerCentermembersandtheexcellenceoftheresearchattheUHCancerCenterasmeasuredbyobjectivenationalcriteriaNotethatthehighsuccessratein2012
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
includesARRAfundingwhichisnotreflectedintheNCIbaserateforthatyear
CancerCenterInvolvementinEducationandInstructionUHCancerCentermembersareactiveinresearchtrainingandteachingThisincludesmentoringstudentsonresearchprojectsteachingclassesatUHMānoaandservingasthesisadvisorandcommitteememberonmasterrsquosanddoctoralcommitteesThemajorityofUHCancerCentermembershaveaffiliationswithdepartmentsandgraduateprogramsthroughouttheUHMānoacampusincludingCellandMolecularBiology(JABSOM)MolecularBiosciencesandBioengineeringInstituteforBiogenesisResearch(JABSOM)ChemistryPublicHealthStudiesHumanNutritionPsychologyandSocialWorkInadditiontosupportfromgrantsforresearcheducationUHCChasadirectcommitmenttoeducationandcareerenhancementthatincludesfundingoftwofirstyeargraduatestudentsintheCancerBiologyandinPopulationSciencesinthePacificprogramsInadditionUHCCprovidesfundsfortheSummerInternshipProgramfromtheMeijiFoundation($20000peryear)andtheFriendsoftheUHCancerCenter($18000peryear)tosupport9-10studentsperyearFinallyoverthepast2yearsUHCChassponsoredmorethan117healthrelatedconferencesforresearchersandanadditional27outreacheventsforthegeneralpublictoincreaseawarenessofcancerpreventiondetectionadtreatment
SummerInternshipProgramTheprimaryhighschoolandundergraduateeducationalactivityatUHCCisthepopularSummerInternshipProgramwhichtrains25studentseveryyearatUHCancerCenterSupportforthisProgramhascomefromtheCancerCenterP30CUREsupplementwhichbeganin2004agrantfromtheMeijiFoundation(since2002)FriendsoftheUHCancerCenter(since2017)andUHCancerCenterinstitutionalfundsInternssponsoredbytheP30CUREsupplementarehighschoolorundergraduatestudentstheinternssponsoredbytheMeijiFoundationandUHCCfundsareundergraduatestudentsTheinternscomefromlocalhighschoolsorfromcollegesinHawailsquoiandtheUSmainlandFrom2012-2017UHCCprovidedcancerresearchtrainingexperiencesto135highschoolandundergraduatestudents Onaveragenearly60ofallparticipantsoftheInternshipProgramandalltraineessponsoredbytheCUREprogramcomefromethnicgroupswhoareunderrepresentedinresearchorarefromdisadvantagedbackgroundsFrom2004-2016theparticipatingstudentssponsoredbytheCureProgramwerecomprisedof48Filipinos40NativeHawaiianPacificIslanders7firstgenerationcollege5Hispanicand1AfricanAmerican
GraduateStudentEducationAround30CancerCentermemberswithaprimaryappointmentatUHCancerCenterparticipateinresearchtrainingandteachingactivitiesTheseincludementoringofpost-doctoralfellowsandmedicalstudentsdirectionofcancer-focusedjournalclubseriesforgraduatestudentsandconductingaclinicaltrialseducationseriesprimarilytargetedtowardmedicalstudents
EducatingLocalScienceTeachersInDecember2016aworkshopwithinterestedhighschoolteacherswasheldtocollectideasonhowUHCCcouldsupportscienceeducationinhighschoolsduringthenextfiveyearsTheparticipantsgeneratedseveralideasforwaysUHCCcanengageourcatchmenthighschoolsidentifiedcurrentissueslimitingsuchengagementandbrainstormedhowtoassistteachersindesigningcurricularelatedtocancerresearchIdeasincludedprovidingteachersasummerresearchexperiencethatwasconstructedtoaidcurriculumdesignengagingcounselorsandstudentfamiliesintheprocesstohelpbuildasupportiveandbetter-informedcommunityaroundtheHighSchoolstudentsdoingresearchprojectsandcoordinatingwiththeschoolstodefinetimeblocksforstudentstodoresearchintheafternoonsSomeoftheseideaswereincorporatedintothenewR25YESapplication(seebelow)
SOCRATrainingforClinicalResearchAssociatesTheUHCCClinicalTrialsOfficerecentlyledtheestablishmentofaHawailsquoichapterofTheSocietyofClinicalResearchAssociates(SOCRA)SOCRAmaintainsanInternationalCertificationProgramtocreateaninternationally-acceptedstandardofknowledgeeducationandexperiencebywhichanyclinicalresearch
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
professionalscanberecognizedasCertifiedClinicalResearchProfessionalsintheclinicalresearchcommunityThestandardsuponwhichthiscertificationprogramisbasedhavebeensetforthbythisorganizationtopromoterecognitionandcontinuingexcellenceintheethicalconductofclinicaltrialsPriortotheUHCC-ledSOCRAchapterinHawailsquoitherewasnoformaltrainingandcertificationprogramforclinicalresearchassociatesintheState
TrainingGrantsUHCChasbeensuccessfulinobtainingextramuralfundingforeducationandtrainingThesegrantsarelistedintheTablebelowInadditiontwotraininggrantproposalsarecurrentlysubmittedforfundingconsiderationndashanR25grantentitledldquoYouthEnjoyScience(YES)ResearchEducationProgramandaT32traininggrantinEpidemiologyBotharesubmittedtotheNCIandarecurrentlyunderreview
CancerCenterCommunityOutreachActivitiesTheUHCancerCenterhostscommunityoutreacheventsthroughouttheyearTheseeventsareopentothegeneralpublicandareessentialtoourmissiontoinformthepeopleofHawailsquoiabouttheverylatestcancerbreakthroughsandthelatestonhowtopreventandtreatcancerhereThisincludesinformationonnewclinicaltrialsAlistingofsomeofthemajoreventsappearsintheTablebelow
CommunityOutreachEvents(October2016-September2017)
Date EventTitle DescriptionofActivityEvent ofAttendees
November22016
ProstateCancerSymposium Communityeducationevent 60
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
November42016
JourneyTogetherHelpingtoShapeCancerSurvivorshipCareinHawaii
ObjectivesforthisconferenceinKonaare1)Identifygapsampneedsforcancersurvivorsaftertreatmentandbeyond2)Identifycurrentstatewideandinstituteorganizationspecificcancersurvivorshipresourceswiththegoalofteachingandsharingwhathasbeensuccessfuland3)Identifywaystoimprovecommunicationbetweencancersurvivorscaregiversandhealthcareprofessionals
100
November122016
HSCOClinicalTrialsParticipationAwards
RecognitionofcommunityprovidersparticipatinginUHCCclinicaltrials
100
December142016
HawaiiComprehensiveCancerCoalitionMoonshotSummit2016
ThegoalofthesummitistounderstandhowourstatewillbeimpactedthroughpolicysystemandenvironmentalapproachesandwhatwecandotoimplementtheMoonshotvisionThisannualCoalitionmeetingwillunveilStateCancerPlan2016-2020(seeAppendixII)
80
May192017NoKeOlaPonooNaKane2017ReporttotheCommunity
AnnualupdateontheprogressoftheNoKaOlaPonooNaKane(forthegoodhealthofNativeHawaiianmen)project
80
June32017 HEROAppreciationEventRecognitionofpatientswhohaveparticipatedinclinicaltrials 140
July182017 TourforJABSOMalumni ToursoftheUHCancerCenter 10
August112017
ClinicalModelsforSurvivorshipCarePlanDelivery
TrainingconductedbyFranciscoCondePhDtounderstandtheneedforcancersurvivorshipcareplansexploremodelsonhowtoimplementplansintopracticeanddiscusschallengeswithimplementation
10
August112017
JABSOMCommunityHealthampServiceProgram
ProvideNCIsCancerClinicalTrialsTheIn-DepthProgramandoverviewofclinicaltrialstoJABSOMfirstyearmedicalstudents
72
August182017
TotheMoonandBacktotheBedsideTheFutureofCancerCareandTreatment
ProvideanoverviewoftheCancerMoonshotandtheimpactoftheMoonshotoncancercarewithspecificreferencestotheoncologyprofessionalsinHawaii
238
September82017
20thAnnualWestHawaiiCancerSymposiumampRunforHopeEvents
ProgramprovidesattendeeswithacomprehensiveviewofcurrentmethodsinthediagnosisandtreatmentofbreastcancerpancreaticcarcinomametastaticprostatecancerlungcancercancerpainmanagementsentinelnodesurgeryandreviewchallengesinhealthcareIncludesweekendofRunforHopeactivitiestennisampgolftournamentsTasteofHawaiiIslanddinnerand5K10KFunRun
150
September212017
4thAnnualProstateCancerSymposium
Communitybasededucationaleventwithinformationaboutprostatecancerpreventionandtreatment
80
September222017
33rdHawaiiSeniorsFairGoodLifeExpo
Showcasesproductsservicesprogramsandorganizationswithover275exhibits
20000
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
September302017
QuestfortheCureLungCancer
Communityeducationaboutlungcancerpreventionandtreatment 80
StateCancerPlanTheStateofHawailsquoihascompletedits2016to2021FiveYearComprehensiveCancerPlanwithsubstantialinputandleadershipfromUHCCmembersTheStateofHawailsquoiComprehensiveCancerPlans(HCCP)similartootherStatesTerritoriesandTribesisdevelopedimplementedandevaluatedthroughtheirrespectivestakeholdercoalitionsTheHCCPincludesthedomainsofpreventionscreeningtreatmentqualityoflifedataandresearchMuchofthedatautilizedindevelopmentofthePlanisderivedfromtheHawailsquoiTumorRegistrydirectedbyDrBrendaHernandezDrNealPalafoxhasbeenamemberofHawailsquoirsquosComprehensiveCancerCoalitionsince2010Heservedatwo-yeartermasViceChairfrom2012to2013andatwo-yeartermasChairfrom2014to2015DuringhistenureasChairDrPalafoxguidedthedevelopmentandwritingofthe2016through2020planwiththeHawailsquoiStateDepartmentofHealthInthecurrentStateplanamajoremphasiswasplacedonaddressingthesocialdeterminantsofhealthandoncancerhealthdisparitiesastheyrelatetocancerpreventionandoutcomes
PartnershipsandCollaborationsOneofthemostimportantcollaborationsfortheUHCancerCenteristheaffiliationofhospitalscalledtheHawailsquoiCancerConsortium(HCC)TheHCCisa501(c)(3)entityformedtosupporttheCancerCenterparticularlyintheareaofclinicalresearchItiscomprisedofQueensHealthSystemHawailsquoiPacificHealthhospitalsKuakiniHealthSystemandJABSOMOverthepastyeartheexpenditurestotheCancerCenterfromHCConrecommendationbytheUHCCDirectorhavebeenadjustedtoensurethattheydirectlyaddresssupportoftheclinicalresearchinfrastructureTheCancerCenterhasworkedtoimproveaccesstoclinicaltrialsfacilitatetheopeningofstudiesprovideimprovedscientificandregulatoryoversightoftrialsandenhancethedataandsafetymonitoringcapabilitiesInrecognitionofimprovedvaluederivedfromtheseeffortstheHCCclinicalpartnersrecentlyvotedtoextendthetermoftheaffiliationinto2019andeachprovidedastrongletterofsupportfortheNCICancerCenterSupportGrantsubmission
AnewaffiliationestablishedoverthepastyearistheTrans-PacificPartnershipforCancerPrevention(TPPCP)ThisisanaffiliationofinstitutionsledbytheUHCancerCenterwithamissiontoimprovecancercontrolandpreventionandpromotecancerpreventionresearchinHawailsquoiandacrossthePacificChartermembersoftheTPPCPinclude
bull UniversityofHawailsquoiCancerCenterbull UniversityofGuambull AmericanSāmoaCommunityCancerCoalitionbull HawailsquoiPacificUniversity
PublicRelationsTheUHCancerCenterhashadextensivecoverageinthelocalprintbroadcastandon-linemediaInadditionfindingsfromseveralresearchstudieshavereceivednationalcoverageAfteralongperiodofnegativepressoverthepastseveralyears100ofthenewsstoriesfromthispastyearwerepositivehighlightingtheexceptionalresearchcommunityoutreachandeducationalactivitiesconductedbyUHCancerCenterfacultyInadditionDrHolcombehasparticipatedinnumerouscommunityforumsincludingFutureFocustheHawaiiBusinessRoundtableTheStateCancerControlPlanunveilingTheOncologyNursingSocietyannualmeetingtheHawaiiBookandMusicFestivalandoncologytumorboardsatalloftheUHCancerCenter-affiliatedhospitalsApartiallistingofnewsstoriesfromthispastyearisincludedbelowStories SubtitlesSubject Date Viewers-
VisitorsKHONLiving808 CoolingCancerndashUHCancerCenter 4-Oct-17 1657
KITVnewsthismorning UHCancerCenterhosts7thannualQuestforaCure 1-Oct-17 14557
KITVnewsat10 UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 12151
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
KFVEHawaiiNewsNowatNINE UHCancerCenterhosts7thannualQuestforaCure 30-Sep-17 24258
HonoluluStar-Advertiser UHMawarded$31Mformultiethniccancerresearch 24-Sep-17 335202
KITVnewsat10 UHCancerCenterhosts4thAnnualProstateCancerForum 20-Sep-17 20013
HonoluluStar-Advertiser UHgranted$31millionforcancerresearch 15-Sep-17 335202
HonoluluStar-Advertiser Lowhealthriskdoesnotcurbdangersofasbestosexposure 2-Sep-17 328598
HonoluluStar-Advertiser Asbestosriskslowforfirefighters 16-Aug-17 328598
TheMauiNews MauiHighgraduatespendssummerturningrawdataintocancerresearch 14-Aug-17 30084
HonoluluStar-Advertiser Studiesshowe-cigsdonthelpkickhabit 13-Aug-17 328598
HawaiiTribune-Herald FuturescientistKealsquoauHighgraduateamongUHCancerCenterinterns 12-Aug-17 60169
BigIslandNow SummerInternsConductCancerResearchinHawailsquoi 7-Aug-17 32861
MauiNow FormerMauiStudentDoesCancerResearchonOahu 3-Aug-17 41220
KITVNewsat6 StudentsconductingimpressiveresearchatUHCancerCenterthissummer 3-Aug-17 34300
KHON FundraiserbenefitingUHCancerCenter 31-Jul-17 7187
KHON-TV[FOX2] UHCancerCenterstudycitedincoverageofcitybillthatwouldbansmokinginvehiclesinpresenceofminors
27-Jul-17 144425
KHON-TV[FOX2] DoctorexplainsdangersofasbestosasMarcoPoloresidentsraisesafetyconcerns
26-Jul-17 144425
HonoluluStar-Advertiser Studieslinkcoffeetolowerdeathdiseaserisks 23-Jul-17 271359
HonoluluStar-Advertiser DietaffectscolorectalcancerriskUHfinds 18-Jul-17 271359
HonoluluStar-Advertiser Vapingamongteensturnsupasthmarisk 18-Jul-17 271359
HawaiiNewsNow StudyTeensusinge-cigsmorelikelytousetobaccoproducts 18-Jul-17 60060
KITVnewsat5 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 34734
KHONHawaiiat10 TeenswhosmokeE-cigarettesaremuchmorelikelytosmoketobaccocigarettes
17-Jul-17 41488
LosAngelesTimes Twobigstudiesbolstertheclaimthatcoffeeevendecafisgoodforyou 11-Jul-17 16709826
ForbesMagazine NoThese2StudiesDontProveThatCoffeeLeadstoLongerLife 11-Jul-17 38775648
NewsweekMagazine IsCoffeeGoodforyouNewStudyShowstheDrinkmayHelpPeopleLivelongerEvenifitsDecaf
10-Jul-17 8706276
KaLeo Cancercenterfindsgenemutationthatmakessomemorecancer-prone 16-Jun-17 40611881
HawaiiNewsNow UHteamsdiscoverycouldproveabreakthroughincancertreatment 14-Jun-17 453312
KITVnewsat10 UHCancerCenterteamsdiscoverycouldproveabreakthroughincancertreatment
14-Jun-17 24170
HeraldTribune QampAEnjoyyoursummerbarbecuebutinmoderation 13-Jun-17 212468
KITVTelevision NativeHawaiiansatgreaterriskofdevelopingdyingfromcancer-associatedsepsis
5-Jun-17 115036
WashingtonPost Evidencegrowslinkinggrilledmeatandcancerbutyoucanlowertherisk 3-Jun-17 34313689
KHONLiving808 Howvolunteeringtoparticipateinaclinicaltrialhelpsadvancemedicalcare 31-May-17 1657
HonoluluStar-Advertiser Postpicturesofyourlunchforscience 30-May-17 257660
KHONChannel2MorningNewsat500
WillingtologyourfoodintakeTheresanappforthat 24-May-17 7075
BigNewsNetwork UHresearcherdevelopsapptolowerabdominalfatfocusgroupapplicantswanted
24-May-17 16366
KGMBSunrise WillingtologyourfoodintakeTheresanappforthat 24-May-17 29408
KHONTelevision UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 24-May-17 307762
HawaiiNewsNow Wanttoburnbellyfat(nofaddietrequired)TheresaUHappforthat 24-May-17 453312
KITVNewsat6 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 39860
KGMBHawaiiNewsNowat5 UHCancerCenterseeksparticipantsinstudytoreduceabdominalfat 23-May-17 48751
KITVTelevision CancerstudyfindssupportgroupiskeyforHawaiianmen 21-May-17 115036
KGMBHawaiiNewsNowat10 CancerstudyfindssupportgroupiskeyforHawaiianmen 20-May-17 50468
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
KHONTelevision AlookatHawaiirsquoscancertreatmentresearchassenatorrecoversfromkidneysurgery
18-May-17 307762
KGMBHawaiiNewsNowat6 SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 59615
KHONTelevision SenMazieHironotoundergotreatmentforkidneycancer 16-May-17 307762
HonoluluStar-Advertiser Islesannualdeathtollfrombreastcanceris125UHCancerCenterreport 30-Apr-17 469403
HonoluluStar-Advertiser $3MgrantgoodnewsforUHCancerCenter 12-Apr-17 469403
KGMB UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 50324
KITVTelevision UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
KHON-TV[FOX2] UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 29897
HonoluluStar-Advertiser UHlabgets$3Mtostudyplantascancertreatment 9-Apr-17 469403
HonoluluCivilBeat SenateCommitteeUnveilsAStreamlinesStateBudget 30-Mar-17 111
BusinessJournals UHcancercentermedicalschoolgettingenergystoragepilotprojects 22-Mar-17 4124434
KITVTelevision NativeHawaiianshighestcancermortalityrates 5-Feb-17
KHNLHawaiiNewsNowatTEN CancerCenterreportonNativeHawaiianhealth 4-Feb-17 23121
HonoluluStar-Advertiser InvestmentinCancerCenterwillbenefithealtheconomy 4-Feb-17 12971
TakeChargeParenting E-CigarettesLuringNon-SmokingTeenstoRegularCigarettes 25-Jan-17 476786
NewsMaxHealth E-CigarettesMayLeadTeenstoSmoke 24-Jan-17 3179123
solonewsnet Cigarettesmaylureteenswhootherwisemightnotsmoke 24-Jan-17 403001
USNewsampWorldReport E-CigarettesNotaSmokingDeterrentforKids 23-Jan-17 9536206
KFVEHawaiiNewsNowat630 ThinkAboutItcommentary 17-Jan-17 8383
KGMBSunrise UHCancerCentergivesvaccinationstats 11-Jan-17 $22670
asbestoscom EarlyDetectionofMesotheliomaLiesinHMGB1Isoforms 9-Jan-17 12971
HonoluluStar-Advertiser Lawmakerhashereyeon$6million 6-Jan-17 330674
CivilBeat SenatorsVoiceConcernsOverUHBudgetRequests 5-Jan-17 4660
HonoluluStar-Advertiser CancerCenterhas$6Mnesteggandlawmakerswantanaccounting 5-Jan-17 330674
KIPO-FMHawaiiPublicRadioonKIPO
StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16
KITVTelevision StatescancerplanwithinterviewsfromUHCancerCenterDirectorDrRandallHolcombe
15-Dec-16 11246
HonoluluStar-Advertiser Igepledges$10Minstatescancerbattleplan 15-Dec-16 304899
KITVTelevision GovIgepledges$10MtoUHCancerCenteraspartofstatesnewbattleplan 14-Dec-16 38009
KFVEHawaiiNewsNowatNINE UHWahinevolleyballcoachDaveShojitakesleaveforcancertreatment 13-Dec-16 29241
HonoluluStar-Advertiser BillpassedbyCongresscouldaidcancercenter 12-Dec-16 304899
asbestoscom EnvironmentalAsbestosRaisesMesotheliomaAmongWomen 22-Nov-16 16863
KITVTelevision ColoncancerkillsmoreNativeHawaiiansthananyotherethnicgroupinHIUHCancerCenteraimstoreversethattrend
21-Nov-16 36062
HonoluluStar-Advertiser CancerCenterbudgetgoesupinsmoke 21-Nov-16 304899
eCancerNews Researcherfindsnewdriverofanaggressiveformofbraincancer 16-Nov-16 118438873
medicalxpresscom Researchersfindnewdriverofanaggressiveformofbraincancer 15-Nov-16 1999619
MSNNews Vapingmayturnteensintoheavycigarettesmokers 15-Nov-16 118438873
HonoluluStar-Advertiser UHdiscoverycouldaidbraincancercare 15-Nov-16 304899
LatinosHealth RegularvapinghabitdevelopedbyteensmayresulttoheavysmokinglaterStudy
12-Nov-16 487565
NBCNews Kidswhovapemorelikelytobecomeregularsmokerstudyfinds 8-Nov-16 16257519
BusinessInsider Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 32027795
healthmedicinetcom Frequentvapingbyteenslinkedtoheavysmokinglater 8-Nov-16 433341
HonoluluStar-Advertiser Partnershipaimstoimprovecancercareforislepatients 8-Nov-16 422755
KSSK-FM PerryandPrice0800am 8-Nov-16
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
KGMB UHCancerCenterwelcomesnewdirector 8-Nov-16 50219
KITVTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 155776
KHONTelevision UHCancerCenterwelcomesnewdirector 8-Nov-16 287676
HonoluluStar-Advertiser UHcancerresearcherwins$45Mingrants 6-Nov-16 422755
WestHawaiiToday Stakeholdersinmedicalfieldconvergeforconferencetoimprovecare 5-Nov-16 97285
HonoluluStar-Advertiser UHtoseek$29millionbudgetboost 4-Nov-16 422755
eCancerNews Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 3-Nov-16 751178
news-medicalnet Scientistsdiscovernoveltherapeutictargetandtreatmentstrategyforacutemyeloidleukemia
2-Nov-16 53337
mmedicalxpresscom Newcancertreatmentstrategydiscoveredforacutemyeloidleukemia 2-Nov-16 5162
MensHealth UHCancerCenterresearchshowscoffeedrinkerslesslikelytodeveloplivercancer
31-Oct-16 5758
HonoluluStar-Advertiser RandallHolcombeDirectorseesbrightfutureforUHCancerCenter 21-Oct-16 422755
HonoluluStar-Advertiser CancersurvivorsfindtherapythroughbloggingSnapchat 16-Oct-16 422755
KHON-TV[FOX2] CoolingCancerorgdonates$50KtoUHCancerCenter 11-Oct-16 287676
TOTAL 458323563
FacultyRecognitionsNumerousUHCancerCenterfacultyreceivednationalandinternationalrecognitionoverthispastyearAsummaryisincludedintheTablebelow
Faculty Recognition Year
GertraudMaskarinec FulbrightGlobalAwardee 2017-2018JeffreyBerenberg MastershipforExtraordinaryServicefromtheAmericanCollegeof
PhysiciansandelectiontotheAllianceforClinicalTrialsOncologyBoardofDirectors
2017
Carl-WilhelmVogel OverseasfellowoftheRoyalSocietyofMedicineLondon 2016JeffreyBerenberg NCORPHealthCareDisparitiesWorkingGroup 2016-presentJaredAcoba NCIGastrointestinalCancerSteeringCommittee 2016-presentRandallHolcombe ChairPhysicianrsquosClinicalLeadershipInitiativeAssociationofAmerican
CancerInstitutes2015-2018
LoiumlcLeMarchand ThomsonReutersldquoWorldrsquosMostInfluentialScientificMindsrdquo 20152016
ClinicalTrialsforPatientswithCancerAnimportantmissionoftheUHCancerCenteristoprovideaccesstoclinicaltrialsforpatientswithcancerThisisessentialbecauseclinicaltrialsprovidethehighestqualityofcareavailableforacancerpatientanditisthroughthisprocessthatimprovedtherapiesaredevelopedOncologycareischangingrapidlytodayrsquosldquostandardrdquotreatmentwasaclinicaltrial5-10yearsagoandtodayrsquosclinicaltrialwillinmanycasesbetheldquostandardrdquo5-10yearsfromnowInadditiontoprovidingaccesstocancerclinicaltrialstheUHCancerCenterfocusesonwaystoreducethehealthdisparitiesexperiencedbyspecificpopulationsacrossHawailsquoiForexampleNativeHawaiianshavehigherratesofdeathfromcancerthananyotherracialorethnicgroupUHCancerCenterinvestigatorsareworkingtodirectlyaddressthisdisparitythroughcancerpreventionresearchandcommunityoutreachandeducationBetween2012and2017over12450patientswereenrolledontoUHCancerCenter-sponsoredclinicaltrialsIn2016over75ofallenrollmentsweretonon-whiteswithNativeHawaiiansaccountingfor17ofenrollmenttotreatmenttrialsand72ofenrollmenttootherinterventional(preventiondiagnosisscreeningetc)trialsClinicaltrialsaccrualinformationisdepictedinthetwoTablesbelow
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
AccrualatUHCCBasedonTypeofTrial
AccrualYear InterventionalNon-therapeutic
InterventionalTherapeutic
Non-InterventionalEpiObsandOutcomeStudies
Total
2012 191 109 280 580
2013 303 100 2002 2405
2014 623 75 2735 3433
2015 105 76 2577 2758
2016 354 177 1805 2336
2017^ 158 166 616 940
Total 1734 703 10015 12452
FacultyandAdministrativeLeadershipRecruitmentsUHCancerCenterhadseveralfacultyandadministrativeleadershiprecruitmentsbetween1012016and1012017TheserecruitmentsincludedtheadditionofanAssociateDirectorforAdministrationtooversee
EnrollmentofWomenandMinoritiestoInterventionaltrials
2016 HawaiiCancerPopulation^
TherapeuticTrialAccruals
InterventionalNon-TherapeuticTrialAccruals
Race
White 2130 323 35 198 37 105
Black 0 00 1 03
NativeHawaiianPacificIslander
994 151 30 169 254 718
Asian 2926 444 69 390 520 147
Chinese 377 57 4 23 8 23
Japanese 1583 240 39 220 33 93
Filipino 967 147 13 73 6 17
OtherAsianor2+Asian NR 13 73 4 11AmIndianAlaskaNative
0 00 1 03
Other 536 81 14 79 0 00
Twoormoreraces 29 164 9 25
Total 177 100 354 100
Ethnicity
HispanicLatino NR 5 30 2 17
Non-HispanicLatino NR 164 970 119 983
Unknown 8 233 Total(forknownonly) 177 100 354 100
Gender
Female 3354 500 96 542 310 881
Male 3350 500 81 458 42 119
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
operationsThisprovidesrenewedbalancedleadershipfortheCancerCenterwhereintheDirectorissupportedbytheADAoverseeingoperationsandtheDeputyDirectorChiefScientificOfficeroverseeingdevelopmentofnewscientificandeducationalprogramsTheclinicaltrialsenterprisewasstrengthenedwiththehiringofanexperiencedmanagerandtwobreastcancer-focusedacademiccliniciansAjuniorfacultymemberinEpidemiologywasalsohiredtostarttoaddressthedearthofyoungfacultyintheCenterduetothelackofrecruitmentsforseveralyearspriorto1012016Recruitmentsarelistedbelow
1 CliffMartinMBAndashAssociateDirectorforAdministration(EM)2 MelissaMerrittPhDndashAssistantResearcher3 JessicaRheeMDndashMedicalDirectorClinicalTrialsOfficeAssociateResearcherProfessor4 JamiFukuiMDndashAssistantResearcherProfessor5 KateBryant-GreenwoodJDndashManagerClinicalTrialsOffice
UHCancerCentertohavebalancedoperatingbudgetinFY2018TheUHCancerCenterwillhaveaslightlypositiveoperatingmarginof$400000inFY2018ThismarksaneliminationoftheoperatingdeficitthatinFY2016wasover$7millionThisisduetomanyfactorsincluding
1 Governorrsquosallocationof$24millionforFY2017andFY2018ThiswasprovidedbecauseofthedefundingoftheCancerCenterbythelegislatureoverthepastdecadeof$5millionperyearandthelegislaturersquosdenialoftherequestduringthepastlegislativesessiontorestorethatfunding
2 Restrictionofmaintenanceandreservefundformajorbuildingexpensesat$6million3 ReductioninexpenseswithintheCancerCenterthroughprospectivebudgetingenhancedbudgetary
oversightandimprovedefficienciesofgreaterthan$05millionperyear4 DistributionfromUHMānoaof$21milliontopartiallycorrectthedeficitintheUHCancerCenter
ldquoGrdquo(general)fundsallocationforsupportofpermanentfacultyandstaffpositionsbringingsupportforthesepositionsfromapproximately30tojustunder80ThisbringstheCancerCenterclosertothelevelofUHMānoasupportprovidedtootherorganizedresearchunitsWeverymuchappreciatethecurrentUHMānoaleadershiprsquoscommitmenttocorrectthepreviouslong-standinginequitiesinGfundallocations
ThesurplusoperatingmarginfundsalongwithreservefundswillbeutilizedtosupportongoingrecruitmentsanticipatedduringFY2018
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
ThedeclineincigarettetaxdisbursementshasresultedinareductioninlegislativefundingoftheCancerCenterbyapproximately$5millionperyearcomparedto2009Theannualdisbursementisnowlessthanthecombinedbuilding-relatedexpendituresforbondpaymentsfacilities-relatedcostsmaintenanceandutilities
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
FutureOpportunitiesWithstableleadershipandUHMānoasupporttheCancerCenterhasabrightfuturetoadvancetheunderstandingofcancerbiologyandcancerincidenceparticularlywithrespecttoHawailsquoirsquosuniqueculturalandethnicdiversityUHCancerCenterresearchactivitieswillcontinuetoprovidesignificanteconomicimpactfortheIslandofOlsquoahulocallyandimpactscientificdiscoverynationallyRetentionofNCIdesignationRetentionofNCIdesignationiscriticaltosupporttheresearcheffortsretaincurrentfacultyrecruitnewfacultyandsupporttheCancerCenterrsquosmissiontoreducetheburdenofcancerforthepeopleofHawailsquoiTheNCIwillsendasitevisitteamtotheCancerCenterJanuary312018AdecisionregardingfundingfortheCancerCenterSupportGrantwillbeavailablebyJune2018ClinicalTrialsInitiativesOverthenextyeartheCancerCenterwillbelaunchingapubliceducationcampaignaboutthebenefitsofclinicaltrialsforcancerpatientsBrandingforthiscampaignwasdevelopedinconjunctionwiththeSchoolofArtGraphicDesignCenterInadditionexpansionofclinicaltrialstoneighborislandsanddevelopmentofanEarlyPhaseClinicalTrialsprogramwillbepursuediffundingcanbesecuredBuildoutofUHCancerCenterAnnexDraftplanshavebeendevelopedwiththeassistanceoftheSchoolofArchitectureCommunityDesignCenterforthepossiblebuild-outof36000sqftofshellspaceadjacenttotheUHCancerCenterProposalshaveincludedcreationofanEarlyPhaseClinicalTrials(ldquoPhaseIrdquo)unitabiotechincubatorandadditionallaboratoryspacefornewfacultyrecruitmentsPlanswillbedependentonsecuringappropriatefundingthroughphilanthropylegislativecapitalimprovementrequestsandorindustryandhealthcarepartnersInstituteforEthnicDiversityandCancerHealthDisparitiesUHCancerCenterfacultyarenationallyrecognizedforexcellenceinresearchfocusedonethnicdiversityandcancerUHCancerCenterhastheopportunitytoexpandthisresearchandsolidifyapositionasthenationalleaderinthisareaEffortsareunderwaytosecurephilanthropicsupportforcreationofanInstitutewithresourcestosupportnewinitiativesandadditionalfacultyFacultyRecruitmentFacultyrecruitmentsareunderwayforCancerEpidemiologyCancerPreventionandCancerBiologyTheserecruitmentswillfocusonresearcherswhowillbecomplementarytocurrentUHCancerCenterfacultybutwillalsoexpandtheportfolioofresearchbeengagedintheeducationalmissionsoftheUniversityandbehighlycollaborativeacrossUHDepartmentsSchoolsandCollegesAreasoffocusforongoingrecruitmentsincludemicrobiomeandhealthcancerimagingcancerpreventionandcancerimmunology
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
APPENDIX1SelectedFY2017publicationsbyUHCancerCenterFacultyCancerCentermembersnamesareboldedIntra=Intra-programmaticcollaborationInter=Inter-programmaticcollaborationInsti=Inter-InstitutionalcollaborationCancerBiology BeltonAXianLHusoTKooMLuoLZTurksonJPageBDGunningPTLiuGHusoDLResarLM
STAT3inhibitorhaspotentantitumoractivityinB-lineageacutelymphoblasticleukemiacellsoverexpressingthehighmobilitygroupA1(HMGA1)-STAT3pathwayLeukLymphoma201657(11)2681-4PubMedPMID26952843PMCIDPMC5580963INSTI
BononiAGiorgiCPatergnaniSLarsonDVerbruggenKTanjiMPellegriniLSignoratoVOlivettoFPastorinoSNasuMNapolitanoAGaudinoGMorrisPSakamotoGFerrisLKDaneseARaimondiATacchettiCKuchaySPassHIAffarEBYangHPintonPCarboneMBAP1regulatesIP3R3-mediatedCa2+fluxtomitochondriasuppressingcelltransformationNature2017546(7659)549-53PubMedPMID28614305PMCIDPMC5581194INTRA
BononiAYangHGiorgiCPatergnaniSPellegriniLSuMXieGSignoratoVPastorinoSMorrisPSakamotoGKuchaySGaudinoGPassHINapolitanoAPintonPJiaWCarboneMGermlineBAP1mutationsinduceaWarburgeffectCellDeathDiffer2017PubMedPMID28665402INTRAINSTI
CarboneMShimizuDNapolitanoATanjiMPassHIYangHPastorinoSPositivenuclearBAP1immunostaininghelpsdifferentiatenon-smallcelllungcarcinomasfrommalignantmesotheliomaOncotarget20167(37)59314-21PubMedPMID27447750PMCIDPMC5312314INTRAINSTI
ChenWLWangYYZhaoAXiaLXieGSuMZhaoLLiuJQuCWeiRRajaniCNiYChengZChenZChenSJJiaWEnhancedFructoseUtilizationMediatedbySLC2A5IsaUniqueMetabolicFeatureofAcuteMyeloidLeukemiawithTherapeuticPotentialCancerCell201630(5)779-91PubMedPMID27746145PMCIDPMC5496656INSTI
GoodisonSOgawaOMatsuiYKobayashiTMiyakeMOhnishiSFujimotoKDaiYShimizuYTsukikawaKFuruyaHRosserCJAmultiplexurinaryimmunoassayforbladdercancerdetectionanalysisofaJapanesecohortJTranslMed201614(1)287PubMedPMID27717367PMCIDPMC5055716INTRAINSTI
HanBShenYZhangPJayabalPCheRZhangJYuHFeiPOverlookedFANCD2variantencodesapromisingportenttumorsuppressorandalternativepolyadenylationcontributestoitsexpressionOncotarget20178(14)22490-500PubMedPMID28157704PMCIDPMC5410239INTERINSTI
HilliardTSMiklossyGChockCYuePWilliamsPTurksonJ15alpha-methoxypuupehenolInducesAntitumorEffectsInVitroandInVivoagainstHumanGlioblastomaandBreastCancerModelsMolCancerTher201716(4)601-13PubMedPMID28069875PMCIDPMC5380601INTRA
MaoWZhangXGuoZGaoZPassHIYangHCarboneMAssociationofAsbestosExposureWithMalignantMesotheliomaIncidenceinEasternChinaJAMAOncol20173(4)562-4PubMedPMID27918607PMCIDPMC5569880INTRAINSTI
NaderiAC1orf64isanovelandrogenreceptortargetgeneandcoregulatorthatinteractswith14-3-3proteininbreastcancerOncotarget2017PubMedPMID28571002
NortonRLFredericksGJHuangZFayJDHoffmannFWHoffmannPRSelenoproteinKregulationofpalmitoylationandcalpaincleavageofASAP2isrequiredforefficientFcgammaR-mediated
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
phagocytosisJLeukocBiol2017101(2)439-48PubMedPMID27601625PMCIDPMC5235904INSTI
PellegriniLXueJLarsonDPastorinoSJubeSForestKHSaad-JubeZSNapolitanoAPaganoINegiVSBianchiMEMorrisPPassHIGaudinoGCarboneMYangHHMGB1targetingbyethylpyruvatesuppressesmalignantphenotypeofhumanmesotheliomaOncotarget20178(14)22649-61PubMedPMID28186988PMCIDPMC5410252INTRAINTERINSTI
PeresRFuruyaHPaganoIShimizuYHokutanKRosserCJAngiogenincontributestobladdercancertumorigenesisbyDNMT3b-mediatedMMP2activationOncotarget20167(28)43109-23PubMedPMID27317771PMCIDPMC5190012INTRAINTER
SulzmaierFJYoung-RobbinsSJiangPGeertsDPrechtlAMMatterMLKesariSRamosJWRSK2activitymediatesglioblastomainvasivenessandisapotentialtargetfornewtherapeuticsOncotarget20167(48)79869-84PubMedPMID27829215PMCIDPMC5346757INTRAINSTI
UrquidiVNethertonMGomes-GiacoiaESerieDJEckel-PassowJRosserCJGoodisonSAmicroRNAbiomarkerpanelforthenon-invasivedetectionofbladdercancerOncotarget20167(52)86290-9PubMedPMID27863434PMCIDPMC5349914INSTI
ZhaoLWongLLShiXJiJShouldhepaticdysplasticnodulesandregenerativenodulesberegardedaspremalignantlesionsandtreatedHepatology201664(4)1370PubMedPMID26754160INTRA
PopulationSciences HernandezBYZhuXGoodmanMTGatewoodRMendiolaPQuinataKPaulinoYCBetelnut
chewing oral premalignant lesions and the oral microbiome PloS one201712(2)e0172196PubMedPMID28225785PMCIDPMC5321455INTRAINSTI
LeMarchandLYonemoriKWhiteKKFrankeAAWilkensLRTureskyRJDosevalidationofPhIP hair level as a biomarker of heterocyclic aromatic amines exposure a feedingstudy Carcinogenesis 201637(7)685-91 PubMed PMID 27207666 PMCIDPMC4936386INTRAINTERINSTI
Maskarinec G Ju D Horio D Loo LW Hernandez BY Involution of breast tissue andmammographicdensityBreastcancer research BCR201618(1)128PubMedPMID27978856PMCIDPMC5159985INTRA
MaskarinecGLimUJacobsSMonroeKRErnstTBuchthalSDShepherdJAWilkensLRLeMarchandLBousheyCJDietQuality inMidadulthoodPredictsVisceralAdiposityandLiverFatness inOlderAgesTheMultiethnicCohortStudyObesity(SilverSpringMd)201725(8)1442-50PubMedPMID28745024INTRA
MatterMLShvetsovYBDugayCHaimanCALeMarchandLWilkensLRMaskarinecGHighmortality due to sepsis in Native Hawaiians and African Americans The MultiethnicCohort PloS one 201712(5)e0178374 PubMed PMID 28558016 PMCIDPMC5448766INTRAINTERINSTI
ParkSYBousheyCJWilkensLRHaimanCALeMarchandLHigh-QualityDietsAssociateWithReducedRiskofColorectalCancerAnalysesofDietQuality Indexes intheMultiethnicCohort Gastroenterology 2017153(2)386-94 e2 PubMed PMID 28428143 PMCIDPMC5526717INTRA
Patel YM Park SL Han YWilkens LR Bickeboller H Rosenberger A CaporasoN LandiMTBruske IRischAWeiYChristianiDCBrennanPHoulstonRMcKay JMcLaughlin JHung RMurphy S StramDO Amos C LeMarchand L Novel Association of Genetic
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Markers Affecting CYP2A6 Activity and Lung Cancer Risk Cancer research201676(19)5768-76PubMedPMID27488534PMCIDPMC5050097INTRAINSTI
Poirion OB Zhu X Ching T Garmire L Single-Cell Transcriptomics Bioinformatics andComputationalChallengesFrontGenet20167163PubMedPMID27708664PMCIDPMC5030210
SargentJDGabrielliJBudneyASonejiSWillsTAAdolescentsmokingexperimentationasapredictor of daily cigarette smoking Drug Alcohol Depend 201717555-9 PubMedPMID28391086PMCIDPMC5443410
SonejiSBarrington-TrimisJLWillsTALeventhalAMUngerJBGibsonLAYangJPrimackBAAndrewsJAMiechRASpindleTRDickDMEissenbergTHornikRCDangRSargentJDAssociationBetween InitialUseofe-CigarettesandSubsequentCigaretteSmokingAmongAdolescents andYoungAdultsA SystematicReviewandMeta-analysis JAMAPediatr2017171(8)788-97PubMedPMID28654986INSTI
WangHSchmitSLHaimanCAKekuTOKatoIPalmerJRvandenBergDWilkensLRBurnettT Conti DV Schumacher FR Signorello LB Blot WJ Zanetti KA Harris C Pande MBerndtSINewcombPAWestDWHaileRStramDOFigueiredoJCHispanicColorectalCancer S LeMarchand L Novel colon cancer susceptibility variants identified fromagenome-wide association study in African Americans International journal of cancer2017140(12)2728-33PubMedPMID28295283PMCIDPMC5505639INTRAINSTI
WillsTASargentJDCommentaryDoE-cigarettesreducesmokingPrevMed2017100285-6PubMedPMID28583659
Wills TA Commentary E-Cigarettes and Adolescents Risk Status Pediatrics 2017139(2)PubMedPMID28115538PMCIDPMC5260160
Wills TA Sargent JD Gibbons FX Pagano I Schweitzer R E-cigarette use is differentiallyrelatedtosmokingonsetamonglowerriskadolescentsTobControl201626(5)534-9PubMedPMID27543564PMCIDPMC5537057INTRAINSTI
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
APPENDIX2FeedbackfromcommunityparticipantsMoonshotSummitDecember2016Moonshot Summit Feedback Report Putting the patient at the center of access and care 1 The biggest concerns for patients include chances of overcomingsurviving cancer impact on patients and lsquoloved ones lives financial barriers what treatments are available how to continue workingjob stability fear of treatment side effects and what happens if treatments do not work 2 Survivors amp caregivers need a support system for long-term mental physical spiritual well-being and financial recovery 3 Providers need to work together to provide patient-centered care 4 Other patients are advocates and can establish a go to team to support newly diagnosed patients 5 Community support for cancer patients in support of challenges such as transportation homecare For example recruit churchesschools educate community partners engage politicians in discussions to advocate for cancer research get the newsmedia involved provide cancer prevention education in schools Disparities in Cancer care 1 Have a national health service to support access to cancer diagnosis and care 2 For non-English speaking patients provide information about clinical trials in the patientsrsquo native language increase medical translators and train community health outreach workers who are culturally part of the community to work with the medical staff 3 Recruit and hire local physicians to return to their home community 4 Create one-stop shops such as cancer resource centers to provide cancer resources and information 5 Work with community organizations and clubs to provide assistance to cancer patients For example work with seniors medical school and Native Hawaiian health organizations for needs such as transportation for medical care translations amp navigation Supporting preventative health behaviors 1 Some key barriers to the adoption of successful prevention strategies include the need to determine cost-effective screenings access to care (many people do not have a primary care physician) education and lack of insurance 2 Some of the biggest drivers for behavior change are having culturally appropriate navigators peer-to-peer help and policy changes 3 The successful strategy for mitigating the risk of over-screening and under-screening would be to increase research and knowledge on screening detection and diagnosis 4 Strategies for early detection and diagnosis include developing a health profile and physician recommendations 5 Effective outreach strategies for encouraging at-risk populations to seek routine screenings would include health fairs with free screenings social media genetic counselors and face-to-face interactions Strategies for integrating advances in Cancer treatment into community care 1 Encourage use by physicians of Physicians Data Query 2 Involvement of Hawaii Cancer Consortium members (local hospitals and medical schoolresearch center) to facilitate knowledge sharing and have researchers present at tumor boards 3 Utilize websites list servers to disseminate information including information about cancer and clinical trials 4 Move medicalresearch expertise from cancer centers to clinicscommunity get researchers out in the field teach medical students about clinical trials advocate for prevention and screening such as Fecal Occult Blood test HPV vaccine motivate community to seek early detection advertise cancer seminars in the news Also have researchers talk about specialties develop a local cancer hotline and invest more in prevention through the Public Health Model with additional funding 5 Develop training for non-oncology physicians in cancer care in isolated areas utilize telemedicine as an educational tool Recruiting and retaining participants in clinical research
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
1 When newly diagnosed provide patients with credible information regarding clinical trials including investigational nature indication for treatment screening for eligibility randomization risks side effects costs etc 2 Conversation regarding clinical trials should be started by patients physician because of existing trust relationship 3 Connect patient with support groups of individuals with similar diagnoses 4 Need a boost in investigator and clinician interactions regarding clinical trials for cross education 5 Engage individuals in learning about clinical trials before a cancer diagnosis to recruit and retain participants in clinical research
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Act 38 and Act 39
Session Laws of Hawailsquoi 2017
BOR Research amp Innovation Committee Meeting November 1 2017
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Signing Ceremony June 19 2017
2
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Overview bull One of UHrsquos strategic directions is to grow the portfolio of sponsored research done at the
University and to promote innovation and workforce diversification in the statersquos economy One critical phase of innovation is the ability to commercialize research ideas generated on campus known as technology transfer which is designed to strengthen economies by getting new ideas inventions and processes developed in universities to the private sector
bull Technology transfer and commercialization legislation was introduced in the 2015 2016 and
2017 legislative sessions successfully introduced and passed as House Bill 425 (Act 38) and House Bill 847 (Act 39) in 2017
bull Act 38 ndash Transfers responsibility to manage ethical issues arising in the context of technology
transfer activities ndash such as financial conflicts of interests or use of public resources--from the State Ethics Commission to the University of Hawailsquoi
bull Act 39 ndash Establishes the innovation and commercialization initiative program under the
direction of the Vice President for Research and Innovation authorizes the University to engage in a range of technology transfer activities and creates a special fund to implement the program
3
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Sunset and Reporting bull Act 38 is effective upon approval [June 19 2017] and repealed on June 30
2022 UH must submit an annual report to the Legislature on its regulatory framework and technology transfer activities
bull Act 39 is effective on July 1 2017 and repealed on June 30 2021 UH
must submit biennial report to Legislature on use of special fund and its coordinated efforts with other state agencies
4
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Act 38 Highlights bull Act 38 transfers responsibility for compliance of technology transfer
activities with ethics from State Ethics Commission to the University Act 38 is not an ldquoexemptionrdquo from any ethics oversight at all
bull Responsibility is transferred as to ldquoactivitiesrdquo not ldquoemployeesrdquo per
Attorney Generalrsquos interpretation of the scope of Article XIV of the State Constitution Code of Ethics
5
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Act 38 Highlights (cont) Typical types of conflict that might arise in the Technology Transfer contextmdashthe ldquowearing two hatsrdquo and ldquodual userdquo problems bull Conflicts of Financial Interests by individual who is both a UH researcher
and the start-up entrepreneurkey employee of an entity that licenses UH patent based on individualrsquos research
bull Conflicts of Time and Attention Commitments by individual who is both a University employee and a private citizen
bull Conflicts of Public vs Private benefits simultaneously resulting from use of University facilities or funds
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Act 38 Highlights (cont) Principles to Manage Conflicts bull Insulate Investment DecisionsDecision makers from Operational
DecisionsDecision makers bull Justify each type of decision by independent ldquodue diligencerdquo appropriate
to that type eg investment committees recommend investments research committee recommends direction of research
bull Recuse conflicted individuals from negotiating influencing or decision
making
ldquoEach hat on its own headrdquo
7
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Notable Powers under Act 39 Act 39 allows the University to bull Contribute equity loan funds or participate directly or indirectly to
finance concepts or proposals that are likely to lead to viable business using university research
bull Acquire personal property of any nature either directly or through intermediate entities formed or established specifically for program purposes
bull Provide instruction training and marketing assistance to support and promote projects in which UH invests
8
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Example of Using Act 39 bull Incorporating UH Ventures LLC a Hawailsquoi limited liability company and
forming single purpose subsidiaries thereunder Benefits Managing Conflicts of Interest
ldquoEach hat on own head - - each head on own corporate bodyrdquo
Compartmentalizing Risks- Firewalls and Bulkheads
Assuring Transparency-Avoiding Comingling of funds
9
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Business Registration
10
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
UH Ventures LLC
Functional Organizational Chart
11
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Office of the Vice President for Research and Innovation
Organizational Chart
12
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Life Cycle of Proposals amp Awards
BOR Research amp Innovation Committee Meeting
November 1 2017
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Proposal Submission
2
Funding opportunity
PI writes proposal amp prepares
budget (one month of
effort)
Unit staff enters into myGRANT
and routes for approvals
ORS reviews proposal and
budget
Submit to sponsor (May take 9 to 12 months for decision)
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
AwardAccount Setup
3
Award received
uncommon to receive a
check from sponsor
ORS creates award record in myGRANT
ORS review grants should be relatively
quick contracts take longer based on negotiation
issues
ORS creates account in
KFS
Unit notified account is
active
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Cost Reimbursement
4
Incur Costs in Project Account
Unit buys supplies
$1
KFS calculates FampA costs $1 x 40 =
40 cents
KFS creates AR for $140
UH Cash is reduced by
$140
40 cents deposited into OH income account
ORS bills sponsor for
$140
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Cost Reimbursement ndash Contrsquod
Get Reimbursed
5
UH Cash is restored by
$140
ORS receives
check wire or EFT for $140 from
sponsor
AR in KFS is reduced by $140
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6
Award Closeout
bull Sponsor withholds final payment until final technical report inventory report invention report and financial report are submitted
bull Federal regulations provide for 90 days after project termination to complete this process
bull Final payments are posted to accounting system like any other payment but account is marked closed
6