Upload
markku
View
24
Download
2
Embed Size (px)
DESCRIPTION
NORMAL SEXUAL DIFFERENTIATION. Suganda Tanuwidjaja. IDENTITAS GENDER. Genotype Gonadale Sex Phenotype Sex Social Gender. GENOTYPE. Chromosomal (Genetic) Sex. Testis-Determining Genes. XY. XX. Ovary-Determining Genes. Gonadale Sex. Gonadale Steroids And Peptidas (T.DHT.AMH). - PowerPoint PPT Presentation
Citation preview
NORMAL SEXUALNORMAL SEXUALDIFFERENTIATIONDIFFERENTIATION
Suganda Tanuwidjaja
IDENTITAS GENDERIDENTITAS GENDER
1. Genotype
2. Gonadale Sex
3. Phenotype Sex
4. Social Gender
GENOTYPEGENOTYPE
Chromosomal(Genetic) Sex
Gonadale Sex
Ovary-DeterminingGenes
Testis-DeterminingGenes
Phenotypic Sex
Gonadale SteroidsAnd Peptidas
(T.DHT.AMH)(Gonadale Steroids)
XY XX
♂ ♀
• Male : 46 XY
• Female : 46 XX
Y Chromosome (SRY Gene)
Diff. of The Bipotential Gonad
Testis
X Chromosome
One Dose Active
CHROMOSOMAL SEXCHROMOSOMAL SEX
• Gonadal Sex is determined by SRY
• Indiff. Gonad (SRY) Ovary
(+SRY) Testis
GONADAL SEXGONADAL SEX
1 X Chromosome : SRY
Gonad Ovary (Fetal Periode)
Ova Atrophy
(Only 1 Chr)
Cholesterol
STEROID METABOLISM OF GONADSTEROID METABOLISM OF GONAD
Androgen
Estrogen
Enzim
• Internal Ducts
• External Genital Appearance
• Peran Androgen
PHENOTYPE SEXPHENOTYPE SEX
Masculine
Wolffian Ducts
INTERNAL SEX DUCTS BIPOTENTIALINTERNAL SEX DUCTS BIPOTENTIAL
Feminine
Mullerian Ducts
Mullerian Duct Inhibitory Factor (MIF)
TESTICULAR PEPTIDE PRDCTTESTICULAR PEPTIDE PRDCT(SERTOLI CELL)(SERTOLI CELL)
Mullerian Duct Atrophy
Wolffian Duct Developed
MIF
WITHOUT...WITHOUT...
Developed :
• Uterus
• Oviduct
• Upper 2/3 of Vagina
LEYDIG CELL
Testosteron
Wolffian Ducts
• Epididymis• Vas Deferens• Seminal Vesicle
• Bipotential 8 Weeks
• Genital Tubercle Clitoris
• Urogenital Fold Labia Minora
• Labioscrotal Swelling Labia Majora
EXTERNAL GENITALIAEXTERNAL GENITALIA
TestosteroneDihydrotestosterone
(DHT)
5α Reductase Enzyme
Androgen Receptor (ARs)
Genital Tubercle Penis
DHT
ARs
Urogenital Slit Penile Urethra
Labioscrotal Fold Scrotum
Maternal Human Chorionic Gonadotropin(hCG)
11stst TRIMESTER TRIMESTER
Fetal Testes
Testosterone
Male Development
Fetal Pituitary Gonadotropin
22ndnd TRIMESTER TRIMESTER
Testicular Activity
Further Normal Growth
of The Penis
• Gender Development :
1. Gender Identity
2. Gender Role
3. Sexual Orientation
4. Desire & Capacity for Parenting
SOCIAL GENDERSOCIAL GENDER
• Surrounding
• Physical Differentiation
• Interaction
• Prenatal Androgen
DETERMINED FACTORSDETERMINED FACTORS
Thank YouThank You