Normal Metabolism: In Response to Insulin, the Liver Continuously Micromanages Glucose

PancreasLiver

• Clears 50% - 80% of insulin

• Stores 30%-50% of glucose

80% - 600% Insulin Oscillations

30% Insulin Oscillations

24/7/36524/7/365

1

Portal Vein Peripheral Vein

Tightly Controlled Peripheral GlucoseRare Occurrences of Hypoglycemia

©Copyright 2014, All Rights Reserved, Diasome Pharmaceuticals, Inc.

Current Insulin Therapies: Insufficient Hepatic Delivery

PancreasLiver

(Insufficient glucose storage)

Pre-meal Injections Provide Non-Physiologic Post Meal Insulin Peaks

2

Portal Vein Peripheral Vein

Long-acting Injections Provide Peripheral Basal Insulin

Poor Peripheral Glucose ControlFrequent HypoglycemiaChronic Hyperglycemia

©Copyright 2014, All Rights Reserved, Diasome Pharmaceuticals, Inc.

Preferred Form of Insulin Therapies: Hepatic and Peripheral Insulin in a Single Dose

PancreasLiver

(Normal Hepatic Glucose Storage)

3

Portal Vein Peripheral Vein

HDV Pre-meal Injections Provide Both Hepatic and Peripheral Insulin

HDV Basal Injections Provide Both Hepatic and Peripheral Insulin

©Copyright 2014, All Rights Reserved, Diasome Pharmaceuticals, Inc.