8/3/2019 Non Linear Pharmaco kinetics

1/37

4330,7

!,72,.4309.8

480/0503/039309.8

&!!#

8/3/2019 Non Linear Pharmaco kinetics

2/37

n

ff

W nfnn

W nfnn

W @nnfn

W -nnfn

8/3/2019 Non Linear Pharmaco kinetics

3/37

@fffnfffnnfffffnnfn%Dnfff

@nffnfff

#fnffffnnf%fnfnffn

8/3/2019 Non Linear Pharmaco kinetics

4/37

ffn,f

W ffnffnf

ff f,nf,

nn

W @nfnf

fffn

8/3/2019 Non Linear Pharmaco kinetics

5/37

0307,70,94385-0900370,.9437,90 ,3/8:-897,90.43.0397,943 147,30320.,9,80/70,.943

#,90

$:-897,90.43.0397,943

7,5-0.42081,9907,890

0320-0.42088,9:7,90/

98:-897,90

8/3/2019 Non Linear Pharmaco kinetics

6/37

#,9041

023,93

#,9041

023,93

44//7:.43. 44//7:.43.

30,7309.82489/7:8

4330,7309.80503943

8/3/2019 Non Linear Pharmaco kinetics

7/37

#,904102

#,9041

,/23

#,904102

#,9041

,/23

44//7:

.43.

44//7:.43.

44//7:

.43.

#,9041,/23 #,9041,/23

44//7:.43.

30,7 4330,7 9890,/89,90

8/3/2019 Non Linear Pharmaco kinetics

8/37

%

%4.

$,10,3/

0110.9;0

7,30

30110.9;0

4%

,3083

987,30

.,:8034

574-028

%4.

$,10,3/

0110.9;0

7,30

30110.9;0

,3083987,30

.,:808074:8

574-028

8/3/2019 Non Linear Pharmaco kinetics

9/37

23,94341/7:89,4

907,50:9.3/0234.48/08

9:2

094970,90

43

!74.,3,2/0

/4.,30!034-,7-9,

!03943

":3/30

%04530

#03,

05,9.

24890.:8;0703,

,3703,$42005,9.

557406:,703,05,9.

,305,9.

8/3/2019 Non Linear Pharmaco kinetics

10/37

nn,,nff%

nfffnnnfff

fffnnf

nnffffnff

n

8/3/2019 Non Linear Pharmaco kinetics

11/37

W @ nnf nf f f nf f f %f

W f nf f nnf nf f f nf f f

W @ nn nnf

f nnf fff n

W D n f f ff n f nnf nf

nf f f

W f f f %If% f fn

8/3/2019 Non Linear Pharmaco kinetics

12/37

n-f

#-f f f n f f$ f

W f f fn nf f nf

W nf ff f f%f nf f fnf f D

W ff f ff f fn nnf f nf f nf

8/3/2019 Non Linear Pharmaco kinetics

13/37

W f f f f

ff f n f f nf f nf fn

nffn f f f f nf

D

W f f n f

f ffnf f nfn f

ff fn n

f nf f nffn f nf

8/3/2019 Non Linear Pharmaco kinetics

14/37

-f9n

nnf

nnf

nfn

fnfnfffff

fnffffff

fnnffnfffnn

8/3/2019 Non Linear Pharmaco kinetics

15/37

,nf, n

W If fff

W,nf nfnnffnf

*f

Wnnf

8/3/2019 Non Linear Pharmaco kinetics

16/37

W @fff%If%

f%nnf

ffff

W ,nnfnn

fIf ff

f%f,%

8/3/2019 Non Linear Pharmaco kinetics

17/37

W ff

W fff

W $ I$+

8/3/2019 Non Linear Pharmaco kinetics

18/37

8/3/2019 Non Linear Pharmaco kinetics

19/37

f-9

W If;ff9f

-f,n,

//04.9/30 f

8/3/2019 Non Linear Pharmaco kinetics

20/37

ffnf

+

@

$ I$

f

8/3/2019 Non Linear Pharmaco kinetics

21/37

W ffnf

W

W +W @

W $ I $ I

W f

8/3/2019 Non Linear Pharmaco kinetics

22/37

8/3/2019 Non Linear Pharmaco kinetics

23/37

8/3/2019 Non Linear Pharmaco kinetics

24/37

W nf

W nfff

W ffnI

8/3/2019 Non Linear Pharmaco kinetics

25/37

W nf

W nff

W ffnI$

8/3/2019 Non Linear Pharmaco kinetics

26/37

f 9

f$% $

fI $f% $f

@fn $%f

fff

ffffff

$%n

$$

8/3/2019 Non Linear Pharmaco kinetics

27/37

110.941309.8439

W $ ffnnfnf

f

W$ I $+

W n $$

W $$ I$+

W $ %+$I

8/3/2019 Non Linear Pharmaco kinetics

28/37

n,,n

8/3/2019 Non Linear Pharmaco kinetics

29/37

9ff9ff

ff-ff

8/3/2019 Non Linear Pharmaco kinetics

30/37

f I$ f

f

n % f

nf ,, n f f

8/3/2019 Non Linear Pharmaco kinetics

31/37

W

W Df%fff

W I $$ff$

W $f

W ffI$+

W $%+

W $fW 9n$f f

f

8/3/2019 Non Linear Pharmaco kinetics

32/37

n

;0,339,/48,070203,3/20,8:705

W470,2501,19072/,582

W88:2022,3/.,.:,90'2

8/3/2019 Non Linear Pharmaco kinetics

33/37

f

8/3/2019 Non Linear Pharmaco kinetics

34/37

8/3/2019 Non Linear Pharmaco kinetics

35/37

f

fnffnf f

Jffn fffnnf$ "nnfff$f

Jffffffnnf"

8/3/2019 Non Linear Pharmaco kinetics

36/37

8/3/2019 Non Linear Pharmaco kinetics

37/37