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1 Edward Fisher, Debra Novak, and Ronald Shaffer Centers for Disease Control and Prevention National Institute for Occupational Safety and Health National Personal Protective Technology Laboratory NIOSH Recommendations for Extended Use and Limited Reuse of N95 Filtering Facepiece Respirators in Healthcare Settings AOHP Online Education Program WEB010-2014 July 1, 2014

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Page 1: NIOSH Recommendations for Extended Use and …...NIOSH: Service life of filters on NIOSH-approved respirators is limited by considerations of hygiene, damage, and breathing resistance;

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Edward Fisher, Debra Novak, and

Ronald Shaffer

Centers for Disease Control and Prevention

National Institute for Occupational Safety and Health

National Personal Protective Technology Laboratory

NIOSH Recommendations for Extended

Use and Limited Reuse of N95 Filtering

Facepiece Respirators in Healthcare

Settings

AOHP Online Education Program

WEB010-2014

July 1, 2014

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Disclosure

Thank you for participating in this continuing educational activity.

Goals/Purpose : To improve knowledge that promotes professional development

and enhance the learners contribution of quality health care in

Employee/Occupational Health.

Successful Completion of this CNE

In order to receive full contact-hour credit for this CNE activity, you must:

Attend the full session

Complete an evaluation

Conflict of Interest (or lack thereof) for Planners & Presenter(s)

A conflict of interest occurs when an individual has opportunity to affect or

impact educational content with which he or she may have a commercial interest

or a potentially biasing relationship of a financial, professional or personal nature.

All planner and faculty/content specialist(s) must disclose the presence or

absence of a conflict of interest relative to this activity. All potential conflicts are

resolved prior to the planning, implementation or evaluation of the continuing

nursing education activity. All activity planning committee members and

faculty/content specialist have submitted conflict of interest disclosure forms.

The planning committee members and faculty/content specialist of this CNE

activity have disclosed no relevant professional, personal or financial

relationships related to the planning or implementation of the CE activity.

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Disclosure (Continued)

Commercial or Sponsor support

This CNE activity received no sponsorships or commercial support.

Non-endorsement of products

The approved provider status of AOHP (Association of Occupational Health

Professionals) refers only to the continuing nursing education activity and does

not imply a real or implied endorsement by

AOHP or the American Nurses Credentialing Center (ANCC) of any commercial

product, service or company referred to or displayed in conjunction with this

activity, nor any company subsidizing costs related to this activity.

Reporting of Perceived Bias

Bias is defined by the American Nurses Credentialing Center’s Commission on

Accreditation (ANCC COA) a preferential influence that causes a distortion of

opinion or of facts. Commercial bias may occur when a CNE activity promotes one

or more products(s)( drugs, devices, serviced, software, hardware, etc,). This

definition is not all inclusive and participants may use their own interpretation in

deciding if a presentation is biased.

The Association of Occupational Health Professionals in Healthcare is accredited

as a provider of continuing nursing education by the American Nurses

Credentialing Center’s Commission on Accreditation.

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Webinar Presenters

NIOSH Recommendations for Extended Use and

Limited Reuse of N95 Filtering Facepiece Respirators

in Healthcare Settings

Debra Novak, PhD, RN Ronald E. Shaffer, PhDEdward Fisher, MS

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Inform professionals who manage respiratory protection programs in healthcare settings about the benefits and risks of implementing extended use and limited reuse of N95 FFRs during both emergency and non-emergency situations

Describe best practices for healthcare facilities to implement extended use and limited reuse of N95 FFRs to minimize the risks of reduced protection and self-inoculation via contact transmission

Webinar Objectives

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Why Healthcare Respiratory

Protection is a Priority

Healthcare is the fastest-growing sector of the U.S.

economy, employing over 18 million workers

Healthcare personnel (HCP) are at higher risk of exposure

to infectious respiratory pathogens than workers in non-

healthcare settings

Preferred methods of reducing exposure (elimination,

substitution, administrative, and engineering controls)

are often not possible or practical to implement,

especially during an emerging outbreak or pandemic

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When should a respirator be worn?

Respirators are often recommended to be used when in

close contact with patients suspected of having an aerosol

transmitted disease. Some *possible examples include:

Influenza (Avian strains capable of causing serious disease in humans or

during certain medical procedures)

Varicella disease (chickenpox, disseminated shingles)

Measles

Monkeypox

Severe acute respiratory syndrome (SARS)

Smallpox

Tuberculosis (TB)

*Note: Infection control guidance for specific pathogens can vary by

jurisdiction and for different medical procedures

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Respiratory Protection in Healthcare

N95 Filtering Facepiece Respirators (FFRs) are the

most commonly used type of respirator in healthcare

NIOSH 42 CFR Part 84

FDA “Surgical N95 respirator”

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Respirator Supply Concerns

N95 FFRs are often discarded after each patient

contact (‘single-use’)

Healthcare facilities experienced increased usage of

FFRs and shortages during previous public health

emergencies

25% of respondents that worked at a facility that treated one or

more possible/confirmed SARS patients experienced FFR

shortages (Srinivasan et al., 2004)

Hospitals in Vancouver reported that the use of N95 FFRs

doubled during the 2009 H1N1 flu pandemic (Mitchell et al. 2010)

50% of California hospital managers reported they had

experience shortages of respirators during the 2009 H1N1 flu

pandemic (Beckman et al. 2013)

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Options

1. Pre-emergency planning:

Purchase excess supplies of respirators and “stockpile” them

until needed

2. During the event:

Minimize # of individuals who need to use respirators through the

preferential use of engineering and administrative controls

Use alternatives to N95 FFRs (e.g., other classes of FFRs,

elastomeric half-mask and full facepiece air purifying respirators,

powered air-purifying respirators)

Implement practices allowing extended use and/or limited reuse

of N95 FFRs

Prioritize the use of N95 FFRs for those personnel at the highest

risk of contracting or experiencing complications of infection

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Background

Historically, N95 FFRs have been used in

industrial settings to reduce worker exposure

to harmful dusts and aerosols

Reuse & continuous use over several hours is

common

More recently, N95 FFRs have been

recommended for use in healthcare settings

Because of infection control concerns, decisions

regarding reuse & long-term use require additional

considerations

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Limited FFR Reuse in Healthcare

Reuse is the practice of the same healthcare worker using the same FFR for multiple patient encounters (‘close contacts’)

The FFR is removed (‘doffed’) after each encounter, stored between uses, and then put on again (‘donned’) for the next encounter

Even when FFR reuse is practiced or recommended, restrictions are in place which limit the # of times the same FFR is reused

FFR reuse is often called “limited FFR reuse”

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Extended FFR Use in Healthcare

Extended use is the practice of wearing the

same FFR for repeated encounters with

several patients, without removing the FFR

between patient encounters

Can result in several hours of continuous wear

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Concerns Expressed by Stakeholders with

Extended Use and Limited Reuse of FFRs

Self-inoculation (e.g., used FFR = fomite?)

Reduction in protection provided by the FFR

(e.g., over time, # of donnings)

Human factors (e.g., comfort, tolerability,

psychological, aesthetics)

Secondary exposures (e.g., reaerosolization)

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Scientific Assessment

2006: IOM report recommended that “avoiding contamination [of FFRs] will allow for limited reuse”and identified key research gaps

2006-2012: NIOSH and others conducted laboratory and human subject studies

2013: NIOSH working group established to reexamine recommendations

Input obtained at the June 2013 NIOSH stakeholder meeting: http://www.cdc.gov/niosh/npptl/resources/certpgmspt/meetings/06182013/HealthcareInvitationLttr06182013.html

Working group recommendations published in the August 2014 issue of the Journal of Occupational and Environmental Hygiene http://www.tandfonline.com/doi/abs/10.1080/15459624.2014.902954

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CDC FFR Limited Reuse and Extended Use

Recommendations – Historical Perspective

Respiratory

Pathogen

Contact

Transmission

Possible(*)?

FFR Shortage

Likely?

Extended

Use/Limited

Reuse Allowed?

TB [1994] No No Yes

SARS [2003] Yes Yes Yes

H5N1 Influenza [2004] Yes No No

H1N1 pandemic [2009] Yes Yes Yes

Seasonal Influenza

(AGP#) [2013]Yes No No

H7N9 Influenza [2013] Yes No No†

Notes:

(*) Some debate exists in the scientific community regarding the primary mode(s) of transmission for

many respiratory viruses; however, most experts cannot rule out contact transmission

(#) Aerosol Generating Procedures (AGP)

(†) Interim recommendations, subject to change

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Fomite fo·mite n. –

An inanimate object or substance that is capable of

transmitting infectious organisms from one individual to

another.

FFRs as fomites?

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FFR doffing and transfer of pathogens

• FFR fomite hazard can be minimized with use of proper doffing techniques

http://www.cdc.gov/HAI/pdfs/ppe/ppeposter1322.pdf

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How contaminated are FFRs in the

field?

Using a simple mathematical model (Fisher et al. 2014)

Scenario Cv*

viruses/m3

IRa

m3/hr

Er

%

T

hr

Ca*

viruses/mask

Low value inputs 168 0.780 0.900 0.160 19

High value inputs 16,000 1.920 0.999 6.600 202,549

Likely 12,000 1.140 0.991 0.330 4,473

(Cv) airborne virus

concentration

(IRa) inhalation rate

(T) time of FFR/SM

use or patient

interaction

(Er) virus retention

of FFR/SM

*Includes both viable and nonviable viruses

and inputs from the literature for influenza in

healthcare settings we can estimate contamination

levels

Pathogens on FFR (Ca) = Cv × IRa × T × Er

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Factors that influence pathogen transfer

efficiency

• Fomites may occur as porous or nonporous surfaces

• Porous surfaces demonstrate lower transfer rates than

nonporous surfaces

Hard Porous

Porous

Hard non-porous

Substrate % transferred

Lego 65

Vinyl 66

Ceramic 55

Wood 17

Shoulder pad <1

Towel <1

Bed sheet <1

Desai et al. American Journal of Infection Control April 2011

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Transfer efficiency of viruses & bacteria

from porous surfaces to skin is poor

10 µm

≈ 0.1%

• Other findings reported in the literature have similar results

Porous surface

Avg % transfer efficiency ± SDE. coli S. aureus B. thuringiensis MS-2

Cotton <6.8 ± 7.0 <1.0 ± 0.6 <0.6 ± 0.1 0.03 ± 0.02

Polyester <0.37 ± 0.28 <0.37 ± 0.48 <0.6 ± 0.6 0.3 ± 0.2

Paper currency <0.05 ± 0.04 0.2 ± 0.1 <0.1 ± 0.1 0.4 ± 0.4

Lopez et al. Transfer Efficiency of Bacteria and Viruses from Porous and Nonporous Fomites to Fingers under Different Relative Humidity

Conditions. Applied and Environmental Microbiology 2013;79: 5728–5734

• Respirators contaminated with Bacillus atrophaeus

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Modeling can be used to estimate the #

of pathogens that will actually make it

to the finger/hand per touch

Pathogens/touch = Ca × transfer efficiency × fingertip/FFR

ratio

Ca = pathogens on the mask

• Using typical values found in the literature the

model estimates that only a few viruses should get

transferred to a finger (<1 - 8 viruses/touch)

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Contact with the contaminated surface

of FFRs

10 µm

EventType of FFR use

Single Use Extended Use Reuse

Improper doffing technique *# Yes Yes Yes

Random touching *# Yes Yes Yes

Adjusting *# Yes Yes Yes

Redonning # No No Yes

User seal check No No Yes

(*) Can be mitigated with proper training and education

(#) Contact with entire surface of the FFR is not anticipated

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Regulatory and Policy Consideration

NIOSH: Service life of filters on NIOSH-approved

respirators is limited by considerations of hygiene,

damage, and breathing resistance; the filter should

be replaced if it becomes damaged, soiled, or

causes noticeably increased breathing resistance

OSHA: For TB, FFRs can be reused by the same

healthcare worker as long as the functional and

structural integrity of the FFR is maintained

FDA: Some surgical N95 FFRs are not intended to be

used more than once

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Qualitative Assessment of Increased Risks of FFR Extended

Use and Limited Reuse Compared with Single Use

Issue FFR Extended Use Limited FFR Reuse

Self-

Inoculation

Minimal risk for typical patient

encounters, but can be mitigated

by limiting touches

Risks can increase from AGP and

can be reduced by limiting

contamination

Moderate risk for typical patient

encounters, but can be mitigated by

limiting unnecessary touches

Risks can increase from AGP and

can be reduced by limiting

contamination

Protection Negligible increased riskMinimal risk, but can be mitigated

through limited # of reuses

Human

Factors

Increased discomfort, but no

additional health risk to a medically

cleared FFR user

No additional health risk to a

medically cleared FFR user

Secondary

Exposures

Negligible for typical patient

encounters

Risks can increase from AGP and

can be reduced by limiting

contamination

Negligible for typical patient

encounters

Risks can increase from AGP and

can be reduced by limiting

contamination

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Key Findings of NIOSH Working Group

Policy makers need to weigh increased risks for

disease transmission from FFR extended use and

limited reuse vs. the alternatives

Research largely supports past CDC

recommendations on FFR Extended Use and Limited

Reuse

Additional cautions and limitations should be used

Extended use is preferred over limited reuse

Decontamination for purposes of reuse should not be

recommended at this time

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Updated Recommendations Published

March 2014

http://www.cdc.gov/niosh/topics/hcwcontrols/RecommendedGuidanceExtUse.html

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Who Makes the Decision to

Implement?

Decisions to permit FFR extended use and/or limited reuse should be made at the local level by professionals who manage the institution's respiratory protection program in consultation with state/local public health departments, infection control, and relevant federal agencies (CDC, OSHA), etc.

Planning is critical

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Implementation During Emergency

Situations

Case by case decision:

Consult current CDC for that pathogen for general infection control guidance

Consider respiratory pathogen characteristics (e.g., routes of transmission, prevalence of disease in the region, infection attack rate, and severity of illness)

Consider local conditions (e.g., number of disposable N95 respirators available, current respirator usage rate, success of other respirator conservation strategies, etc.)

Some healthcare facilities may wish to implement extended use and/or limited reuse before respirator shortages are observed, so that adequate supplies are available during times of peak demand

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Implementation in Non-Emergency

Situations

Current CDC recommendations for that pathogen should be consulted

TB: limited FFR reuse permitted

Other pathogens: extended use or limited FFR reuse not recommended at this time

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General Recommendations When Implementing

FFR Extended Use and Limited Reuse

Healthcare facilities should develop clearly written procedures to advise staff to:

Follow the FFR manufacturer’s user instructions

Discard the FFR: (1) if contaminated with blood, respiratory or nasal secretions, or other body fluids from patients, (2) if damaged or hard to breathe through, (3) following aerosol generating procedures, (4) exiting the care area of a patient co-infected with an infectious disease requiring contact precautions

Perform hand hygiene before and after touching or adjusting the FFR (if necessary for comfort, to maintain fit, or redon)

Limit FFR surface contamination, whenever feasible

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Additional Recommendations for

Limited FFR Reuse

Healthcare facilities should develop clearly written procedures to advise staff to:

Follow the FFR manufacturer’s maximum number of donnings (or up to 5 if none is provided) and recommended inspection procedures

Hang used FFRs in a designated storage area or keep them in a clean, breathable container between uses

Pack or store used FFRs between uses so they do not become damaged or deformed or touch each other

Avoid sharing used FFRs

Label containers used for storing FFRs or label the FFR directly (e.g., on the straps) with the user’s name

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Creative strategies are needed to educate healthcare workers……tools, templates, online resources

Draft

California Respirator Program Administrators go to-

http://www.cdph.ca.gov/programs/ohb/Pages/RespToolkit.aspx

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Summary

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Contact Information

Edward Fisher, M.S.

Associate Service Fellow

National Personal Protective Technology Laboratory

(NPPTL)

National Institute for Occupational Safety and

Health (NIOSH)

Centers for Disease Control and Prevention (CDC)

Pittsburgh, PA 15236

Phone: 412-386-4017

Email: [email protected]

Debra Novak, DSN, RN

Senior Service Fellow

National Personal Protective Technology Laboratory

(NPPTL)

National Institute for Occupational Safety and

Health (NIOSH)

Centers for Disease Control and Prevention (CDC)

Pittsburgh, PA 15236

Email: [email protected]

Ronald Shaffer, Ph.D.

Chief, Research Branch

National Personal Protective Technology Laboratory

(NPPTL)

National Institute for Occupational Safety and

Health (NIOSH)

Centers for Disease Control and Prevention (CDC)

Pittsburgh, PA 15236

Phone: 412-386-4001

Email: [email protected]

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References/Sources

Example lists of aerosol transmitted diseases

http://www.cdc.gov/hicpac/pdf/isolation/Isolation2007.pdf

https://www.dir.ca.gov/title8/5199a.html

http://www.cdc.gov/niosh/topics/ryanwhite/

References:

‒ Srinivasan, A., D.B. Jernign, L. Liedtke, and L. Strausbaugh: Hospital preparedness for severe acute

respiratory syndrome in the United States: views from a national survey of infectious diseases

consultants. Clin Infect Dis 39(2): 272-274 (2004).

‒ Murray, M., J. Grant, E. Bryce, P. Chilton, and L. Forrester: Facial protective equipment, personnel,

and pandemics: impact of the pandemic (H1N1) 2009 virus on personnel and use of facial protective

equipment. Infect Control Hosp Epidemiol 31(10): 1011-1016 (2010).

‒ Beckman, S., B. Materna, S. Goldmacher, et al.: Evaluation of respiratory protection programs and

practices in California hospitals during the 2009–2010 H1N1 influenza pandemic. Am. J. Infect.

Control 41(11):1024–1031 (2013)

‒ IOM: Reusability of facemasks during an influenza pandemic: facing the flu. Washington, D.C.:

National Academies Press, 2006.

‒ Siegel, J.D., E. Rhinehart, M. Jackson, and L. Chiarello: "2007 Guideline for isolation precautions:

preventing transmission of infectious agents in health care settings." [Online] Available at

http://www.cdc.gov/hicpac/pdf/isolation/isolation2007.pdf , (2007).

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37

References (continued)

• CDC: "Guidelines for preventing the transmission of Mycobacterium tuberculosis in health care facilities."

[Online] Available at http://www.cdc.gov/mmwr/pdf/rr/rr4313.pdf , (1994).

• CDC: “Interim Domestic Guidance on the Use of Respirators to Prevent Transmission of SARS” [Online]

Available at http://www.cdc.gov/SARS/clinical/respirators.html, (2003).

• CDC: “Interim Recommendations for Infection Control in Health-Care Facilities Caring for Patients with

Known or Suspected Avian Influenza” [Online] Available at http://www.cdc.gov/flu/avian/professional/infect-

control.htm, (2004).

• CDC: "Questions and Answers Regarding Respiratory Protection For Preventing 2009 H1N1 Influenza

Among Healthcare Personnel" [Online] Available at

http://www.cdc.gov/h1n1flu/guidelines_infection_control_qa.htm, (2010).

• CDC: “Interim Guidance for Infection Control Within Healthcare Settings When Caring for Confirmed

Cases, Probable Cases, and Cases Under Investigation for Infection with Novel Influenza A Viruses

Associated with Severe Disease” [Online] Available at http://www.cdc.gov/flu/avianflu/h7n9-infection-

control.htm, (2013).

• Fisher, E.M., J.D. Noti, W.G. Lindsley, F.M. Blachere, and R.E. Shaffer: Validation and Application of

Models to Predict Facemask Influenza Contamination in Healthcare Settings. Risk Analysis in press(2014).

• Fisher, E.M., and R.E. Shaffer: Considerations for Recommending Extended Use and Limited Reuse of

Filtering Facepiece Respirators in Healthcare Settings Journal of Occupational and Environmental

Hygiene: 11:8, D115-D128 (2014).

• OSHA: "Enforcement procedures and scheduling for occupational exposure to tuberculosis." [Online]

Available at

https://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=DIRECTIVES&p_id=1586 , (1996).

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References (continued)

Desai, Rishi, et al. "Survival and transmission of community-associated methicillin-resistant< i>

Staphylococcus aureus</i> from fomites." American journal of infection control 39.3 (2011): 219-

225.

CDC: "Sequence for donning personal protective equipment PPE/Sequence for removing personal

protective equipment." [Online] Available at http://www.cdc.gov/HAI/pdfs/ppe/ppeposter1322.pdf

Lopez et al. Transfer Efficiency of Bacteria and Viruses from Porous and Nonporous Fomites to

Fingers under Different Relative Humidity Conditions. Applied and Environmental Microbiology 79:

5728–5734 (2013)

NIOSH: “Recommended Guidance for Extended Use and Limited Reuse of N95 Filtering Facepiece

Respirators in Healthcare Settings” [Online] Available at

http://www.cdc.gov/niosh/topics/hcwcontrols/RecommendedGuidanceExtUse.html, (2014)

California Respirator Program Administrators Toolkit:

http://www.cdph.ca.gov/programs/ohb/Pages/RespToolkit.aspx

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Quality Partnerships Enhance Worker

Safety & Health

Thank you

Visit Us at: http://www.cdc.gov/niosh/npptlDisclaimer:

The findings and conclusions in this presentation have not been

formally disseminated by the National Institute for Occupational

Safety and Health and should not be construed to represent any

agency determination or policy.