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Vol. 18, No. 11, March 31, 1989

POTICES

CANCER EDUCATION PROGRAM ................................................... 1 Nat ional Cancer I n s t i t u t e WIndex: CANCER

STEVENS AMENDMENT TO THE DEPARTMENT OF DEFENSE APPROPRIATIONS ACT .......... 1 Publ ic Heal th Serv ice Index: PUBLIC HEALTH SERVICE

METHODS OF MOLECULAR MECHANICS AND DYNAMICS OF BIOPOLYMERS WORKSHOP, PITTSBURGH SUPERCOMPUTING CENTER .................................. 1 Divis ion o f Research Resources Index: RESEARCH RESOURCES

N I H REGIONAL CONFERENCE I N GRANTS ADMINISTRATION ............................. 2 National I n s t i t u t e s of Health Index: NATIONAL INSTITUTES OF HEALTH

DATED ANNOUNCEMENTS (RFPs AND RFAs)

DEVELOPMENT AND TESTING OF NEW MALE AND FEMALE CONDOMS (RFP) ................ 3 National I n s t i t u t e of Child Heal th and Human DevelopmentIndex: CHILD HEALTH, HUMAN DEVELOPMENT

HOUSING, MAINTENANCE AND ROUTINE TESTING OF A I D S INFECTED RESEARCH ANIMALS (RFP) ...................................................... National I n s t i t u t e of A l l e r g y and I n f e c t i o u s Diseases Index: ALLERGY, INFECTIOUS DISEASES

3

COMPUTATIONAL NEURONAL MODELING (RFP) ....................................... National I n s t i t u t e of Neurological Disorders and St rokeIndex: NEUROLOGICAL DISORDERS, STROKE

4 W’

REDUCING FRAILTY AND INJURIES I N OLDER PERSONS (RFA) ........................ National I n s t i t u t e on AgingNational Center f o r Nursing Research Index: A G I N G , NURSING RESEARCH

4

MINORITY MENTAL HEALTH RESEARCH CENTERS (RFA) ............................... National I n s t i t u t e of Mental Health

6

Index: MENTAL HEALTH

RESEARCH T R A I N I N G AND CAREER DEVELOPMENT AWARDS FOR PHYSICIANS I N NUTRITION (RFA) .......................................................... National I n s t i t u t e of Diabetes and Diges t ive and Kidney Diseases Index: DIABETES, DIGESTIVE AND KIDNEY DISEASES

7

O N G O I N G PROGRAM ANNOUNCEMENTS

M I N O R I T Y RESEARCH PROGRAM ADMINISTRATIVE SUPPLEMENTAL AWARDS ................ 8 National I n s t i t u t e on Alcohol Abuse and Alcoholism National I n s t i t u t e on Drug Abuse Index: ALCOHOL ABUSE, ALCOHOLISM, DRUG ABUSE

ERRATUM

STUDIES OF DIABETES MELLITUS AND RELATED PROBLEMS (PA) ...................... 9 National I n s t i t u t e of Diabetes and Diges t ive and Kidney Diseases Index: DIABETES, DIGESTIVE AND KIDNEY DISEASES -SPECIAL EMPHASIS RESEARCH CAREER AWARD (SERCA) I N LABORATORY ANIMAL SCIENCE (PA) ......................................................... 9 Divis ion of Research Resources Index: RESEARCH RESOURCES

NOTICES

CANCER EDUCATION PROGRAM (R25)

P.T. 34; K.W. 0715035, 0403004, 0795003

'I4 Nat iona l Cancer I n s t i t u t e

The nex t a p p l i c a t i o n r e c e i p t d a t e s f o r t h e Cancer Education Program (R25) w i l l be October 1 , 1989, f o r new a p p l i c a t i o n s and November 1 , 1989, f o r renewal a p p l i c a t i o n s . The June and J u l y 1989 receipt d a t e s w i l l be skipped; t h e r e f o r e , any a p p l i c a t i o n s r ece ived on t h o s e d a t e s w i l l be d e f e r r e d t o t h e nex t c y c l e . The t i m e t a b l e f o r a l l t h e s e a p p l i c a t i o n s w i l l be as fo l lows : i n i t i a l review f o r s c i e n t i f i c merit, February 1990; second l e v e l review by t h e Nat iona l Cancer Advisory Board, May 1990. Please c o n t a c t t h e Cancer T r a i n i n g Branch, ( D r . Robert Adams, (301) 496-8580), i f you have any q u e s t i o n s concerning t h i s announcement.

STEVENS AMENDMENT TO THE DEPARTMENT OF DEFENSE APPROPRIATIONS ACT

P.T. 34; K.W. 1014002, 1014006

Pub l i c Heal th S e r v i c e

The Office of Management and Budget has advised t h e heads o f a l l departmentsand agenc ie s about a government-wide requirement se t f o r t h i n S e c t i o n 8136 o f t h e Department o f Defense (DOD) Appropr ia t ions A c t f o r f i s c a l yea r 1989. S p e c i f i c a l l y , S e c t i o n 8136 (The "Stevens Amendment") r e a d s as fo l lows :

"When i s s u i n g s t a t emen t s , p r e s s releases, r e q u e s t s f o r p roposa l s , b i d s o l i c i t a t i o n s , and o t h e r documents d e s c r i b i n g p r o j e c t s o r programsfunded i n whole o r i n p a r t wi th Fede ra l money, a l l g r a n t e e s r e c e i v i n g Fede ra l funds, i nc lud ing but n o t l i m i t e d t o S t a t e and l o c a l giovernments, s h a l l c l e a r l y s ta te ( 1 ) t h e percentage o f t h e t o t a l c o s t o f t h e p r o ram o r p r o j e c t which w i l l be f inanced wi th Federa l money, and (27 t h e d o l l a r amount o f Fede ra l funds f o r t h e p r o j e c t o r program."

w/ A l l r e c i p i e n t s o f P u b l i c Heal th S e r v i c e g r a n t s (and coope ra t ive agreements)invo lv ing f i s ca l yea r 1989 appropr i a t ed funds must comply wi th t h e requi rements of S e c t i o n 8136.

PETHODS OF M OLECULAR MECHANICS AND DYNAMICS OF BIOPOLYMERS WORKSHOP. PITTSBURGH SUPERCOMPUTING CENTER

P.T. 42; K.W. 0790010, 0760060, 1004000

Div i s ion o f Research Resources

The P i t t s b u r g h Supercomputing Center (PSC) is conducting a three-day.workshop on "Methods of Molecular Mechanics and Dynamics o f Biopolymers," May 31, June 1-2, 1989, f o r biomedical r e s e a r c h e r s . Th i s workshop is funded by a g r a n tfrom t h e Div i s ion o f Research Resources' Biomedical Research Technology (BRT)Program o f t h e Na t iona l I n s t i t u t e s o f Heal th ( N I H ) .

The workshop w i l l f a m i l i a r i z e biomedical r e s e a r c h e r s w i th computa t iona lmethods and provide p r a c t i c e i n apply ing supercomputing r e s o u r c e s t o problemso f concern i n molecular mechanics; Previous programming o r supercomputingexper ience is d e s i r a b l e bu t n o t necessa ry . Pract ical expe r i ence on t h e P i t t s b u r g h Supercom u t i n g Cen te r ' s Cray Y-MP/832 w i l l be ga ined i n t h e a p p l i c a t i o n t o : (1'3 t h e problem o f conformat iona l mapping and a n a l y s i s o f po lypep t ide s t r u c t u r e s ; ( 2 ) t h e s t r u c t u r a l re f inement o f po lypep t ides ,p r o t e i n s , and n u c l e i c a c i d s us ing c o n s t r a i n t s from measured NMR d a t a ; and ( 3 )computation o f i n t e r a c t i o n e n e r g i e s and free e n e r g i e s f o r pro te in-drugi n t e r a c t i o n s . The use o f s t a t e - o f - t h e - a r t macromolecular computationalpackages w i l l be i l l u s t r a t e d . The workshop w i l l be l e d by D r . Char les L . Brooks 111, Carnegie Mellon U n i v e r s i t y .

T h i s th ree-day workshop w i l l i nc lude an o p t i o n a l ha l f -day s e s s i o n t h e morningof May 31 l e d by PSC s t a f f members. Topics t o be covered du r ing t h e o p t i o n a ls e s s i o n inc lude VAX, VMS, and UNICOS, t h e Cray v e r s i o n o f t h e AT&T System V

w Unix o p e r a t i n g system.

Vol. 18, No. 11, March 31, 1989 - Page 1

Trave l , meals, and h o t e l accommodations are covered f o r U.S. academic p a r t i c i p a n t s under t h e g r a n t . Enrollment is l i m i t e d t o 20 p a r t i c i p a n t s . THE DEADLINE FOR SUBMISSION OF APPLICATIONS I S APRIL 20, 1989.

To apply f o r t h e workshop send a l e t t e r accompanied by a cur r icu lum v i t a e t o Cherolyn Brooks a t t h e a d d r e s s below. The l e t t e r should o u t l i n e your r e s e a r c h background and c u r r e n t r e s e a r c h a c t i v i t i e s and i n t e r e s t s , t o g e t h e r wi th a b r i e f d e s c r i p t i o n (one paragraph) o f a problem t h a t may be addressed i n t h i s workshop. The a p p l i c a n t ’ s l e v e l of FORTRAN programming expe r i ence and supercomputing expe r i ence , i f any, should a l s o be inc luded . I n a d d i t i o n , gradua te s t u d e n t s should submit a l e t t e r o f recommendation w r i t t e n by a f a c u l t y member.

For f u r t h e r in format ion , c a l l or write t o :

Cherolyn A. Brooks User S e r v i c e s P i t t s b u r g h Supercomputing Center 4400 F i f t h Avenue P i t t s b u r g h , Pennsylvania 15213 Telephone: (412) 268-5206? 1-800-222-9310 (Pennsylvania)

1-800-221-1641 ( o u t s i d e Pennsylvania)

FIH REGIONAL CONFERENCE I N GRANTS ADMINISTRATION

P.T. 42; K.W. 1014006

Nat iona l I n s t i t u t e s o f H e a l t h

A two-day conference cove r ing t o p i c s r e l a t e d t o both program funding and g r a n t s a d m i n i s t r a t i o n a t t h e Nat iona l I n s t i t u t e s o f Hea l th is planned f o r May25-26, 1989, a t M i s s i s s i p p i S t a t e U n i v e r s i t y i n S t a r k v i l l e . The conference is t a r g e t e d f o r audience of r e s e a r c h e r s and r e s e a r c h a d m i n i s t r a t o r s a tan i n s t i t u t i o n s i n t h e sou the rn r eg ion which i n c l u d e s Alabama, F l o r i d a , Georgia,Kentucky, M i s s i s s i p p i , North Caro l ina , South Caro l ina , and Tennessee. Those i n t e r e s t e d from Arkansas and Louis iana are a l s o encouraged t o a t t e n d . I n v e s t i g a t o r s and s t a f f from smal l and minor i ty c o l l e g e s , f o r - p r o f i t r e s e a r c h o r g a n i z a t i o n s , h o s p i t a l s , u n i v e r s i t i e s , and r e s e a r c h i n s t i t u t e s are i n v i t e d . T h i s two-day conference h a s a d u a l focus o f i n t e r e s t t o both r e s e a r c h e r s and g r a n t s a d m i n i s t r a t o r s . D i scuss ions o f c u r r e n t i s s u e s t h a t affect N I H fundingand g r a n t s a d m i n i s t r a t i o n a r e inc luded t o g i v e conference p a r t i c i p a n t s a comprehensive, up-to-date view o f NIH-sponsored r e s e a r c h .

The first day o f t h e conference is devoted t o d i s c u s s i o n s o f c u r r e n t i n t e r e s t t o t h e r e s e a r c h programs o f t h e v a r i o u s i n s t i t u t e s t h a t comprise t h e N I H . P r e p a r a t i o n o f an N I H p roposa l and t h e N I H review p rocess are inc luded as agenda t o p i c s . Program r e p r e s e n t a t i v e s from t h r e e o f t h e N I H i n s t i t u t e s and t h e Na t iona l I n s t i t u t e on Drug Abuse of t h e Alcohol, Drug Abuse and Mental Hea l th Admin i s t r a t ion are f e a t u r e d speake r s . Time w i l l be a v a i l a b l e f o r conference p a r t i c i p a n t s t o meet i n fo rma l ly wi th t h e N I H r e p r e s e n t a t i v e s and d i s c u s s t o p i c s o f s p e c i a l i n t e r e s t .

The program for t h e second day cove r s t o p i c s a s s o c i a t e d wi th pre-award and post-award a d m i n i s t r a t i o n o f N I H g r a n t s . Po l i cy and p rocedura l i s s u e s a f f e c t i n g N I H g r a n t s a d m i n i s t r a t i o n form t h e b a s i s f o r t h e program. General d i s c u s s i o n s on c u r r e n t i s s u e s and t h e changes t h e y p r e c i p i t a t e are i n t e g r a t e dwi th more s p e c i f i c d i s c u s s i o n s r ega rd ing s p e c i a l career development programsand l a b s a f e t y . M r . Geoffrey Grant, Grants P o l i c y Officer i n t h e O f f i c e of Extramural Research a t N I H , and r e p r e s e n t a t i v e $ from t h e Div i s ion o f Research Grants and pcogram and g r a n t s management staff of s e v e r a l i n s t i t u t e s are f e a t u r e d speake r s .

uc

Conference informat ion w i l l be mailed ou t i n e a r l y A p r i l ,conference r e g i s t r a t i o n is May 5 t h . D r . Bev. R. Norment U n i v e r s i t y is i n charge o f conference arrangements. For c o n t a c t him or h i s a s s i s t a n t , M s . Donna Echols, a t (601)

and t h e d e a d l i n e f o r a t M i s s i s s i p p i S t a t e more informat ion , 325-3570.

Vol. 18, No. 1 1 , March 31, 1989 - Page 2

DATED ANNOUNCEMENTS (RFPs AND RFAs)

PEVELOPMENT AND TESTING OF NEW MALE AND FEMALE CONDOMS

RFP AVAILABLE$ NICHD-BAA-89-16

*d P.T. 34; K.W. 0750020

Nat iona l I n s t i t u t e o f Chi ld Heal th and Human Development

The Cont racept ive Development Branch of t h e Center f o r Popu la t ion Research, Nat iona l I n s t i t u t e o f Chi ld Heal th and Human Development, has a requirement t o develop, des ign , and t e s t new non-latex o r modified l a t e x condoms f o r male and female use posses s ing t h e fo l lowing c h a r a c t e r i s t i c s : ( a ) t e n s i l e and a i r b u r s t s t r e n g t h g r e a t e r t h a n p r e s e n t l a t e x condoms; ( b ) uniform w a l l t h i c k n e s s ; (c ) non- sens i t i z ing , ( d ) pin-hole f r e e , o r p o r o s i t y sma l l e r t h a n 40 microns; ( e ) spermic ide c o m p a t i b i l i t y ; ( f extended s h e l f - l i f e ; ( g ) sh ipp ing s t a b i l i t y . Proposa ls t o develop new p o t e n t i a l m a t e r i a l s o r t o t es t o r compare marketed produc t s w i l l n o t be accepted under t h i s RFP. It is a n t i c i p a t e d t h a t t h r e e c o n t r a c t awards w i l l be made f o r a maximum pe r iod of f i v e y e a r s each depending upon t h e n a t u r e and complexity o f t h e proposed r e s e a r c h .

T h i s is n o t a Request f o r P roposa l s . RFP-NICHD-BAA-89-16 w i l l be i s sued on o r about A p r i l 11, 1989, as a Broad Agency Announcement a s de f ined i n FAR 6.102 ( d I ( 2 ) . Proposa ls w i l l be due approximately 90 days t h e r e a f t e r . Copies o f t h e RFP may be ob ta ined by sending w r i t t e n r e q u e s t s t o Mr. Paul J . Duska a t t h e addres s l i s t e d below. Requests may a l s o be made by FAX Telephone ( 3 0 1 ) 496-0962.

Paul J . Duska, Con t rac t ing O f f i c e r Cont rac t s Management Sec t ion , OGC Nat iona l I n s t i t u t e o f Chi ld Heal th and Human DevelopmentExecut ive P l a z a North, Room 610 9000 Rockv i l l e P ike Bethesda, Maryland 20892

HOUSING9 MAINTENANCE AND ROUTINE TEST1NG OF AIDS INFECTED RESEARCH ANIMALS

RFP AVAILABLE: RFP-NIH-NIAID-OSD-90-12 *lb-r

P.T. 34; K.W. 1002002, 0715008

Nat iona l I n s t i t u t e o f A l l e rgy and I n f e c t i o u s Diseases

The In t r amura l Research Program, Office of t h e S c i e n t i f i c D i r e c t o r of t h e Nat iona l I n s t i t u t e o f A l l e rgy and I n f e c t i o u s Diseases, has a requirement f o r housing and maintenance of up t o 12 a d u l t chimpanzees whi le conducting d i r e c t e d r e s e a r c h s t u d i e s wi th human immunodeficiency v i r u s e s . Of fe ro r s must have f a c i l i t i e s and t r a i n e d personnel f o r working wi th i n f e c t i o u s d i s e a s e a g e n t s i n chimpanzees.

Any c o n t r a c t awarded w i l l be s u b j e c t t o DHHS r e g u l a t i o n s r ega rd ing t h e use o f animal s u b j e c t s i n r e s e a r c h . The I n s t i t u t e p l a n s t o make one award from t h i s s o l i c i t a t i o n .

RFP-NIH-NIAID-OSD-90-12 w i l l be i s s u e d on o r about A p r i l 14, 1989, wi th a c l o s i n g d a t e f o r r e c e i p t of proposa l s t e n t a t i v e l y set f o r June 2, 1989. To r e c e i v e a copy o f t h e RFP, please supply t h i s o f f i c e wi th two ( 2 ) se l f - addres sed ma i l ing l a b e l s . A l l r e s p o n s i b l e sou rces may submit a proposa l which w i l l be cons idered by N I A I D .

Request f o r t h e RFP should be d i r e c t e d t o :

Ms. Joyce U. SagamiNat iona l I n s t i t u t e of A l l e rgy and I n f e c t i o u s Diseases Westwood Bui ld ing , Room 707 5333 Westbard Avenue Bethesda, Maryland 20892 Telephone: (301) 496-2509

This adver t i sement does n o t commit t h e Government t o award a c o n t r a c t .

Vol. 18, No. 11, March 31, 1989 - Page 3

COMPUTATIONAL NEURONAL MODELING

RFP AVAILABLE: NIH-NINDS-89-06

P.T. 34; K.W. 0705055, 1004000

Nat iona l I n s t i t u t e o f Neurological Disorders and S t r o k e

The Nat iona l I n s t i t u t e of Neurological Disorders and S t r o k e (NINDS) h a s a new requirement f o r computat ional neuronal modeling. T h i s c o n t r a c t is t h e f irst phase o f a long-term e f f o r t t o develop a sound f u n c t i o n a l mathematical d e s c r i p t i o n o f t h e n a t u r e and behavior o f l e a r n i n g , s t o r a g e , and recal l i n v e r t e b r a t e b i o l o g i c a l systems. Such a mathematical d e s c r i p t i o n , even i n i t s e a r l y s t a g e s o f development w i l l s e r v e two p r i n c i p a l , mutual ly r e i n f o r c i n g f u n c t i o n s . It w i l l f a c i l i t a t e t h e des ign o f f u r t h e r n e u r o b i o l o g i c a l experiments and it w i l l s e r v e as t h e b a s i s f o r t h e development o f numerical models t h a t c l e a r l y demonstrate t h e p a t t e r n r e c o g n i t i o n and c l a s s i f i c a t i o n c a p a b i l i t i e s o f animals and man.

The work r e q u i r e d o f t h e Cont rac tor s h a l l c o n s i s t o f t h e fo l lowing i n t e r r e l a t e d t a s k s : 1 ) develop a d e t a i l e d , lumped-parameter model ( t h a t can be numer ica l ly emulated u s i n g a computer as a t o o l ) o f i n v e r t e b r a t e and v e r t e b r a t e n e u r a l systems e x h i b i t i n g a s s o c i a t e l e a r n i n g , s t o r a g e , and recal l t h a t b e a r s a one-to-one r e l a t i o n s h i p t o b i o l o g i c a l r e a l i t y ; 2 ) develop a mathematical model of t h e under ly ing input /output r e l a t i o n s o f t h e models; 3 ) demonstrate t h e v a l i d i t y o f t h e mathematical model by numerical emulat ion o f t h a t model u s i n g t h e mathematical model r a t h e r t h a n a one-to-one d e s c r i p t i o n of b i o l o g i c a l r e a l i t y ; and 4 ) u t i l i z i n g t h e emulat ions, demonstrate as c l e a r l y as p o s s i b l e t h e a b i l i t y of t h e s e a lgor i thms t o l e a r n , s t o r e , reca l l , and a s s o c i a t e i n p u t s , u s i n g r ea l i s t i c t e s t cases.

O f f e r o r s must have: 1 ) exper ience i n computer modeling and mathematical a n a l y s i s o f n e u r a l networks ( a r t i f i c i a l and n a t u r a l ) , non- l inear systems, a n d l o r non- l inear o p t i m i z a t i o n t h e o r y and a p p l i c a t i o n s ; 2 ) personnel q u a l i f i e d t o perform i n t e r d i s c i p l i n a r y r e s e a r c h spanning computerscience/engineering/physics/systems s c i e n c e on t h e one hand and biomedical s c i e n c e s on t h e o t h e r ; and 3) computer hardwarelsof tware r e s o u r c e s adequate t o c a r r y o u t t h e proposed work, i n c l u d i n g f a c i l i t i e s t o execute e f f i c i e n t l y l a r g e n e u r a l network computer programs wi th consequent l a r g e datalprogram memoryrequi rements .

It is a n t i c i p a t e d t h a t one c o n t r a c t award w i l l be made under t h i s RFP, f o r a th ree-year p e r i o d .

T h i s is n o t a Request f o r Proposa ls (RFP). RFP No. NIH-NINDS-89-06 w i l l be i s s u e d on or about March 27, 1989, wi th t e n t a t i v e d a t e f o r r e c e i p t o f p r o p o s a l s se t a t May 19, 1989.

To r e c e i v e a copy of t h e RFP, p l e a s e submit a w r i t t e n r e q u e s t t o t h e fo l lowing a d d r e s s and supply t h i s o f f i c e wi th two se l f -addressed mai l ing l a b e l s .

All r e s p o n s i b l e s o u r c e s may submit a proposa l which w i l l be cons idered by t h e Government.

Contrac t ing Officer C o n t r a c t s Management Branch, DEA Nat iona l I n s t i t u t e of Neurological Disorders and St roke , N I H Federa l Bui lding, Room 9 0 1 7550 Wisconsin Avenue Bethesda, Maryland 20892

Attn : RFP-NIH-NINDS-89-06

REDUCING FRAILTY AND INJURIES I N OLDER PERSONS

RFA AVAILABLE: 89-AGlNR-04

P.T. 34; K.W. 0715027, 0745027, 0745030, 0710010, 0415003

Nat iona l I n s t i t u t e on AgingNat iona l Center f o r Nursing Research

Appl ica t ion Receipt Date: J u l y 19, 1989

-.)

*F

Vol. 18, No. 11, March 31, 1989 - Page 4

PURPOSE

T h i s announcement i n v i t e s coope ra t ive agreement a p p l i c a t i o n s f o r : i) S i t e s t o c a r r y ou t biomedical, behav io ra l o r environmental i n t e r v e n t i o n s t u d i e s designed t o reduce t h e loss o f f u n c t i o n a l c a p a c i t i e s and t o preventf a l l - r e l a t e d i n j u r i e s i n o l d e r persons; and ii) a Coordina t ing Center f o r t h e s e i n t e r v e n t i o n s t u d i e s . Two r e l a t e d i n v e s t i g a t i v e approaches are sought:

Id o S t u d i e s aimed a t i n c r e a s i n g phys ica l f u n c t i o n a l c a p a c i t i e s and

reducing i n j u r i e s by improving mob i l i t y , s t r e n g t h , and ba lance .

o S t u d i e s aimed a t op t imiz ing h e a l t h behaviors and/or environmental c o n d i t i o n s wi th t h e i n t e n t of reducing fear o f f a l l i n g , t h e a c t u a l occur rence of fa l l s , consequent i n j u r i e s , o r o t h e r nega t iveseque lae .

BACKGROUND

A major goa l o f r e s e a r c h r e l a t e d t o ag ing is t o i n c r e a s e t h e p e r i o d o f time t h a t o l d e r i n d i v i d u a l s are a b l e t o f u n c t i o n independently and i n r e l a t i v e l ygood h e a l t h . The September 1988 "Workshop on Reducing F r a i l t y and Fa l l -Re la t ed I n j u r i e s i n Older Persons" sponsored by t h e Nat iona l I n s t i t u t e on Aging ( N I A ) , Nat iona l Center f o r Nursing Research ( N C N R ) and t h e Cen te r s f o r Disease Cont ro l , p re sen ted c u r r e n t knowledge on t h e s e s u b j e c t s .Recommendations were f o r t h e need t o : i) conduct i n i t i a l s t u d i e s t o t e s t t h e e f f i c a c y o f d i f f e r e n t i n t e r v e n t i o n approaches; ii) encourage i n t e r v e n t i o n s i n popu la t ions wi th e i t h e r low, in t e rmed ia t e o r h igh f u n c t i o n a l impairment w i th t h e i n t e r v e n t i o n well matched t o t h e a p p r o p r i a t e t a r g e t popula t ion ; iii)select outcome measures ve ry c a r e f u l l y and wi th f u l l awareness o f r e q u i r e dsample s i z e ; i v ) emphasize f u n c t i o n a l c a p a c i t i e s and h e a l t h behav io r s as c r i t i c a l outcome measures; and v i ) e v a l u a t e f a c t o r s which may affect compliance wi th t h e i n t e r v e n t i o n s i n t h e s e popu la t ions .

RESEARCH GOALS AND SCOPE

A p p l i c a t i o n s are i n v i t e d which propose s t u d i e s t o t e s t i n t e r v e n t i o n s t r a t e g i e sf o r t h e p reven t ion , r e d u c t i o n o r compensation of phys i ca l f r a i l t i e s o r environmental haza rds which p l a c e o l d e r persons a t r i s k f o r i n j u r i e s . It is a n t i c i p a t e d t h a t t h e r e w i l l be 6-8 S i t e s and one Coordina t ing Center which must be independent o f t h e S i t e s . A m u l t i d i s c i p l i n a r y approach is encouraged as a p p r o p r i a t e t o t h e proposed i n t e r v e n t i o n .

* l l l j

Examples o f i n t e r v e n t i o n s t o i n c r e a s e phys ica l c a p a c i t i e s i nc lude , bu t are n o t l i m i t e d t o :

o R e h a b i l i t a t i o n programs t o r e s t o r e f u n c t i o n a l d e f i c i t s r e l a t e d t o c a r d i o v a s c u l a r , musculoske le ta l and o t h e r dys func t ions among o l d e r pe r sons .

o Exerc i se and/or n u t r i t i o n a l i n t e r v e n t i o n s designed t o improvemuscular s t r e n g t h and/or bone s t r e n g t h .

o Exerc i se regimens t o improve p o s t u r a l s t a b i l i t y and/or range of mot i o n .

o I n t e r v e n t i o n s t o i n c r e a s e mob i l i t y and s t r e n g t h i n o l d e r i n d i v i d u a l s w i th a r t h r i t i s .

Examples o f i n t e r v e n t i o n s t o enhance h e a l t h behav io r s and/orenvironments i nc lude , bu t are n o t l i m i t e d t o :

o I n t e r v e n t i o n s t o i d e n t i f y and e l i m i n a t e r i s k - r e l a t e d environmental haza rds i n t h e home or i n s t i t u t i o n a l s e t t i n g .

o Behavioral s t r a t e g i e s t o i n c r e a s e o l d e r i n d i v i d u a l s ' r e c o g n i t i o n of i n j u r y r i s k , avoidance o f imprudent behav io r s a s s o c i a t e d wi th i n j u r y r i s k , and adopt ion o f a p p r o p r i a t e behav io ra l responses t o reduced f u n c t i o n a l c a p a c i t i e s .

o Psychosocia l i n t e r v e n t i o n s t o reduce i n c a p a c i t a t i n g fear o f f a l l i n gand i n c r e a s e psychosocia l f u n c t i o n i n g .

o Development and t e s t i n g of s p e c i a l f a l l s r e d u c t i o n programs i n i n s t i t u t i o n a l s e t t i n g s .

*I

Vol. 18, No. 11, March 31, 1989 - Page 5

MECHANISM OF SUPPORT

The a d m i n i s t r a t i v e and funding mechanism t o be used t o suppor t t h e s e awards w i l l be coope ra t ive agreements between each awardee and N I H . T h i s s tudy w i l l involve t h e coope ra t ion of s c i e n t i s t s from: 1 ) m u l t i p l e r e s e a r c h S i t e s , 2 ) a Coordina t ing Center , and 3) two N I H u n i t s ( N I A and NCNR) . A S t e e r i n g Committee w i l l s e r v e as t h e s t u d y ' s primary governing body. The proposed s t a r t d a t e is A p r i l 1 , 1990. Support may be r eques t ed f o r up t o 3 y e a r s f o r -b

S i t e s bu t must be r eques t ed f o r t h e f u l l 3 y e a r s by t h e Coordina t ing Cen te r .

REVIEW PROCEDURES AND C R I T E R I A

Appl i ca t ions w i l l be r ece ived by t h e N I H D iv i s ion o f Research Grants and w i l l be d u a l l y a s s igned t o N I A and NCNR. App l i ca t ions judged by N I A o r NCNR t o be nonresponsive w i l l n o t be accep ted . Responsive a p p l i c a t i o n s may be s u b j e c t e d t o t r i a g e by a pee r review group t o determine t h e i r s c i e n t i f i c merit r e l a t i v e t o t h e o t h e r a p p l i c a t i o n s r ece ived i n response t o t h i s RFA. App l i ca t ions w i l l be reviewed i n accord wi th t h e usua l N I H pee r review procedures .

METHOD OF APPLYING

The f u l l v e r s i o n o f t h i s RFA should be r eques t ed and t h e i n s t r u c t i o n s it c o n t a i n s f o r completing a p p l i c a t i o n s should be fo l lowed. Researchers c o n s i d e r i n g an a p p l i c a t i o n i n response t o t h i s RFA are s t r o n g l y encouraged t o d i s c u s s t h e i r p r o j e c t wi th N I A o r NCNR program a d m i n i s t r a t o r s i n advance of formal submission. T h i s can be done e i t h e r th rough a t e l ephone conve r sa t ion o r a b r i e f l e t t e r g i v i n g t h e t i t l e of t h e proposed p r o j e c t , t h e p r i n c i p a l i n v e s t i g a t o r and, when known, o t h e r key p a r t i c i p a n t s . Th i s l e t t e r should be s e n t t o t h e a p p r o p r i a t e s t a f f c o n t a c t l i s t e d below by June 14, 1989.

INQUIRIES

Presubmission i n q u i r i e s and correspondence can be d i r e c t e d t o t h e s e N I A and NCNR c o n t a c t o f f i c e s l i s t e d below.

Geriatrics Branch Nat iona l I n s t i t u t e on AgingBui ld ing 31, Room 5C27 Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-1033

Behaviora l and S o c i a l Research ProgramNat iona l I n s t i t u t e on AgingBui ld ing 31, Room 5C32 Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-3136

Heal th Promotion and Disease Prevent ion Branch Nat iona l Center f o r Nursing Research Bui ld ing 31, Room 5 B 1 3 Bethesda, Maryland 20892 Telephone3 ( 3 0 1 ) 496-0523

MINORITY MENTAL HEALTH RESEARCH CENTERS

RFA AVAILABLE: MH-89-02

P.T. 0 4 , FF; K.W. 0715095, 0710030

App l i ca t ion Rece ip t Date : November 15, 1989

Na t iona l I n s t i t u t e of Mental Heal th

The Na t iona l I n s t i t u t e o f Mental Heal th ( N I M H ) is r e q u e s t i n g a p p l i c a t i o n s f o r Minor i ty Mental Heal th Research Centers t o suppor t coord ina ted ,m u l t i d i s c i p l i n a r y r e s e a r c h on t h e mental h e a l t h needs and i s s u e s o f minor i typopu la t ions . E l i g i b l e a p p l i c a n t i n s t i t u t i o n s inc lude any non-p ro f i t o r f o r - p r o f i t o r g a n i z a t i o n which has an e s t a b l i s h e d r e l e v a n t r e s e a r c h c a p a c i t y o r has a documented a f f i l i a t i o n wi th an i n s t i t u t i o n wi th such a r e s e a r c h c a p a c i t y .

I n f i s ca l y e a r 1989, N I M H funded f o u r c e n t e r s f o r a t o t a l amount o f about $2.3 m i l l i o n . I n f i s ca l yea r 1990, N I M H hopes t o fund up t o f o u r new c e n t e r s under t h i s RFA. The i n i t i a l funding pe r iod of a new c e n t e r w i l l be f o r no more t h a n 3 yea r s , a t which time a competing a p p l i c a t i o n f o r renewal w i l l be cons ide red '+le.

f o r f u t u r e funding .

Vol. 18, No. 11, March 31, 1989 - Page 6

P o t e n t i a l a p p l i c a n t s are r eques t ed t o submit a one-page l e t t e r o f i n t e n t byA p r i l 3 0 , 1989. The l e t t e r should be s e n t t o Mrs. Edna Hardy-Hill, w i th a copy t o D r . Freda K . Cheung a t t h e fo l lowing addres ses :

Mrs. Edna Hardy-Hill, Chief Research Development and S p e c i a l P r o j e c t s Review Branch Div i s ion of Extramural A c t i v i t i e s Room 9C-15 Telephone: (301) 443-6470

D r . Freda Cheung, Act ing Chief Minor i ty Research Resources Branch Div i s ion o f Applied Biometry and Applied Sc iences Room 18-101 Telephone: ( 3 0 1 ) 443-3724

The mai l ing addres s f o r bo th o f t h e above is:

N I M H 5600 F i s h e r s Lane Rockvi l le , Maryland 20857

NIMH w i l l accept a p p l i c a t i o n s i n response t o t h i s r e q u e s t for a p p l i c a t i o n s on November 15, 1989, and t h e r e a f t e r under t h e r e g u l a r Pub l i c Heal th S e r v i c e receipt d a t e s f o r a p p l i c a t i o n s . For f u r t h e r in format ion , p o t e n t i a l a p p l i c a n t s should c o n t a c t D r . Cheung as l i s t e d above.

JESEARCH T R A I N I N G AND CAREER DEVELOPMENT AWARDS FOR PHYSICIANS I N NUTRITION

RFA AVAILABLE: 89-DK-06

P.T. 34; K.W. 0710095

Nat iona l I n s t i t u t e o f D iabe te s and Diges t ive and Kidney Di seases

Appl i ca t ion Rece ip t Date: J u l y 17, 1989

The Nat iona l I n s t i t u t e o f D iabe te s and Diges t ive and Kidney Diseases ( N I D D K ) i n v i t e s a p p l i c a t i o n s f o r n u t r i t i o n r e s e a r c h t r a i n i n g and f o r career development f o r p h y s i c i a n s . The N u t r i t i o n Program of t h e Div i s ion of

-I(I Diges t ive Diseases and N u t r i t i o n ( D D D N ) , NIDDK, s u p p o r t s r e sea rch , r e s e a r c h t r a i n i n g , and c a r e e r development programs on n u t r i e n t metabolism, o b e s i t y ,e a t i n g d i s o r d e r s and energy r e g u l a t i o n . The o b j e c t i v e o f t h i s s o l i c i t a t i o n i s t o i n c r e a s e t h e number o f phys i c i ans who can conduct h igh q u a l i t y n u t r i t i o n r e s e a r c h . The award mechanisms o f f e r e d t o achieve t h i s a r e : 1 . The Nat iona l Research S e r v i c e Award I n s t i t u t i o n a l T ra in ing Grant . 2. The Na t iona l Research S e r v i c e Award I n d i v i d u a l Pos tdoc to ra l Fellowship. 3. The Phys ic ianS c i e n t i s t Award 4. The C l i n i c a l I n v e s t i g a t o r Award.

ELIGIBILITY REQUIREMENTS

These requi rements are i n a d d i t i o n t o t h e s t anda rd e l i g i b i l i t y c r i t e r i a for t h e s e Pub l i c Heal th S e r v i c e award mechanisms and apply only t o t h e s e awards under t h i s RFA: 1 . Nat iona l Research S e r v i c e Award I n s t i t u t i o n a l T ra in ingGrant: t h e a p p l i c a n t o r g a n i z a t i o n must be or must be a s s o c i a t e d wi th a majormedical i n s t i t u t i o n , must have or be a b l e t o develop a p o t e n t i a l b a s i c s c i e n c e t r a i n i n g s ta f f who have N I H or o t h e r compe t i t i ve ly awarded r e s e a r c h suppor t ,and must ev idence a c a p a c i t y t o a t t r ac t and t r a i n phys ic i ans from under - represented minor i ty groups. T ra inees are t o have completed a r e s idencyi n i n t e r n a l medicine, su rge ry , or p e d i a t r i c s . Consu l t a t ion with DDDN s ta f f is important t o t h e p o t e n t i a l a p p l i c a n t . 2 . Nat iona l Research Se rv ice Award I n d i v i d u a l Pos tdoc to ra l Fellowship, Phys ic i an S c i e n t i s t Award, and C l i n i c a l I n v e s t i g a t o r Award: t h e a p p l i c a n t is t o have completed, by t h e t i m e an award would be a c t i v a t e d , a r e s idency i n i n t e r n a l medicine, su rge ry , or p e d i a t r i c s .

TERMS OF THE AWARDS AND AVAILABILITY OF FUNDS

The N I D D K p l ans , under t h i s RFA, assuming normal funding c a p a c i t y and t h e r e c e i p t o f m e r i t o r i o u s a p p l i c a t i o n s , t o award 1 I n s t i t u t i o n a l T ra in ing Grant, a t o t a l of 2 Phys ic ian S c i e n t i s t and/or C l i n i c a l I n v e s t i g a t o r Awards, and 4 I n d i v i d u a l P o s t d o c t o r a l Fellowship Awards.

Vol. 18, No. 11, March 31, 1989 - Page 7

For t h e complete RFA document, which i n c l u d e s guidance f o r p r e p a r a t i o n of a p p l i c a t i o n s , p l e a s e c o n t a c t :

Office o f t h e D i r e c t o r Reseach T r a i n i n g and Career Development ProgramDiv i s ion o f D iges t ive Di seases and N u t r i t i o n , N I D D K Westwood Bui ld ing , Room 3A15 Bethesda, Maryland 20892 Telephone: (301) 496-7455

O N G O I N G PROGRAM ANNOUNCEMENTS

ITY RESEARCH PROGRAM ADMINISTRATIVE SUPPLEMENTAL AWARDS

P.T. 3 4 , FFj K.W. 0404003, 0404009, 0710030

Na t iona l I n s t i t u t e on Alcohol Abuse and Alcoholism Na t iona l I n s t i t u t e on Drug Abuse

INTRODUCTION

The Nat iona l I n s t i t u t e on Alcohol Abuse and Alcoholism ( N I A A A ) and t h e Nat iona l I n s t i t u t e on Drug Abuse ( N I D A ) are announcing an oppor tun i ty f o r a d m i n i s t r a t i v e supplements t o e x i s t i n g ex t ramura l r e s e a r c h g r a n t s , i nc lud ingt h e t r a d i t i o n a l r e s e a r c h p r o j e c t s ( R o l l , program p r o j e c t g r a n t s ( P o l ) , and s p e c i a l i z e d c e n t e r s ( P 5 0 ) t o suppor t r e s e a r c h by a minor i ty r e s e a r c h e r or o t h e r r e s e a r c h e r s w i th s p e c i a l e x p e r t i s e i n a l c o h o l and o t h e r drug abuse i s s u e s as t h e y affect minor i ty popu la t ions . Th i s r e s e a r c h e r w i l l be r e f e r r e d t o as t h e "proposed r e s e a r c h e r " f o r t h e remainder of t h i s announcement.

PURPOSE

The purpose of t h i s program announcement is t o i n c r e a s e r e s e a r c h suppor t t o minor i ty sc!.entists and o t h e r r e s e a r c h e r s t o expand t h e i r knowledge about a l c o h o l and o t h e r drug abuse, t o g a i n r e s e a r c h expe r i ence , and t o i n c r e a s e t h e i r commitment t o examining problems of a d d i c t i o n and drug abuse amongminor i ty p o p u l a t i o n s . Admin i s t r a t ive supplements w i l l be made f o r a pe r iod of up t o t h r e e y e a r s on b e h a l f of a proposed r e s e a r c h e r , who w i l l work i n c o l l a b o r a t i o n wi th t h e p r i n c i p a l i n v e s t i g a t o r of an ongoing N I A A A or N I D A g r a n t . N I A A A and N I D A encourage a p p l i c a t i o n s f o r suppor t o f r e s e a r c h e r s a t H i s t o r i c a l l y Black Col leges and U n i v e r s i t i e s and o t h e r minor i ty i n s t i t u t i o n s . The ongoing N I A A A or N I D A g r a n t must have a t l eas t two y e a r s of remainingnon-competit ive suppor t a t t h e t ime o f submission. The proposed r e s e a r c h a d m i n i s t r a t i v e supplemental a p p l i c a t i o n must be c l o s e l y r e l a t e d t o t h e c u r r e n t l y funded r e s e a r c h g r a n t . An a d m i n i s t r a t i v e supplemental a p p l i c a t i o nw i l l n o t be accepted i n t h e f i n a l yea r o f t h e g r a n t . It must examine some a s p e c t of a lcohol i sm and/or drug abuse among minor i ty popu la t ions or suppor t a minor i ty r e s e a r c h e r . It must r e p r e s e n t an inc reased e f f o r t i n an a l r e a d yapproved o b j e c t i v e of t h e r e s e a r c h p r o j e c t or propose t o enhance t h e e f f e c t i v e n e s s of t h e o v e r a l l r e s e a r c h p r o j e c t . The n a t u r e o f t h e r e s e a r c h should provide t h e proposed r e s e a r c h e r wi th an oppor tun i ty t o c o n t r i b u t e i n t e l l e c t u a l l y t o t h e program and t o broaden h i s / h e r r e s e a r c h p o t e n t i a l . The scope of t h e p r o j e c t w i l l g e n e r a l l y be comprehensive enough t o r e q u i r e two y e a r s f o r completion and t h e a d m i n i s t r a t i v e supplemental a p p l i c a t i o n should inc lude such a r e s e a r c h p l an and r eques t ed budget .

APPLICATION RECEIPT AND REVIEW SCHEDULE

App l i ca t ions i n response t o t h i s announcement may be made a t any time dur ingt h e f iscal y e a r . Review of t h e s e a p p l i c a t i o n s f o r a d m i n i s t r a t i v e supplementsw i l l be conducted by N I A A A and N I D A s ta f f and o t h e r e x p e r t s .

Copies of t h e Program Announcement may be ob ta ined by sending a w r i t t e n r e q u e s t t o :

NIDA

Ca the r ine Bell-Bolek, M.S. Program D i r e c t o r S p e c i a l Popu la t ions Research

ProgramNat iona l I n s t i t u t e on Drug Abuse Telephone: ( 3 0 1 ) 443-0441

N I A A A

Albe r t A. Pawlowski, Ph.D Assoc ia t e D i r e c t o r D iv i s ion o f Bas ic Research Nat iona l I n s t i t u t e on

Alcohol Abuse and Alcoholism Telephone: ( 3 0 1 ) 443-1273

Vol. 18, No. 11, March 31, 1989 - Page 8

1

STUDIES OF DIABETES MELLITUS AND RELATED PROBLEMS

P.T. 34, FF; K . W . 0715075, 0710030, 0755030, 0765033, 0785055, 0745065, 0404000 %&

Nat iona l I n s t i t u t e of Diabetes and Diges t ive and Kidney Diseases Nat iona l I n s t i t u t e o f AgingNa t iona l I n s t i t u t e of Al le rgy and I n f e c t i o u s Diseases Nat iona l I n s t i t u t e of Chi ld Heal th and Human DevelopmentNat iona l I n s t i t u t e of Denta l Research Nat iona l I n s t i t u t e of Environmental Heal th Sc iences Nat iona l Eye I n s t i t u t e Nat iona l Hear t , Lung, and Blood I n s t i t u t e Nat iona l I n s t i t u t e of Mental Heal th Nat iona l I n s t i t u t e of Neurologica l D i so rde r s and S t roke Nat iona l Center f o r Nursing Research

T h i s Program Announcement was publ i shed i n t h e N I H Guide for Grants and Con t rac t s , Vol. 18, No. 7, March 3, 1989, on page 7 . A b u l l e t was i n a d v e r t e n t l y omi t ted under I . PROGRAM SPECIFICATIONS, B. Research Scope. The a d d i t i o n a l a r e a of r e s e a r c h recommended inc ludes :

o Behavior and Psychosocia l Risk Fac to r s , Complications and I n t e r v e n t i o n s

SPECIAL EMPHASIS RESEARCH CAREER AWARD (SERCA) I N LABORATORY ANIMAL SCIENCE;

P.T. 34; K.W. 0201058, 0710030

Div i s ion of Research Resources

App l i ca t ion Rece ip t Date: June 1, 1989

The ongoing program announcement t i t l e d as above, which was pub l i shed i n t h e N I H Guide f o r Grants and Con t rac t s , Vol. 18, No. 7, March 3, 1989, i n c o r r e c t l yconta ined r e f e r e n c e to an a n t i c i p a t e d number of awards t o be made under t h i s announcement ( refer t o APPLICATION s e c t i o n of t h e announcement). The

W sen tence , which r eads , "Approximately 35-40 awards are expected to be made under t h i s announcement" should be d i s r ega rded i n i t s e n t i r e t y .

Q u e s t i o n s r ega rd ing t h i s c o r r e c t i o n should be

D i r e c t o r , Laboratory Animal Sc iences Program,Div i s ion of Research Resources Nat iona l I n s t i t u t e s o f Heal th Westwood Bui ld ing , Room 853 5333 Westbard Avenue Bethesda, Maryland 20892 Telephone: (301) 496-5175

addressed to:

ARP