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NIDA Director’s Report to the National Advisory Councils of
NIDA, NIAAA, & NCI
Nora D. Volkow, M.D., Director
February 4, 2015
0
200,000
400,000
600,000
800,000
1,000,000
1,200,000Budget Authority Appropriation in 1998 Dollars
NIDA Program Level in Appropriated Dollars and Constant 1998 Dollars
$ (
in t
hou
san
ds)
30% Budget is for AIDS research
NIDA Applications, Awards & Success Rates
0
5
10
15
20
25
30
35
40
45
0
500
1000
1500
2000
2500
Applications Awards Success Rate (%)
No. of
Ap
pli
ca
tion
s vs.
Aw
ard
s
Fiscal Year
%
%
%
%
%
%
%
%
%
%
0
10
20
30
40
50
60
91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11 12 13 14
Percentage of U.S. 12th Grade Students Reporting Past Month Use of
Cigarettes, Marijuana and Alcohol
SOURCE: University of Michigan, 2014 Monitoring the Future Study.
Cigarettes
Marijuana
Alcohol
Status of Marijuana Laws in the US
Nu
mb
ers
in M
illio
ns
3.1+ 3.1+ 3.2+ 3.4+
3.1+
3.6+ 3.9+
4.1+
4.6+ 5.0+
5.4
4.8+ 4.9+ 4.9+ 5.1+ 5.1+ 5.1+
5.5+
6.2+
6.9+ 7.1+
7.6
0
1
2
3
4
5
6
7
8
2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012
Marijuana on 20 or More Days in Past Month
Marijuana on 300 or More Days in Past Year
National Survey on Drug Use and Health (NSDUH)
0
2
4
6
8
10
12
0
10
20
30
40
50
60
70
80
90
Da
ily
Use
(P
erce
nt)
Per
ceiv
ed R
isk
(P
erce
nt)
Perceived Risk
Daily Use
Source: The Monitoring the Future study,
the University of Michigan
Monitoring the Future (MTF)
Regular Marijuana Use, Persons
Aged 12 or Older: 2002-2012
% 12th Graders Reporting Regular Marijuana Use vs. Perceived Risk of
Regular Marijuana Use
Source: National Survey on Drug Use and Health, SAMHSA
Subcortical Structures Differences Between Regular Marijuana Users and Nonusers
Weiland B J et al. J. Neurosci. 2015;35:1505-1512
Effects of Prenatal Nicotine Exposure on Brain Development in Boys and Girls
Chang et al, PING CONSORTIUM
Subcortical PC: NIC*Gender interaction p=0.017 (post-hoc interaction: left: p=0.17; right: p=0.68)
NIC exposed females had smaller GP than controls, males show no difference
Left and Right Pallidum
Vo
lum
e (
mm
3)
Age(years) V
olu
me
(m
m3)
Age(years)
2 4 6 8 10 12 14 16 18 20
2 4 6 8 10 12 14 16 18 20
Left Right
Adolescent Brain Cognitive Development National Longitudinal Study
Ten year longitudinal study of 10,000 children from age 10 to 20 years to assess effects of drugs on
individual brain development trajectories
NIDA, NIAAA, NCI, NICHD, NIMHD, ORWH, OBSSR, NIMH, NINDS, NEI
• Expert panel workshop developed recommendations on best
large-scale designs and measures to assess developmental effects
of substance exposure (beginning prior to exposure) during childhood
through adolescence (in human subjects) May 27-28, 2014
• RFI solicited input on proposed study design/measures
June-August 2014
• Revised design based on input from RFI and satellite symposium
at SfN November 17, 2014
• Notices of Intent to Publish: FOA January 2015
• Updates at: www.addictionresearch.nih.gov
Adolescent Brain & Cognitive Development (ABCD)
National Longitudinal Study NIDA NIAAA NCI NICHD NIMHD
ORWH NIMH NINDS OBSSR NEI
Time
Prospective cohort study of ~10,000 youth beginning ~ ages 9-10
Substance use, Cognition, Emotion, Mental Health, Physical health, Executive Function, General Intelligence, Environment, Biospecimens: Genetics, Epigenetics
Notice of Intent to Publish a Funding Opportunity Announcement for A Longitudinal Study of Adolescent Brain and Cognitive Development (ABCD) Research Sites (U01)
Notice Number: NOT-DA-15-001 Key Dates Release Date: November 26, 2014 Estimated Publication Date of Announcement: January 2015 First Estimated Application Due Date: April 2015 Earliest Estimated Award Date: September 2015 Earliest Estimated Start Date: September 2015 Related Announcements NOT-DA-15-002 NOT-DA-15-003 Issued by National Institute on Drug Abuse (NIDA) National Cancer Institute (NCI) National Institute on Alcohol Abuse and Alcoholism (NIAAA) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Lo
w
H
igh
R
elev
an
t to
ad
va
nci
ng o
f k
no
wle
dg
e
Chalmers et al, Lancet 2014, 383, 9912, 11-17 How to increase value and reduce waste when research priorities are set
Pure basic research without consideration of relevance to
practical issues (Current 55%)
Waste
Pure applied research to address important practical
questions (35%)
Use-inspired basic research to address important practical
questions (Current 10%)
Low High
Relevant to immediate application
N Bohr
L Pasteur
T Edison
D E Stokes. Pasteur's quadrant—basic science and technological innovation. Brookings Institution Press, Washington, DC (1997)
NIDA Strategic Plan
2010-2015 Basic
Epi, Prevention Services (HIV)
Treatment (HIV)
CTN
IRP
RM&S
*30% Budget HIV/AIDS
Current/Future Issues • Leveraging new technologies • Developing standards, infrastructure, and tools to support Big Data • Integration with BRAIN Initiative • Responding to changes in SUD landscape (i.e., marijuana policies, healthcare reform, E-cigarettes as drug delivery devices) • Accelerate translation research (i.e., medications, devices) • Training for next generation of scientists
NIDA Strategic Plan 2010-2015
Input from multiple sources - NIDA staff, NIDA Advisory Council, Researchers,Practitioners, Constituent organizations, Consumer groups, Other Stakeholders • Key Mechanisms: - Request for Information (RFI)/Public Comment - Bold Goals Challenge Prizes - Priority Area/Cross - Cutting Work Groups • Publication: Fall 2015
Updating NIDA Strategic Plan • RFI released Dec 10 for feedback on draft priorities:
– Understanding basic science of drug use, addiction, vulnerability, and recovery
– Supporting development of new and better interventions and treatments
– Increasing the public health impact of NIDA research
– Enhancing the national research infrastructure
• Comment period closed January 30th (more than 200 comments)
• Next steps: – Priority Area Workgroups with internal and external experts:
• Big Data
• Gene x Environment x Development interactions
• Complex patients (multiple comorbidities) and phenotyping
• Health disparities
– Division strategic plans
• Timeline – RFI –Review – By March 6, 2015
– Priority Area Workgroups – Feb-July
– Division Strategic Plans Drafts – By February 6, 2015
– Draft Strategic Plan to Council – May 2015
– Final Strategic Plan – Fall 2015