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Newsletter, Issue 1 SYMPHONY Newslettersymphony- · PDF file SYMPHONY onsortium 3 SYMPHONY objectives SYMPHONY is a demand-driven project pursuing: Advancement of MN S devices toward

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  • SYMPHONY Newsletter Integrated SYsteM based on PHOtonic microresonators and

    Microfluidic Components for rapid detectioN of toxins in milk

    and dairY products

    Fondazione Bruno Kessler April 2015 Newsletter, Issue 1

    This project has received funding from the European Union’s Seventh Framework Programme FP7-ICT-2013-10 under

    grant agreement No 610580. Project duration: 1st November 2013 - 31st October 2016.

    www.symphony-project.eu

    The project SYMPHONY is a research and

    innovation project, funded by

    the European Commission to

    find a rapid, cheap and

    effective solution to detect

    toxins in milk. More infos

    about the project and the

    consortium at pag. 2-3

    Achievements First prototypes of Photonic

    sensors demonstrated to

    achieve Limit Of Detection

    (LOD) of 0.8*10-6 Refractive

    Index Units (RIU) . Find more

    results after 18 months of the

    project at page 4.

    The “Milk Day” Experts in milk analysis and

    quality, scientists in

    microsystem technologies and

    biosensors and end users

    gathered in a workshop

    organized in Trento in February

    2015, to talk about milk. More

    details from pag. 6.

    IN THIS ISSUE

  • SYMPHONY in a nutshell Integrated SYsteM based on PHOtonic

    microresonators and Microfluidic Components for

    rapid detectioN of toxins in milk and dairY products

    I n the dairy industry, one of the most pressing needs for food quality and safety is the timely detection of aflatoxin M1 contaminations that originate

    from animal feed and are secreted into milk. This issue represents a hazard

    for human health and an economic loss for the dairy industry. The available

    technology for aflatoxin detection is laboratory-based, in most cases

    requiring sample preparation and does not provide timely identification of

    contaminants, thus fails to deliver cost-effective management of milk

    quality. The entire supply chain relies on the fact that the dairy products

    delivered to consumers are safe. Current best practices for Aflatoxin

    management in milk in the modern dairy industry recommend aflatoxin M1

    analysis to be carried out routinely for quality assurance and quality control

    purposes as well as for feed-back mechanisms to farm and animal health

    management, as requested by European Commission regulation (EC) No.

    1881/2006. The current procedure involves the collection of samples from

    collection tanks. The milk samples are analysed in a laboratory with

    screening tests such as Enzyme-Linked Immunosorbent Assay (ELISA).

    Contaminated milk that exceeds the 50 ng/Kg (ppt) aflatoxin limit is not

    allowed in the market and has to be disposed.

    T he SYMPHONY STREP project (FP7-ICT-2013-10) addresses the needs of the dairy industry with novel microfluidic technologies and biochemistry for

    sample preparation, photonic integrated sensors and compact hardware for

    integration in the production chain of the dairy industry, leading toward

    precision process management.

    This project has received funding from the European Union’s

    Seventh Framework Programme FP7-ICT-2013-10 under grant

    agreement No 610580. Project duration: 1st November 2013 -

    31st October 2016.

    Interview with the coordinator

    Dr. Leandro Lorenzelli, Head of

    the MST research unit at Fonda-

    zione Bruno Kessler, Trento

    Could you explain what SYM-

    PHONY is about?

    SYMPHONY is proposing a

    new generataion of high-tech

    devices allowing for fast and

    reliable analysis of the dairy

    products quality. These would

    lead to a more precise and

    effective management of pro-

    duction and distribution pro-

    cesses.

    What is SYMPHONY main

    objective?

    The objective is to integrate

    different technologies like

    photonics, microfluidics and

    microbiology to create a por-

    table and quick tool to detect

    aflatoxin in milk.

    SYMPHONY Newsletter N. 1, April 2015

    Grant agreement 610580

    www.symphony-project.eu

  • SYMPHONY Consortium

    3

    SYMPHONY objectives SYMPHONY is a demand-driven project pursuing:

     Advancement of MNBS devices toward real-world applications by providing:

     Integrated sample preparation for analytical tools in dairy industry,

     Advancement in high sensitivity photonics biosensors, by using aptamers to provide selectivity to targets and improved sensor stability and hybrid integration of sources and detectors.

     Improvement of milk quality assurance by making available new technologies and procedures for the detection of aflatoxin and other contamination

     Improvement of dairy industry competitiveness by early detection and effec- tive corrective action against aflatoxin outbreaks and contaminants:

     On field simultaneous detection of various contaminants, thanks to arrays of photonic sensors;

     Analysis of raw milk and other liquid dairy products, such as yogurt, butter milk, kefir, whey;

     Quality assurance at various HACCP

     Improvement of food quality with positive impact on human health

    Symphony facts

     EU STREP project

     7 partners in 5 country

     3 years project

     3 M€ Funding

     3 private companies

     3 research and academic

    centers

     1 dairy cooperative

     www.symphony-project.eu

     Follow us on

    Grant agreement 610580

    SYMPHONY Newsletter N. 1, April 2015

    www.symphony-project.eu

    C:/Users/morganti/Documents/Algorithm research https://www.linkedin.com/grp/home?gid=8205910&trk=my_groups-tile-grp

  • First year scientific achievements Stakeholders needs, system specifications & architecture

     Stakeholder needs were surveyed by interviews and questionnaires for the definition of user requirements, specifi-

    cations and the general architecture of the system.

     Antibiotics were selected as best additional target to be evaluated in addition to Aflatoxin for multianalyte system.

    Development of photonic sensors

     SiN asymmetric Mach-Zehnder interferometers (aMZI) were developed by LioniX

     SiON microring resonators (mRR) were jointly developed by FBK and UniTN

     The achieved Limit Of Detection (LOD) was 0.8*10-6 Refractive Index Units (RIU) and 1.6*10-6 RIU in the case of aMZI

    and mRR, respectively.

     VCSEL sources and photodiodes are being integrated by means of heterogeneous assembly

    Functional surfaces and analytical methods

     Aflatoxin purification is based on functional surfaces based on surface coating with mussel foot protein.

     Anti-aflatoxin aptamers are immobilized by FBK on the detector surface for the selective detection of aflatoxin,

    with a demonstrated layer density around 1013 aflatoxin molecules per cm2

     The sensor regeneration and reusability was demonstrated up to 17 regeneration cycles.

    Development of microfluidic components

     Microfluidic modules for fat separation and milk fractionation produced and tested showing a fat reduction compa-

    rable with laboratory techniques.

     Reversible Sensor packaging with integral flow cells, has been designed and fabricated.

    4

    Grant agreement 610580

    SYMPHONY Newsletter N. 1, April 2015

    www.symphony-project.eu

    Micro Ring Resonators Watch the video on: http://symphony-project.eu/

    node/3

    Aflatoxin response of functionalized

    microring resonator

    Hybrid integration of microfluidics and silicon chip

    Success criteria for SYMPHONY project

  • 5

    SYMPHONY dissemination

    Other events Workshop on biosensing,

    Trento 30th March 2015.

    http://webmagazine.unitn.it/

    evento/dphys/4244/workshop

    -on-biosensing

    Workshop on “Smart sy-

    stems for food industries”,

    Trento 15th November

    2013

    http://www.symphony-

    project.eu/node/21

    Researcher’s Night 2013,

    Trento

    Upcoming events

    21th World micromachine

    summit, Berlin 10-13 May

    2015

    http://www.mms2015.org/

    Recent Advance in Food

    Analysis (RAFA 2015), Pra-

    gue 3-6 November 2015.

    http://www.rafa2015.eu/

    index.html

    3rd EOS Conference on Op-

    tofluidics (EOSOF 2015)

    held under the umbrella of

    the World of Photonics

    Congress 2015 , Munich 22-

    23 June 2015.

    http://www.myeos.org/

    Grant agreement 610580

    SYMPHONY Newsletter N. 1, April 2015

    www.symphony-project.eu

  • The Milk Day rationale

    The Milk Day was organized

    in Trento on February 4th in

    the framework of the AISEM

    conference to discuss rele-

    vant open issues in the appli-

    cation of MST in the analysis

    of milk contaminations.

     Can the use of Micro

    System Technologies

    and biosensors provide a

    solution to overcome

    these limitations?

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