New TechnologyTo treat Prostatitis

The Prostate

Heat can be used for medical purposes

Hyperthermia in cancer research.

Historical development, current status of research, future perspectives

and differentiation from alternative medical procedures.

Issels R, Wadepohl M, Cramer H, Krieger K, Wilmanns W.

…”Already at the beginning of the 19th century first clinical trials with systemically induced fever were performed on malignant tumors”…..

Effect of temperature on living tissues

Effects of temperature

Normal Ramge 33º C to 37º C

Hyperthermia 37º C to 43.5º C

Termotherapy 45º C to 99º C COAGULATION

Vaporization 100º C and more ABLATION

Cell kill by heat

Termotherapy :Efects of Temperature on

tissuesTemperature above 45º C produces

Coagulative Necrosis

Denaturization of proteins.Immediate cell kill

Harnessing RF Waves for Treatment

RFRF is a safe and effective treatment for many medical is a safe and effective treatment for many medical

conditions, used routinely for surgical procedures.conditions, used routinely for surgical procedures.

RFRF energy in contact with tissue will produce heating energy in contact with tissue will produce heating

and therefore its coagulation or vaporization.and therefore its coagulation or vaporization.

Range used for medical applicationsRange used for medical applications

is between 100kHz and 1200MHzis between 100kHz and 1200MHz

RF WavesRF Waves

The Nervous system system operates at low FrequencyThe Nervous system system operates at low Frequency

Low Frequency signal cause : muscle contractions Low Frequency signal cause : muscle contractions Pain Pain

Large Dose Large Dose Cardiac Arrest Cardiac Arrest

Heating MethodsT.U.M.T. Microwave (Cooled)

T.U.M.T. Microwave Un-cooled

W.I.T. Water Induced Thermotherapy

T.U.R.F. AND T.U.N.A.Monopolar Radio Frequency

TEMPROBipolar Radio Frequency

Heat can be applied to PROSTATE by 2 technologies

Microwaves : T.U.M.T. =Trans Urethral Microwave Thermotherapy

Radiofrequency: T.U.R.F. =Trans Urethral Radio Frequency

Non uniform distribution of energy using microwaves TUMT

                                                                                                                              

Uniform distribution of Radio Frequency heating

TemproBi-Polar RF Thermotherapy

The device that applies the The device that applies the Radio Frequency energy in Radio Frequency energy in

Tempro Tempro

The Applicator is a unique transurethral The Applicator is a unique transurethral multi-polar electrode with conductive heating multi-polar electrode with conductive heating rings and temperature sensing elements rings and temperature sensing elements (thermocouples)(thermocouples)

The applicator diameter is 16Fr. (about The applicator diameter is 16Fr. (about 5.5mm)5.5mm)

HeatingHeating RingsRings

Balloon for Balloon for Applicator’s Applicator’s PositioningPositioning

Bladder Bladder Drainage Drainage OpeningOpening

3 3 ThermocouplThermocoupleses

Functions of the Applicator

Delivers RF energy from the controller to the prostate, producing tissue coagulation.

Allows urine to be drained during treatment.

Measures prostate temperature at 3 different locations.

Testimonios

Amstelland Hospital Holanda

Amstelland HospitalDept. of Urology Men’s Health ClinicY. Reisman MD, PhDLaan vd Helende Meesters 8,1186AM, Amstelveen, Noord-Holland,The NetherlandsTelephone number: +31-(0)20- 3474747

I have started to use the Tempro system for BPH , but later on decided to use Tempro Thermal Therapy also for ChronicalProstatitis , which as we all know is very difficult to treat . Theinitial results with several of my patients are very positive and itappears to be a very helpful procedure “. Dr. Y. Reisman

Age: 35Chronic Abacterial Prostatitis from date: 04-01-2008Previous treatments: NSAID, Ciproxin, TamsulosineSymptoms: Perineal pain, sexual dysfunction, LUTSTempro treatment date: October, 2008.Follow up: 12 month free of complains

The Institute for Thermotherapy- Alemania

Testimonios

The Institute for ThermotherapyDr. C. BeckKleppingstrase 8,44135 DortmundTelephone: +49 231 14 12 88Germany

One of my patients could hardly stand up straight even though he was taking prescription drugs. After a Thermal Therapy treatment with Tempro Device he began to notice relief and he felt no pain at all."Dr. Christian Beck

Age: 32 Chronic Abacterial Prostatitis from date: 15-10-2003Previous treatments: NSAID, Ciproxin, TamsulosineSymptoms: Perinea pain, sexual dysfunction, LUTSTempro treatment date: January, 2009.Follow up: 9 month free of complains

Testimonios

Private Medical Clinic and Laboratory-Polonia

Private Medical Clinic and LaboratoryDr Zenon RudzkiKilinskiego St 78Tel: + 48 34 365 1404CzestochowaPoland

“I have always thought Thermal Treatment may benefit my Prostatitis patients. Now that I have started to use the Tempro for Chronical Abacterial Prostatitis. I am surprised by the excellent results with some of the initial patients I have treated “. Dr. Z. RudzkiAge: 65Chronic Abacterial Prostatitis from date: 03-10-1999Previous treatments: NSAID, Ciproxin, TamsulosineSymptoms: Pain in Testicles, Pubic area, Bladder, tip of Penis.Tempro treatment date: December, 2008.Follow up: 10 month free of pain or discomfort, Free urination

TEMPRO Bipolar Radio Frequency Thermal TreatmentFOR ABACTERIAL CHRONIC PROSTATITIS : Initial resultsByun, Jae Sang MD, , Byoung Kyu Han MD, Kihyuck Moon MD

Gangman Zaii urology Hospital.Nonhyeon-dong   164-2 Seoul

Republic of Korea

Table 1. Patients demographics

CharacteristicsValue

Numbers of the patients

41

Mean age (range) 42.6 ± 11.4) 28 – 72(

Mean prostate size (cc)

25.3 ± 6.1

NIH classification(%)

Category II 13) 31.8%(

Category IIIA 14) 34.1%(

Category IIIB 14) 34.1%(

Table 2. Comparison of Chronic Prostatitis Symptom index scores between pretreatment (baseline) and TEMPRO after 3 months (post TEMPRO) CPSI score

Baseline CPSI score

Post-TEMPRO CPSI score

p value

Mean Total score 23.4 ± 7.3 16.5 ± 4.9 0.072

Mean pain domain score 11.2 ± 5.4 6.5 ± 3.8 0.034

Mean Urination domain score

5.7 ± 3.3 5.2 ± 2.3 0.872

Mean Quality of life domain score

6.6 ± 2.4 4.6 ± 1.6 0.138

Table 3. Subgroup analysis according to the decline of CPSI score more than 50 percent at 3 month after TEMPRO.

Group A : CPSI scores decreased more than 50% after TEMPRO (= successful group)Group B : CPSI scores does not decreased more than 50% after TEMPRO (= unsuccessful group)

Group AGroup B

p value

Total Success19 ) 46

( %22 ) 54

(%

Age group

50 or Younger than 50 years old

12 170.638

Older than 50 years old

7 5

NIH classification(%)

Category II 8 5

0.052Category IIIA 9 5

Category IIIB 2 12

4.ConclusionsThese initial results look very positive with an overall success rate of 46 %. Perineal and/or perianal pain, as well as orchalgia, are substantially improved in the majority of the patients. Considering the complexity of the illness we consider it a simple and effective treatment.Side effects are minimal, therefore the Tempro treatment for prostatitis should be considered as a safe and effective one. We will continue to explore the potential of this treatment.

Congreso Mundial de Endourologia WCE 2009 Munich Octubre 2009

Congreso Mundial de Endourologia WCE 2009 Munich Octubre 2009

Congreso Mundial de Endourologia WCE 2009 Munich Octubre 2009

Congreso Mundial de Endourologia WCE 2009 Munich Octubre 2009

Maneken Pis

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