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7/25/2019 New Scientist - June 18, 2016 http://slidepdf.com/reader/full/new-scientist-june-18-2016 1/60 MONKEY ARCHAEOLOGY Dig reveals primate cultur is stuck in the Stone Ag NO MAGIC BULLETS Is proton therapy reall a cancer cure-all YOU WAIT 100 YEARS.. LIGO spies a second gravitational wave TRIAL AND ERROR Five ways forensics can get you falsely convicted WHITE FRIGHT  How ethnic change is pushing the US to the right WEEKLY June 18 -24, 2016 0  70989 30690  5 2 4 Science and technology new www.newscientist.com US jobs in scienc No3078 US$5.95 CAN$5.95 Rethinking the evolution of the universe HOW TO MAKE DARK ENERGY DISAPPEAR

New Scientist - June 18, 2016

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    MONKEY ARCHAEOLOGYDig reveals primate cultur

    is stuck in the Stone Ag

    NO MAGIC BULLETSIs proton therapy realla cancer cure-all

    YOU WAIT 100 YEARS..LIGO spies a second

    gravitational wave

    TRIAL AND ERROR Five ways forensics can get you falsely convicted

    WHITE FRIGHTHow ethnic change is pushing the US to the right

    WEEKLYJune 18 - 24, 2016

    0 7 0 9 8 9 3 0 6 9 0 5

    2 4

    Science and technology newwww.newscientist.com

    US jobs in scienc

    No3078 US$5.95 CAN$5.95

    Rethinking the evolution of the universe

    HOW TO MAKEDARK ENERGYDISAPPEAR

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    Subscribe toNewScientist

    Visitnewscientist.com/9016 orcall

    1-888-822-3242andquoteoffer9016

    FOCUS LONGER

    Live Smarter

    ANDRZEJWOJCICK/SPLI/GETTY

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    Professor Dame CarolRobinson20 15 Laureate for United K ingdom

    B y B r ig it te Lacomb e

    Science

    needs

    w om enD am e C arol R obinson, Professor ofC hem istry at O xford University, invented a ground-breakingm ethod for studying how m em brane proteins function, which play a critical role in the hum an body.

    roughout the world, exceptional wom en are at the heart ofm ajor scientific advances.

    For 17 years, LO ral has been running the LO ral-UN ESC O For W om en In Science program m e,honouring exceptional wom en from around the world. O ver 2000 wom en from over 100 countrieshave received oursupport to continue to m ove scienceforward and inspire future generations.

    LOR A LUNESCOAW A RDS

    J O I N U S O N F A C E B O O K C O M / F O R W O M E N I N S C I E N C E

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    18 June 20 16 |NewScientist |3

    O T TVolume 23 0 No 3078

    Thisissu eonline

    news cientist.com /issue/3078

    Com in gnextw eek

    Thefutu reofw ork

    Yournine-to-five is changing forever

    Lightrelief

    Banishing pain with the flick of a switch

    Coverim age

    GandeeV asan/GettyImages

    28

    36

    G ravitational

    w aves again

    N ow a secondripple in

    space-tim e has been

    detected by LIGO

    8

    JEROENHOFMAN

    /GALLERYSTOCK

    WILLIAMWIDMER/REDUX/EYEVINE

    H ow tom ake

    darkenergy

    disapp ear

    Ret hinking the

    evolution of

    the universe

    Trialanderror

    Five ways forens ics

    can get you false ly

    accused

    N ew s

    O nthecover

    Features

    9 M onkey archaeology

    Stuckinthe StoneAge

    8 You wait 100 years

    LIGOspies second

    gravitationalwave

    18 No magic bullets

    Proton therapys potential

    36 Trial and error

    Five flaws offorensics

    4 0 W hite fright

    Ethnic change is pushing

    US to the right

    N ew s

    6 U P FR O N T

    Calls forgay blood donationlaw change after

    Orlando. Killerb ears inJapan. Light pollution

    hides Milky Way. Names fornew elements

    8 T H IS WE EK

    Primate archaeology. Supernovaeffect on

    early humans. Bettergene-editing to stop

    Zika. GMmonkeys to unlockbraindisease?

    15 IN B R IEF

    Froggy style sex. Turn CO2 intorocks.

    Alien life could be on ice. Nospace elevators.

    Ancestorof allbacteria. Planet makes its

    starspin. Indoorweather

    Techn olog y

    22 Taking babiesfingerprints. Onthe trailofa

    missing elephant. Bot spots hidden ads on

    socialmedia. Listening out foricebergs

    A n alysis

    18 Cancer therapy Whats driving the push

    forprotons?

    20 CO M M EN T

    High time to tackle the pills killing America.

    Noneed forspeed at aviations new frontier

    2 1 IN S IG H T

    Why antidepressants are so popular

    Features

    28 How to make dark energy disappear

    (see above left)

    32 Commandand cure Acheap and easy

    way to fixgeneticproblems

    36 Trial and error (see left)

    4 0 P EO P LE

    Ethnic change is pushing the US to the right

    Cu lture

    4 2 Children of tomorrow When itcomes to

    making babies,it could allbe overforsex

    4 3 Click festival Tech meets art inDenmark

    4 4 Penis thieves Geograph y of odd disorders

    R egulars

    52 LET TER S Empathy versus compassion

    56 FEED B A CK Berries that smellofdirty feet

    57 T H E LA ST WO R D Autonomous trains

    A pertu re

    26 A century of tourism inUS NationalParks

    Leaders

    5 Like it ornot,primate research remains

    necess ary. Dont let project fearwin

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    18 June 2 016 |NewScientist |5

    L

    TH E useofanim als in biom edical

    research is som ethingofan

    elephant in the room .M odern

    m edicinewouldbeim possible

    without it,and forthem ost part

    society has tacitly accepted that

    sacrificing anim als forthe greater

    good is tolerable.Bu t we rarely

    discuss it explicitly.

    Thenews that scientists in

    Japan and Ch ina are ram pi ng upbrain research usi ng genetically

    engineeredm onkeys has

    reopened the debate (see page 12).

    Prim ate research is especially

    contentious;the fact that public

    opposition is lowerin these

    countries than in theW est,and

    that W estern neuroscientists hope

    toshare in the resultsto bypass

    ethicalqualm s at hom e, wil l only

    A s a c r if ic e w o r t h m a k in g

    D o n t le t P r o je c t F e a r w in

    Likeitornot,prim aterese arch rem ains a necessity

    addto som e peoples disquiet.

    Anim alexperim entation

    shouldalways beup for

    discussion.But it is hard to see

    howthis substantially changes

    anything.Prim ate research still

    happens in W estern countries and

    the debate aroundit was settled

    longago.Them ost recentUK

    assessm ent, the2006 W eatherall

    Report, found a strong scientificcase forthe carefully regulated

    useofnon-hum an prim ates

    where there are no otherm eans to

    address clearly defined quest ions

    ofparticularim portance.

    Thereis nodoubtthat the

    questions are im portant.In

    Europe alone, a third ofpeople

    are affected by brain-related

    disorders, and the cost oftreating

    them is around 800 billion a

    year, m ore than the com bined

    cost of treatin g cancer, diabetes

    and coronary heart d iseas e.

    Som e m ay find it especially

    objectionable that the p rim ates

    are genetical ly engineered to

    m im ic the sy m p tom s ofhu m an

    brain diseases.That adds a

    new dim ension tothe debate,

    but existingstandards oughtto beable to deal with any

    welfare is sues.

    The bald fact is t hat Japan and

    Ch ina are going t o do thi s research

    any way.It i s surely bet ter for it

    to be part of a global sci enti fic

    program m e accom panied by a

    welfare debate so we can all

    benefit from the research as

    ethically as possi ble.

    TH E poli tical im pulseknown as

    nativism is on them arch.In the

    US, D onaldTrum p is runningan

    openly racist cam paign.In the

    UK , Eurosceptics are stoking

    resentm ent of im m igrants to

    propel the country towards th e

    Brexit door.N ativist s i n other EU

    countries are licking t heir lip s i n

    anticip ation of a dom ino effect.

    That th e US is flirting wi th th e

    notion of President Trum p

    beggars belief.In the words of the

    m an him self, we need to figure

    out what th e hell is going on.

    Political com m entators point the

    fin ger at th e frus tration of th e

    whi te working class , who have

    seen their incom es stagnate.

    But th at is only p art of the st ory.

    To understand com plex issu es,

    it i s often a good idea to ask a

    scien tis t.O ne factor un covered by

    research is t he USs shifting racial

    dem ographics, which m any find

    threatening and respond to bybecom ing racially intolerant

    (see page 40).The changing

    dem ographics oftheUK seem s

    to be having a sim ilar effect.

    Fearofchangeis a natural

    im pulse;thedesire topull up

    the drawbridge follows.But as

    we have repeatedly reported, that

    resp onse i s i rrational an d self-

    defeatin g.W e urge everyone t o

    thin k about what th e hell is really

    going on before decidin g whi ch

    way to vote.

    L O C A T IO N S

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    6 |NewScientist |18 June 2 016

    FO R G ET earth ,w in d,w ateran d

    fire th ere are fou rn ew elem ents

    in tow n .Th e In tern ation alU n ion

    ofP u re an d A pp lied Ch em istry

    (IU PA C)h asan n ou n ced nam esfor

    th e recen tly d iscovered elem en ts

    113,115,117 an d 118.Th ey w illbe

    called nih on iu m ,m oscoviu m ,

    tenn essin e and ogan esson ,

    pen din g a p u blic review .

    Th e fou relem en ts com p lete

    th e seven th row ofthe period ictable.Th ey go tth e officialn od of

    ap p rov alin Jan u ary th is year after

    discov eries by team s in Jap an ,

    Ru ssia an d th e U S,w h o suggested

    nam esto govern in g bod y IU PA C.

    R esearchersat R IKEN in Wako,

    Jap an ,offered nih on iu m (sym bo l

    N h)for th eir d iscovery,elem en t

    113,afterN ih on ,on e of th e

    Jap an ese w ords for Jap an .

    M oscow and Tenn esseeget

    th eirm om en to fglory w ith

    m osco viu m (M c),ak aelem en t115,

    PEO PLE th ou gh tIw asm ad,says

    Jen ny R em in gton -H ob bs,w h o w as

    d iagn osed w ith m u ltip le sclerosis

    in h erlate 20 s.Sh e w as abo u tto try

    a rad icalnew treatm en tth atcan

    cureM S by rebooting the im m un e

    system bu titcan also be dead ly.

    R esu lts released lastw eek fro m

    a trialsh ow th ata sim ilar

    treatm en tstop p ed th e disease

    progressin g in 70 p ercent of

    cases,bu tth ere w asa 4 p ercen t

    risk ofd yin g from com p lication s

    ofth e chem oth erapy itinv olves

    (TheLancet,doi.org/b jzz).

    G

    In am e y o u ... D an g e ro u s M S c u re

    O T

    E le m e n t s 1 1 3 , 1 1 5 , 1 1 7

    an d 1 1 8 are n o w n ih o n iu m ,

    m o s c o v iu m , te n n e s s in e

    an d o g an e s s o n

    A rare s igh t

    Waiting to d onate

    an d ten n essin e (Ts),form ally 117.

    Team s atth e Join tIn stitu te for

    N u clearR esearch in D u bn a,

    R u ssia,and O ak R id ge N ation al

    Lab oratory,V an d erbiltU n iversity

    an d Law ren ceLiverm ore N ation al

    Lab oratory (LLN L)in th e U S,

    suggested th ose n am es.

    Fin ally,th e D u bn a an d LLN L

    team scam e up w ith o ganesson

    (O g)after Yu riO gan essian ,

    a R u ssian p hy sicistw h o h elp ed

    d iscov erelem en t114 in 199 9 .Th at

    elem en t,no w called fleroviu m ,

    an d liverm oriu m ,116 ,w ere th e

    lastto join th e p eriod ic tab le,

    back in 20 11.

    D u rin g th e treatm ent,bo n e

    m arrow cells are ex tracted ,th en

    allth e im m u n e cells th atrem ain

    in th e bo dy are killed .Th e stored

    bo n e m arrow is th en tran sp lan te

    back in to th e bo dy.Thisreboo ts

    th e im m u n e system ,stop p in g it

    from attackin g n erve cells,w h ich

    isth e cau se ofM S.

    D esp ite th e risks,R em in gton -

    H ob bs w ent ah ead w ith treatm en

    in 20 11,bu tw a rns its n o q u ick fix

    Th e year th atfollow ed w as qu ite

    a d ark tim e, she says.B u tth e

    treatm en tstop p ed th e M S in its

    tracks,an d p u she d itin to reverse

    She has now m ade a fullrecovery

    SEE IN G stars is gettin g h arde r.A

    th ird o fu s can tsee th e M ilky Way

    atn igh t,accordin g to a n ew m ap

    ofligh tp ollu tion across th eglo be

    A rou nd 80 percentofthe

    w orld sp o p u lation live su n d er

    skiesobscu red tosom ed eg reeby

    h u m an -m ade ligh t.Sin gap ore

    n everexp erien cestru e n igh t

    co n d itio n s artificialtw iligh t

    m asksthed arkn ess.C h ad ,th e

    C en tralA frican R ep u b lican d

    M ad ag asca rh avethelow estlevel

    M ilk y w h e re?

    CARLOSFERNANDE

    Z/GETTY

    B lo o d ru le s c h a lle n g e dDONORS have be en que uing up

    outs ide blood b anks in Orlando since a

    shooting at a g ay nightclub in the city

    on Sunday left 4 9 d ead a nd at least 5 0

    serious ly wounde d. Th e traged y h as

    rene wed calls for ch ang es to th e US

    gu idelines on d onation that seve rely

    limit gay me n from giv ing b lood.

    Under new rules unve iled by t he

    USFood a nd Drug Ad ministration

    (FDA)in December,men wh o h ave

    sex with men mu st h ave b een celibate

    for a ye ar before d onating . Th e rule

    change rescinded a 3 2-year ban on

    alldonat ions from g ay men.

    The revis ed policy is s till

    dis criminatory, rea d a s tatement from

    th e NationalGay Blood Drive,a g roup

    camp aig ning for relax ation of the FDA

    gu idelines th at favours a syste m whe re

    each donor is as ses se d individ ua lly.

    Pau lVolbe rding ,director of

    th eAIDS Res earch Institute at

    th eUnive rsit y of California,Sa n

    Francisco,says th at p olicies around

    blood donation are outda ted .

    Cu rrent HIV blood te st s are

    incred ibly s ensitive and accurate.

    Infection can be detected within days

    of exp osu re,making th e cu rrent

    USFDA requ irement of a 12 -month

    gap from last sex ua lact to donation

    meaning les s, h e say s.

    Th ere are not any significant

    scientific ju st ifications for th e

    ban,ag ree s Winst on Berkman

    atNew York Unive rsit y.

    A stud y two years ago by th e

    Williams Inst itu te es timated th at if

    more g ay me n were allowed to g ive

    blood,the US nationalsu pp ly would

    grow by between 2 and 4 per cent.

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    18 June 2 016 |NewScientist |7

    STO P th e gene bom b!T hats

    th e rallyin g cry ofo p po n en ts of

    techn ology kn ow n as gen e drives.M ore research n eeded ,w asthe

    rath er lessd ram atic callfrom th e

    U S N ation alAcadem y ofScien ces,

    w h ich released its rep orton gen e

    d rives lastw eek.

    G ene drivesare bitso fD N A

    th atcan sp read them selves

    rap idly th rou gh a p op u lation .

    Th ere are m any natu ralgene

    d rives,an d b iolog ists are n ow

    creatin g artificialo n es.In th eo ry,

    gen e drives cou ld be u sed to

    stop m osq u itoe s tran sm ittin g

    d iseases,or even to d rive p ests to

    ex tin ction ;in p ractice,this w illb e

    d ifficu ltb ecau se organ ism s can

    evo lve resistan ce (see p age 10 ).

    Som e w antallw ork on genedrivesban n ed b ecause ofth e

    risks,w h ich in clu d e th eir

    p otentialuse asb iow eapo n s.

    Ith asb een sugg ested th atgen e

    d rives cou ld be u sed to m od ify

    bitin g in sects to m ake th em

    p rodu ce tox in s th atkillanyon e

    th ey b ite,for in stan ce.Th e N A S

    rep ortaccepts th ere are seriou s

    risksb u tcon clu de s th atth e

    p oten tialb en efits are so great

    th atlab an d h igh ly con tro lled

    field stu d ies sh ou ld b e allow ed .

    Sp rea ding fea r

    S

    For new stories every day, visit new scientist.com /new s

    K yoto crunching

    TH E results are in .Th e fin al

    em ission s figu res from th e

    cou n tries th atp articip ated in

    th e Kyoto Protocolh ave n ow

    been assessed bu tw h eth erit

    w asa successd epends on how

    yo u in terp retth em .

    U n d erthe 19 9 7 clim ate treaty,

    38 d evelop ed cou n tries agreed

    to reduce th eirm ean ann u al

    greenh ou seg asem ission s

    betw een 200 8 and 20 12 to 5 per

    cen tb elow 19 9 0 levels.While th e

    U S and C anada dropp ed out,the

    figu ressh ow th ato verall,th e

    rem ain ing 36 nation sm anaged

    to m eetth ese redu ction s(Clim ate

    P o licy ,doi.org/b jz4 ).

    In large p artth is w as becau se

    th e em ission s ofform erSo viet

    statesh ad p lu m m eted before th e

    dealw as even sign ed.

    Ten co u n tries ach ieved their

    targets p artly th an ks to bu yin gcarbon cred its rath er th an en tirely

    th rou gh tru e redu ction s.Th e

    fin an cialcrisis an d th e sh iftin g

    o fin du strialactivities to n ation s

    such as Ch in a also h elped .

    These nu m berscan be

    in terp reted o n e w ay or an other,

    says stu dy au th or Igor Sh ishlov

    o fthe In stitu te for C lim ate

    Econ om icsin P aris.B u t,h e says,

    th e p rotocoldid h elp lay the

    fou n dation sforth e 20 15 Paris

    clim ate agreem en t. Attacks are commonb ut rarely fatal

    o fligh tp ollu tion ,w ith three-

    q u arterso fth eirp op u latio n s

    en joyin gp ristin e n igh tskies.

    Th eM ilkyWay,visible in

    d arkn essasad im glow streakin gacrossth esky,is h id d en fo r6 0 p er

    centofEu rop ean s an d 80 p ercen t

    ofN orth A m ericans.

    Its a big p arto fo u rco n n ection

    to th e cosm os an d its b een lost,

    saysstu dy au th or C h ris Elvid ge o f

    th eU SN ation alO cean ic an d

    A tm osp h ericA d m in istration ,

    w h obu iltthe m ap u sin g satellite

    im ages,com p u term od els an d

    citizen -scien ce m easu rem en ts

    from th e grou n d (Scien ce

    A d van ces,doi.org/b jz2).

    6 0 S ECO N D S

    First of many?Say goodbye to the B ramble Cay

    melomys. This rodent,which lived

    only on a Great B arrier Reef island,is

    thought to be the first mammal to be

    made extinct primarily by human-

    made climate change. The s pecies

    hasnt been s een since 200 9,

    probably w iped out by se a-level rises .

    T hrees not a crowdA controversial three -parent ge ne

    fertility therapy could be us ed in

    humans within two years,afte r new

    trial results s how it can produce

    healthy embryos free from diseas e.

    The te chnique aims to prevent

    fatal mitochondrialdisease beingpassed fromparent to childby

    placingt he nucleus froma fertilised

    egg intoa healthydonoregg

    (Nature,doi.org/b jz3).

    Double sun giantSometimestwo suns are betterthan

    one.Astronomers havediscovered

    thelargest-everplanet toorbit a

    binarystar. Knownas Kepler-1647b,

    it is agas giant slightlybiggerthan

    Jupiter ands its inthe habitablezone

    of its star,meaning anyrockymoonsinorbit couldhave liquidw ateron

    theirsurface.

    Organ boostTheUS W hiteHouse has announced

    new initiatives to helpimprove organ

    transplants,including a $160 million

    investmentby theUS Department of

    Defense,a data-sharing agreement

    between transplant centres,and

    funding forresearchers working

    ong roundbreakingregenerative

    therapies.

    Not such a bird brainW hos a cleverb irdy? Someb irds

    behavef armoreintelligentlythan

    we wouldexpectfromtheirtiny

    brains. Now we know why by

    denselycrammingas many neurons

    into theirbrainsas someprimates

    (PNAS ,doi.org/bjzx). Th e macaw ,

    forexample,has more neurons in its

    forebrain than a macaque,despite

    its brain being walnut -sized.

    M an-eat ing bea r s hot in Jap anAN ASIATIC black be ar shot in

    Japanhad human t iss ue in its gu t.

    The animal was killed by hunters near

    the site of the f ourth fatal bear attack

    in the Akita prefecture in the space of

    three weeks.

    B ear attacks are common in this

    area of Japan,but t hey rarely result

    inpeople b eing killed as prey. It

    remains unclear whether the b ear

    that was shot caused all four deaths,

    says David Garshelis,co-chair of t he

    IUCN Bear S pecialist Group.

    The most recent victim,a

    74-year-old woman,had bee n

    gathe ring edible plants in a forest.

    The previous atta cks were all on men

    picking ba mboo shoots in the reg ion,

    in three separate incidents. P eople

    who gathe r edible plants at t his time

    of year are at high risk,because be ars

    eat thes e plants too,says Garshelis.

    B ear numbers in northern Japan

    are high this year,after more cubs

    than us ual survived to adulthood

    thanks to a b umper crop of beechnuts

    in spring. There have already b een

    1200 bear sightings in the region this

    year double the numbe r for the

    whole of 20 15. In Iwate prefecture,

    eight people have been attacked by

    bears since April.

    Newly mature bears can behave

    unpredictably,says Lori Egg ert at the

    University of M issouri in Columbia.

    Th eyre prospecting in areas w here

    they havent g rown u p, she s ays . If

    its b een in an a rea where there have

    not bee n humans,th en they re not

    going to be af raid of us.

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    8 |NewScientist |18 June 20 16

    TH EYV E do n e itagain .O n

    26 D ecem ber,20 15,for th e secon d

    tim e,th e Laser In terferom eter

    G ravitation alWave O b servatory

    (LIG O )cau gh tth e rip p les in space-

    tim e shaken o ffby th e death

    spiralofa p airo fb lack h oles.

    In oth er w o rds,w e are officially

    in th e era o fgravitatio n alw ave

    astron om y.

    Th is gives u s con fiden ce,

    says Salvatore V itale atthe

    M assachu setts In stitu te ofTech n ology,on e ofth e LIG O team .

    Itw as n ot ju sta lu cky acciden t.

    Seein g a secon d o n e tells u s clearly

    th atth ere is a p op u lation o fb lack

    h oles th ere,an d w e w illsee a lot of

    th em in th e com in g scien ce ru n .

    Th e discovery w asan n ou n ced

    atth e A m erican A stron om ical

    So ciety m eetin g in S an D iego

    on 15 Ju n e,an d w illbe p u blished

    in th ejou rnalPhysical Review

    Letters.

    T h eLIG O team m ad eh istoryin

    Febru ary w hen th ey ann ou n ced

    th e firstd etection ofg ravitation al

    w av es.A lb ertEin stein p redicted

    they w o u ld be produ ced w h en

    m assive ob jects like black h oles

    m ove arou nd .D ubbed G W1509 14,

    th e sign alarrived attw in

    d etectors in H an ford ,Wash in gton ,

    an d Livin gsto n ,Lou isian a,

    on 14 Sep tem ber lastyear.

    Th e detectorsp icked u p the

    m in u scu le stretchin g of space-

    tim e spu rred b y th e collision o fa

    pairofb lack ho lesabo ut 30 and

    35tim esthe m assofthe sun ,

    1.3 b illion ligh tyears aw ay.

    Th e secon d sign al,called

    G W151226,also cam e from a p air

    of black h oles m ergin g.Bu tth ese

    w erem u ch ligh ter abo u t14.2

    and 7.5 tim esth e m asso fth e su n .

    Th ey m erged to form a black h ole

    of 20 .8 solar m asses,m ean in g

    abou t1solarm asso fenergy

    radiated aw ay in grav itation al

    w aves du rin g th e collision .

    Th is even tradiated th e

    equ ivalento fth e m asso fou rsun

    in a cou p le of secon ds, V itale

    says.O u ro w n su n radiated ab ou

    a m illio n th o fits m ass in 5 billio n

    years.Th is really gives yo u th e

    scale ofh ow violent an d su dd en

    th is release o fen ergy is,as

    T W

    L IGO s e e s s e c o n d b lac k h o le m e rg e rG r a v it a t io n a l w a v e a s t ro n o m y is re a lly h e re , s a y s Lisa Grossman

    T h is e v e n t ra d iat e d th ee q u iv ale n t o f t h e m as s

    o f o u r s u n in a c o u p le

    o f s e c o n d s

    CH R IS T M A S R U IN E D

    Another in the b a

    LIGO saw its second signalat

    03 :38 :53 UTC on Boxing Day last

    year,which was still25 December in

    th e US . It was a Christmas gift,

    say s team member Salvatore V itale.

    Th at means the fact that it was

    dis covered at a llis a b it of a lu cky

    break,as the team deb ated wh ether

    or not to keep th e d etector running

    over th e winter h oliday s.

    Bu t it was awkward timing for

    V itale,who h ad be en vis iting family

    in Italy in S epte mber whe n th e first

    signa larrived. As part of th e te am

    stu dying the signalto learn th e

    properties of th e black h oles ,his

    holiday wa s ab rup tly cu t sh ort by

    frantic d ata ana lys is.

    Obviously my time th ere wa s

    totally d es troyed by th e first eve nt,

    he s ays. Th e team was sworn to

    se crecy,so h e cou ldnt ev en t ellhis

    parents what had happ ened.

    I h ad to ju st say its imp ortant ,

    bu t d ont worry,I willmake it u p to

    you at Christmas, he says . Th e

    morning of th e 26 th ,I woke up,and

    this is what happens. This teaches

    you a less on:never check your email

    th e morning of th e 2 6 th .

  • 7/25/2019 New Scientist - June 18, 2016

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    18 June 2 016 |NewScientist |9

    com pared to ou reveryday

    ex p erien ce.

    Ify ou cou ld see it,th e collision

    w o u ld b e 10 ,0 0 0 tim esb righ ter

    th an a gam m a-ray bu rst,th ebrigh testexp losion sw e kn ow of

    in th e u n iverse,says A viLoeb at

    H arvard U n iversity.

    Into the m a instream

    Th ose sm allerm assesare

    reassu rin g,becau se th ey fit

    squ arely in the 5 to 20 solarm ass

    ran ge ofb lack h oles,th e kin d

    already o bserved w ith X -ray

    telescop es.Th ose black h oles

    u su ally p airu p w ith o rd in ary

    stars,an d w e can see th e discof

    h otgas th ataccum u latesarou nd

    th e b lack h ole as itsteals m aterial

    from its com pan ion .

    Th e factth atth ey d etected

    low erm assb lack h oles brin gs it

    closerto m ain stream astron om y,

    w h ere su ch b lack h olesare often

    seen , Lo eb says.Ite stab lish es

    gravitation alw ave astron om y

    as a field.

    Wh en w e m ade th e first

    d iscovery,itw as kin d o f

    surprisin g because th ey h ave

    zero o verlap w ith the kn ow n

    d istribu tion ofb lack h oles, V itale

    says.N ow w e are back on tw o

    black h oles w ith m asses th atare

    totally co m p atible w ith w h atw e

    ex p ect.Its n ice to see th atw e can

    target a sim ilar p op u latio n .

    Italso m ean tth atLIG O

    w atched m ore oftheird eadly

    w altz.T h e black h o les in th e first

    eventw ere so m assive th atth ey

    sw u ng arou n d each oth erless

    th an 10 tim es before m ergin g.

    In th e secon d collision ,th e teamw atche d 55 fu llorbits b efore

    the end.

    B u tth esign alfrom thesm aller

    b lackh olesw asalso m o red ifficu lt

    tod etect.T h efirston ew asso

    p ow erfulthatyou co u ld seeitin

    thed ataw iththen ak ed ey e.You

    co u ld ev en h ea rit:tran slatin gthe

    sign alin tosou n d w avesgav ea

    ch irp ,arisein p itch an d volu m e

    asth eb lackh olescircleea ch oth er

    fasteran d faster.

    Th isn ew o n erequ iredm ore

    In this section

    GM monkeys could unlock human brain dise ase ,page 12

    W e c an fi n g e r p rin t b a b i e s sh o u ld w e ? p a g e 1 8

    W h a ts d r iv in g t h e p u s h fo r p r o to n c an c e r t h e ra p y ? p a g e 2 2

    targeted algo rith m s an d

    sop h isticated p rocessin g,to

    tease th e sign alou tofthe n oise.

    Th e firsteven tw as so lou d an d

    so scream in g in th e data,itw asfou n d by algo rith m s th atju st

    loo ked for an ythin g really,n ot

    p articu larly b in ary b lack h oles,

    V itale says.For th is on e itw as

    im po rtantto kn ow w e w ere

    loo kin g fo rco m p actb in aries.

    Ifyo u tried to m ake a chirp

    ou tofth e data allyou w ou ld h ear

    iskssh h h h h h h , saysLIG O

    team m em ber N ergis M avalvala,

    also atM IT.

    R egardless,seein g m ore

    cycles m akes th is system a better

    lab o ratory to testEin stein s

    th eo ry o fg en eralrelativity.

    Ifthere is an y sm alldev iation

    from ge n eralrelativity,itw ill

    accu m u late, V itale says.Ify ou

    have m ore cyclesyou h ave a better

    h op e to see ifth ere is som eth in g

    w ron g. So far,th e even tm atches

    ge n eralrelativity p erfectly.

    Th e team also m easu red a

    n ew attribu te of th e black h oles:

    one ofthe behem oths w as

    spin n in g slow ly.

    M easu rin g spin isa w ay to

    probe h ow th e black h olesform ed .

    Ifth ey cam e from a p airo fstars

    th atboth ex plod ed and b ecam e

    black h olestogeth er,th ey ou gh t

    to spin in the sam e d irection .

    Ifthey w ere alread y b lack h o les

    w h en they fou n d each oth erin a

    den seen viron m en tlike a glob u lar

    clu ster,th ey sho u ld n ot.

    M ore detection s w illhelp g au ge

    th e size ofthe u n iverse,probe th e

    n atu re ofm atteran d testgen eral

    relativity to ever h igh er p recision .

    Theseareth e kin ds ofth in gsw e w antto do,and w e can

    h ardly do them in an y oth erw ay,

    V itale says.

    B u tw ew illn eed alotm o re

    sign alstoan sw ersu ch qu estion s.

    T h esign ifican ceo fthisp ap er

    isitestab lish esap o p u lation ,

    ratherthan asin gleex am p le,

    say sLo eb .T h ereisab ig

    qu alitatived ifferen cebetw een

    h avin go n ed atap oin tan d h avin g

    tw o.Ilookforw ard toim p rovin g

    th estatistics.

    T H E fir s t m o n k e y a rc h a e o lo g y

    d ig h a s u n c o v e re d t h e to o ls u s e d

    b y p r e v io u s g e n e ra tio n s o f w ild

    m a c aq u e s a g r o u p o f p r im a te s

    s e p a ra te d f ro m h u m a n s b y s o m e

    2 5 m i lli o n y e a r s o f e v o lu t io n . T h e

    d is c o v e r y m e a n s h u m a n s a re n t a lo n e

    i n le a v in g a re c o r d o f p a s t c u lt u r e th a t

    c an b e p rie d o p e n b y a rc h a e o lo g y .

    A ll s o r ts o f a n i m a ls c a n u s e t o o ls ,

    b u t t h e y a r e u s u a lly m a d e f ro m

    p erish ab le m aterials like leaves an d

    t w ig s . T h is m a k e s th e o r ig i n o f t h i s

    b e h a v io u r d i ff ic u lt to s t u d y .

    B u r m e s e lo n g -t aile d m a c aq u e s a r e

    a ra re e x c e p t io n . T h e y a re re n o w n e d

    fo r th e ir u s e o f s to n e t o o ls t o c r a c k

    o p e n s h e llf is h , c ra b s a n d n u t s , m a k i n g

    t h e m o n e o f t h e v e ry f e w p r im a te s

    t h a t h a ve f o llo w e d h o m i n i n s i n t o

    t h e S to n e A g e .

    M ic h a e l H a s la m at t h e U n i ve r s it y

    o f O x fo r d a n d h i s t e am c o n d u c te d t h e

    d ig o n t h e s m a ll is la n d o f P ia k N a m Y a i

    in T h a ila n d , o n e o f th e is la n d s w h e re

    t h e m o n k e y s liv e an d u s e s t o n e t o o ls .

    T h e y s ift ed t h r o u g h t h e s an d y

    s e d i m en t s at th e s it e a n d fo u n d 1 0

    s t o n e t o o ls a t tr ib u t e d t o m a c aq u e s ,

    b a s e d o n t h e i r w e a r p a tt e rn s .

    B y d a tin g t h e o y s t er s h e lls fo u n d

    i n t h e s a m e s e d i m e n t la y e r s , t h e y

    d e t er m in e d t h e to o ls c o u ld b e as

    o ld a s 6 5 y e a rs , g o in g b a c k t w o

    m a c aq u e g e n e r a tio n s .

    W e k n o w fro m e y ew it n e ss ac co u n t s

    t h a t t h e s e m o n k e y s h a ve b e e n u s in g

    t o o ls f o r a t le a s t 1 2 0 y e a r s , s o t h e

    s t u d y d o e s n t p u s h t h e ag e o f t h e

    b e h a v io u r b a c k . B u t H a s la m s e e s it

    a s a fir s t s t e p t o w a rd s d ig g in g d e e p e r

    in t o t h e o r ig i n s o f th e b e h a v io u r.

    Its a very clever id ea an d its

    s o m e th i n g t h at w a s w a it in g to b e

    d o n e , s a y s M ic h a el H u f fm an at K y o t o

    U n i v e rs it y in Ja p a n , a p r im a to lo g i s t

    w h o s tu d ie s ro c k h an d lin g b e h av io u r

    in Ja p a n e s e m a c a q u e s . It ju s t t o o k

    s o m e o n e to g o o u t a n d d o it .

    E x a c t ly h o w fa r b a c k in t i m e th e

    m a c aq u e s St o n e A g e e x t e n d s is

    a n y o n e s g u e s s . A ra re c h im p a n z e e

    a rc h a e o lo g y d i g a d e c a d e ag o

    s h o w e d th i s a p e h a s b e en u s in g

    s to n e t o o ls f o r m o r e t h a n 4 0 0 0 y e a rs .

    A lo n g re c o rd o f a n c ie n t s t o n e

    t o o ls c o u ld t e ll u s i f t h e m o n k e y s

    p i c k ed u p t o o l u s e in r e s p o n s e to a n

    e n v i ro n m e n t a l s t r e s s , s u c h a s ra p i d

    sea level ch an g es, fo r exam p le.

    It m a y o n e d a y b e p o s s i b le t o a d d r e s s

    q u e st io n s ab o u t h o w an d w h y t o o l

    u s e a ri s e s in a n i m a l p o p u la t io n s , a n d

    ab o u t t h e e x te n t to w h i ch t h at k in d

    o fb eh avio u r is o r isn t u n iqu ely

    h u m a n , s a y s H a s la m . Alex Kasprak

    M onkey archae ology hint s at p rim ate culture

    U s in g t h e i r t o o ls o f t h e t r a d e

    T h e s e m a c a q u e s a re o n eofthe few prim at es tofo llow hom in ins in to the

    S t on e A g e

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    10 |NewScientist |18 June 2 016

    T W

    Sh annon Hall

    TW O stel larblasts m ay havem ade

    life interesting forearly hum ans.

    Roughly 2m illion years ago,

    twos upernovae explodedso close

    toEarth that they showeredthe

    planetwith debris, leaving behind

    traces ofradioactivei ron-60 now

    buried in the sea floor.

    Those sup ernovae were several

    hun dred light -years from Earth,farenough away that their

    radiation didnt lead to a m ass

    extinction, but close enough to

    have affected ouran cestor o m o

    e r e c t u s , which was descending

    from thetrees atthetim e.

    N ow, Brian Thom asat

    W ashburn University in Topeka,

    Kansas, and his colleagues posit

    that the twosupernovaecould

    havehurled enough radiation

    at Earth to affect our ancest ors

    behavioural patterns, andpotentially increase cancer rates.

    The first radiat ion t o hit Earth

    would have sim ply been visible

    light .Supernovae can be so bright

    that they briefly outshine all the

    stars in theirhost galaxy which

    wouldn t go unnot iced on Earth.

    In fact, such a close supernova

    would h ave been as bright as a ful l

    m oon every ni ght for up to a year

    after the ini tial explosion.The

    added light pollut ion could have

    had som e biological im pact.

    Certain sp ecies use light from

    the m oon to navigate, Thom as

    says.They al so use th at cue for

    m ating, reproduction, layin g eggs,

    thin gs like th at.Even jus t foraging

    for food.This can s crew wi th their

    usual behavioural p rocesses.

    Increased light at n ight can

    also affect horm one producti onin p eople.Take m elatonin for

    exam ple:it doesnt just pu t us to

    sleep, it also m ediates som e of the

    repair m echanism s in our bodies.

    W ere not talkin g about wip ing

    out species here, but there m ay

    be som e im pact on one or two

    generations, says Thom as.

    But visi ble light isn t the only

    radiat ion that would have burst

    from these stellar expl osions.

    Roughly 500 years after the

    supernova faded, it s radioactive

    particles would have p elted Earth

    Thom as and his colleagues

    calculated that th e average globa

    radiat ion woul d have been three

    tim es the backgroundlevelstypical today.They speculate

    ourancestors m ay have faced an

    increased cancer risk as a result

    (arxiv.org/abs/160 5.0 49 26).

    But they m ight not have had

    m uch to worry about, says M icha

    W eil at Colorado State University,

    as t he average is nt very t elling

    theres a considerable range acros

    the globe.Forexam ple, theres

    a radiation hotspot in Kerala,

    India, where the radiation can

    be20 tim es the global average.

    People havestruggled to showan increase in cancer rates i n

    those areas, and they havent

    m anaged to do it, W eil says.

    Thom as andhis colleagues

    calculated that the increased

    doseis equivalent to getting one

    CT scan p er year, which recent

    studies have shown can increase

    the risk of leukaem ia and brain

    tum ours in children ( h e L a n c e t ,

    doi.org/f2fm fz).

    Any dam age caused by the

    supernovae is hard to quanti fy.Luckily, nearby blasts only happ e

    once every bil lion years, says

    M ichael Sivertz at the NA SA Space

    Radiation Laboratory.You

    wouldn t h ave to take out a life

    insu rance policy on it, he says.

    E arly h u m an s felt

    su pern ovae blasts

    N

    A

    SA

    /CX

    C/SA

    O

    Itco u ld stop m o squ ito es

    carryin g Zika viru s,bu t w e

    do ntkn ow w hat the othe r

    consequ en ces m igh tb e

    Cancer caus ing?

    INTRODUCING the gene drive 2.0.

    An improved way ofcreating gene

    drives could help wipe out some of

    the worlds most des tructive disease s.

    A gene drive is a piece ofselfish

    DNA that cansp read rapidly through

    a popu lation. Biologists have created

    gene drives that spread among

    insects and are already testing

    them inlabs around the world.

    The proposed use ofgene drives is

    controversial(see pag e 6 ),because if

    they turn outto haveu nexpected

    Gen e -ed itin g

    tech n iqu e

    cou ld stop Zika

    conseq ue nces after be ing releas ed

    th ere may b e little we ca n do ab out it.

    Bu t th ere are also many p otential

    benefits,such as stopping mosquitoes

    from ca rrying malaria or Zika.

    In rea lity,flaws in exis ting d es igns

    mean th at g ene d rives w ouldnt las t

    long in the wild. Bu t sou pe d-up

    versions are in th e works t hat might

    ju st d eliver on th e tech nology s h u ge

    potentialto do good or bad.

    Gene drives based on the CRISPR

    gene-editing technique recognise

    a specific DNA sequence in a

    chromosome, cut it, and splice a copy

    of themselves into the gap. By copying

    and pasting themselves from one

    chromosome to another in this way

    they ensure all offspring inherit them.

    In practice, though, resistance to a

    gene drive often evolves in just a few

    generations because natural variation

    means that some organisms have

    chromosomes in which the target DNA

    is different. These chromosomesspread through a population in

    response to the release of a specific

    gene drive, stopping the gene drive

    spreading further.

    The copy-and-paste process can

    also go awry. Instead of a copy of a

    gene drive being pasted in after the

    target DNA is cut, sometimes the

    severed ends are stuck back togethe

    introducing mutations into the target

    DNA. This can create chromosomes

    resistant to the gene drive.

    Now, George Churchs team at

    Harvard University has a plan: to makthetarget DNApartof a crucial gene

    andto cutthisgenein severalplaces

    (Biorxiv, doi.org/bjzt). The gene drive

    includes the sequences needed to

    repair the crucial gene and insert a new

    gene. This means that if the process

    goes awry, the gene containing the

    target DNA is wrecked. Because this

    gene is crucial to the organisms

    survival, a chromosome carrying a

    wrecked version will not spread even

    if the organism becomes resistant to

    the gene drive. M ichaelLePage

  • 7/25/2019 New Scientist - June 18, 2016

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    e t a G r ip o n C a lc u lu sa lc u lu s h a s m a d e it p o s sib le to b u ild b r id g e s th a t sp a n m ile s o f

    v e r , to tr a v e l to th e m o o n , a n d to p r e d ic t p a tte rn s o f p o p u la tio n

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    o w h y d id n t y o u g r a sp c a lc u lu s th e fir st tim e ? I n sc h o o l, m a n y o f

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    m a in s a c lo s e d d o o r . A n d fo r th o s e o f u s w h o d id , a w a rd -w in n in g

    r o f e sso r M ic h a e l S t a rb ir d c o a u t h o r o f th e a c c la im e d m a th b o o k

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    id its b e a u ty . In th e 24 le c t u r e s o f C hange and M otion:C alculusM ade C lear, 2ndEdition, th e c o n c e p ts a n d in sig h ts a t th e h e a r t o f

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    12 |NewScientist |18 June 2 016

    Andy Cogh lan

    TH E w orldsfirstm onkey

    genetically engineered to have

    Parkinsonsdisease hasbeen

    created by researchersin Japan ,

    N ew Scientist can reveal.O ther

    m onkeyscreated aspartof

    the sam e projectm im ic

    Alzheim ersdisease and m otor

    neuron e disease.

    While m any scientistsw ere

    encou raged by the possibility of

    gaining uniqu e insightinto hard-

    to-treatbrain disorders,the new s

    w illalarm thosew ho feelitis

    w rong to use prim atesin research

    (seeLeader,page 5).

    Than kstoourcloseevolutionary

    history,thebrainsofprim atesare

    farm oresim ilartooursthan those

    ofthem ice,fliesan dw orm sthat

    currentlydom inatebrainresearch.

    M arm osets,forinstance,haveone

    partner,severaloffspringan d

    m akeeyecontactw itheachother.

    Lackofpublicsupporthas

    lim itedprim ateresearchin

    EuropeandtheU S.M ost

    neu rologicalresearchinthese

    countriesfocu sesonm icebutit

    islim itedinitsscope.Forex am ple,

    hundredsofcom pou ndsthat

    show edprom iseinm icew itha

    versionofAlzheim ershavefailed

    com pletelyw hentheyaregivento

    peoplew iththedisease.

    InJapan an dChina,opposition

    ism utedbycom parison.Lastm on th,H ideyukiO kan oat

    theKeioU niversitySchoolof

    M edicineinTokyorevealedhis

    team sm arm osetm odelof

    ParkinsonsattheStateofthe

    Brainm eetinginAlpbach ,Austria.

    Th eteam m odifiedm arm osets

    tohavem utatedcopiesofa

    hum angenecalledSN CA,w hich is

    linkedtoParkinsonsdisease.

    Whenthisgeneisfau lty,aprotein

    calledalph a-syn ucleinbuildsup

    inthebrain,disruptingan dthen

    killingthebraincellsthatm ake

    dopam ine,asign allingchem ical

    vitalform ovem ent.

    Inthethreeyearssincethe

    engineeredm arm osetsw ereborn,

    theydevelopedParkinson s

    sym ptom sinthesam ew ay

    peopledo.Thisbegan w ithsign s

    ofsleepdisturbanceintheirfirst

    year,follow edbytheappearance

    ofa-synuclein-associated

    globules,kn ow nasLew ybodies,

    intheirbrainstem sthenextyear.

    Bytheirthirdyear,them onkeys

    began toshow thecharacteristic

    trem orsassociatedw iththe

    condition.A sfurthereviden ceof

    how sim ilarthesem onkeysareto

    hum answ ithParkinsons,O kan o

    show edthattheirtrem orscou ld

    beeasedbygivingthem L-D O PA ,

    adruggiventopeoplew ith

    Parkinsonstom akeupforthe

    lackofdopam ine.

    Withthesediseases,itsvery

    difficulttoinvestigatew hatshappen inginlivingpeople,so

    know ledgeofthebraincircuits

    responsiblearem ostly

    uniden tified,saysO kano.H is

    team hopestow orkoutthekey

    neu ralcircuitsdam agedateach

    stageofthem onkeysdecline.

    Wehopetofindw aystopredict

    theonsetofeach sym ptom ,

    and develop drugsto slow dow n

    disease progression ,he says.

    InChina,thereare40breeding

    com paniesw hichtogetherhave

    250 ,00 0cynom olgusm onkeys

    and40 ,00 0rhesusm acaquesthat

    couldbeusedforscientific

    research,saysM u-M ingPooofthe

    ChineseA cadem yofSciencess

    InstituteofN eu roscience,an d

    leaderofagovernm ent-funded

    plan fora15-yearnationalbrain

    projectalsoinvolvinggen eticallym odifiedm on keys.O kan osays

    thatJap an alsohascolonies

    hou singarou nd1000 m arm oset

    Itsgettingm orean dm ore

    difficultforneu rosciencelabsin

    theWesttodoresearch onnon-

    hum anprim ates,saysTerrence

    Sejnow skioftheSalkInstitutefor

    BiologicalStudiesinLaJolla,

    California,an dco-organiserofth

    StateoftheBrainm eeting.H e

    hopesthatresearcherscan

    produceaglobalbrain

    program m ethatw illbring

    togethertherespectivestrengths

    ofteam sfrom arou ndthew orld.

    N oteveryoneishappyw iththi

    kindofprim ateresearchbeing

    carriedoutatallregardlessof

    w hereinthew orlditisbeing

    done.Therew illbem anyinthe

    scientificcom m unityw ho,like

    m e,w illbeveryconcernedbythi

    research,saysV ickyRobinson,

    chiefexecu tiveoftheU KN ationa

    CentrefortheReplacem ent,

    Refinem entandRedu ctionof

    Anim alsinResearch.The

    availabilityofm onkeysan dless

    stringentregu lationsarepoor

    reasonsforjustifyingtheuseof

    theseanim alsinresearch w her

    theresnoguaranteethatthe

    resultsw illtran slatetohum an s

    an ym oreeffectivelythan ifthe

    scientistsusedotherspeciesor

    technologies,shesays.

    M akingG M m onkeysm eans

    youcanstudycom plex

    behavioursoverlongertim e

    span s,saysRogerBarkerattheU niversityofCam bridge,w ho

    research esfetalcelltreatm en ts

    forParkinsons.Buthecau tions

    thatm od ifiedm onkeysare

    unlikelytoan sw erallofour

    question s.M osthum anbrain

    diseasesdontoccurbecauseof

    singlegen edefects,saysBarker.

    Becauseofthis,hesaysthat

    m onkeysgivenfau ltyversionsof

    onlyonegen ew illprobablybeof

    onlylim itedclinicalrelevanceto

    eachofthesediseases.

    M o n k e y s c re a te d

    w ith P ark in s o n s

    GETTY

    IM

    AGES

    B y t h e ir t h ird y e a r, t h e

    m o n k e y s b e g a n t o s h o w

    t h e c h a ra c t e r is t ic tr e m o r so f t h e d is e a s e

    Primate b rains are similar to ou rs

    T W

  • 7/25/2019 New Scientist - June 18, 2016

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    Find your hero (or heroine)

    on New Scientist Connect

    there are p lenty to choose from.

    Meet like-minded people who

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    N EW SCIEN TIST

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    18 June 2 016 |NewScientist |15

    A FARAWAYp lanetlocked in a

    closedancew ithitsstarism aking

    itspartnerspinfaster.Theorbital

    w altz,w hichm irrorsthatofEarth

    an ditsm oon,couldbethebest

    labyetforstudyinghow plan ets

    affecttheirstarsandviceversa.

    Astronom ersusingthe

    H un garian-m adeAutom ated

    TelescopeN etw ork-Sou th

    Exoplan etSurveyspottedthebig,

    gassyw orldaroundastardubbed

    H A TS-18,w hich isalm ostiden tical

    in sizeand tem peratureto our

    sun .Itsso close to the starthat

    itorbitsinjust20 hours.

    KaloyanPenevofPrinceton

    U niversityan dhiscolleagu es

    noticedthestarw asspinningtoo

    fastforitssizean dage,m eaning

    som ethingw ascau singittorotate

    faster.Theyfou ndthattheplan et

    ism ovingeverclosertothestar,

    speedingitupthrou gh aprocess

    know n astidaldissipation(arxiv.org/abs/1606.00 848).

    The opp osite happ ensin the

    Earth-m oon system :the m oon

    ism ovingaw ayfrom Earthand

    Earthsspinisslow ingdow n,w ith

    daysgraduallygettinglonger.The

    pronounced effectin H ATS-18

    m eans researchersw illbe able

    to usethesystem tostudytidal

    dissipationelsew hereinthe

    cosm os,from distantstarsystem s

    totheinteractionofJupiterandits

    m oons,saysPenev.

    n c e s t o r o f a ll b a c t e r ia s p e n t

    it s t im e in a h o t b a t h

    THE ancestor of all bacteria may have had sophisticated

    enzymes 3.4 billion ye a rs a g o ju s t 6 0 0 m i lli o n y e a r s

    a f te r t h e o r ig i n o f li fe o n E a r th . T h a t s a ls o a b o u t a b i llio n

    y e ars b e fo r e m a n y p e o p le t h o u g h t t h e e n z y m e s e vo lv ed .

    M o d e rn e n z y m e s fit t h e m o le c u le s t h e y re ac t w it h

    lik e a lo c k t o a k e y . In c o n t ra s t, t h e e a rlie s t e n z y m e s

    w e re s lo p p i e r a n d le s s s p e c if ic .

    N o w R ein h a rd S te rn e r a t t h e U n iv ers it y o f R e g e n s b u r g

    in Ge rm an y an d h i s c o lle ag u e s h av e lo o k e d at a n e n z y m e

    c a lle d t ry p t o p h a n s y n t h a se .It a id s t h e c re at io n o f a n

    a m in o a c id c r u c i al to b a c te r ia , ar ch a e a, p la n t s a n d f u n g i,

    s o a f o r m o f it h a s p ro b a b ly b e e n a r o u n d f o r a lo n g t i m e .

    T h e y fe d t h e g e n e s eq u e n c e s th at co d e fo r th e e n z y m e

    in m o d e rn b a c te ria an d a rc h a e a in t o a c o m p u t e r p r o g ra m

    t h a t s e ar c h e d f o r s im i la ri ti e s . T h e y t h e n r an s i m u la t io n s

    o f w h a t th e D N A s e q u e n c e m ig h t h a ve b e e n b e fo r e th e

    g r o u p s s p lit . T h e te a m re c o n s t ru c t e d t h e m o s t p r o b a b le

    s e q u e n c e a n d i n s e r te d t h e g e n e i n t o E .co lic e lls , w h i c h

    c h u r n e d o u t a n e n z y m e t h at b e h av ed m u c h lik e t h e

    m o d e rn v ers io n s (CellChe m icalB iolog y, d o i .o r g / b jz k ) .

    T h e e n z y m e k e p t it s s tru c tu r e u p to ab o u t 7 0 C.

    Y o u c a n in f e r w it h s t ro n g c o n f id e n c e th a t t h e o r g a n is m

    liv e d i n a h o t e n v i ro n m e n t , s ay s M a th ie u G ro u s s in a t

    t h e M a s s ac h u s e t ts In s t it u t e o f T e c h n o lo g y . T h is ad d s

    w e ig h t to h y p o t h e s e s ab o u t th e fir s t b a c t e ria liv in g i n

    h o t w a te r, h e a d d s .

    P la n e t s c lo s e d a n c e s p e e d s s t a r s s p in

    B o n e h o r m o n e

    r e j u v e n a t e s m u s c le

    WIN D backtheclock.Wevefou nda horm one thatcan rejuvenate

    the m usclesofelderly m ice.

    O steocalcin a horm one

    secreted by bonebooststhe

    abilityofm usclestoburnfuel

    andgenerateenergy,G erard

    KarsentyofColum biaU niversity

    an dhiscolleagu esdiscovered.

    Whentheteam injectedthe

    horm oneintooldm ice,the

    anim alsw ere able to run justas

    farastheiryoungercou nterparts,

    despitebeing up to a yearolder

    a longtim einm ouseyears.

    O ldm icethatdidnotreceive

    thehorm oneranabouthalf

    asfar(Cell M etabolism,D O I:

    10.1016/j.cm et.20 16.05.004).

    Itw asextrem elysurprising,

    saysKarsenty.

    O steocalcinlevelsdeclinew ith

    ageinbothm icean dhum ans,

    an dtheteam now plan stotest

    w hetherthehorm on ecan

    im provem usclefunction in

    peopletoo.

    S p a c e e le v a t o r s

    c a n t w o r k

    BYE-BYE,spaceelevator.Carbon

    nanotubesarefam edforbeing

    super-strong.Butjustoneout-of-

    placeatom seem senough tocut

    theirstren gthbym orethan half.

    Th atm eanson eofthem ore

    outlan dishapplicationsaspace

    elevatorbetw eenEarthan da

    satellitem igh tbedoom ed.Fen gD ingoftheH ongKon g

    Polytech nicU niversityan dhis

    colleagueshavesim ulatedcarbon

    nanotubesinw hichasingleatom

    isoutofplace,creatingakinkin

    thetube.Theyfou ndthekinkacts

    asaw eakpoint,easilysnap ping

    thenorm allystrongbonds

    betw eenthecarbon atom s.O nce

    thishappen s,thebondsinthe

    adjacenthexagonsalsobreak,

    unzippingtheen tiretube(ACS

    Nano,doi.org/bjzj).

  • 7/25/2019 New Scientist - June 18, 2016

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    16 |NewScientist |18 June 20 16

    Fo rnew storieseveryday,visitnew scientist.com /new

    Froggystyleinthe

    heatofthenight

    HOP on,hop off. Th e frog Kama S u tra

    jus t got u pdated . An Indian nigh t

    frog has been caug ht in a new sexu al

    position d ub bed the dorsalstradd le.

    Sathya bh ama Das Biju at th e

    University of Delhi a nd his team

    spe nt 4 0 night s filming th e sex

    lives of B om bay nig ht frogs

    (N y c tib a t r a c h u s h u m a y u n i

    ) in a

    fores t in th e W es tern G hats in India.

    They have now spotted the seventh

    known m ating p osition in frogs.

    M a ny frogs d o it dogg y st yle ,

    w ith a m ale on top of a fem ales back.

    The new position is a va riation of

    this, but t here is no contact between

    the s ex organs .Inste ad, w hen a

    m a le straddles a fem ale, spe rm is

    releas ed on he r back.The fem ale

    the n lays here ggs and the spe rm

    trickles down to fertilise the m .

    It was une xpected,says D as B iju.

    The team observed other

    unusual behaviours in these frogs.

    In addition to m ale m a ting calls ,

    w hich are ty pical in all frogs , they

    found that fem ales occasionally

    initia te d calls whe n they couldnt

    m ake contact with a vocal m ale

    (P e e r

    , DO I:10.77 17 /pee rj.211 7).

    Ry an Taylorat Salisbury

    University, M aryland, w ho studies

    frog courts hip, th inks t hat t he

    successive release ofsem en and

    egg s is p articularly interest ing.

    This be haviourapp ears to be

    unique and it is unclearhow orwhy

    it evolved,he says .

    A llsetforlargestindoorw eathertest

    N EX T m onth, the Biosp here 2

    glas sed-in ecosyst em in the Arizona

    dese rt w ill start the largest -ever

    expe rim ent to study how waterm oves through the landscap e.

    The p rocess ofwe athe ring

    underlies everything in an

    ecosystem .All the calcium ,

    potass ium and m agnesium we eat ,

    forex am ple , origina tes from rocks,

    says Jean D ixon, a geom orphologist

    at M ontana S tate University in

    B ozem an.Chem ical we athe ring is

    the first t hing y ou nee d in order to

    form a habitable planet ,she says .

    B ut we st ill know little about it.

    Th at s wh ere Bios phe re 2 com e s

    in.The e xpe rim e nt will begin with

    three hills weighing 500 ,00 0

    kilogram s each, m ade from crus hedbasalt a volcanic rock tha t w ill be

    exp osed to sim ulate d rain.

    The hills are studded with m ore

    than 180 0 em bedded sensors, which

    m e as ure everything from carbon

    dioxide levels to watercontent .

    Eventu ally, plants will be added, too.

    The tea m hopes this w ill faithfully

    sim ulate weathering at real-world

    scales unlike previous lab studies

    tha t gave different result s to thos e

    obse rved in natu re.

    A SM A L L p ilo t p ro ject in Icelan d

    h as sh o w n th at carb o n d io x id e

    can b e safely sto red in b asalt ro ck s.T h e fin d in g co u ld b e u sed to h elp

    tac k le clim ate ch an g e,es p ec ially

    in co u n tries su ch as In d ia th at

    h ave little sed im en tary ro ck o f th e

    so rt reg ard ed as b est fo r sto rin g

    CO2b u t lo ts o f b asalt ro ck .

    T h e team fo u n d th at w h en CO2

    d isso lved in w ater is in jected in to

    h o t b asalt d eep u n d er g ro u n d ,

    it rap id ly r eacts w ith th e ro ck

    to fo rm carb o n ates.Fo r

    p erm an en t sto rag e,th is is th e

    u ltim ate in safety, say s team

    m em b er Ju erg M atter at th e

    Un iv ersity o f So u th am p to n in

    th e UK .Carb o n ate m in erals arereally st ab le.

    In jectin g CO2in to b asalt is

    slig h tly m o re ex p en siv e th an

    o th er sto rag e m eth o d s,su c h as

    p u m p in g i t in to d ep leted o ilan d

    g as reservo irs.It also req u ires a

    lo t o f w ater.B u t o n th e p lu s sid e,

    o n ce it tu rn s to sto n e,th ere w i ll

    b e n o n eed to k eep ch eck in g it h as

    stay ed p u t (Science,d o i.o rg /b jw q ).

    Its n o t n ecess ary to tu rn CO2to

    sto n e to sto re it secu rely,say s

    Jo h an n es M io cic at th e Un iversity

    o f Ed in b u rg h ,UK ,b u t u sin g

    m eth o d s lik e th is c o u ld ease

    fears ab o u t safety an d so b o o stp u b lic su p p o rt fo r carb o n cap tu re

    an d sto rag e.

    T h e m ain p ro b lem ,h o w ever,

    is cap tu rin g th e CO2,w h ich co sts

    far m o re th an sto rin g i t.B ecau se

    o f th e co sts,su ch tech n o lo g ies

    are u n lik ely to catch o n u n less

    g o vern m en ts eith er p ay fo r th em

    o r in tro d u ce a carb o n p rice h ig h

    en o u g h to fo rce co m p an ies to

    cap tu re th eir CO2w aste.T h ere

    seem s t o b e little ap p etite fo r

    eith er ap p ro ach at th e m o m en t.

    CO2injectedundergroundturnstorockandstaysthere

    A lienlifecouldlurk

    underdeepice

    SOM E p lan ets aro u n d o th er stars

    co u ld h ave life h id d en u n d er

    lay ers o f w eird h ig h -p ressu re ice,

    in o cean s far d eep er th an Earth s.

    Ex trem e p ressu res can create

    u n u s u alfo rm s o f ice rarely seen

    o n Earth .T o in vestig ate w h at th is

    m ean s fo r o th er p lan ets,Len a

    N o ack at th e Ro y alO b servato ry

    o f B elg iu m an d h er c o lleag u es

    m o d elled ro ck y w o rld s w ith very

    d eep o cean s.

    T h ey fo u n d th at o n a p lan et

    w ith Earth s m ass,a lay er o fh ig h -

    p ressu re ice can fo rm in o cean s

    ab o u t 170 k ilo m etres d eep m o re

    th an 15 tim es th e d ep th o f th e

    lo w es t p o in t in E arth s o cean s.

    Given am p le h eat fro m th e

    p lan ets in terio r,w ater can rem ain

    liq u id u n d er th e ic e lo n g en o u g h

    fo r life to tak e h o ld .T h e m o d elw o rk s fo r p lan ets u p to 10 Earth

    m asses (Icarus,d o i.o rg / b jx k ).

    Su ch m o d ellin g is sp ec u lative ,

    b u t co u ld ap p ly to w o rld s w i th in

    o u r so lar sy stem . N o ack n o tes th at

    Ju p ite rs m o o n Gan y m ed e h as a

    lo t o f w ater as a p ro p o rti o n o f its

    m ass,far m o re th an Eart h d o es.

    D ep en d in g o n h eat fro m th e

    in te rio r,it s p o ssi b le Gan y m ed e

    co u ld h ave h ig h -p res su re ic e

    co ver in g a liq u id lay er,an d N o ack

    p lan s to ap p ly h er m o d els th ere.

    SD

    BIJU

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    S ix n ig h t s a c co m m o d a tio n in R e y k ja v ik a n d c o u n t r y s id e h o te ls

    P r iv a te c o a c h o c a l e x p e r t g u i d e s ll e n tr a n c e fe e s

    Fr om 1738 per per s on(l oc al pr i ces a vai l a bl e)

    GEOTHERMALPOWERS

    MAGICALLANDSCAPES

    VOLCANOESAND GLACIERS

    Marvelat the sights,sounds and smells

    oferupting geysers,hot springs and

    bubbling pools ofmud. Relax in the

    warm,mineral-rich waters ofthe Blue

    Lagoon.Enjoyfood cooked by the

    Earths heat,visit a geothermalpower

    plant,and see where tomatoesgrow

    evenin deepest winter.

    Explore UNESCO-listed Thingvellir

    nationalpark,where tectonic plates rip

    the land apart to create a dramatic rift

    valley. Witness the thunderous force

    and beauty ofthe Gullfoss waterfall.

    Discover Icelands south shore,famous

    for its sheer cliffs,picturesque villages

    and black sand beaches overlooked by

    towering glaciers.

    Drive across Europes second largest

    glacierin an eight-wheeltruck,and see

    shades ofblue you neverknewexisted in

    Langjkullicecave. Hikeacross the

    dramatic Slheimajkullglacier. See

    howaneruption 8000 years ago

    sculpted beautifulshapes in Vatnshellir

    lavacave. Visit the famous

    Eyjafjallajkullvolcano.

    DAVIDCLAPP/GETTYIM

    AGES

    2 5 FEB RUARY 3 M ARCH 2017

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    18 |NewScientist |18 June 20 16

    IN A U G U ST 20 14,th e B ritish

    pu blic w ere grip ped by th e story

    of A shya Kin g,a 5-year-old bo y

    w ho h ad a form ofbrain cancer

    called m ed u llob lasto m a.H e w as

    rem oved from h ospitalby h is

    parentsw ith ou tth e consentor

    kn ow ledge ofh isd octors.

    A n in tern ation alhu n t

    w a s sparked w h en itw as realised

    th ey had taken A shy a abroad in

    th e h op e ofgettin g h im h igh -

    en ergy proton beam th erapy

    (PB T),a typ e of rad iotherapy

    u n available in th e U K.

    Like so m any p arentso f

    ch ild ren w ith b rain can cer,B rett

    and N aghm eh Kin g w ere w orried

    abo u tth e sid e effects of X -ray-

    based radioth erapy an d h ow

    th is cou ld affecth is fu tu re

    develop m ent.Scou rin g th e w eb

    for altern atives,th ey d ecid ed th at

    PBT w o u ld pu tA shya atlow errisk.

    So th ey setofffor a PB T centre in

    Pragu e,on ly to b e jailed in Sp ain

    for over 24 ho u rs w h ile en route.

    A few d ays later,a U K cou rtru led

    th atA shya cou ld receive treatm en t

    atth e Proton Th erapy C entre in

    Pragu e,w h ich w as even tu ally p aid

    for by th e U Ks N ation alH ealth

    Service.Fastforw ard tw o ye ars

    and A shya isn ow w elleno ugh

    to atten d sch oo l.M ean w h ile,tw o

    PB T centresare schedu led to op en

    in the U K in 20 18.A lth ou gh m ore exp ensive

    th an co n ven tion alrad iotherapy,

    th e pu sh forp roton sisb ased on

    th e id ea th atth ey cause less

    collateraldam age .Proto n s can

    be p rog ram m ed tod eliverth eir

    en ergy in ap ow erfu lp u n ch at

    w ell-d efin ed p o in tsw ithin a

    tum ou r.In co n trast,X -raysp ass

    th rou gh tu m ou rsan d irrad iate

    n earby h ealth ytissu es.

    Yetthed atain su p p o rtof

    p roton therap y,esp eciallyfor

    m edu llob lasto m a,is

    contentiou s h ence th e N H Ss

    relu ctan ce to send A shy a abroad

    for treatm en t,som eth in g ith as

    don e foron ly asm allnum berof

    peop le since 20 0 8.So w hatisth e

    eviden ceto sup po rtproton so ver

    X -rays?A n d ifits so scan t,w h y the

    glob alp roton d rive?

    M e dica l a rm s ra ce

    Proton therapy h asb een u sed

    on a sm allscale for decades.B u t

    recen tly th ere h as been a surge in

    in terest,stoked by th e m edia an d

    techn icaladvan cesth atm ean a

    10 0 -m illion p article accelerator

    th e size of a foo tba llfield is n o

    lon ger th e on ly op tion .Tod ays

    m ach in es can costas little as

    15 m illion .

    Itis estim ated th atw o rldw ide

    th ere are 43 h igh -en ergy p roton

    beam centres.B y 20 18 th at

    n u m ber w illrise to 6 6 ,in clu din g

    th e tw o N H S centresb ein g bu ilt

    atthe C h ristie h osp italin

    M an chesteran d U n iversity

    C ollege H osp italin Lo n do n .

    B oth w ere app roved in 20 11at

    a co m bin ed co sto f250 m illion .

    A cco rdin gtoasen io rN H Sad viser,

    th ego vernm en td ecid ed togo

    ah ea d w iththecen treso n the

    basisofthep h ysicsofh ow X -ray s

    an d p roton sb eh averath erth an

    an yco n vin cin gclin icald ata.

    In th e U S,w h ere th ere are

    u p w ards of 20 cen tres,critics

    h ave d escribe d th e situ ation

    as a m ed icalarm srace,w ith big

    h o sp italseach w an tin gtheirow n

    sh in yp ieceo fkit.

    Th econ trov ersyarisesbecau se

    thereislittleu n d isp u ted d atato

    su p p orttheid eathatthem o re

    ex p en sive p roton saresign ifican tly

    betterthan con ven tion al

    rad io th erapy in term s o fo verall

    p atien tsu rvival.In fact,for10 years

    orm ore,severalstud iesh av e

    attem p ted w ith ou tm u ch su ccess

    toform u lateaco st-ben efitan alysis

    ofp roton sfora range ofcancers.

    B u tith asntb een p ossible to

    set u p ran d o m ised clin icaltrials

    cap ab leofcom p arin gp roton s

    w ith X -rays,esp ecially for rare

    ch ild h oo d can cers.In p art,th is is

    because parents often in form ed

    by m ed ia coverage can be

    relu ctan tfor th eir ch ild to m iss

    ou to n w h atthey seeas a sup erior

    treatm en t,saysR ichard G ru n dy at

    th e U n iversity o fN ottin gh am ,U K.

    M u ch ofthe eviden ceis th erefore

    based on w eakerdata provided by

    oth ertyp eso fstu dy.In 20 12,fo rin stan ce,a review

    ofP BT for centralnervou s system

    tu m o u rs,gastroin testin al

    m align an cies,lu n g,head an d

    n eck,prostate an d p aed iatric

    tu m ou rsp rodu ced m ixed

    results w ith n o clear ben efit

    over con ven tion alrad iotherapy,

    exceptp erh aps fortum ou rsin

    children s n ervo u s system s

    ( a d io t h e r a p y O n c o lo g y ,do i.

    org/b jq3).A n d arev iew th isyea r

    fou n d thatfor11of15ch ild h ood

    can cerstherew aslittleev id en ce

    tosu ggestp roton sw erean ybette

    th an X -rays( n t e r n a t io n a l Jo u r n a

    o f R a d ia t io n O n c o lo g y B io lo g y

    P h y s i c s

    ,doi.org/b jq 4).B u tn ow astu dyh asp rov id ed

    thefirstev id en cethatPB Tm igh t

    in d eed be w orth itfor child ren

    w ith m edu llob lastom a.Itw asn t

    a ran d om ised trialb u titfollow ed

    ch ild ren w h oh ad o n eofthetw o

    treatm en tsforaro u n d seve n

    years,an d h as been d escribed

    LY T Y

    T he rus h for protonsH as p ro ton b eam radio therapy b een p rematu rely cast as ag ame-ch an g in g can cer treatmen t, asks Steve Connor

    AM

    ELIEBEN

    OIST/BSIP/SCIEN

    CE

    PH

    OTO

    LIBRARY

    Su rvival rat es are s im ilarbut proton propone nt ssa y t here are few er sideeffects than w ith X -rays RE

    U

    TERS/DAVID

    W

    CERN

    Y

    Ashy a got the rapy in Pragu e-

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    20 |NewScientist |18 June 2 016

    O T

    Dont tolerate thisA deadly catch-22 is fuelling the pres cription opioid epidem ic inthe US.Tim e to confront it, says Samanth a Mu rph y

    H O W d id A m e ric a s p r o b le m w it h

    o p io i d p a in k i lle r s g e t s o b a d ?

    S i n c e 1 999, s a le s o f p r e s c r ip t io n

    o p io i d s h a v e n e a r ly q u a d r u p le d ,

    a n d c lo s e t o 20 0 ,0 0 0 p e o p le in

    t h e U S h a v e d i e d a f t e r o v e r d o s in g

    o n t h e m , w h i le r e la te d e m e r g e n c y

    h o s p i t a l v is it s n u m b e r a lm o s t

    40 0,0 00 a y e a r . In 20 14 a l o n e ,

    c lo s e t o 20 ,0 00 d ie d o f a n

    o v e r d o s e , a c c o r d in g t o a n

    e d it o r ia l in t h e jo u r n a l JA M A .

    It d o e s n t h a v e t o b e t h is w a y .

    T o o m a n y U S c it iz e n s a p p e a r

    t o s tr u g g l e w it h p a in , p ills a n d

    p h y s ic a l d e p e n d e n c e . A m o n g

    t h e m w a s m u s ic ia n P r in c e ,

    w h o r e p o r te d ly h a d c h r o n ic h ip

    p a in . W e n o w k n o w h e d ie d a g e d

    57 o f a n a c c id e n t a l o v e r d o s e o f

    f e n t a n y l , a p r e s c r ip t io n o p io id

    m a n y t im e s m o r e p o t e n t

    t h a n h e r o i n .

    T h e b a c k d r o p t o t h is s o r r y s to r y

    is a h e a lt h c a re f ie ld t h a t h a s m a d e

    h u g e p r o g r e s s i n a w a r e n e s s a n d

    id e n t if ic a t io n o f c h r o n ic p a i n ,

    le a d in g t o a d r a s tic in c r e a s e i n

    d ia g n o s e d c a s e s . A c c o r d i n g t o a

    20 1 1 s tu d y b y t h e U S In s tit u t e o f

    M e d ic in e , e a c h y e a r m o r e t h a n

    30 p e r c e n t o f A m e r ic a n s b a t tle

    s o m e f o r m o f c h r o n i c p a in .

    It s ta n d s t o r e a s o n t h a t

    d o c to r s h a v e b e e n f ig h t in g t h is

    w it h p a i n k i lle r s . S u r e , t h e r e a r e

    o t h e r t r e a tm e n t s s u c h a s ta lk i n g

    t h e r a p ie s a n d a c c e p t a n c e a n d

    c o m m it m e n t th e r a p y (w h i c h is

    e x a c tly w h a t it s o u n d s lik e )

    b u t it m a k e s s e n s e t h a t t h e s in g le

    m o s t e f f e c tiv e r e m e d y h a s b e e n

    p a i n k ille r s . It is p e r h a p s h a r d ly

    s h o c k in g t h a t t h e m o s t p o t e n t o f

    t h e s e , t h e o p io i d s , a r e n o w a m o n

    t h e m o s t c o m m o n ly p r e s c r ib e d

    m e d ic a tio n s i n t h e U S .

    A n d in t h e a b s e n c e o f a f ix

    f o r t h e u n d e r ly in g c a u s e o f

    p a in , t h e p ills n e e d t o k e e p

    c o m in g . U n f o r t u n a t e ly , t h e

    r e p e a t e d u s e o f a n o p io i d w ill

    Slow revolutionIfpioneering flight is no longerabout shrinking

    the world, what is it for, wondersPau lMarks

    W H E N p i lo t s Jo h n A lc o c k a n d

    A r t h u r B r o w n b e c a m e t h e f ir s t

    t o f ly a p la n e n o n -s to p a c r o s s t h e

    A t la n t ic 97 y e a r s a g o , in c e n t iv e s

    in c lu d e d a 1 0 ,0 00 p r iz e p u t u p

    b y t h e o w n e r o f t h e D a ily M a il

    w o r t h a b o u t 1 m illio n t o d a y .

    S u c h c o m p e t it io n s s p u r r e d

    in n o v a t io n a n d h e lp e d u s h e r in

    t h e g l o b a l a v ia t io n s y s t e m w e

    h a v e n o w , w h ic h h a s u t t e r ly

    t r a n s fo r m e d o u r p l a n e t .

    A t t e m p t s to s e t flig h t r e c o r d s

    s till g o o n t o d a y b u t a r e le s s a b o u t

    c a s h p r iz e s , a n d c e r ta i n ly le s s t o d o

    w it h s h r in k i n g t h e w o r ld . M o s t

    p r o m in e n t a m o n g t h e s e is t h e

    S w is s -le d a t te m p t t o c ir c le t h e

    g l o b e in t h e s u n -p o w e r e d a i r c r a ft

    S o la r Im p u ls e 2. T h is , t o o , is a b o u t

    t o c r o s s t h e A t la n t ic , b u t w ill t a k e

    f iv e d a y s r a t h e r t h a n t h e 1 5 h o u r s

    A lc o c k a n d B r o w n c lo c k e d u p .

    W it h 1 7,0 00 s o l a r c e l ls o n w in g s

    a s b r o a d a s a ju m b o je t s a n d h a lf a

    t o n n e o f lit h iu m b a t te r ie s t o s t o r es o la r p o w e r a n d k e e p it s fo u r

    p r o p e l le r s t u r n in g a t n ig h t , it s

    e f fe c t iv e l y a n o u t s iz e d , m o t o r is e d

    g lid e r w it h c r a m p e d r o o m f o r o n e .

    It is n o p r o t o - a ir lin e r . In s t e a d ,

    it s p o t e n t ia l f o r s p a r k in g a n e a r -

    t e r m r e v o lu t io n lie s in m o r e

    e f f ic ie n t e l e c t r ic m o t o r s a n d

    b a t t e r ie s w it h h ig h e n e r g y d e n s it

    t h a t c o u ld f ir s t h e lp t r a n s fo r m lif

    o n t h e g r o u n d , a s w e t r y t o s h a k e

    o f f f o s s il-f u e l d e p e n d e n c e a n d

    s e e k m o r e e f f ic ie n t w a y s t o s t o r e

    s o l a r e n e r g y f o r u s e a t n ig h t .A s t h e p la n e s c r e a t o r s s t a t e ,

    e v e r y o n e c o u l d u s e t h e s a m e

    t e c h n o l o g i e s o n t h e g r o u n d t o

    h a lv e g lo b a l e n e r g y c o n s u m p t io n

    B u t p u s h in g t h e lim it s o f e le c t ric

    f lig h t w a s n e v e r g o in g t o b e e a s y .

    S o la r Im p u ls e 2s jo u r n e y b e g a n

    in A b u D h a b i b a c k in M a r c h 20 15.

    It s g r e a t e s t f e a t c a m e t h a t Ju n e ,

    w h e n it fle w 720 0 k i lo m e t re s f o r

    f iv e d a y s f r o m Ja p a n t o H a w a ii,

    w in n in g e x h a u s te d p ilo t A n d r

    B o r s c h b e r g a w o r ld r e c o r d f o r t h e

    Eve ryo ne could u se th e

    sam e techn olog ies on the

    grou n d to ha lve glob al

    ene rgy con sum ption

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    18 June 2016 |NewScientist |21

    Clare W ilson

    AN OT H ER w eek,anotherstudy

    casting d ou bt on a ntide pressants.

    T his on e says that forch ildren and

    tee na ge rs w ith m ajor de pression ,13

    of the 14 drugs an alysed d on tw ork.

    Previou s resea rch sug ge sts that

    for adults too ,the Prozac class of

    an tide pressa nts selective se roton in

    reu ptake inh ibitors is no be tter tha n

    a placebo ,atlea stfor peo ple w ith m ild

    or m od erate d ep ression .Co nfusingly,

    otherresea rch find s the se drugs do

    w o rk for ad ults w ith m ajor de pression .

    What is go ing on ? Itis difficultfor

    studies to draw firm con clusion s

    un less resea rche rs have access to

    allthe trialdata.Lastyea rw hen

    G laxo Sm ithKline relea sed fulldata on

    on e of its studies in teen ag ers,the

    rate o fside effectssuch as suicida l

    thou ghts w as m uch higherthan had

    initially ap peared.

    D espite this,the nu m be rof

    prescriptions w ritten for these d rugs

    rises every yea r.In the po orestareas of

    the U Ka stagg ering on e in six pe op le

    is taking them .A ntide pressan ts can b e

    life-saversforth ose w ith severe

    de pression bu tthey are b eing dishe d

    ou ttoo e asily for pe op le w ith e veryday

    sadne ss,say critics.Ifthe drugs do so

    little g oo d,w hy are the y so p op ular?

    Fam ily do ctors,w ho w rite m ost of

    the prescription s,m ay fee lthe y have

    little else to o ffera patientsitting in

    fron to fthem .U K gu ide line s say that

    talking therap ies shou ld be the first

    option forpeo ple w ith m ild d ep ression ,

    bu titcan take overa yearto get seen.

    M an y patien ts fee lthe se drug s

    are he lpful.H ow eve r,a large parto f

    this cou ld be the placeb o effect,

    psych iatristJoan na M on crieffo f

    U niversity Colleg e Lon do n w arne d a

    m ee ting o fthe U Ks A ll-Party

    Pa rliam en tary G roup for Prescribed

    D rug D epen dence in M ay.

    O ne factor be hind the grow ing

    acceptance of antide pressant use

    cou ld b e the w ide spread b elief

    prom oted b y the irm an ufacturers

    that the d rug s correcta chem ical

    im ba lan ce in the brain.Th ey are said to

    w ork by rep len ishing leve ls of the fee l-

    go od chem ical,seroton in.Th is

    probab ly isnttrue.While the drug s do

    bo ost serotonin,there is no p roo fthat

    low leve ls cau se d ep ression.In fact,

    tho ugh the ories ab ou nd,w e stilldon t

    know w h attrigg ersd ep ression .

    A ntidep ressants do chang e how w e

    fee l,in a w ay thatso m e find helpful

    and others do nt.B ut that do esnt

    m ean the y are correcting a chem ical

    im ba lan ce.M an y pe op le find alcoh ol

    he lps the m relax,bu tthats no t

    be cau se its correcting an alcoh ol

    deficiency in theirb rain.

    T he che m icalim ba lan cem yth

    could e ncou rage som e p eo ple to take

    the drug s w ho w ou ldn to the rw ise.

    Itis a de cision thatsho uldn tb e taken

    ligh tly,since an tide pressa ntsca n have

    do w nside s includ ing w ithd raw al

    sym p tom s,loss of sex drive an d

    w eigh tga in.M o stalarm ingly,in a

    few pe op le the y trigg er violen to r

    suicida lthou gh ts.

    Th e lateststud y sugge sts thato f

    allthe an tide pressan ts,one called

    ven lafaxine w as the m ost likely to

    m a ke tee nagers suicida l(The Lancet,

    doi.org/bjzh ).Prozacw a sdeem edto

    bethe m osteffective .B uttheau thors

    com p lainedthatthe ycouldntproperly

    assesssom eofthe drugsbecau seof

    alackofdata.

    Sothetruebalanceofriskve rsus

    benefitw illprobablyonlyem erge

    w he nind ep en de ntrese arche rscan

    accessallthedatafrom clinica ltrials

    som ethingdrug m an ufacturersare

    stillresisting.

    Why take depression

    pillsifthey donthelp?

    T etet

    PETERDAZELEY/GETTY

    B itter pill

    The chemical imbalancemyth could encouragesome people to take drugswho wouldnt otherwise

    For more opinion articles, visit newscientist.com/opinion

    almost inevitably cause problems.In a cruel twist, tolerance to

    opioids painkilling and euphoriceffects happens rather quickly,

    unlike tolerance to toxic effects.In other words, every doseincrease because its not workingas well raises the risk of overdose.It is impossible to predict who willdevelop tolerance most rapidly.

    And because people stay on topof their pain by taking more pills,it becomes harder to stop or onlytake them when needed; physicaldependence threatens withdrawalsymptoms similar to those ofheroin users, such as diarrhoea,insomnia and vomiting. That

    means those in pain are driven totake the medication regularly,whether needed for pain or not.

    Unliketolerance and physicaldependence,addiction is less ofa risk. In fact, true addiction onlyoccurs in a small percentage ofpeople. So referring to those withprescription opioid problems asdrugaddicts is bothmisleadingand stigmatising.

    Sure,theriskofaddiction isreal,but it isnt the biggest problem.

    Tolerance is where the dangerbegan, and where doctors need tofocus more attention to stem thisincreasingly deadly epidemic.

    Samantha Murphy is a science writer

    based in Pennsylvania

    longest-duration fixed-wing flight.Celebrations were short-lived.

    Postflight analysis found thebatteries lost storage capacityafter overheating. New ones were

    sent outand tested, groundingtheprojectuntil April 2016.This may have been overcautious:once the overheated batteries hadbeen returned to Germany, saysBorschberg, engineers discoveredthey could easily have flown on.

    No matter: this global flight isnot about speed but the politics ofenergy. Its a slow revolution buta welcome one.

    Pau lMarks is a freelance science writer

    based in London

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    22 |NewScientist |18 June 2 016

    T O L O Y

    M

    B a b y b io m e t ric s

    A d e v ic e t h a t s c a n s t h e f in g e r p r in t s o f in f a n t s c o u ld h e lp m a n a g e

    c h ild re n s h e a lt h c a r e b u t m a k e s s o m e u n e a s y , s a y s

    Aviva Rutkin

    JU ST 6 h o u r s o ld . T h ats t h e ag e

    o f o n e p artic ip an t i n a r ec en t

    stu d y lo o k i n g at w ay s t o tak e t h e

    fi n g e rp r in t s o f i n fa n t s . T h e

    p at te rn i s t h e re at b i r th , s ay s

    A n il Jai n at M ic h i g a n State

    U n iv er sit y i n E as t L an s in g . B u t i t

    is h ard to c ap tu re.N o w Jain an d

    h i s c o lle ag u e s a re d ev elo p i n g a

    d ev ic e th a t co u ld b e u p to th e task .T a k in g fi n g e rp r in ts fr o m v er y

    y o u n g ch i ld r en even n ew b o r n s

    is p ar t o f a d riv e i n d e velo p i n g

    c o u n t ries to m o n it o r t h e h ealt h

    o f i n f an t s, w h o o ft en lac k

    o th er fo rms o f id entificatio n .

    A b i o m e tr ic s y s te m , su c h as a

    n ation al fin gerp r in t d atab ase,

    cou ld allo w clin ic ians to m atch a

    c h i ld w i th t h e ir v ac c in e sc h e d u le

    o r h e lp w o r k e rs k e ep r ec o r d s o f

    w elfare services,say s Jain .

    V accin ation s are first given at

    ab o u t 1 m o n t h ,so th ats w h e n w e

    w o u ld lik e t o u s e b i o m e tric s fo r

    recog n ition p u rpo ses, he says.

    Jain also th in ks th at takin g

    in fantsfin gerp r in ts cou ld h elp

    fin d m issin g ch ild ren o r reso lve

    c as es in w h i