This outcome resulted from the characteristic of ethanol that easily evaporate, bringing higher extract concentration on skin (increase of thermodynamic activity carried drug to pass stratum corneum), and/or because of ethanol changed physical integration of stratum corneum barrier, hence enhancing drug penetration. By the great chance of its absorp ethanol showed relatively low concentration of alcohol and acetaldehyde metabolite in blood, lower from toxic concentration. However, ethanol can present side effects such as skin irritation or dermatitis allergy although rarely reported. Other potential side effect is regarding high compotition of ethanol, despite higher compotition of ethanol increase penetration on skin, this would also feasible for transdermal absorption of potential xenobiotic from carsinogenic contaminant from cosmetic formulation.