itch, scratch, lick,itch, scratch ...

relax.

www.atopica.com

NEWFOR CATS

References: 1. Health News Digest, 22 May 2007; Veterinary Pet Insurance (VPI), the [US] nation’s oldest and largest provider of pet health insurance, listed most common medical claims in 2006. 2. Hill PB et al. Vet Record 2006; 158: 533-539. 3. Prost C. EJCAP 2009; 19: 223-229. 4. Rush JE et al. J Am Vet Med Assoc 2002; 220(2): 202-207. 5. Smith SA et al. Int J Appl Res Vet Med 2004; 2(3): 159-170. 6. Ployngam T et al. Am J Vet Res 2006; 67(4): 583-587. 7. Lowe AD et al. Vet Derm 2008; 19: 340-347. 8. Clinical Trial Participant Survey: Burke Market Research, May 2001. 9. Data on file, Study NAH-07-0029. 10. Data on file, Study CYCINT-0105. 11. Data on file, Study CYCINT-0205. 12. Data on file, Study NAH-07-0028.

Atopica for Cats POM-V contains cyclosporine A. Atopica is indicated for symptomatic treatment of chronic allergic dermatitis in cats. Atopica® is a registered trademark of Novartis AG, Basel, Switzerland.

© 2011 Novartis Animal Health Inc., Basel, Switzerland. 2011000058

The d

isease

itch, scratch, lick, itch, scratch…

Allergic dermatitis in cats• Allergic dermatitis is one of the most common reasons for pet owners to take their cats to the vet1.

• 12% of all consultations are for dermatological problems and of these, 34% are for pruritus or alopecia2

• It typically manifests as self-induced alopecia, eosinophilic plaques, miliary dermatitis, and/or head and neck excoriations3

Typical lesion manifestations seen in cats with allergic dermatitis

Miliary dermatitis

Symmetrical self-induced alopecia

Eosinophilic plaques

Head and neck excoriations

Steroids are not always the answer for cats• Studies show that steroids may contribute to the development of congestive heart failure4-6

or diabetes mellitus7 in cats

• Treatment of allergic dermatitis with corticosteroids is associated with potential health risks4-7

• Many pet owners prefer an alternative to steroids8

“ The recurrent problems of allergic dermatitis are frustrating for both vets and pet owners. We need a new way of treating cats with this condition.”

Diane R. Eigner, VMD

When you’re presented with an itchy cat, what treatment do you prescribe?

Atopica for Cats is easy to administer4

Cats taking it in food

32%68%

Cats doseddirectly intothe mouth

Dosing guide• Initially, 7mg/kg (0.07ml/kg) once daily until a good response is obtained

• Then taper dose frequency according to clinical response: every other day, then twice weekly

• The lowest effective frequency of dosing should be used to maintain the remission of clinical signs

Ad

min

istration

...relax with new Atopica for Cats

Easy to dose in cats• Oral liquid cyclosporine 100mg/ml

• Available in 17ml or 5ml bottles for induction and maintenance dosing

• Unique dip tube dispensing system enables dose withdrawal without spills

• Supplied with a calibrated dosing syringe

• Atopica for Cats is the first and only non-steroid medication approved by the FDA for the control of allergic dermatitis in cats

• It’s the new addition to the proven Atopica family

• An oral solution that is easy to dose and administer

• Atopica for Cats can be administered in the food or directly into the mouth

• In studies, around one-third of cats took Atopica for Cats in their food and two-thirds were dosed directly into the mouth9

“ One of the most important features about any new medication for cats is that it must be easy to administer.”

Dr Tim Nuttall, BSc BVSc CertVD PhD CBiol MSB MRCVS

Easy to administer to cats

Atopica for Cats answers your need for a new way of treating cats with allergic dermatitis.

Safety

Atopica for Cats is generally well-tolerated10, 11

Proven safety profile• In field trials, no clinically significant

abnormalities were associated with cyclosporine treatment

• No clinically significant effects on vital organs at up to 5x the dose for 6 months

• There is no evidence of any increased risk of infections during treatment with Atopica for Cats

Reversible side effects• Cats may experience some gastrointestinal signs

such as vomiting, diarrhoea or inappetence

• These are generally mild and transient, and do not require cessation of treatment

The patient’s current health statusCats that are prescribed Atopica for Cats should:

• Be FeLV/FIV negative

• Have no neoplasia or history of malignancy

Whether the patient might be exposed to Toxoplasma• Cats with no previous exposure to Toxoplasma gondii may be at risk of developing

clinical toxoplasmosis if they become infected while under treatment with Atopica for Cats

• Pet owners should be advised to minimise potential exposure of seronegative cats to Toxoplasma by keeping cats indoors, avoiding giving them raw meat and not letting them scavenge

• Treatment with Atopica for Cats has been shown not to increase Toxoplasma oocyte shedding, a potential source of zoonotic disease

What to consider when prescribing Atopica for Cats

1

2

No need for monitoring

As with Atopica for Dogs, there is no need to monitor blood levels of cyclosporine during administration of Atopica for Cats, as no correlation has been shown between blood levels and efficacy or safety.

Atopica for Cats answers your need for a long-term solution for cats with allergic dermatitis.

“ Because Atopica for Cats is not a corticosteroid, I can prescribe it for long-term use without worrying about the health risks that can be associated with steroids.”

Dr. Keith A. Hnilica, DVM, MS, MBA, DACVD

Mo

de o

f actio

n / effi

cacy

Unique mode of action Proven efficacy

• Atopica for Cats contains cyclosporine A

• It specifically targets the T-lymphocytes and other immune cells involved in the allergic reaction

• It inhibits the production of inflammatory cytokines, breaking the recurrent itch/scratch cycle

New Atopica for Cats significantly relieves pruritus and reduces skin lesions, helping cats to relax

Works within weeksBefore After

Skin lesions before treatment with Atopica for Cats

Skin lesions after 6 weeks treatment with Atopica for Cats

Helps cats to relax12

• In a clinical trial, 84% of cats were considered to be uncomfortable at the start of the study

• After 42 days treatment with Atopica for Cats, 78% of cats were considered to be comfortable

• 75% of placebo-treated cats were still considered to be uncomfortable

Rated highly by vets and pet owners• 60% of vets rated the overall clinical improvement with Atopica for Cats as excellent/good,

compared with only 23% for placebo10

• Pet owners considered treatment with Atopica for Cats to be successful in 79% of cases versus only 26% in the placebo group12

% comfortable cats% uncomfortable cats 1000100

Placebo

Atopica

Placebo

Aft

er 0

day

sA

fter

42

day

s

Atopica

84%

84%

16%

16%

75%

22% 78%

25%

Atopica for Cats provides you with an effective treatment to help make cats with allergic dermatitis healthier again.

“ I’ve used Atopica with great success in atopic dogs, so with Atopica for Cats I know I’ve at last got something that will provide relief for pruritic cats.”

Dr. Paul Bloom, Dipl. ACVD, Dipl. ABVP, Canine and Feline Specialty

Photographs© courtesy of Paul S Coward BVSc BSc CertSAD MRCVS

Sum

mary

Prescribe new Atopica for Cats with confidence

Confidence in a good safety profile

• Side effects are generally mild and transient, and do not require cessation of treatment

• No clinically significant effects on vital organs at up to 5x the dose for 6 months

Confidence in an effective treatment

• Atopica for Cats is proven to significantly relieve pruritus and reduce skin lesions10-12

• In most cats, Atopica for Cats provides relief within 3 to 6 weeks12

• Both vets and pet owners rated Atopica for Cats as excellent/good in around 75% of cats11

Confidence in long-term relief for pets and owners

• Atopica for Cats is administered according to clinical need

• Atopica for Cats can be used for an unlimited time period

• Most pets gain long-term relief with a tapered dose of Atopica for Cats – every other day, then twice weekly9,11

Now you can make pets healthier and clients happier by prescribing Atopica for Cats – the new treatment for allergic dermatitis in cats.