© 2014 HCL – Proprietary & Confidential

7th EPLS Conference, Prague

Manuela Mueller-Gerndt

Manuela.m@hcl.com

23rd September 2014

New business models – interface with Pharma

201

3© 2014 HCL – Proprietary & Confidential

HCL: Quick Facts

3

B I L L I O N C O U N T R I E S P E O P L E

HCL Technologies

Global Market Focus

Enterprise & Custom Applications,

Infrastructure Services ,Product

Engineering & R&D and BPO Services

HCL Infosystems

Indian Market Focus

Hardware, System Integration,

Networking Solutions, Managed ISP

Services, Homeland Security & ICT

Distribution

$6.2 31 90000

What HCL Stands for

HCL EnterpriseHCL

Avitas

426

5© 2014 HCL – Proprietary & Confidential

Life Sciences Service Offerings

Information

Management &

Professional

Services

BPO & Infrastructure

Application Support

& Enhancement

Application Dev.

& Management

Portals &

Content Management

Compliance

& Validation

Target

Identification &

Validation

Hit Identification

Lead Generation &

Optimization

Predictive

Computational

Chemistry Tools

Lab Automation

Procurement

Factory

Solutions

Enterprise

Solutions

Automation

Solutions

Consulting

MES

LEAN

Marketing

Management

Sales Force

Management

Sales Support

Solutions

Consulting

CRM

Validation

GAMP5

ASTM

Submission

Consultancy

Audit

Compliance:

ICH

USFDA and

related

regulations

Preclinical

Protocol

Development

Clinical Trial

Management

Clinical Data

Management

Data Analysis

Submissions

Lab

Automation

ERP

Middleware

Content

Management

Consulting

Service

Management

DW/BI

Siebel eClinical

Oracle Clinical

Remote Data

Capture

LIMS, ELN

CDS, SDMS

Phase Forward

ICH, GCP,

SOPs

Oracle iLife

Sciences

MSFT

Dynamics

Veeva

SFDC

Oracle AERS

Argus

Siebel AECM

eMDR

Document

Management

Oracle Agile

OPSM

OTM

Demantra

LIMS, ELN

CDS, SDMS

SAP

Fusion, BEA

Aqua Logic

Siebel

JDE

Oracle EBS

PeopleSoft

CRM On

Demand

SAP

Accelrys

LIMS

ELN

Drug DiscoveryManufacturing

& SCM IT

Sales &

MarketingRegulatory

Drug

DevelopmentEnterprise IT

Clinical Transformation Real World Evidence Commercial Transformation• Discovery Drug Design Optimization

• Comparative Effectiveness Research (CER)

• Clinical Trial Optimization

• Value Based Pricing (VBP)

• Optimal Treatment Indicators

• Evidence based Medicine (EBM)/Evidence

based Practice (EBP)

• Sales Operations Outsourcing

• Sales Reporting and Analytics:

• Enhanced Direct Sales Support (Call Centre):

• Campaign and Brand Management

• Compliance Services (Statutory Compliance)

• Contract Sales Organization Optimization

• Integrated Clinical Platform SI and ADM

Services across EDC, CTMS, LSH, Safety,

Risk Management, CDW for Oracle

HSGBU Products and Custom Apps

• Unified Clinical Platform on a Hosted

Model – Integrated EDC, CTMS, LSH ,

Safety and CDA Environment

• Functional KPO Services

Fu

lly L

oa

de

d

Se

rvic

e L

ine

s

HCL’s Investments

2.400+ consultants250+ consultants 500+ consultants 80 consultants 190 consultants 260 consultants 800+ consultants

6© 2014 HCL – Proprietary & Confidential

Representative customers across all functional areas

Drug Discovery

Drug Development

Manufacturing & SCM IT

Distribution/ Enterprise IT

Sales & Marketing

7© 2014 HCL – Proprietary & Confidential7

“Creatively converge Technology, Data and Services around the

patient to fundamentally transform Patient Insights, Patient

Outcomes, Patient Experience and HC Reach Globally. “

Our Vision is based on four convergent drivers continuing to create a major inflexion point

on Patient behaviours and expectations relating to Healthcare globally. Over the foreseeable

future they will have an increasing impact in transforming the way patients perceive, receive

and believe in Healthcare; to move Patients from a victim mindset of ‘Heal Me’ to a more

positive, proactive mindset of ‘Help me heal myself’.

HCL Healthcare : Vision Statement

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The opportunity: healthcare inefficiency

Source: IBM Institute for Business Value

9© 2014 HCL – Proprietary & Confidential

Industry challenges

and opportunities

Market Forces Driving Life Science Transformation

Quality and efficiency

of Life Sciences products challenge

the current drug safety models

New market entrants

and treatment

approaches challenge

existing models

Complex and

inefficient Life

Sciences R&D

contribute to

weak pipeline

Tougher and tighter

regulations mandate higher

standards of compliance

Globalization

and the new economic

environment tax

development resources

Generic versions of

blockbuster drugs create

pricing pressures

Empowered patients call

for more effective therapies

Source: IBM Institute for Business Value

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Business Structure Modernization

Information Readiness and Analytics

Evolution of

Care DeliveryEcosystem

Convergence

Movement to

Consumerism

We see transformation in the Healthcare and Life Sciences industries

around three major business trends, supported by two fundamental

capabilities

11 9/29/2014

New care delivery models are evolving to be preventative and more

focused on wellness and outcomes

Today’s Care Tomorrow’s Care

Our patients are those who are registered in our medical home or invisible in an ACO

Care is determined by today’s problem and time available today

Care is determined by a proactive plan to meet health needs, with or without visits

Care varies by scheduled time and memory or skill of the doctor

Care is standardized according to evidence-based guidelines

Patients are responsible for coordinating their own care

A prepared team of professionals coordinates all patients’ care

I know I deliver high quality care because I’m well trained

We measure our quality and make rapid changes to improve it

It’s up to the patient to tell us what happened to them

We track tests and consultations, and follow-up after emergency department and hospital

Clinic operations center on meeting the doctor’s needs

An interdisciplinary team works at the top of our licenses to serve patients

My patients are those who make appointments to see me

Source: Adapted with permission by IBM from Daniel F. Duffy, M.D.

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Piloting a care coordination solution enabled with predictive analytics to prevent crisis in progressive chronic disease patients

Developing advanced analytics predictive models to improve physician targeting and segmentation defining next best action

Developed remote heath monitoring light weight care coordination solution

Piloting a hospital transition in care solution offering targeting reducing 30 day readmissions for CHF, AMI, PNA

Traditional product provider

Product wrap around service

Therapeutic area solution provider

Health Solutions Provider

Traditional model of increased market share, quicker uptake, and improved brand loyalty

Traditional model of increased market share based on improved market place perception, value add services, and differentiation

B2B business model targeting government entities as the customers; revenue through an initial fee and then a per patient charge

B2B model, targeting hospitals as the primary customers; charging an initial fee, a per patient charge, then evolving to a B2B2C model

Advanced commercial analytics

Front end and patient engagement services

More sophisticated front end, care coordination services, data integration, and advanced Healthcare analytics

More sophisticated front end, sophisticated care coordination services, and data integration

Scope

System

Business Model

Commercial Effectiveness Business Transformation

There is a desire to move to large-scale, patient-centric services that

monitor outcomes

Value to Healthcare EcosystemSupplier ofProducts / Devices

SolutionsProvider

Source: IBM Institute for Business Value

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Healthcare model disruption and scalability

Source: Ernst & Young, The New Healthcare Ecosystem

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Data is called the new „oil“

Source: Gartner, 2013

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Big Data is more than just volume

Volume

Terabytes to

exabytes of

existing data

to process

Velocity

Streaming data,

milliseconds to

seconds to

respond

Variety

Structured,

unstructured,

text and

multimedia

Veracity

Uncertainty from

inconsistency,

ambiguities, etc.

Source: IBM Institute for Business Value

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vital-signs are captured by

bedside monitoring devices

Volume Velocity Variety

1,000/sec

Real-time analysis of

device data, images &

alerts will change the role

of monitoring devices in

healthcare outcomes and

patient wellbeing.

Research data is spread

across huge databases of

patents, compounds, journals,

biomarkers, structure activity

relationships, genomics, and

medical records

Advancing population health

and personalized medicine

with variety of data inputs from

medical records, notes and

dictation; public health reports;

social media and web content

unstructured data in EMRs,

devices, publications, drug

structures…

80%

unique molecules in the

ChemSpider chemical

database, from 400+ sources

26million

What does Big Data mean for Life Sciences?

Source: IBM Institute for Business Value

17© 2014 HCL – Proprietary & Confidential

Real-time monitoring platform with a patient centricity approach,

covering a multi-device approach – one of many examples

Design Interventions

Hea

lth

sta

te

mo

nit

ori

ng

Doctor

Manufacturer

Patient

Monitoring and data transmission

Data capture and analysis

Data Aggregation

AnalyticsData

CollectionInterventions

Health informationand actions

Family

Smart Packaging

Home Monitoring

Pill Dispensers

Smartphone Apps

Payor

Up

dat

e m

edic

al

reco

rds

Outcomes Monitoring Portal

Source: IBM HCLS

18© 2014 HCL – Proprietary & Confidential

Cognitive computing is a rapid evolving landscape and

combines transformational technologies

Understands

natural language

and human

communication

Adapts and learns

from user

selections and

responses

Generates and

evaluates

evidence-based

hypothesis

In 2020, approx. 80% of the technology on the

market will have cognitive services:

discovery, probabilistic, big data,

natural language.

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2

3

Source: IBM WATSON

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Oncology Advisor created by IBM for Wellpoint and Cancer

Centers

Source: IBM WATSON

20© 2014 HCL – Proprietary & Confidential

Implantable Pain Management System

500+ patients are

implanted with the

device in Europe.

Recently

approved by FDA

Product: Implantable device, delivers drug to spinal

chord for management of pain from muscle

contractions. The drug can be refilled from outside

and the device can be configured from outside

wirelessly for dosage management.

HCL responsibilities: Complete development of

HW and SW, prototyping and verification. Offered

support for risk management (FMEA, SHA) and

regulatory submission.

21© 2014 HCL – Proprietary & Confidential

Selected Nerve Stimulator

Nominated for

MDEA 2012

Awards

Product: Delivers electrical pulses

transcutaneously to the nerves for

treatment of over active bladder (Urinary

incontinence) for Women.

HCL responsibilities: Complete

development of HW and SW, prototyping

and verification. Offered support for risk

management (FMEA, SHA) and regulatory

submission.

22© 2014 HCL – Proprietary & Confidential

Disease Management Ecosystem

Product: iPad based SW application that can collate information from service

providers, suppliers and care givers. Can talk to set of smart devices through

blue tooth for data management and alerts

23© 2014 HCL – Proprietary & Confidential

To enable patient-centric services at scale, the

underlying technology needs to be developed in detail

CommercialModel

DeliveryModel Workflow

ProcessesReportingMetricsGovernance

Flexible, scalable architectureCloud-based or hybrid model

Robust failsafe operationsSecurity and data integrity

Virtual Counselor:Education CenterLifestyle Consults

Community Services

Real-Time Monitoring System:Health metrics monitoringData tracking and storage

Analytics & visualization

Additional Heart Health Services

Capture, aggregate & distributeAnalyse and present

User groups and rolesPersonal Profile management

Business Processes

SW Architecture

IT Infrastructure

Data ManagementApplication IntegrationPortal for multiple rolesAlerts/ CommunicationComplianceCare Protocol DeliveryRemote device monitoringClinical and operational analytics

Physicians

Patients Payors

Partners

Hub

Services

Heart Health Ecosystem

Source: IBM

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Automotive Industry is investing in healthcare

Consuming Health on the Road

„Healthy car“

Collection of health data, vital

parameter etc.

Massage within the car

Special, „customized“ chairs

In USA: Health Teaching during

rush hours (drug education,

disease education)

Collaboration with Pharma and

IT

http://www.manager-magazin.de/lifestyle/auto/0,2828,403537-2,00.html

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Health in the car

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Genentech and PatientsLikeMe close a large groundbreaking 5 year

research agreement (use patient‘s real experience with diseases and

drugs for better research)

Elli Lilly & Co is rolling out a web-based service to help people learn

about particular drugs (guiding patients before diagnosis)

Bayer works with Microlife (med. dev. manufacturer) and distributes a

screening device with automated diagnosis software to physicians in

Switzerland (blood pressure and pulse, pre-diagnosis through evaluation

of measurements)

Pfizer Integrated Health: project aimed at stepping beyond the pill and

bringing together science, drugs and technology to improve patients

outcomes (help physicians making an accurate diagnosis of lower back

pain -> closed down after 2 years.)

Further examples

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Google: Calico focuses on the challenge of aging and

associated diseases

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