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Susan E. Langmore, PhD, BCS-SBoston University School of MedicineBoston University, Sargent CollegeBoston University Medical Center
NeuroStimulationTechniques for Dysphagia
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THREE STIMULATION TECHNIQUES TO BE COVERED… in 17 minutes or less!
§ Transcutaneous electrical stimulation
§ Pharyngeal stimulation
§ Transcortical brain stimulation
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For each technique…...
§ 1. How it works and the desired effect§ 2. Evidence for actually attaining the desired effect
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1. Transcutaneous Electrical Stimulation
§ Neuromuscular Electrical Stimulation - NMES§ “Vital Stim” – a brand of NMES
§ some key differences from common NMES devices§ Constant stimulation on;; § Multiple electrode placements above/below hyoid and larynx
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Example of traditional Estim device: BMR NeuroTech (NT) 2000
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How it Works§ Electrodes placed on the skin overlying muscles of interest;; current at high level will trigger peripheral nerves in region to fire à muscles they innervate contract (= NMES)§ Used to augment contraction;; increase force of swallow;; increase speed of contraction
§ OR Can be set at lower level of current flow;; only the sensory nerves are stimulated, The patient feels TINGLING, VIBRATION.§ TENS is example;; to alleviate pain§ A few studies in dysphagia: Aim: to facilitate a brisker swallow
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Have studies proven a positive effect?
§ Many studies …§ Most of them used VitalStim –§ Most done on stroke patients
§ Many uncontrolled studies…....
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Controlled Treatment Studies with Estim -‐> mixed results
§ Stroke – (Ludlow 06)–estim helped some patients; worsened the swallow in others
§ Stroke – RCT no significant effect on patients (Bulow et al., 2008)
§ Stroke -‐ RCT (Lim et al, 2009) – estim group did signif better than pts w/ alternate tx
§ Stroke – RCT (reported by Carnaby-‐Mann – not yet published) Estim group did worse than alternate therapy group
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Recent study
§ Terre 2015 (Spain) – 20 acute stroke or TBI (mean time post = 3 month). Randomized to NMES or sham
§ Results: some sig different measures at 1 month….. but at 3 months, no difference!
§ Their conclusion – NMES accelerated recovery
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Chen 2015. Systematic Review & MetaAnalysis§ Identified 8 controlled studies of post stroke dysphagia : § 6 compared NMES plus Swallow tx to Swallow txalone;;
§ 3 compared NMES to Swallow Tx aloneConclusions:NMES plus Swallow Tx was signif better than Swallow Tx alone or NMES alone
Boston UniversitySlideshow Title Goes Here§ Ryu – 2008 § Lin – 2009 § Long -2015weaker designs
NMES for Head/Neck Cancer?
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Our Study: Randomized Clinical Trial: The Efficacy of Electrical Stimulation for Dysphagia in Patients with Head and Neck Cancer
Susan Langmore - (PI) Co-Investigators: Tim McCulloch,CathyLazarus, Doug VanDaele, Jeri Logemann
Just published: 2015, Head & Neck
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Patients
§ 179 Subjects enrolled:§ HNC treated with RT/CRT at least 3 months prior to enrolling (range 3 months to 15 years post RT)
§ Moderate to severe dysphagia
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The Intervention
Subjects randomized to 2 intervention groups;; 1. Estim group - swallow exercises with e-stim, 2. “Sham Estim” group - swallow exercises w/ sham
estim device (no current)
Stretching and Swallow exercises = Mendelsohn maneuver, supra superglottic, and Effortful swallowsHome program;; exercises 2x/day, 6d/week, 3 months
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§ Two electrodes placed submentally to activate the suprahyoid muscles
§ Patient swallowed each time thestimulation came on…..relaxedbetween cycles of stimulation
Estim device = NT2000 (BMR)
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Outcome Measures
Swallow function – from MBS studies§ PAS (Rosenbek, 1996)§ OPSE (Rademaker, 1994)§ Hyoid superior, hyoid anterior movement§ Percent Pharyngeal residue (from OPSE)
§ Diet and quality of life§ PSS (Performance Status Scale, (List, 1990)§ HNCI (Head/Neck Cancer Inventory, Funk, 2003)
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Question #1
§ Was there a significant difference in measures of swallowing, diet, or quality of life in the Estimgroup vs. the Sham Estim group at the end of the trial?
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Results: Q#1
Only 1 significant difference: § Sham Estim group - significantly lower PAS scores than the Active Estim group
§ Effect size analysis = “moderate effect” (Cohen’s d = 0.472);; not impressive, clinically
No other significant differences between the 2 groups
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Question #2
§ Did either or both groups show a significant improvement over time – from start to end of treatment (Week 12) -- in swallowing, diet or QOL measures?
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Results: Change over Time
§ Sham group improved PAS score – small decrease
No other MBS measures improved over the trial
§ Both groups significantly improved diet and quality of life
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Conclusions from our Study
§ E-stim did not add therapeutic benefit
§ Neither group improved significantly in any swallow outcome measure over the therapy - from the estim - or the swallow maneuver exercises
§ But quality of life and diet improved
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Should you use NMES?
§ Promising studies with acute stroke – but mixed results – more research needed (what parameters are best? How long? etc)
§ Good evidence that it should be paired with swallowing to stimulate neuroplasticity
§ No support for NMES with other medical conditions, including chronic stroke - and negative evidence for HNC
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Pharyngeal Stimulation
§ Catheter containing the electrodes - passed transnasally –electrical stimulators are positioned within the pharynx against the mucosa
§ Stimulus delivered at a given intensity –mostly at a sensory level but some motor effect
§ Stimulation induces swallowing§ Usually done 10-20 min/day for 3 days
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Pharyngeal Stimulation§ How does it work?
§ Stimulate the pharyngeal mucosa at right frequency -> excites the motor cortex for an hour after stimulation ends
Phagenesis device (www.phagenesis.com)
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Pharyngeal Electrical Pharyngeal Stimulation indluces cortical activity
In normals:§ Shaneen Hamdy’s lab (UK)
§ Fraser, (2002) – pharyngeal stim showed changes in cortical excitability with pharyngeal stimulation w/ normals – lasted 30-60 min post stimulation
§ Sundrup (2014) confirmed this;; added to knowledge of cortical processing w/ magnetoencephalography
§ (This has not been shown for NMES)
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Good Evidence for Pharyngeal Stimwith Acute Stroke/Dysphagia§ Jayasekeran, et al (2010) – reported signifimprovements in swallowing-related outcomes in 28 patients (PharyStim vs Sham)
§ Suntrup 2015: (Germany) 30 stroke patients w/ trachsreceived pharyngeal stim or sham for 3 days. Decannulation signif sooner in pharyn stim group cf to sham group
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More Research on Pharyngeal Stim§ Restivo 2013 (Italy): 20 MS patients: pharyngeal stimvs sham. Pharyn Stim pts signif better on all swallow measures
BUT§ Largest RCT (P Bath, PI, Nottingham) on stroke patients showed NO significant difference in pharynstim vs sham groups in any outcome (not published yet)
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SHOULD YOU USE PHARYNGEAL STIMULATION?
Not yet approved in US by FDA Research pending in US to show efficacyBut promising! Good research will prove whether it is effective and for whomDifferent frequencies, other parameters reflect cortical activity differently – these must be established before used clinically
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Transcranial Neurostimulation
§ Non-invasive brain stimulationused to enhance neuroplasticity
§ Two most common types:
(1) Transcranial Direct Current Stimulation (tDCS)
(2) Transcranial Magnetic Stimulation (TMS) repetitive Transcranial Magnetic Stimulation (rTMS)
This image cannot currently be displayed.
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tDCS
§ Creates an electric current
§ Anodal current (excitatory)§ Cathodal current (inhibitory)
§ Region stimulated is fairly discrete, localized
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Electromagnetic induction produces magnetic fields inside the brain
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High frequency stimulation causes brain excitationLow frequency stimulation causes neuronal inhibition
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Swallowing Innervation§ Swallowing is innervated from both hemispheres but contains a dominant hemisphere (more often on right)
§ A lesion in the dominant hemisphere is likely to result in oropharyngeal dysphagia
§ The contralesional side may produceinhibitory effects to suppressthe ‘damaged, dominant
hemisphere’ and try totake over dominance
Hamdy et al.,1996;; 1997;; 1998;; Khedr et al., 2008;; Li et al., 2009;; Teismann et al., 2011
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Hemispheric InnervationWhich hemisphere should be stimulated?
Kedhr et al., 2005Kedhr et al., 2009Yang et al., 2012
Theory 1: Stimulate the affected hemisphereàRestore its outputàCounteract suppressive effects from the unaffected side
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Hemispheric InnervationWhich hemisphere should be stimulated?
Verin & Leroi, 2009Yun et al., 2011
Theory 2: Inhibit the unaffected hemisphere so it cannot suppress swallowing-and allow damaged hemisphere to maintain dominance
àDecrease transcallosal inhibition
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Hemispheric InnervationWhich hemisphere should be stimulated?
Kumar et al., 2011Park et al., 2013Vasant et al., 2014
Theory 3: Stimulate the unaffected hemisphere so dominance can shift to that hemisphere
àEncourage plasticity
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Systematic Review and Meta-Analysis
Jessica Pisegna, 2015, Clinical Neurophysiology
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Research Question
§ Does transcranial neurostimulation (tDCS, TMS, or rTMS) improve swallowing in patients with post-stroke dysphagia?
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Overall, in these 8 trials,
transcranial neurostimulation improved dysphagia.
(Pooled ES=0.55;;
95% CI= 0.17, 0.93;; p=0.004)
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All 8 studies pooled together
-0.13-0.09-0.030.550.840.861.091.15
<0.4 SMALL 0.4 – 0.7 MODERATE
>0.7 LARGE
Heterogeneity I2=20%
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tDCS vs. rTMS
§ Similar effect sizes (0.52, p=0.12 vs. 0.56, p=0.03)
§ Both were effective
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Which hemisphere to stimulate?§ Stimulating the unaffected hemisphere resulted in a larger, and significant, effect size
Affected Unaffected Pooled ES = 0.46;; p=0.16 Pooled ES=0.66,
p=0.02
Increasing the representation in the unaffected hemisphere helped swallowing more
(Hamdy et al., 1998, p. 1109)
Baseline 1 month
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Our Working Philosophy
Can a magnet, pair of wires and a battery can fix everything ?
Not really, more well designed studies are needed!!
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Ongoing study in Boston: Fostering Eating After Stroke using tDCS (FEASt) Trial (Kumar, PI – Beth Israel)Aim: To determine safety and effect of 2 different doses of tDCS, compared to sham- in acute stroke patients with dysphagiaDesign: Randomized, sham-controlled clinical trial;;Stimulating the unaffected hemisphere
(NIH/NIDCD funded)
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Kumar study – in progress
• Total sample size = 99 AIS patients [day 2 to 6 after stroke onset]
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FEASt-Outcomes
• Primary efficacy outcome• change in PAS score
• Primary safety endpoints