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Neurological Disorders Lesson 3.3 Why does applying pressure relieve some of our pain?

Neurological Disorders Lesson 3.3

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Neurological Disorders Lesson 3.3. Why does applying pressure relieve some of our pain?. Do Now: Review the steps of synaptic transmission with a partner. Ca 2+. Synaptic Transmission. 2. Voltage-gated Ca 2+ channels open. . 4. Ca 2+ sensitive proteins fuse synaptic vesicles to membrane. . - PowerPoint PPT Presentation

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Page 1: Neurological Disorders Lesson 3.3

Neurological DisordersLesson 3.3

Why does applying pressure relieve some of our pain?

Page 2: Neurological Disorders Lesson 3.3

Ca2+

Do Now: Review the steps of synaptic transmission with a partner

Page 3: Neurological Disorders Lesson 3.3

Synaptic Transmission2. Voltage-gated Ca2+

channels open. 6. NTs bind to postsynaptic

receptors. 4. Ca2+ sensitive proteins fuse synaptic vesicles to

membrane.

Ca2+

7. Ion channels open on postsynaptic membrane,

allowing ions to flow into cell.

8. Excess NTs are degraded by enzymes or pumped

back into presynaptic cell.

3. Ca2+ flows into cell

5. NTs are released into synaptic cleft

1. Action Potential

Page 4: Neurological Disorders Lesson 3.3

Student Model of Pain Pathway

Page 5: Neurological Disorders Lesson 3.3

Why would you ever want to decrease the activity of neurons?

Page 6: Neurological Disorders Lesson 3.3

How could you decrease the activity of neurons?

Sodium (Na+) Calcium (Ca2+)

Positive Positive

Chloride (Cl-)

Negative

Page 7: Neurological Disorders Lesson 3.3

Getting to Threshold

Inhibitory Postsynaptic potentials (IPSP) caused by entry of negative ions

Threshold – Voltage at which Na+ channels open

Excitatory Postsynaptic potentials (EPSP) caused by entry of positive ions

Page 8: Neurological Disorders Lesson 3.3

Excitatory and Inhibitory Synapses

Excitatory Synapse:Neurotransmitters open Na+ channels producing EPSPs.

Inhibitory Synapse:Neurotransmitters open Cl- channels producing IPSPs.

Axon hillock reaches threshold and action potential is fired.

IPSPs encounter EPSPs. Threshold is not reached and no action potential is fired.

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Page 9: Neurological Disorders Lesson 3.3

Decreasing Neuronal Activity:

Why do we instinctively apply pressure to something that is

painful?

Page 10: Neurological Disorders Lesson 3.3

Projection Neuron

Pressure neuron

Pain neuron

Build the Circuit in the Spinal Cord

To the Brain

Page 11: Neurological Disorders Lesson 3.3

Pain neuron

Projection neuron

To BrainInterneuron

+Pain

Build the Circuit in the Spinal Cord

Page 12: Neurological Disorders Lesson 3.3

Pain neuron

Pressure neuron

Projection neuron

To BrainInterneuron

Add the Pressure Neuron

+PainPain

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