NBTS PROGRAM 497

24TH ANNUAL MEETING OF THENEUROBEHAVIORAL TERATOLOGY SOCIETY (NBTS)

ANDTHE 19TH ANNUAL MEETING OF THE

BEHAVIORAL TOXICOLOGY SOCIETY (BTS)

In conjunction with the 40th Annual Meeting of the Teratology Society

THE BREAKERSPalm Beach, Florida

June 24-29, 2000

NBTS 2000 TRAVEL AWARDS

S. Beaudin (nominated by B.J. Strupp)Department of Psychology and Division of Nutritional Sciences, Cornell University, Ithaca, NY�ENDURING ATTENTIONAL DYSFUNCTION FOLLOWING A SHORT PERIOD OF EARLYPOSTNATAL LEAD EXPOSURE: EVIDENCE FOR AN INVERTED U-SHAPED DOSE-RESPONSE CURVE�

K. Gray (nominated by M. Longnecker)National Institute of Environmental Health Sciences, Research Triangle Park, NC �IN UTEROEXPOSURE TO BACKGROUND LEVELS OF POLYCHLORINATED BIPHENYLS ANDCOGNITIVE FUNCTION AMONG SCHOOL-AGE CHILDREN.�

A. Bansal (nominated by R.M. Booze)Department of Anatomy and Neurobiology, Neurology, Pharmacological Sciences and GraduateCenter for Toxicology, University of Kentucky, Lexington, KY � PERINATAL HIV-1 INFECTION:DEVELOPING A RODENT MODEL TO STUDY THE CONSEQUENT NEUROTOXICITY.�

Dr. K. Flynn (nominated by Sherry Ferguson)Division of Neurotoxicology, NCTR/FDA, Jefferson, AR �MULTIGENERATIONAL GENISTENEXPOSURE INCREASES SALT SOLUTION CONSUMPTION IN RATS�

TERATOLOGY 61:497–511

498 NBTS PROGRAM

24TH ANNUAL MEETING OF THE NEUROBEHAVIORAL TERATOLOGY SOCIETY(NBTS)

AND THE 19TH ANNUAL MEETING OF THE BEHAVIORAL TOXICOLOGY SOCIETY(BTS)

THE BREAKERSPalm Beach, Florida

June 24-29, 2000

PROGRAM

Saturday, June 24, 2000

6:00 p.m.-8:00 p.m. Registration for BTS and NBTSSOUTH LOGGIA

Sunday, June 25, 2000

8:00 a.m.-12:00 Noon BTS Business Meeting and Platform SessionsPONCE DE LEON III

12:00 Noon-1:00 p.m. Lunch Break

1:00 p.m.-5:00 p.m. BTS Symposium. Impulsivity: precursor to and sequel oftoxicant exposure. Frans van Haaren and Philip J. Bushnell,Chairs, Department of Psychology, University of Florida andUSEPA, Research Triangle Park, NC.PONCE DE LEON III

SPEAKERS:

1:00 p.m.-1:10 p.m. Introduction. Frans van Haaren, Department of Psychology,University of Florida

1:10 p.m.-1:40 p.m. Genetic modulation of drug effects on impulsive behavior.John Evenden, Astra Arcus, Boston, MA.

1:40 p.m.-2:10 p.m. Laboratory models of impulsive behavior: application todrug abuse. Jerry B. Richards, West Virginia University, WV.

2:10 p.m.-2:40 p.m. Chronic low-level lead exposure: attention and Impulsivebehavior. Becky Brockel, Kansas State University, KS.

2:40 p.m.-3:00 p.m. Break

NBTS PROGRAM 499

Sunday, June 25, 2000 (continued)

3:00 p.m.- 3:30 p.m. Impulsivity and self-control in male and female rats. Fransvan Haaren, Department of Psychology, University of Florida,FL.

3:30 p.m.-4:00 p.m. The assessment of impulsivity: from the laboratory to theclinic. John J. Chelonis, Arkansas Children�s Hospital andUniversity of Arkansas at Little Rock, Little Rock, AR.

4:00 p.m.-4:30 p.m. Impulsivity in the drug-dependent: application of delaydiscounting procedures. Warren Bickel, University ofVermont, VT.

4:30 p.m.- 5:00 p.m. Discussion

6:00 p.m.-7:30 p.m. President�s Reception (TS/NBTS/BTS/OTIS)PONCE DE LEON IV

Monday, June 26, 2000

8:00 a.m.-9:30 a.m. NBTS Publications Committee MeetingGULFSTREAM C

8:00 a.m.-9:30 a.m. NBTS Public Affairs Committee MeetingGULFSTREAM D

9:30 a.m.-11:30 a.m. NBTS Council MeetingGULFSTREAM D

11:30 a.m.-12:30 p.m. Inaugural PRIMEDICA Lecture: �Probing dynamic humanbrain function using fMRI.� Gregory McCarthy, Ph.D.,Departments of Radiology and Psychology, Brain Imaging andAnalysis Center, Duke University Medical Center, Durham, NC.PONCE DE LEON III

12:30 p.m.-2:00 p.m. BTS/NBTS LuncheonMAGNOLIA ROOM

2:00 p.m.-2:30 p.m. Break

500 NBTS PROGRAM

Monday, June 26, 2000 (continued)

2:30 p.m.-5:30 p.m. NBTS/BTS Symposium I. REVISITING THEDEVELOPMENTAL NEUROTOXICITY TESTGUIDELINE

PONCE DE LEON III

Virginia (Ginger) C. Moser and Mark E. Stanton, ChairsU.S. Environmental Protection Agency, NeurotoxicologyDivision, Research Triangle Park, NC

SPEAKERS

2:30 p.m.-2:40 p.m. INTRODUCTION Virginia C. Moser, USEPA,Neurotoxicology Division

2:40 p.m.-3:10 p.m. NBTS 1. The developmental neurotoxicity study and Its usein the regulation of pesticides and toxic substances by the USEPA. MAKRIS, S.L., Office of Pesticide Programs, US EPA,Washington, DC.

3:10 p.m.-3:40 p.m. NBTS 2. Reaching scientific consensus on a new OECD TestGuideline for a Developmental Neurotoxicity Study,KOETER, H., Principal Administrator of the OECDEnvironmental Health and Safety Division, Paris, France.

3:40 p.m.-4:10 p.m. NBTS 3. A Screen for DevelopmentalNeurotoxicity�An Industry Perspective. SHEETS*,L.P. (Introduced by G. Moser), Toxicology Department,Bayer Agro Corp., Stilwell, KS.

4:10 p.m.-4:30 p.m. Break

4:30 p.m.-5:00 p.m. NBTS 4. Assessing Learning and Memory in DevelopmentalNeurotoxicity Studies. STANTON, M.E., NHEERL,Neurotoxicology Division, US EPA, Research Triangle Park,NC.

5:00 p.m.-5:30 p.m. NBTS 5. The Role of Sensory and Motor Assessments inDevelopmental Neurotoxicity Testing. BUELKE-SAM, J.,Toxicology Services, Greenfield, IN.

4:00 p.m.-10:00 p.m. Exhibits openPONCE DE LEON IV

NBTS PROGRAM 501

Monday, June 26, 2000 (continued)

6:00 p.m.-7:30 p.m. Graduate Student and Postdoctoral Fellow Career Event.Sponsored by the Middle Atlantic Reproduction and TeratologyAssociation (MARTA) and the Midwestern TeratologyAssociation (MTA). Mixer with light dinner provided. Thisevent is generously supported by Pfizer.PONCE DE LEON II

7:30 p.m.-10:00 p.m. NBTS/BTS/TS Poster Session/Mixer IPONCE DE LEON IV

POSTERS:

Travel Award RecipientNBTS 6. Perinatal HIV-1 infection: Developing a rodent model to study the consequentneurotoxicity. BANSAL, A.K., C.F. MACTUTUS, A. NATH and R.M. BOOZE. Department ofAnatomy and Neurobiology, Neurology, Pharm. Sciences and Graduate Center for Toxicology,University of Kentucky, Lexington, KY.

NBTS 7. The Effects of Prenatal Methanol Exposure on Simple and Choice Reaction Time inNonhuman Primates. CARDENAS*, A.M., N.A. LIBERATO*, K.S. GRANT, AND T.M.BURBACHER. Department of Environmental Health, School of Public Health, University ofWashington, Seattle, WA.

NBTS 8. Gender differences in the anxiolytic action of tetrahydroprogesterone in the rat.DARWISH, M., K. FELSZEGHY, C. NYAKAS, L. KORÁNYI, O.F.X. ALMEIDA* SemmelweissUniversity, Faculty of Health Sciences, Budapest, Hungary; *Max Planck Institute of Psychiatry,Munich, Germany

NBTS 9. Multigenerational genistein exposure does not affect ethanol intake in rats.FERGUSON, S.A., FLYNN, K.M., and R. R. NEWBOLD*. Division of Neurotoxicology, NCTR/FDA, Jefferson, Arkansas and NIEHS, Lab. of Toxicology, Research Triangle Park, NC.

Travel Award RecipientNBTS 10. In utero exposure to background levels of polychlorinated biphenyls and cognitivefunctioning among school-aged children. GRAY, K., LONGNECKER*, M., KLEBANOFF*, M.,BROCK*, J., ZHOU*, H., & NEEDHAM*, L. National Institute of Environmental Health Sciences,Research Triangle Park, NC.

NBTS 11. Serving our society online: The NBTS website. LIVEZEY, G.T., NeuroscienceDepartment, University of Minnesota, Minneapolis, MN.

NBTS 12. Acute effects of quinpirol on operant behavior in rhesus monkey offspring exposed tococaine in-utero. MORRIS, P., GILLAM*, M.P. and M.G. PAULE, Division of Neurotoxicology,National Center For Toxicological Research, Jefferson, AR.

502 NBTS PROGRAM

Monday, June 26, 2000 (continued)

POSTERS (continued)

NBTS 13. The effects of early postnatal lead exposure on selective attention. STANGLE*, D.,HERMER-VASQUEZ*, L., WHITE*, T.L., BEAUDIN*, S., & B.J. STRUPP, Department ofPsychology and Division of Nutritional Sciences, Cornell University, Ithaca, NY.

NBTS 14. Long-term effects of early postnatal lead exposure on extradimensional shiftperformance. WHITE*, T.L., L. HERMER-VAZQUEZ*, S. BEAUDIN*, D. STANGLE*, & B.J.STRUPP, Department of of Psychology and Division of Nutritional Science., Cornell University,Ithaca, NY.

NBTS 15. Low-level nicotine exposure during periadolescence alters conditioned-place-aversionto haloperidol, in adult C57 mice. WILMOUTH*, C.E., J.E. Bridgewater College,Bridgewater, VA.

Tuesday, June 27, 2000

8:30 a.m.-12:00 Noon NBTS/TS Symposium II. FOLATE SUPPLEMENTATIONAND BIRTH DEFECTSPONCE DE LEON V

Elizabeth A. Yetley and Deborah K. Hansen, Chairs, Centerfor Food Safety and Applied Nutrition, FDA, Washington,D.C. and Division of Genetic & Reproductive Toxicology,NCTR, Jefferson, AR

8:30 a.m.-8:35 a.m. INTRODUCTION. Deborah K. Hansen, Division of Geneticand Reproductive Toxicology, NCTR, Jefferson, AR.

SPEAKERS:

8:35 a.m.-9:10 a.m. NBTS 16. Potential mechanism(s) for folate prevention ofneural tube defects. HANSEN, D.K., Division of Genetic &Reproductive Toxicology, NCTR/FDA, Jefferson, AR.

9:10 a.m.-9:45 a.m. NBTS 17. Supplementation with methyl group donors,folate or choline, during late pregnancy in rats improvesvisuospatial memory of the offspring. WiLLIAMS*, C.L., R.W. Wong*, S. H. Zeisel^, M.-H. Mar^, and W. H. Meck*,Department of Psychology: Experimental, Duke University,Durham, NC.

NBTS PROGRAM 503

Tuesday, June 27, 2000 (continued)

9:45 a.m.-10:00 a.m. Break

10:00 a.m.-10:35 a.m. NBTS 18. National folic acid fortification: how we got thereand next steps. YETLEY*, E.A., Center for Food Safety andApplied Nutrition, FDA, Washington, DC

10:35 a.m.-11:10 a.m. NBTS 19. Pre- and post-fortification monitoring of folateand vitamin B12 status. JACQUES, P.F., J SELHUB, S.F.CHOUMENKOVITCH, A.G. BOSTOM, P.W.F. WILSON, I.H.ROSENBERG, Jean Mayer USDA Human Nutrition ResearchCenter on Aging, Tufts University, Boston, MA.

11:10 a.m.-11:45 a.m. NBTS 20. Changes in NTD rates: evaluating the impact offood fortification with folic acid. ERICKSON, J.D., BirthDefects Branch, Centers for Disease Control and Prevention,Atlanta, GA.

11:45 a.m.-12:00 Noon Discussion

12:00 Noon-1:00 p.m. Lunch Break

1:00 p.m.-5:30 p.m. NBTS Symposium III. GENDER DIFFERENCES INBRAIN DEVELOPMENT: ROLE OF PSYCHOACTIVESUBSTANCESPONCE DE LEON III

Diana Dow-Edwards, Chair, Department of Pharmacology,SUNY Brooklyn, Brooklyn, NY.

SPEAKERS:

1:00 p.m.-1:05 p.m. INTRODUCTION. Diana Dow-Edwards, Department ofPharmacology, SUNY Brooklyn, Brooklyn, NY.

1:05 p.m.-1:45 p.m. NBTS 21. Sex differences and neural plasticity.JURASKA*, J.M., Department of Psychology and NeuroscienceProgram, University of Illinois, Urbana/Champaign, Il.

1:45 p.m.-2:25 p.m. NBTS 22. Emergence of sex differences in response tococaine. KUHN*, C.M. and WALKER*, Q.D. Department ofPharmacology, Duke Medical Center, Durham, NC.

504 NBTS PROGRAM

Tuesday, June 27, 2000 (continued)

2:25 p.m.-3:05 p.m. NBTS 23. Gender-specific cocaine effects: neuroanatomicalbasis for the behavioral differences.DOW-EDWARDS, D.L., Department of Physiology/Pharmacology, State University of New York, Brooklyn, NY.

3:05 p.m.-3:20 p.m. Break

3:20-p.m.-4:00 p.m. NBTS 24. Sex and drugs: the case for sex differences in theascending dopamine system. BECKER, J.B., Department ofPsychology, Reproductive Sciences Program, and NeuroscienceProgram, University of Michigan, Ann Arbor, MI.

4:00 p.m.-4:40 p.m. NBTS 25. Prenatal cocaine-Induced serotonergicimpairments in rat offspring: ontogeny and genderdifferences. BATTAGLIA, G., VAN DE KAR,* L.D. and T.M.CABRERA-VERA*, Department of Pharmacology, LoyolaUniversity of Chicago, Maywood, Il.

4:40 p.m.-5:20 p.m. NBTS 26. Gender differences in serotonergic functioning andthe role of estrogen and progesterone. UPHOUSE*, L.L.,Department of Biology, Texas Woman�s University, Denton, TX.

5:20 p.m. Discussion

4:00 p.m.-10:00 p.m. Exhibits OpenPONCE DE LEON IV

7:30 p.m.-10:00 p.m. TS/NBTS/OTIS Poster Session/Mixer IIPONCE DE LEON IV

POSTERS:

NBTS 27. Role of peroxynitrite and apoptotic related proteins p53 and bcl-2 inmethamphetamine-induced dopaminergic neurotoxicity. ALI1, S.F., IMAM1,3*, S.Z., CADET2*,J.L., NEWPORT1*, G.D., ISLAM3*, F., SLIKKER1, W., JR. and Y. ITZHAK4*. 1NeurochemistryLaboratory, Division of Neurotoxicology, NCTR/FDA, Jefferson, AR., 2NIDA/NIH, Baltimore, MD.,3Jamia Hamdard, New Delhi, India, 4Department of Psychiatry, University of Miami, Miami, FL.

Travel Award RecipientNBTS 28. Enduring attentional dysfunction following a short period of early postnatal leadexposure: Evidence for an inverted U-shaped dose-response curve. BEAUDIN*, S., T.L.WHITE*, L. HERMER-VASQUEZ*, D. STANGLE*, & B.J. STRUPP. Department of Psychologyand Division of Nutritional Sciences, Cornell University, Ithaca, NY.

NBTS PROGRAM 505

Tuesday, June 27, 2000 (continued)

POSTERS (continued)

NBTS 29. Effects of fluoxetine exposure initiated prior to gestation on developmental andbehavioral measures: preliminary findings. COUNTRYMAN, R.A., M.A. HARRIS*, D.J.MORRELL*, and R.E. MORGAN, Department of Psychology, Western Illinois Univ.,Macomb, Il.

NBTS 30. Developmental exposure to propylthiouracil (PTU) disrupts long-delay visualeyeblink conditioning in juvenile rats. ERWIN1, R.J., ROBINETTE2, B.L., and STANTON2, M.E.1Toxicology Curriculum, UNC, Chapel Hill, NC. 2Neurotoxicology Division., U.S. EPA, ResearchTriangle Park, NC.

NBTS 31. Long term consequences of developmental aluminum (Al) in mice. GOLUB, M.S. andS.L. GERMANN*, Department of Internal Medicine, University of California, Davis, Davis, CA.

NBTS 32. In utero cocaine-exposure increases lipid peroxidation in fetus and placenta.LIPTON, J.W.*, MANGAN, K., LING, Z.D., WEESE-MAYER, D.E. and P.M. CARVEY. RushUniversity and Rush Children�s Hospital, Chicago, Il.

NBTS 33. Low-level nicotine exposure during periadolescence alters the locomotor effects ofhaloperidol in adult C57 mice. MACLEOD*, J.E., C.E., WILMOUTH, and B.M. KELLEY.Department of Psychology, Bridgewater College, Bridgewater, VA.

NBTS 34. Effect of perinatal buprenorphine on striatal cholinergic neurons. ROBINSON, S.E.and L.M. HALFON*, Department of Pharmacology and Toxicology, MCV Campus/VirginiaCommonwealth University, Richmond, VA.

NBTS 35. The uterine position effect (UPE) for rat fetal brain and body weight: dependenceupon horn size. WELCH, M.A., C.E. BROWNING. and C.F. MACTUTUS. Div. Pharm. Sci., Coll.of Pharmacy, THRI, Dept. Psychology, and Grad. Ctr. Toxicol., Univ. of Kentucky,Lexington, KY.

NBTS 36. Perinatal exposure to aroclor 1254 impairs auditory function in rats. WIDHOLM,J.J.1, LASKY*, R.E.2, CROFTON, K.M.3, and SCHANTZ, S.L.1, 1Dept. of Vet. Biosciences, Univ. ofIllinois, Urbana, Illinois; 2Center for Population Health, UT-Houston Medical School, Houston,Texas; 3NHEERL NTD, USEPA, RTP, NC.

NBTS 37. Prenatal iv cocaine: effects of gestational exposure period. WOOD, M.L., R.M.BOOZE, M.A. WELCH, B.J. STRUPP, and C.F. MACTUTUS, Grad. Ctr. Toxicol., Div. Pharm. Sci.,Coll. of Pharmacy/THRI, Dept. Anat. & Neurobiol., Coll. of Medicine, Univ. of Kentucky, Lexington,Kentucky, & Dept. Psychol., Cornell Univ., Ithaca, New York

506 NBTS PROGRAM

Wednesday, June 28, 2000

8:00 a.m.-12:00 Noon NBTS Symposium IV: TOXIC AND ESSENTIAL TRACEELEMENTSPONCE DE LEON III

Mari S. Golub and Carl L. Keen, Chairs, CaliforniaRegional Primate Research Center and Department ofNutrition, University of California, Davis, Davis, CA.

SPEAKERS:

8:00 a.m.-8:05 a.m. INTRODUCTION. Carl L. Keen, Department of Nutrition,University of California at Davis, Davis, CA.

8:05 a.m.-8:45 a.m. NBTS 38. Zinc: toxic and essential to brain function.GOLUB, M.S. California Regional Primate Research Center,University of California, Davis, Davis, CA.

8:45 a.m.-9:20 a.m. NBTS 39. Perinatal manganese exposure in the rat.PAPPAS, B.A. Institute of Neuroscience, Life SciencesResearch Centre, Carlton University, Ottawa, Ontario Canada.

9:20 a.m.-10:00 a.m. NBTS 40. TITLE: TO BE ANNOUNCED. L. Beard, ThePennsylvania State University, University Park, PA.

10:00 a.m.-10:15 a.m. Break

10:15 a.m.-10:55 a.m. NBTS 41. Influence of low dietary boron (B) onreproduction: a multigenerational approach. URIU-ADAMS*, J.Y., C.K. REECE*, B.J. HORVATH*, F.J.MURRAY*, P. STRONG*, and C.L. KEEN* (Introduced byM.S. Golub). Nutrition Department, University of California,Davis, Davis, CA.; Murray & Associates, San Jose, CA; U.S.Borax Inc., Valencia, CA.

10:55 a.m.-11:35 NBTS 42. The new dietary reference intakes (DRIs) foressential minerals, including tolerable upper intake levels.PENLAND,*, J.G., (Introduced by M.S. GOLUB), USDA/ARSGrand Forks Human Nutrition Research Center, Grand Forks,ND.

11:35 a.m.-12:00 noon Discussion

12:00 p.m.-1:30 p.m. Lunch Break

NBTS PROGRAM 507

Wednesday, June 28, 2000 (continued)

1:30 p.m.-3:30 p.m. NBTS Platform Session IPONCE DE LEON III

Rosemarie M. Booze, Department of Anatomy, University ofKentucky Medical Center, Lexington, KY., Chair

SPEAKERS:

1:30 p.m.-1:45 p.m. NBTS 43. A chick embryo model for heroinneurobehavioral teratogenicity using imprinting as region-specific behavior. YANAI, J., G. GVARYAHU, N. SNAPIRand A. KATZ, Ross Laboratory for Neural Birth Defects,Department of Anatomy and Cell Biology, Hebrew University-Hadassah Medical School and Department of Animal Science,Hebrew University, Jerusalem, Israel

1:45 p.m.-2:00 p.m. NBTS 44. Cocaine alters locus coeruleus neuron behavior invitro. SNOW, D.M., J.D. SMITH, R.M. BOOZE, M.A.WELCH, and C.F. MACTUTUS. Department of Anatomy andNeurobiology, THRI, Pharmaceutical Sciences. and GraduateCenter for Toxicology, University of Kentucky,Lexington, KY.

2:00 p.m.-2:15 p.m. NBTS 45. Spatial learning impairment following postnatalcocaine exposure in the adult rat. MELNICK*, S.M., J.L.KUBIE*, R. LAUNGANI*, and D. DOW-EDWARDS,Department of Pharmacology and Physiology, State Universityof New York Health Science Center, Brooklyn, NY.

2:15 p.m.-2:30 p.m. NBTS 46. Cocaine induces cell death within the primatefetal cerebral wall. LIDOW*, M.S., N. HE* and Z-M.SONG*, (Introduced by M. PAULE) Department OCBS,University of Maryland, Baltimore, MD.

2:30 p.m.-2:45 p.m. NBTS 47. Chronic in-utero exposure to cocaine (COC) inrhesus monkeys: effects on behavioral adaptability inoffspring when examined as adults. CHELONIS, J.J.;GILLAM, M.P.; ALLEN R.R.; and PAULE, M.G. NationalCenter for Toxicological Research, FDA and Peak StatisticalServices, Jefferson, AR. and Arkansas Children�s Hospital,Little Rock, AR.

508 NBTS PROGRAM

Wednesday, June 28, 2000 (continued)

2:45 p.m.-3:00 p.m. NBTS 48. Differential effects on visuospatial tasks inadolescent offspring as a function of prenatal exposure tomarihuana or cigarettes: top-down versus bottom-upprocessing consequences. FRIED, P.A. and B.WATKINSON*, Department of Psychology, CarletonUniversity, Ottawa, Ontario, Canada.

3:00 p.m.-3:15 p.m. Break

3:15 p.m.-4:30 p.m. NBTS Business Meeting/Web-site DemonstrationPONCE DE LEON III

Thursday, June 29, 2000

8:30 a.m.-10:00 NBTS Platform Session IIPONCE DE LEON III

Sherry A. Ferguson, Division of Neurotoxicology, NationalCenter for Toxicological Research, Jefferson, AR., Chair

8:30a.m.-8:45 a.m. NBTS 49. Phosphodiesterase 1B-deficient mice demonstratehyperactivity and learning deficits. REED, T.M.1, REPASKE,D.R.2* and C.V. VORHEES1. Divisions of 1DevelopmentalBiology and 2Endocrinology, Children�s Hospital ResearchFoundation, Cincinnati, OH.

8:45 a.m.-9:00 a.m. Travel Award RecipientNBTS 50. Multigenerational genistein exposure increasessalt solution consumption in rats. FLYNN, K.M.,FERGUSON, S.A., GRAY*, E.P., and R. R. NEWBOLD*,Division of Neurotoxicology, NCTR/FDA, Jefferson, AR. andNIEHS, Laboratory of Toxicology, Research TrianglePark, NC.

9:00 a.m.-9:15 a.m. NBTS 51. A narrow window of vulnerability to the lethaleffects of gestational retinoic acid exposure in rats.HOLSON, R.R. and J. ADAMS, Departments of Psychology,New Mexico Tech and University of Massachusetts,Boston, MA.

NBTS PROGRAM 509

Thursday, June 29, 2000 (continued)

9:15 a.m.-9:30 a.m. NBTS 52. Interlaboratory comparison of control data forsix developmental indices in prenatal/postnatal studies withsprague dawley rats. WEISENBURGER1, W.P., ITO2*, R.,HORIMOTO2*, M., DESSAY3*, F., and M. LEONARD3*,1Pfizer Central Research, Groton, CT., 2Pfizer Central Research,Taketoyo, Japan. 3Pfizer Centre de Recherche, Amboise,France.

9:30 a.m.-9:45 a.m. NBTS 53. Utility of the mini-swine in non-clinical testingfor pediatric drug development. HELTON*, D.R. and J.R.SMITH* (Introduced by J. BUELKE-SAM), Biological TestCenter, B. Braun, Irvine, CA.

9:45 a.m.-10:00 a.m. BREAK

10:00 a.m.- 11:00 a.m. NBTS Platform Session IIIPONCE DE LEON III

Thomas M. Burbacher, Department of EnvironmentalHealth, University of Washington, Seattle, WA.,Chair

10:00 a.m.-10:15 a.m. NBTS 54. Developmental neurotoxicity of phenytoin onmouse cerebellum and hippocampus. OHMORI, H. 1, 2, 4, H.OGURA 3*, K. YAMASHITA 2*, M. YASUDA 2*, T.MICHIKAWA 5*, S. NAKAMURA 4* and K. MIKOSHIBA 5*.1IGL Corporation for Welfare and Education, 2Department ofAnatomy and 4Third Department of Internal Medicine,Hiroshima University School of Medicine, 3Tsukuba ResearchLaboratories, Eisai Co. Ltd., 5Department of Neurobiology,Institute of Medical Science, University of Tokyo,Japan.

10:15 a.m.-10:30 a.m. NBTS 55. Cognitive deficits following gestationalmonotherapy with phenobarbital and carbamazepine.ADAMS, , J., E.A. HARVEY2*, and L.B. HOLMES2,1Psychology, Univ. of Massachusetts, 2Genetics and TeratologyUnit, Mass General Hospital, Boston, MA.

510 NBTS PROGRAM

Thursday, June 29, 2000 (continued)

10:30 .a.m.-10:45 a.m. NBTS 56. Effects of chronic NMDA receptor and fastsodium channel blockade during development on theacquisition of color/position discrimination and matching-to-sample performance in monkeys. PAULE, M.G.; POPKE,E.J.; ALLEN, R.R.; PEARSON, E.; and HAMMOND, T.National Center for Toxicological Research and Peak StatisticalServices, Jefferson, AR., and Safety Assessment, AstraZenecaCharnwood, Loughborough, Leics, England.

10:45 a.m.-11:00 a.m. NBTS 57. Effects of chronic developmental exposure toNMDA receptor and fast sodium channel blockade onbehavioral acquisition in rhesus monkeys. POPKE, E.J.,ALLEN, R.R.; PEARSON, E.; HAMMOND, T.; and PAULE,M.G. National Center for Toxicological Research and PeakStatistical Services, Jefferson, AR., and Safety Assessment,AstraZeneca Charnwood, Loughborough, Leics, England.

11:00 a.m. Meeting Adjourns