Neuregulin and Schizophrenia. Schizophrenia Debilitating mental illness affecting 1 % of the general population across the world. Onset in adolescent

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  • Neuregulin andSchizophrenia

  • SchizophreniaDebilitating mental illness affecting 1 % of the general population across the world.

    Onset in adolescent age.

    Symptoms

    Positive symptomsHallucinations, delusions

    Negative symptomsAvolition, ApathyDisorganization symptomsInappropriate social behavior

    Cognitive deficitsPerceptual deficits - Visual, Auditory.Deficits in memory.Emotional changes.

  • Schizophrenia is associated with many alterations in brain structure and function.Many regional reduction in gray matter.Thompson et al., , 2001Achim et al., , 2005Reduction in brain activation during cognitive tasksVan der stelt et al., , 2005

  • Genetics of SchizophreniaKirov et al., , 2003

  • Neuregulin 1 Linkage in 8pStefansson et al., 2002

  • Harrison et al., 2006

  • Functions of Neuregulin

  • Flames et al., 2004

  • Chih et al., 2004

  • Michailo et al., 2004

  • Conclusions

    Evidences so far, show NRG plays a vital role in neurodevelopmental processes.

    Association with Schizophrenia and late onset Alzhimers suggest a link between this gene and various diseases of nervous system.

    The role of NRG is still being studied. Further studies are required to identify its mechanisms of action.

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