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12-02-2014 Neo-SensitabsTM Susceptibility Rosco Diagnostica A/S Product list 2014 Neo-Sensitabs Susceptibility Testing Potencies according to EUCAST and CLSI Product list 2014 Unique characteristics ensure that NEO-SENSITABS™ are ideal for use in the laboratory Long shelf life (Dry crystalline form) Stable products (No false positives due to antibiotic destruction) Optimal phenotypic method (Detect genotypic false negatives) High sensitivity and specificity Inexpensive and reliable method Susceptibility testing with NEO-SENSITABS™ practice is performed according CLSI and EUCAST guidelines. Rosco Diagnostica is the leader in the field of phenotypic methods for detection of beta-lactamases.

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Page 1: Neo-Sensitabs Susceptibility Testing · Susceptibility testing with NEO-SENSITABS™ practice is performed according CLSI and EUCAST guidelines. ... 62312 Fosfomycin FO200 200 nnnn

12-02-2014 Neo-SensitabsTM Susceptibility Rosco Diagnostica A/S Product list 2014

Neo-Sensitabs Susceptibility Testing

Potencies according to EUCAST and CLSI

Product list 2014 Unique characteristics ensure that NEO-SENSITABS™ are ideal for use in the laboratory

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Susceptibility testing with NEO-SENSITABS™ practice is performed according CLSI and EUCAST guidelines.

Rosco Diagnostica

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

kl
Stamp
Page 2: Neo-Sensitabs Susceptibility Testing · Susceptibility testing with NEO-SENSITABS™ practice is performed according CLSI and EUCAST guidelines. ... 62312 Fosfomycin FO200 200 nnnn

12-02-2014 Neo-SensitabsTM Susceptibility Rosco Diagnostica A/S Product list 2014

Neo-Sensitabs - Products in Alphabetical Order

Packaging Neo-Sensitabs are packed in cartridges containing 1 x 50 tablets Minimum sale: 1 package containing 5 cartridges (250 tablets) Please order per package on your order sheets

REF No. Antibiotic Code Potency

µg 2-8° EUCAST CLSI

A

60012 Amikacin AMI30 30 x x

70112N Amoxycillin AMOXY 30 x

69812 Amoxycillin + Clavulanate AMC.3 2+1 nnnn x

60112 Amoxycillin + Clavulanate AMC30 20+10 nnnn x x

66712 Ampicillin AMP.2 2 x

60212 Ampicillin AMP10 10 x x

63412 Ampicillin + Sulbactam SAM20 10+10 x

60312 Azithromycin AZI15 15 x x

63612 Aztreonam AZT30 30 x x

B

70812N Bacitracin BACIT 40

C

65012 Cefaclor CCL30 30 x x

60412 Cefazolin CFZ30 30 x

63712 Cefepime FEP30 30 nnnn x x

64812 Cefepime + Clavulanate FEP+C 30+10 nnnn

63312 Cefixime CFM.5 5 x x

89312 Ceftolozane + Tazobactam C / T 30 + 10 x

65812 Cefotaxime CTX05 5 x

63912 Cefotaxime CTX30 30 x

64712 Cefotaxime + Clavulanate CTX+C 30+10 nnnn

66612 Cefotaxime + Boronic Acid CTXBO 30

66512 Ceftazidime + Boronic Acid CAZBO 30

80612N Cefoxitin CFCID 10

62912 Cefoxitin CFO30 30 x x

63212 Cefpodoxime CPD10 10 nnnn x x

80912 Cefpodoxime + Clavulanate CPD+C 10+1 nnnn

69312 Ceftaroline CPT30 30 x

89012 Ceftaroline CPT. 5 5 x

66012 Ceftazidime CAZ10 10 x

64012 Ceftazidime CAZ30 30 x

64612 Ceftazidime + Clavulanate CZ+CL 30+10 nnnn

68412 Ceftibuten CBT30 30 x

64112 Ceftizoxime ZOX30 30 x

67212 Ceftobiprole CFBIP 30 nnnn x

64212 Ceftriaxone CTR30 30 x x

60512 Cefuroxime CXM30 30 x x

72812N Cephalexin CFLEX 30 x

60612 Cephalothin CEP30 30 x

73012N Cephradine CFRAD 60 x

60712 Chloramphenicol CLR30 30 x x

65312 Ciprofloxacin CIPR1 1

60812 Ciprofloxacin CIRP5 5 x x

60912 Clarithromycin CLA15 15 x x

62512 Clindamycin CLI.2 2 x x

66312 Colistin CO.10 10 x x

D

80312N Daptomycin DAPCa 30 (+100)

63012 Doxycycline DOX30 30 x x

66212 Doripenem DOR10 10 x x

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12-02-2014 Neo-SensitabsTM Susceptibility Rosco Diagnostica A/S Product list 2014

REF No. Antibiotic Code Potency

µg 2-8° EUCAST CLSI

E

80712 Ertapenem ETP10 10 nnnn x x

61012 Erythromycin ERY15 15 x x

F

62312 Fosfomycin FO200 200 nnnn x

67712 Fucidin FUC10 10 x x

74312N Fucidin FUCID 100 x

74412N Furazolidone FURAZ 50 x

G

61112 Gentamicin GEN10 10 x x

69512 Gentamicin GEN30 30 x

43012N Gentamicin GN250 250 x x

I

61212 Imipenem IMI10 10 x x

66412 Imipenem + EDTA IM10E 10 + 750

K

62412 Kanamycin KAN30 30 x

43112N Kanamycin KA500 500 x

L

74812N Levofloxacin LEVOF 5 x x

67812 Linezolid LIZ10 10 x

75112N Linezolid LINEZ 30 x

M

61312 Mecillinam MEC10 10 x x

64312 Meropenem MRP10 10 x x

59711 Metronidazole MTR.5 5 x x

75512N Metronidazole MTR16 16

63112 Minocycline MIN30 30 x x

79812N Moxifloxacin MOXIF 5 x x

75712N Mupirocin MUPIR 10

69212 Mupirocin MP200 200 x x

N

61412 Nalidixan NAL30 30 x x

75912N Neomycin NEOMY 120

69412 Netilmicin NET10 10 x

61512 Netilmicin NET30 30 x

67012 Nitrofurantoin NI100 100 x

65712 Nitrofurantoin NI200 200

62612 Nitrofurantoin NI300 300 x

76212N Norfloxacin NORFX 10 x x

76312N Novobiocin NOVO5 5 x

O

61612 Ofloxacin OFL.5 5 x x

68312 Oxacillin OXA.1 1 x x

P

76912N Pefloxacin (stop production) PEFLX 10 x

77012N Pefloxacin PEF.5 5 x

66912 Penicillin (Penicillin G) PENG1 1 x x

61712 Penicillin (Penicillin G) PEN10 10 x

77212N Pipemicid Acid PIPEM 30 x

68112 Piperacillin PIP30 30 x

77312N Piperacillin PIPRA 100 x

66812 Piperacillin + Tazobactam PTZ36 30 + 6 x

77412N Piperacillin + Tazobactam PI+TZ 100 + 10 x

77512N Polymyxins (Colistin) CO150 150

Q

80012N Quinupristin - Dalfopristin SYN15 15 x x

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12-02-2014 Neo-SensitabsTM Susceptibility Rosco Diagnostica A/S Product list 2014

REF No. Antibiotic Code Potency

µg 2-8° EUCAST CLSI

R

67312 Retapamulin RETA.2 2

62712 Rifampicin RIF.5 5 x x

S

77812N Spectinomycin SPECT 200 x

61812 Streptomycin STR10 10 x

44712N Streptomycin ST500 500 x

78112N Sulphonamides SULFA 240 x

T

61912 Teicoplanin TPN30 30 x x

80112N Telithromycin TEL15 15 x x

78312N Temocillin TEMOC 30 nnnn x x

62012 Tetracyclines (Oxytetracycline) TET30 30 x x

64912 Ticarcillin TIC75 75 nnnn x x

64412 Ticarcillin + Clavulanate TIM85 75 + 10 nnnn x x

80412N Tigecycline TIG15 15 x x

62112 Tobramycin TOB10 10 x x

64512 Trimethoprim TRIM5 5 x x

62212 Trimethoprim + Sulfamethoxazole SxT25 1.25 + 23.7 x x

65512 Trimethoprim 2,5

V

68812 Vancomycin VAN.5 5 x

62812 Vancomycin VAN30 30 x

nnnn= Store at 2–8 °C Our product have 2 years to 5 years of expire date. For more product information www.rosco.dk When cartridges are opened and placed in a dispenser: Cartridges to be kept at room temperature: To be used within the next 12 months. nnnnCartridges to be kept at 2-8 degrees: To be used within 2 months.

Accessories

REF No. Product

97105

Dispenser 1 cartridge single dispenser

97109

Dispenser 7 cartridges – round Petri dishes of 9 cm diameter

97112

Dispenser 12 cartridges – round Petri dishes of 14-15 cm diameter

97104

Dispenser 16 cartridges – square Petri dishes of 12 x 12 cm

93402

ID Plate - Zone readings

95001

Zone Measuring stick

ROSCO Diagnostica A/S Taastrupgaardsvej 30,

DK-2630 Taastrup Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

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01-01-2014 DiatabsTM

Rosco Diagnostica A/S Product list

Diatabs

Identification of Bacteria and Fungi

Product list 2014

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01-01-2014 DiatabsTM

Rosco Diagnostica A/S Product list

Diatabs - Products in Alphabetical Order

REF No. Product Diatabs 2-8° Code Tablets

per vial Tablet in mm

A 52011 Adonitol ADO 50 6 55921 Alkaline Phosphatase nnnn Alk P 25 6 50211 Alpha-Galactosidase α-GAL 50 6 50411 Alpha-Glucosidase α-GLU 50 6 52121 l-Arabinose nnnn ARA 25 6 56211 Arginine Dihydrolase ADH 50 6

B 40211 Bacitracin Low 0.4 U BaL 50 6**

50511 Beta-Glucosidase β-GLU 50 6 50611 Beta-Glucuronidase PGUA 50 6 45521 Beta-Lactamase nnnn ACIDO 25 6 50821 Beta-Xylosidase β-XYL 25 6 40411 Bile Esculin BE 50 6 10041 Boronic Acid BORON 25 9** 40511 Brilliant Green 100 µg BrG 50 6**

C 41621 C-390 40 µg C-390 25 9*’ 10031 Cloxacillin nnnn CLOXA 25 9** 58911 Cycloheximide CYC50 50 9**

D 59611 Deferoxamine 250 µg DEFRX 50 9** 10051 Dipicolinic Acid D.P.A. 25 9** 54021 d-Xylose nnnn XYL 25 6

E 56611 Esculin Hydrolysis ESC 50 6

F 42611 Factor V nnnn 50 6** 42511 Factor X nnnn 50 6**

42711 Factor X + V nnnn 50 6**

G 46711 Gamma-Glutamyl Aminopeptidase g-GLU 50 6 52611 Glucose GLU 50 6

H 56711 Hippurate Hydrolysis HIP 50 6

I 59501 Indoxyl Acetate nnnn IAC 10 6 52711 Inulin INU 50 6

L 52811 Lactose LAC 50 6

58411 LDC/Indole (Lysine Decarboxylase/Indole) LDC/IND 50 6

46811 Leucine Aminopeptidase LAP 50 6 56811 Lysine Decarboxylase LDC 50 6

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01-01-2014 DiatabsTM

Rosco Diagnostica A/S Product list

nnnn = Store at 2 – 8 °C ** Diatabs tablets to be used on agar media – for more information: www.rosco.dk (Diatabs User’s Guide)

REF No. Product Diatabs 2-8° Code Tablets

per vial Tablet in mm

M 52911 Maltose MAL 50 6 53011 Mannitol MAN 50 6 53111 Mannose MSE 50 6

59711 Metronidazole 5 µg MTR.5 50 9** 43611 Metronidazole 50 µg MTR50 50 9**

N 43711 Nitrate Reduction NO3 50 6

O 45421 O/129 (Vibriostaticum) 150 µg O/129 25 9**

50311 ONPG (Beta-Galactosidase) ONPG 50 6 44211 Optochin 10 µg OPT 50 6** 57011 Ornithine Decarboxylase ODC 50 6 44311 Oxgall 1000 µg OXG 50 6** 45711 Oxidase OXI 50 6

P 59011 PGUA/Indole (Beta-Glucuronidase/Indole) PGUA/IND 50 6

57321 Porphyrin (d-Ala) ALA 25 6 46911 Proline Aminopeptidase nnnn PRO 50 6 59311 Ps. aeruginosa Screen 80 µg PSAER 50 9** 59811 Pyrazinamidase PZA 50 6 47011 Pyrrolidonyl Aminopeptidase PYR 50 6

R 53411 l-Rhamnose RHAM 50 6

S 44611 S.P.S. 1000 µg SPS 50 6** 53711 Sorbitol SOR 50 6 53811 Sucrose SUC 50 6

T 57811 TDA or Indole (Tryptophan Deaminase or Indole) TDA or IND 50 6 45011 Tellur 500 µg TEL 50 6** 53911 Trehalose TRE 50 6 48821 Tributyrin nnnn TRIB 25 6 47211 Trypsin TRYP 50 6

U 57511 Urease URE 50 6 57611 Urease/Indole URE/IND 50 6 57911 Urease/TDA URE/TDA 50 6

V 57711 Voges-Proskauer VP 50 6

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01-01-2014 DiatabsTM

Rosco Diagnostica A/S Product list

Reagents

REF NO

Product Reagents Stored at

2 – 8 °°°°C

ML per sales Unit

91731 Ninhydrin 3,5% solution nnnn 20 ml 92031 Kovac’s Reagent nnnn 20 ml 92231 Aminopeptidase reagent nnnn 20 ml 91831 N-N-Dimethyl-a-naphtyl. nnnn 20 ml

91931 Sulfalinic Acid nnnn 20 ml

CE Marking

All products are CE marked according to the European Directive 98/79/EC for In Vitro Diagnostic Medical Devices. Instructions For Use The relevant Instructions for use of each product are made freely available on our Website: www.rosco.dk in 7 – 12 different European languages. Diatabs User’s Guide The latest version of the Diatabs User’s Guide is downloadable from our website www.rosco.dk.

ROSCO Diagnostica A/S Taastrupgaardsvej 30,

DK-2630 Taastrup Tel (45) 43 99 33 77

E-mail: [email protected] www.rosco.dk

CVR-No.: 27 21 03 41

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01-01-2014 Neo-Sensitabs Antifungal Agents Rosco Diagnostica A/S Product list 2014

Neo-Sensitabs Antifungal Agents

Product list 2014

Unique characteristics ensure that NEO-SENSITABS™ are ideal for use in the clinic

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Susceptibility testing with NEO-SENSITABS™ practice is performed according CLSI and EUCAST guidelines.

Rosco Diagnostica

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

Page 10: Neo-Sensitabs Susceptibility Testing · Susceptibility testing with NEO-SENSITABS™ practice is performed according CLSI and EUCAST guidelines. ... 62312 Fosfomycin FO200 200 nnnn

01-01-2014 Neo-Sensitabs Antifungal Agents Rosco Diagnostica A/S Product list 2014

Neo-Sensitabs™ Antifungal Agents- Products in Alphabetical Order Packaging Neo-Sensitabs Antifungals are packed in cartridges containing 1 x 50 tablets Minimum sale: 1 package containing 5 cartridges (250 tablets) Please order per package on order sheets

REF No.

Product Code Potency 2-8°

81012N Amphotericin B AMPHO 10 nnnn

82412N Caspofungin CASP5 5 nnnn

81112N Ciclopirox CICLO 50

81212N Clotrimazole CTRIM 10

81312N Econazole ECONZ 10

82512N Fluconazole FLUCZ 25

81512N Fluorocytosine FLU.1 1

81812N Itraconazole ITRAC 10

81912N Ketoconazole KETOC 15

82012N Miconazole MICOZ 10

82212N Nystatin NYSTA 50

82612N Posaconazole POSAC 5

87412N Terbinafine TERBI 30

82312N Voriconazole VOR.1 1

nnnn = Store at 2–8 °C

Instructions for Use – Neo-Sensitabs™ The Instructions for Use are made freely available on our web site www.rosco.dk It can be downloaded in PDF format in different European languages. CE Marking All products - except the Veterinary Antimicrobials - are CE marked according to The European Directive 98 /79/ EC for In Vitro Diagnostic Medical Devices. For more product information go to Rosco website www.rosco.dk

ROSCO Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup

Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

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12-02-2014 Kits Product list Rosco Diagnostica A/S

Kits for Detection of Resistance Mechanisms

Product list 2014

Unique characteristics ensure that NEO-SENSITABS™ are ideal for use in the laboratory

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Susceptibility testing with NEO-SENSITABS™ practice is performed according CLSI and EUCAST guidelines.

Minimum orders for kits are 1 package.

Rosco Diagnostica

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

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12-02-2014 Kits Product list Rosco Diagnostica A/S

Screening and Confirmation of ESBL’s

REF no. Product Tests pr. kit Detection of:

98014

Total ESBL Confirm Kit

(EUCAST)

Cefotaxime Cefotaxime + Clavulanate

Ceftazidime Ceftazidime + Clavulanate

Cefepime Cefepime + Clavulanate

50 ESBL

98011

ESBL Confirm (acc. to CLSI) Kit

Cefotaxime Cefotaxime + Clavulanate

Ceftazidime Ceftazidime + Clavulanate

50 ESBL

98012

ESBL Confirm (Chrom. AmpC) Kit

(EUCAST)

Cefepime Cefepime + Clavulanate

100 ESBL

New 98022

Rapid ESBL Screen Kit

Cefotaxime + tazobactam + Indicator Cefotaxime + Indicator

50 ESBL

Screening and Confirmation of ESBL+AmpC

REF no. Product Tests pr. kit Detection of:

98008

ESBL + AmpC Screen Kit

Cefotaxime Cefotaxime + Clavulanate

Cefotaxime + Cloxacillin

Cefotaxime + Clavulanate + Cloxacilin

50 ESBL + AmpC

98019

Total ESBL + AmpC Confirm Kit

Cefotaxime + Cloxacillin

Cefotaxime + Clavulanate

Ceftazidime + Cloxacillin

Ceftazidime + Clavulanate

Cefotaxime + Cloxacillin + Clavulanate

Ceftazidime + Cloxacillin + Clavulanate

50 ESBL + AmpC

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12-02-2014 Kits Product list Rosco Diagnostica A/S

Screening and Confirmation of Carbapenemases

REF no. Product Tests pr. kit Detection of:

98021

Rapid CARB Screen Kit

Imipenem + Indicator (CARB) Diatabs

CARB Negative Control Diatabs

50

Carbapenemases

Enterobacteriaceæ P. aeruginosa

98006

KPC and MBL Confirm Kit

(EUCAST)

Meropenem

Meropenem + Dipicolinic Acid

Meropenem + Phenylboronic Acid

Meropenem + Cloxacillin

50

Carbapenemases Enterobacteriaceae

68912

Triple disk, for detection of KPC + MBL

Meropenem + Phenylboronic + Dipicolinic acid

50 Carbapenemases

98015

KPC, MBL and OXA-48 Confirm Kit

Meropenem

Meropenem + Dipicolinic acid Meropenem + Cloxacillin

Meropenem + Phenylboronic acid Temocillin

50 Carbapenemases

Enterobacteriaceae

98020

KPC/MBL in P. aeruginosa/Acinetobacter

Confirm Kit

Meropenem Meropenem + Phenylboronic acid

Meropenem + Cloxacillin High Imipenem

Dipicolinic acid

50 Carbapenemases P.

aeruginosa/Acinetobacter

98016

Total MBL Confirm kit

Imipenem

Imipenem + EDTA Imipenem + Dipicolinic acid

Meropenem Dipicolinic acid

50 MBL all species

New 98023

OXA-48+CARB Screen kit (30-60 min)

Imipenem + Brthymol Blue Ertapenem + Brthymol Blue

Negative Control Blue

50

Carbapenemases All species

Lysis buffer Not needed

Confirmation of AmpC’s

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12-02-2014 Kits Product list Rosco Diagnostica A/S

REF no. Product Tests pr. kit Detection of:

98007

AmpC Confirm Kit

Cefotaxime

Cefotaxime + Cloxacillin

Ceftazidime

Ceftazidime + Cloxacillin

50 AmpC

Other Kits

REF no. Product Tests pr. kit Detection of:

98017

Detection of hGISA,GISA,VRE,Daptomycin

resistance

Vancomycin Teicoplanin Daptomycin

50 Staphylococci Enterococci

98018

Detection of COLISTIN resistance in

Enterobacteriaceae, P. aeruginosa and Acinetobacter

COLISTIN Prediffusion

100

MDR Gram negatives

98009

Urin Kit Privat Praksis

Ampicillin

Ciprofloxacin

Mecillinam

Nitrofurantoin

Sulphonamide

Trimethoprim

Beta-Glucuronidase

50 Susceptibility

testing urines

All products are CE marked according to the European Directive 98/79/EC for In Vitro Diagnostic Medical Devices. Detection of resistance mechanisms User’s Guide The latest version of detection of resistance mechanisms User´s Guide is downloadable from our website www.rosco.dk. Minimum orders for kits are 1 package.

ROSCO Diagnostica A/S Taastrupgaardsvej 30,

DK-2630 Taastrup Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

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AmpC Confirm Kit Ref. 98007 Okt. 2013

AmpC Confirm Kit

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Tablets are used for in vitro identification of microbial resistance mechanisms by the agar tablet/disc diffusion method, in order to confirm the mechanism by which the organism has gained resistance to specific antimicrobial agents.

Content and formulation

4 cartridges, formulated for maximum stability, each containing approximately 50 tablets: Cefotaxime 30 µg, coded CTX30 Cefotaxime 30 µg + Cloxacillin, coded CTXCX Ceftazidime 30 µg, coded CAZ30 Ceftazidime 30 µg + Cloxacillin, coded CAZCX

Quality Control As positive Q. C. stains the following may be used: Enterobacter cloacae NCTC 13406, AmpC positive Enterobacter cloacae ATCC BAA – 1143, Amp C positive E. coli ATCC 25922 is a negative Q. C. stain

References

Hansen F et al: “Evaluation of Rosco Neo-Sensitabs for phenotypic detection and subgrouping of ESBL,AmpC and carbapenemase-producing Enterobacteriaceae.”APMIS 120, 724-732, 2012.

Edquist P et al : “ Phenotypic detection of plasmid-acquired AmpC in E. coli- evaluation of screening criteria and performance of 2 commercial methods for the phenotypic confirmation of AmpC production “ Eur J Clin Microbiol Infect Dis 32,1205-1210, 2013.

Cefotaxime 30 µg CTX30

Ceftazidime30 µg CAZ30

AmpC CTXCX ≥ 5mm -

AmpC CAZCX - ≥ 5mm

Rosco Diagnostica A/S

is the leader in the field

of phenotypic methods for

detection of

beta-lactamases.

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices.

ROSCO Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup

Tel (45) 43 99 33 77

E-mail: [email protected] www.rosco.dk

CVR-No.: 27 21 03 41

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Product list 2013 Neo-Sensitabs Susceptibility Testing Potencies according to EUCAST and CLSI

Okt. 2013

Susceptibility testing of Antifungals

REF NO. PRODUCT

98967 Mueller Hinton agar – BBL - II

ANTIFUNGAL AGENTS

REF NO. PRODUCT CODE POTENCY STORE 2-8°

81012N Amphotericin B AMPHO 10 nnnn 82412N Caspofungin CASP5 5 nnnn 81112N Ciclopirox CICLO 50

81212N Clotrimazole CTRIM 10

81312N Econazole ECONZ 10

82512N Fluconazole FLUCZ 25

81512N Fluorocytosine FLU.1 1

81812N Itraconazole ITRAC 10

81912N Ketoconazole KETOC 15

82012N Miconazole MICOZ 10

82212N Nystatin NYSTA 50

82612N Posaconazole POSAC 5

87412N Terbinafine TERBI 30

82312N Voriconazole VOR.1 1

PACKAGING

The cartridges contain 50 tablets. Packed in boxes containing 1 x 5 cartridges = 250 tablets.

STORAGE

Our product have 2 years to 5 years of expire date.

When cartridge are opened and placed in a dispenser: Cartridges to be kept at room temperature: To be used within the next 12 months. Cartridges to be kept at 2-8°: To be used within 2 months.

ROSCO Diagnostica A/S Taastrupgaardsvej 30,

DK-2630 Taastrup Tel (45) 43 99 33 77

E-mail: [email protected] www.rosco.dk

CVR-No.: 27 21 03 41

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Detection of COLISTIN resistance in Enterobacteriaceae, P. aeruginosa and Acinetobacter Ref. 98018

Okt. 2013

Detection of COLISTIN resistance in Enterobacteriaceae, P. aeruginosa and Acinetobacter

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Tablets are used for qualitative in vitro identification of microbial resistance mechanisms by the agar tablet/disc diffusion method, in order to confirm the mechanism by which the organism has gained resistance to specific antimicrobial agents.

The prediffusion method is very useful for testing high molecular antimicrobials.

Content and formulation

2 cartridges of COLISTIN Prediffusion Neo-Sensitabs, formulated for maximum stability, each containing 50 tablets. Totaling 100 tests

Quality Control

As Q. C. strains the following may be used: E. coli ATCC 25922 Ps. aeruginosa ATCC 27853.

References

Boyen F et al: “Disk prediffusion is a reliable method for testing Colistin susceptibility in porcine E. coli strains”. Vet Microbiol 144,359-362, 2010.

Nastro M et al “Evaluation of the prediffusion method for Colistin in K. pneumonia. Rev Argent Microbiol 44, supl1, P40, 2012 (Spanish)

COLISTIN Prediffusion Sensitive Intermediate Resistant

Enterobacteriaceae ≥ 16 mm 15-12 mm < 12 mm

Ps aeruginosa ≥ 16 mm 15-12 mm < 12 mm

Acinetobacter spp. ≥ 20 mm 19-14 mm < 14 mm

Rosco Diagnostica A/S

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices.

ROSCO Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup

Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

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Detection of hGISA, GISA, VRE and Daptomycin susceptibility Ref. 98017 Okt. 2013

Detection of hGISA, GISA, VRE and Daptomycin susceptibility

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Tablets are used for qualitative in vitro identification of microbial resistance mechanisms by the agar tablet/disc diffusion method, in order to confirm the mechanism by which the organism has gained resistance to specific antimicrobial agents.

The prediffusion method is very useful for testing high molecular antimicrobials.

Content and formulation 3 cartridges of tablets, formulated for maximum stability, each containing approximately 50 tablets: Vancomycin 30 µg, coded VAN30 Teicoplanin 30 µg, coded TEI30 Daptomycin 30 µg, coded DAP30

Quality Control As Q. C. strains the following may be used:

Staph aureus ATCC 700698; hVISA and Daptomycin susceptible Staph aureus AST 403, GISA and Daptomycin susceptible Enterococcus faecalis ATCC 51299, Van B. Staph aureus AST 408, GISA and Daptomycin resistant

References Nielsen SV,Casals JB:” Detection of decreased susceptibility to glycopeptides in S. aureus using tablet(disc) prediffusion”.Presented at ECCMID 2005. Koeth L et al: “Multisite evaluation of the Daptomycin Neo-Sensitab prediffusion method against 20 S. aureus”.Presentation P-1065, ECCMID 2011.

Vancomycin 30 ug Teicoplanin 30 ug Daptomycin 30 ug

hGISA < 20 mm or < 20 mm

GISA < 20 mm and < 20 mm < 5mm

VRE Van A

Van B

Van C

no Zone

< 16mm(hazy)

< 12 mm (sharp)

No zone

> 20 mm

> 20 mm

Daptomycin resistance

Staphylococci < 20 mm

Enterococci no zone

Rosco Diagnostica A/S

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices.

ROSCO Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup

Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

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ESBL + AmpC Screen Kit Ref. 98008 Okt. 2013

ESBL + AmpC Screen Kit

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Tablets are used for in vitro identification of microbial resistance mechanisms by the agar tablet/disc diffusion method, in order to confirm the mechanism by which the organism has gained resistance to specific antimicrobial agents.

Content and formulation

4 cartridges, each containing approximately 50 tablets, formulated for maximum stability: Cefotaxime 30 µg, coded CTX30 Cefotaxime 30 µg + Clavulanate, coded CTX+C Cefotaxime 30 µg + Cloxacillin, coded CTXCX Cefotaxime 30 µg + Clavulanate + Cloxacillin, coded CTXCC

Quality Control As positive Q. C strains the following may be used: Enterobacter cloacae NCTC 13406, Amp C positive

Enterobacter cloacae ATCC BAA – 1143, Amp C positive

Klebs. pneumoniae ATCC 700603 ESBL positive

References

Hansen F et al: “Evaluation of Rosco Neo-Sensitabs for phenotypic detection and subgrouping of ESBL,AmpC and carbapenemase-producing Enterobacteriaceae.”APMIS 120, 724-732, 2012.

Edquist P et al : “ Phenotypic detection of plasmid-acquired AmpC in E. coli- evaluation of screening criteria and performance of 2 commercial methods for the phenotypic confirmation of AmpC production “Eur J Clin Microbiol Infect Dis 32,1205-1210, 2013.

Cefotaxime CTX30 A

Cefotaxime + Clavulanate

CTX+C B

Cefotaxime + Cloxacillin

CTXCX C

ESβL CTX+C or B CTXCC D

≥ 5 mm -

- <5 mm

- ≥ 5 mm

AmpC CTXCX or C CTXCC D

≥ 5 mm -

- ≥ 5 mm

- <5 mm

ESβL + AmpC CTX+C and B CTXCC D

<5 mm (AmpC) -

- ≥ 5 mm (AmpC)

- ≥ 5 mm (ESBL)

Rosco Diagnostica A/S

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices.

ROSCO Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup

Tel (45) 43 99 33 77

E-mail: [email protected] www.rosco.dk

CVR-No.: 27 21 03 41

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Total ESBL + AmpC Confirm Kit Ref. 98019

Okt. 2013

Total ESBL + AmpC Confirm Kit

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Content and formulation

6 cartridges of tablets, formulated for maximum stability, each containing 50 tablets: Cefotaxime + Cloxacillin, coded CTXCX Cefotaxime + Clavulanate, coded CTX+C Ceftazidime + Cloxacillin, coded CAZCX Ceftazidime + Clavulanate, coded CAZ+C Cefotaxime + Cloxacillin + Clavulanate, coded CTXCC

Ceftazidime + Cloxacillin + Clavulanate, coded CAZCC

Quality Control

As positive Q. C. stains the following may be used: Enterobacter cloacae NCTC 13406, AmpC positive Klebs. pneumoniae ATCC 700603, ESBL positive Enterobacter cloacae ATCC BAA-1143 AmpC positive

References

Hansen F et al: “Evaluation of Rosco Neo-Sensitabs for phenotypic detection and subgrouping of ESB, AmpC and carbapenemase-producing Enterobacteriaceae.”APMIS 120, 724-732, 2012.

Edquist P et al: “ Phenotypic detection of plasmid-acquired AmpC in E. coli- evaluation of screening criteria and performance of 2 commercial methods for the phenotypic confirmation of AmpC production “Eur J Clin Microbiol Infect Dis 32,1205-1210, 2013.

Enterobacteriaceae

Cefotaxime + Cloxacillin + Clavulanate CTXCC

Ceftazidime +

Cloxacillin + Clavulanate CAZCC

ESBL

Cefotaxime + Cloxacillin

Ceftazidime + Cloxacillin

>= 5 mm and/or -

>= 5 mm

AmpC

Cefotaxime +

Clavulanate

Ceftazidime + Clavulanate

>= 5 mm

and/or

-

>= 5 mm-

ESBL + AmpC

Cefotaxime + Cloxacillin

Cefotaxime + Clav

Ceftazidime + Cloxacillin

Ceftazidime + Clav

>= 5 mm and

>= 5 mm

>= 5 mm and

>= 5 mm

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices.

ROSCO Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup

Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

Rosco Diagnostica A/S

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

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ESBL Confirm kits Ref. 98011 – 98012 – 98014 Okt. 2013

ESBL Confirm Kits

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Tablets are used for in vitro identification of microbial resistance mechanisms by the agar tablet/disc diffusion method, in order to confirm the mechanism by which the organism has gained resistance to specific antimicrobial agents.

Content and formulation

ESBL Confirm (acc. to CLSI/EUCAST) Kit (98011) Comprises one cartridge (50 tests) each of the following Cefotaxime 30 µg Cefotaxime 30 µg + Clavulanate Ceftazidime 30 µg Ceftazidime 30 µg + Clavulanate Testing of Enterobacteriaceae Group 1 (without chromosomal AmpC) according to CLSI/EUCAST. ESBL Confirm (Chrom. AmpC) Kit (98012) It comprises two cartridges (100 tests) each of the following: Cefepime 30 µg Cefepime 30 µg + Clavulanate Testing of Enterobacteriaceae Group 2 (possessing chromosomal AmpC) according to EUCAST. Total ESBL Confirm Kit (98014) Comprises one cartridge (50 tests) each of the following: Cefotaxime 30 µg Cefotaxime 30 µg + Clavulanate Ceftazidime 30 µg Ceftazidime 30 µg + Clavulanate Cefepime 30 µg Cefepime 30 µg + Clavulanate Testing of any kind of Enterobacteriaceae, including chromosomal AmpC producers.

Quality Control

As positive Q.C. strains the following may be used: Klebsiella pneumoniae ATCC 700603,ESBL positive,(except cefepime)

Enterobacter cloacae NCTC 13464, ESBL positive (use Cefepime and FEP+C)

References

Hansen F et al: “Evaluation of Rosco Neo-Sensitabs for phenotypic detection and subgrouping of ESBL, AmpC and carbapenemase-producing Enterobacteriaceae.”APMIS 120, 724-732, 2012.

Reuland E.A.et al: High prevalence of ESBL-producing Enterobacteriaceae carriage in Dutch community patients with gastrointestinal complaints” Clin Microbiol Infect 19, 542-549, 2012.

Rosco Diagnostica A/S

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices.

ROSCO Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

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KPC/MBL in P. aeruginosa/Acinetobacter Confirm Kit Ref. 98020 Okt. 2013

KPC/MBL in P. aeruginosa/Acinetobacter

Confirm Kit

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Tablets are used for qualitative in vitro identification of microbial resistance mechanisms by the agar tablet/disc diffusion method, in order to confirm the mechanism by which the organism has gained resistance to specific antimicrobial agents. The kit is intended for detection of the carbapenemases; KPC and MBL in Pseudomonas aeruginosa and MBL in Acinetobacter spp.

Content and formulation

5 cartridges of tablets, formulated for maximum stability, each containing approximately 50 tablets: Meropenem 10 µg, coded MRP10 Meropenem 10 µg + Phenylboronic Acid (KPC and AmpC inhibitor), coded MRPBO Meropenem 10 µg + Cloxacillin High (AmpC inhibitor), coded MPCXH Imipenem 10 µg, coded IMI10 Dipicolinic acid (DPA)

Quality Control

As positive Q. C. strains the following may be used: P. aeruginosa ATTC 10145/CCUG 59626, MBL positive K. pneumoniae CCUG 58547, MBL positive K. pneumoniae NCTC 13439, MBL positive K. pneumoniae CCUG 56233, KPC positive K. pneumoniae NCTC 13438, KPC positive

References

Dongeun Yong et al: “Evaluation of double-disk potentiation tests using Dipicolinic acid for detection of MBL-producing Pseudomonas spp and Acinetobacter spp.” J. Clin. Microbiol 50, 3227-3232, 2012.

Miriagou V et al:”Detecting VIM-1 production in P. mirabilis by an Imipenem-Dipicolinic acid double disk synergy test: J. Clin Microbiol 48,667-668, 2010

Mc Conkey agar Meropenem + Phenylboronic

MRPBO

Meropenem + Cloxacillin High

MPCXH DPA

KPC P. aeruginosa

Meropenem 10 µg MRP10

≥ 4mm and < 3 mm

Meropenem + Cloxacillin High

MPCXH ≥ 4 mm

MβL P. aeruginosa Imipenem

10 µg

IMI10

- - Synergism

Acinetobacter - - Synergism

Rosco Diagnostica A/S

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices.

ROSCO Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup

Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

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KPC/Metallo-β-Lactamase Confirm Kit Ref. 98006 KPC/MBL and OXA-48 Confirm Kit Ref. 98015 Meropenem+Boronic Acid+Dipicolinic Acid Ref. 68912

Oct. 2013

KPC/Metallo-β-Lactamase Confirm Kit KPC/MBL and OXA-48 Confirm Kit Meropenem+Boronic Acid+Dipicolinic Acid

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Tablets are used for qualitative in vitro identification of microbial resistance mechanisms by the agar tablet/disc diffusion method, in order to confirm the mechanism by which the organism has gained resistance to specific antimicrobial agents. The kit is intended for detection of the carbapenemases; KPC, MBL and OXA-48 in Enterobacteriaceae

Content and formulation

4 or 5 cartridges of tablets, formulated for maximum stability, each containing approximately 50 tablets:

Meropenem 10 µg, coded MRP10 Meropenem 10 µg + Phenylboronic Acid (KPC and AmpC inhibitor), coded MRPBO Meropenem 10 µg + Cloxacillin (AmpC inhibitor), coded MRPCX Meropenem 10 µg + Dipicolinic acid (Metallo-β-Lactamase inhibitor), coded MRPDP Temocillin 30 ug (only in the OXA-48 Confirm kit 98015)

Quality Control As positive Q. C. strains the following may be used: Klebs. pneumoniae NCTC 13438, KPC positive Klebs. pneumoniae NCTC 13439, MBL positive Klebs. pneumoniae ATCC BAA-1705, KPC positive Klebs. pneumoniae ATCC BAA-2146, MBL positive As negative Q.C strain the following may be used: Klebs. pneumoniae ATCC 700603

References

Giske CG et al: A sensitive and specific phenotypic assay for detection of MBL and KPC in K. pneumoniae with the use of meropenem disks supplemented with phenylboronic acid,dipicolinic acid and cloxacillin.Clin Microbiol Infect 17,552-556,2011. Ambrettii S et al:” Evaluation of phenotypic and genotypic approaches for the detection of Class A and Class B carbapenemases in Enterobacteriaceae”.Microbial Drug Res 19,212-215, 2013.

Miriagou V et al:”Combined disk methods for the detection of KPC and/or VIM positive K. pneumoniae: improving reliability for the double carbapenemase producers”.Clin Microbiol Infect E412-E415,2013

Giakkoupi P et al:” Evaluation of the modified KPC+MBL Confirm kit for the phenotypic detection of Class A and B carbapenemases in K. pneumoniae isolates”. Presented at the ECCMID 2012.

Rosco Diagnostica A/S

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices.

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KPC/Metallo-β-Lactamase Confirm Kit Ref. 98006 KPC/MBL and OXA-48 Confirm Kit Ref. 98015 Meropenem+Boronic Acid+Dipicolinic Acid Ref. 68912

Oct. 2013

Meropenem + Phenylboronic

MRPBO

Meropenem + DPA

MRPDP

Meropenem + Cloxacillin MRPCX

Temocilin 30 µg

AmpC + porin loss

Meropenem 10 µg MRP10

≥ 4mm and

≤ 3 mm ≥ 5mm ≥ 12mm

ESBL + porin loss (a)

Meropenem 10 µg MRP10

≤ 3 mm ≤ 3 mm ≤ 3 mm ≥ 12mm

KPC

Meropenem 10 µg MRP10

≥ 4mm ≤ 3 mm ≤ 3 mm Variable

Meropenem + Cloxacillin (MRPCX)

≥ 4mm - - -

MβL Meropenem

10 µg MRP10

< 4mm ≥ 5mm ≤ 3 mm Variable

OXA-48 and similars

Meropenem 10 ug MRP10

≤ 3 mm ≤ 3 mm ≤ 3 mm No zone of inhibition

OXA-48 + ESBL (a)

Meropenem 10 ug MRP10

≤ 3 mm ≤ 3 mm ≤ 3 mm No zone of inhibition

Triple Disk MER + DPA + BO double inhibitor

KPC MRPDP ≥ 4 mm

MBL MRPBO ≥ 4 mm

KPC + MBL MRPDP MRPBO

≥ 4 mm and ≥ 4 mm

ROSCO Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

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Rapid CARB Ref. 98021 Okt. 2013

Rapid CARB Screen Kit

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Tablets are used for in vitro screening of carbapenemase producing bacteria. The method is valid for Enterobacteriaceae and Pseudomonas aeruginosa.

Content and formulation

Two vials with 6 mm tablets; Imipenem + Indicator (CARB), formulated for maximum stability, each containing 25 tablets equivalent to a total of 50 tests: One vial with 6 mm. tablets: CARB Negative Control Diatabs, 50 tablets.

Interpretation of results

A change of color from red to yellow indicates a positive reaction, indicating that the test strain possesses a carbapenemase. If the reaction is positive after 30 minutes or 1 hour, it is not necessary to incubate further. In most cases, a carbapenemase is detected in 30 min. Please notice: Some Enterobacteriaceae producing OXA – 48 (or similar), showing MIC’s for Imipenem <= 0.5 µg / ml may show a negative result with Rapid CARB Screen Kit. These isolates should be reported as susceptible to Imipenem/meropenem according to CLSI and EUCAST recommendations.

Quality Control

References

Nordmann P et al. Rapid detection of carbapenemase producing Enterobacteriaceae. Emerg. Infect. Dis. 18, 1503-1507, 2012.

Nordmann P et al. Rapid detection of carbapenemase production in Pseudomonas. Presentation CI-078, ICAAC, 2012.

Tijet N et al:" Evaluation of the Carba NP Test for rapid detection of carbapenemase-producing Enterobacteriaceae and Ps aeruginosa." Antimicr Ag. Chemother 57,4578-4580, 2013.

DIATABS POSITIVE NEGATIVE

Imipenem + Indicator (CARB) Klebsiella pneumoniae BAA 1705 E. coli ATCC 25922

Rosco Diagnostica A/S

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices.

ROSCO Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup

Tel (45) 43 99 33 77

E-mail: [email protected] www.rosco.dk

CVR-No.: 27 21 03 41

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Rapid ESBL Ref. 98022 Jan. 2014

Rapid ESBL Screen Kit

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Tablets are used for in vitro screening of ESBL producing bacteria. The method is valid for Enterobacteriaceae.

Content and formulation

One vial with 6 mm tablets; Cefotaxime + Indicator (ESBL) Diatabs, formulated for maximum stability, each containing 50 tablets equivalent to a total of 50 tests. One vial with 6 mm. tablets: Cefotaxime + Tazobactam + Indicator (ESBL) Diatabs, 50 tablets.

Interpretation of results

A change of color from red to yellow indicates a positive reaction. If the reaction is positive after 30 minutes or 1 hour, it is not necessary to incubate further. The tube must be incubated for no more than 2 hours, because positive reactions may fade out.

Quality Control

DIATABS

Positive Negative

Enterobacter cloacae

NCTC 13464

E. coli ATCC 25922

Cefotaxime + Indicator

Yellow

Red

Cefotaxime + Tazo

+ indicator Red Red

References

Nordmann P et al. Rapid detection of Extended-spectrum-beta-lactamase-producing Enterobacteriaceae. J.Clin Microbiol. 50, 3016-3022, 2012.

Rosco Diagnostica A/S

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices. ROSCO Diagnostica A/S Taastrupgaardsvej 30,

DK-2630 Taastrup Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

Page 27: Neo-Sensitabs Susceptibility Testing · Susceptibility testing with NEO-SENSITABS™ practice is performed according CLSI and EUCAST guidelines. ... 62312 Fosfomycin FO200 200 nnnn

Total Metallo-β-Lactamase Confirm Ref. 98016

Okt. 2013

Total Metallo-β-Lactamase Confirm

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Tablets are used for qualitative in vitro identification of microbial resistance mechanisms by the agar tablet/disc diffusion method, in order to confirm the mechanism by which the organism has gained resistance to specific antimicrobial agents.

Content and formulation 5 cartridges of tablets, formulated for maximum stability, each containing approximately 50 tablets: Meropenem 10 µg, coded MRP10

Dipicolinic acid, coded DPA Imipenem 10 µg, coded IMI10 Imipenem 10 µg + DPA, coded IM+DP Imipenem 10 µg + EDTA, coded IM10E

Quality Control As positive Q. C. stains the following may be used: Klebs. pneumoniae NCTC 13438, MBL positive Klebs. pneumoniae ATCC BAA-2146, MBL positive

References Dongeun Yong et al: “Evaluation of double-disk potentiation tests using Dipicolinic acid for detection of MBL-producing Pseudomonas spp and Acinetobacter spp.” J. Clin. Microbiol 50, 3227-3232, 2012.

Miriagou V et al:”Detecting VIM-1 production in P. mirabilis by an Imipenem-Dipicolinic acid double disk synergy test: J. Clin Microbiol 48,667-668, 2010 Enterobacteriaceae

DPA Imipenem + DPA

IM+DP Imipenem + EDTA

IM10E

MBL Meropenem 10 µg

MRP10 Synergism - -

MBL Imipenem 10 µg

IMI10 Synergism ≥ 5 mm ≥ 10 mm

Pseudomonas aeruginosa. Mc Conkey agar Acinetobacter spp. Mc Conkey agar

DPA Imipenem + DPA

IM+DP Imipenem + EDTA

IM10E

MBL Imipenem 10 µg

IMI10 Synergism

≥ 5 mm or

≥ 10 mm

MBL Meropenem 10 µg

MRP10 Synergism - -

Rosco Diagnostica A/S

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices.

ROSCO Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup

Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

Page 28: Neo-Sensitabs Susceptibility Testing · Susceptibility testing with NEO-SENSITABS™ practice is performed according CLSI and EUCAST guidelines. ... 62312 Fosfomycin FO200 200 nnnn

Okt.2013

Neo-Sensitabs - a Unique Solution Unique characteristics ensure that NEO-SENSITABS™ are ideal for use in the clinic

� Long shelf life (Dry crystalline form)

� Stable products (No false positives due to antibiotic destruction)

� Optimal phenotypic method (Detect genotypic false negatives)

� High sensitivity and specificity

� Inexpensive and reliable method

Susceptibility testing with NEO-SENSITABS™ practice is performed according to

CLSI and EUCAST guidelines.

For the Neo-Sensitabs marked 2 - 8°C the following applies:

Unopened cartridges in stock Store in a refrigerator at 2 - 8°C

Cartridges opened and in use Use and store at room temperature within 2 months.

For all other Neo-Sensitabs:

Unopened cartridges in stock Store at room temperature

Cartridges opened and in use Use and store at room temperature within 12 months.

Rosco Dispensers 7 cartridges – round Petri dishes of 9 cm diameter 12 cartridges – round Petri dishes of 14-15 cm diameter 16 cartridges – square Petri dishes of 12 x 12 cm For convenient and accurate dispensing of one or a few tablets at a time, use this handy single cartridge dispenser.

References Justesen U.S et al:" Comparison of Rosco Neo-Sensitabs with Oxoid paper disks in EUCAST disk diffusion antimicrobial susceptibility testing on Mueller-Hinton agar".Eur J Clin Microbiol Infect Dis 32,621-625, 2013.

Rosco User’s Guides The User’s Guide contains comprehensive data and information on several subjects.

• NEO-SENSITABS • EUCAST-and CLSI potency NEO-SENSITABS • DETECTION OF RESISTANCE MECHANISMS • REGRESSION LINES NEO-SENSITABS

The contents are continuously updated the latest edition is from 2013. Freely available on the Rosco website can be read or downloaded. www.rosco.dk

Rosco Diagnostica A/S

is the leader in the field of

phenotypic methods

for detection of

beta-lactamases.

All products from Rosco

Diagnostica A/S are

marked in compliance

with the European Union

directive 98/79/EC for

In Vitro Diagnostic Medical

Devices.

REF. No. 97105

Rosco Diagnostica A/S

also produces Diatabs

– a range of enzymatic

tests for rapid identification

and differentiation

of bacterial species.

ROSCO Diagnostica A/S Taastrupgaardsvej 30,

DK-2630 Taastrup Tel (45) 43 99 33 77 E-mail: [email protected]

www.rosco.dk CVR-No.: 27 21 03 41

kl
Stamp