C. Pathophysiology

Predisposing Factors Precipitating Factors

Conception of a sperm and an empty ovum

whose nucleus has been lost or activated

Mitotic cellular replication begins and

fertilization and formation of trophobast occur

Trophoblast adhere to the endometrium marked increase

in serum hCG

(>15 mUI/mL)

There is an abnormal proliferation of the

vomiting trophoblastic villi and trophoblast cells nausea

produce hCG greater than normal

Complete mole, degeneration of cells occur Partial mole, the syncytiotro- and they become filled with fluid and appear phoblastic layer of vili as clear fluid-filled, grape- sized vesicles. is swollen and mishappen.

Uterus is larger compared to expected size and stated

Abdominal cramps Uterine distention AOG No fetal heart sound

Women over 35 – 40 years

old (47 years old)

Asian heritage

Low protein intake

Vitamin A deficiency

Maternal blood escapes to the uterine

cavity associated with the absence

of placenta

clear fluid-filled Blood and fluid-filled vesicles vaginal beeding

vesicles discharges escape the cervix to the vagina

Anemia from blood loss decrease in blood

components

Hgb = 41 g/L

Hct = 0.12 L/L

RBC = 11.98 x 1019 /L

(Date taken: 6/10/15)

Gestational Trophoblastic Disease