The Pioneer In Natural Bioactives

Natural Healthy Living

Leading the way of

Natural mediterranean solutions for modern age health issuesReduces body damages

incurred by the sun

Age gracefully withan active lifestyle andless pain

MetabolAid

Prevents & treatsmetabolic syndrome

The new age oral photoprotector

Be afraid of the sun no more!

Effective & safe natural solutionthat safeguard your body fromdamages caused by the sun.

Focus on living life ratherthan hiding away from the sun.

Stay active under the sun withless sunburn & less skin damage.

oral photoprotectorWhat damages does the sun causes to our body?

Immediate damage from acute exposure of unprotectedskin to solar ultraviolet (UV) radiation

Sunburn

Chronic effects from repeated exposure to solar ultraviolet radiation

Skin cancer

Majority of the visible signs of skin ageing: Photoageing

Protected SkinUnprotected Skin

Ref: Matts et al. 2010 Photochemical & Photobiological Sciences

oral photoprotectorPhotoageing : Sun exposure causes wrinkles

Wrinkles, mottled pigmentation, poor skin elasticityand dryness.

Signs of photoageing

Ref: Chung et al. 2001 ARCHDERMATOL

Subjects: 407 Koreans

Sun exposure indexes and wrinklegrades for the face were measured.

Conclusion:Direct correlation betweensun exposure index and wrinkleseverity was found.

oral photoprotectorWrinkle is a major beauty concern

It is of no doubt that any product that minimise wrinkle formation is going to have potential in the mass market. It is a beauty problem that everyone faces.

As we age, formation of wrinkles is inevitable. But consumers are awarethat this condition is exacerbated by various external atmospheric conditionsincluding ultra violet radiations.

Ref: Chung et al. 2001 ARCHDERMATOL

oral photoprotectorConsumers believe that sun exposure is responsiblefor premature skin ageing

Ref: Matts et al. 2010 Photochemical & Photobiological Sciences

A product that conveys the messageof reducing damages from sun exposure will be easily correlatedby consumers as a product thatcan help with reducing prematureskin ageing.

Large-base survey conducted on women aged 18–65 years, 1000 each in the UK, Germany and the USAMost of them believe that daily and past sun exposures are responsible for premature ageing.

It is not a difficult message to carryaccross as consumers are well versewith the effects of sun exposure.

oral photoprotectorThe ozone layers protect us from the sun.It doesn’t help that the ozone is depleting!

Ref: National Institute of Water andAtmospheric Research, New Zealand

The world is experiencing exponential economic growth contributed mainly by industrialization. This leads to increments of greenhouse gases emission, which is responsible for depletion of the ozone layer. Therefore more UV rays could penetrate through the ozone layer and reaches our skin. The risk of UV damage will only increase by the minutes and not decrease.

Ozone levels over New Zealandwere displaying a downtrend from 1970-2008.

oral photoprotectorScientifically established that sun exposureis the main cause of all skin cancer

Ref: English et al. 1998 InternationlJournal of Cancer

Case-control study of sun exposure and squamous cell carcinoma (SCC) of the skin within a population based, longitudinal study of skin cancer.

Main finding : Sun exposure, especially during childhood and adolescence, increases the risk of SCC.

oral photoprotectorThe issue of skin cancer and ozone depletionis a global concern

Ref: World Health Organization

The world community recognizes the damages that

chronic ultra violet exposurecan bring upon us.

Since many years ago,world leaders have been implementingprotocols to reduce greenhouse gases emisions, these include Kyoto Protocol and Montreal Protocol.

Estimates of ozone depletionand skin cancer incidence show a trend of exponential growth.

oral photoprotectorThe world is in a constant hunger for a solutionthat can minimise the negative effects of sun exposure

But we can’t simply stay away from the sun, as it is crucial for vitamin D production and for maintaining healthy state ofmind.

We found the answersfrom Murcia, Spain

Due to high amount of sunlight in the region, plants are adapating to the environment by producing potent antioxidants that could fight off the free radicals generated due to ultraviolet radiations.

Fresh ruby red grapefruits from the orchards of Beniel contain high levels

The first secret of NutroxSunis grapefruit.

of citrus bioflavonoids such as naringenin.

oral photoprotector

The second secret of NutroxSun is rosemary.

Fresh rosemary leaves from the orchards of Lorca containhigh levels of rosemary polyphenols which include rosmarinic acid, carnosol and carnosic acid.

Lorca, a region high in seismic activity is blessed with fertile soils.

1Kg of NutroxSun contains 5 kgs of rosemary leaves and 37.5 kgs of fresh grapefruits

The result is

Scientifically proven to be safe & effective in the following applications:

Dermatology productfor sun sensitive skin

Beauty product to improve skin complexions

General health productto prevent skin cancer

Reduces UV-induced skin redness quicker

Increases minimal erythemal dose (MED), minimum dose necessary to cause a clearly visible erythema reaction

Protects cells against UV-induced damages

Reduces wrinkle depth

Increases skin elasticity

Decreases UV-induced lipid peroxidation

oral photoprotectorQuicker reduction of UV-induced redness

Ref: Study conducted by Farcoderm, Italy (still undergoing & pending publication)

Figure : variation of skin redness after intake of NutroxSun & placebo

Subjects: 5 femalesDuration: 5 daysMethod: The skin erythema reaction after a series of UV exposures (6 exposed sites using a series of UV exposures based on MED) is measured using a colorimeter/spectrophotometer CM-700D (Konica Minolta). The parameter measured is the a* parameter of the CIELAB (1976) chromatic space. The a* parameter correlates with skin redness.Treatments: Consumed100mg NutroxSun/day Consumed 250mg NutroxSun/day Consumed Placebo: Maltodextrin/day

Results: 100mg - Statistically significant reduction in redness in 2 days. 250mg - Statistically significant reduction inredness in 25 hours.Placebo - Statistically significant reduction in redness in 3 days.

100mg & 250mg groups generally had lower skin redness than placeboNutroxSun was able to reduce redness quicker than placebo

oral photoprotectorIncreases Minimal Erythemal Dose (MED)

Ref: Study conducted by Farcoderm, Italy (still undergoing & pending publication)

Figure : variation of MED after intake of NutroxSun

MED is inversely correlated with individual susceptibility to UV-induced skin redness occurrence. In another words, the higher the MED is, more time is needed to induce skin redness and moreprotected the individual is.

Results: 100mg & 250mg of NutroxSun increased MED significantly in 15 days (11.7% - 250mg & 15.2% - 100mg).

NutroxSun conferssignificant protection in halfa month.

Method: 90 subjects. 30 each assigned to100mg NutroxSun, 250mg NutroxSunand placebo.

oral photoprotectorIncreases Minimal Erythemal Dose (MED)

Ref: Perez-Sanchez et al. 2014 Journal of Photochemistry and Photobiology B: Biology

Figure : change in MED with days after consumption of NutroxSun

Results: 250mg of NutroxSun increased MEDby 34% in 57 days and 56% in 84 days.

NutroxSun’s protection isaccumulative and augments with time.

Method: 10 subjects assigned to consume 250mgof NutroxSun per day. MEDs measuredat various time intervals.

oral photoprotectorProtects cells against UV-induced damages

Ref: Perez-Sanchez et al. 2014 Journal of Photochemistry and Photobiology B: Biology

Figure : UVB induced cell deathNutroxSun increased cell survival.Rosemary & citrus displayed synergistic effect.

Citrus Extract Rosemary Extract NutroxSun

Method: Cells were treated with either citrus extract, rosemary extract or NutroxSun,they were then subjected to UV, viabilitieswere then measured.

Result: Dose dependent relationships between concentrations of extracts and cell viability.

oral photoprotectorProtects cells against UV-induced damages

Ref: Perez-Sanchez et al. 2014 Journal of Photochemistry and Photobiology B: Biology

Figure : UVB induced DNA damage in human keratinocytes

Method: Human keratinocytes were treated with either NutroxSun or without treatment, they were then subjected to UV, Comet score measured.

Comet score is a way of measuring DNA integrity. The higher the score is, the more damaged the DNA is and vice versa.

NutroxSun reducedUV induced DNAbreakages.

DNA damage was assessed in 50 nuclei per slide area by visual blind-scored from 0 (undamaged, no discernible tail) to 4 (almost all DNA in tail, insignificant head)

oral photoprotector

Ref: American Society for Dermatologic Surgery

Dermatology productfor sun sensitive skin

+ General health productto prevent skin cancer

Sales channels : Dermatologist & OTCTarget markets : Health conscious, educated & middle-high income consumers who are aware of the implications of UV exposure and skin cancer.

Most of the proceduresperformed were for skincancer treatments and photoaging symptoms.

Dermatologists can crosssell oral photoprotectiveproducts to their patients.

oral photoprotectorReduces wrinkle depth

Figure : variation of wrinkle depth after intake of NutroxSun

100mg & 250mg decreased wrinkle depths significantly.

Method: Wrinkle depth was quantitatively measured using Primos 3D (GFM Messtechnik GmbH). Primos 3D is a non-contact in vivo skin measurement device based on structured light projection. In conjunction with a comprehensive 3D measurement and evaluation software, the sensor allows to evaluate skin surface properties

Ref: Study conducted by Farcoderm, Italy (still undergoing & pending publication)

100mg NutroxSun250mg NutroxSun

Placebo

NutroxSun reduced wrinkles by 9.1% in half a month.

oral photoprotectorIncreases skin elasticity

Figure : Variation of Skin elasticity (R2 parameter) after intake of NutroxSun

Method: The measurement of skin elasticity is based on the suction method using a negative pressure deforming the skin mechanically (Cutometer® method). A Negative pressure is created in the device and the skin is drawn into the aperture of the probe for 3 seconds and after a defined time released again. Inside the probe, the penetration depth is determined by a non-contact optical measuring system.

Ref: Study conducted by Farcoderm, Italy (still undergoing & pending publication)

NutroxSun increased R2 by 4.6% in 2 months.

Skin

ela

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ity v

aria

tion

- R

2 -

(%)

R2: overall elastic recovery of the skin to its basal state

100mg & 250mg increased R2significantly

oral photoprotectorIncreases skin elasticity

Figure : Variation of Skin elasticity (R5 parameter) after intake of NutroxSun

Ref: Study conducted by Farcoderm, Italy (still undergoing & pending publication)

NutroxSun improvedoverall skin elasticity in half a month. Elasticityimproved by 9.0% in 2 months.

R5: elastic recovery of the skin to its basal state due to its elastic component.

100mg & 250mg increasedelastic component of the skin significantly.

oral photoprotectorDecreases UV-induced lipid peroxidation

Figure : Variation of UV-induced LPO (4 hours after UV exposure) after intake of NutroSun

Ref: Study conducted by Farcoderm, Italy (still undergoing & pending publication)

NutroxSun reducedlipid peroxidation significantly in half amonth.

21.7% reduction in lipidperoxidation in 2 months.

Method: the level of peroxidation is evaluated by means of MDA test. Method by Erdelmeier and collaborators (1998). the assay is based on the capability of a cromogen, N methyl 2 phenylindole (NMPI), to react with MDA at 45°C and acid pH to produce a stable chromophore that has an absorption peak at 586 nm. The lipo-peroxide levels are measured after the induction of unstable hydroperoxides decomposition, produced in the oxidative processes by means of a pro-oxidant agent (CuSO4 500 µM).

oral photoprotectorBeauty product to improve skin complexions

A successful Japanese product that onlyhas NutroxSun as its active ingredient Sales channel : Beauty SalonsTarget market : Females

Taglines: Support for sunlight from the inside Everyday Be-max in your beauty

Marketing strategy focuses on benefits of NutroxSun and is based on the following:Origin and scientific evidencesClient has utilized marketing tools that we have in place which includes ambassador of NutroxSun,and dedicated website of NutroxSun translated into Japanese.

oral photoprotectorBeauty product to improve skin complexionsMarketing tools that you can use

Brand ambassador : Miss Spain 2010 - Paula Guillo

Customers canutilise her as the ambassador of theirproducts as well.Incorporating herimages into marketingmaterials.

Support from our R&D and marketing teams

Hand in hand, we will help you to materialise your product & make it a success

Research Identify bioactivesthat work in yourfunctional applications

Dr. Nuria CaturlaDr. Vicente Micol

DevelopmentWe have the technicalexpertise to developbioactives that workin your processes.

Francisco Cremedes(Product Development)

Marketing

Market research andassist you in generationsof marketing strategies

Fernando Cartagena(Marketing Manager)