Calmer Mind

Immune Health

Higher Energy

Healthy Aging

Cortisol LevelsConcentration

& Clarity

Antioxidants & Micronutrients

Vitality & Strength

StressHormones

SUPPORTS REGULATES

Cellular Health

Cytokines

Healthy Aging

Immune Health SupportBy Natreon

Build an enduring body and mind with Sensoril® Ashwagandha,

Capros® Amla and PrimaVie® Shilajit – our natural adaptogens designed

to support immune system health and healthy aging.

WHITE PAPER SERIES #3July 2020 | natreoninc.com

Healthy Sleep

Focus Cortisol Levels

Cytokines

Free Radicals

Free Radicals

DHEAGSH

BMD

GSH

Vitality

Minerals

Heart Health

Testosterone

Concentration& Clarity

Antioxidants & Micronutrients

HealthyAging

StressHormones

SUPPORTS REGULATES

Cellular Health

Cytokines

Free Radicals

Cytokines

Cytokines

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. 2

Figure 1: Infographic

As many products in the market today focus on improvements in performance, sleep and healthy aging as well as reduction in occasional stress and fatigue, many overlook the basic but always important benefit of immune support.

Natreon’s 3 potent adaptogens, Sensoril® Ashwagandha, Capros® Amla and PrimaVie® Shilajit, not only target specific health benefits but also support a healthy immune response. (Figure 1)

Immune health Support

Sensoril® Ashwagandha, backed by more than 14 randomized, double-blind, placebo-controlled clinical studies, is a combination of the leaves androots extracted using a specialized, water-based extraction process and is standardized to three key bioactives: withanolide glycosides, oligosaccharides & withaferin A. Withanolide glycosides are a group of naturally occurring compounds found in a variety of plants.(15, 16) Withanolide glycosides support a healthy immune response and have been clinically studied for reducing everyday stress.(2)

Withanolide glycosides have hundreds of metabolites; however, the predominant bioactives are Withaferin A, Withaferin D and Withanone.(17-21) Withaferin A is one of the most studied withanolides, supporting heart health, brain health, and a healthy immune response.(22-27) Specifically, the bioactives found in only 125 mg dose of Sensoril® have strong antioxidant properties and support the body’s immune response.(28-31) The potent bioactives of ashwagandha support the body’s immune system by modulating reactive oxygen species (ROS), lipid peroxidation.(1-14, 17-27)

Sensoril® Ashwagandha provides these benefits both directly and indirectly. Directly, ashwagandha has been shown to impact oxidative stress by influencing compounds such as free radicals and malondialdehyde (MDA)(29-31) and antioxidants such as glutathione (GSH)(30, 31) along with cytokines and C-reactive protein.(28-31)

Together, from these antioxidant properties and effect on oxidative stress, ashwagandha promotes immune system and cellular health. Indirectly, ashwagandha has been shown to reduce everyday stress and improve emotional well-being,concentration and sleep(28) along with 500 mg twice a day promoting circulation and heart health by improving endothelial function,(29, 32) all indirectly supporting the immune system and cellular health.

These indirect improvements are once again contributed to the immune-modulating bioactives unique to the leaves and roots found only in Sensoril®.

Ashwagandha is an ancient Ayurveda herb providing numerous health benefits to the body and brain. It is primarily used to enhance cognitive function and support the body’s immune system. These benefits are promoted by the bioactives in the plant. For example, the leaves from the ashwagandha plant contain bio-actives, which are shown to support improvement in cognition, sleep and oxidative stress as well as a healthy immune response.(1-12) The roots from ashwagandha are most commonly used to promote longevity, enhance vitality and support a healthy immune system.(13, 14)

Healthy Sleep

Cortisol LevelsFocus

MDA

DHEA

GSH

Cytokines

SUPPORTS REGULATES

Concentration& Clarity

Antioxidants & Micronutrients

HealthyAging

StressHormones

Cellular Health

Cytokines

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. 3

Sensoril® Ashwagandha

Amla, also known as Indian Gooseberry, is a fruit traditionally used in Ayurveda to support healthy digestion, circulation, healthy cell function and resistance to oxidative stress.

Amla being a food with some of the most antioxidant properties, (Figure 2) further supports its immune system benefits. Natreon’s Capros® Amla extract is supported by 10 human clinical studies.(33-37)

Capros® Amla

Comparison of ORAC Values

*Data expressed as µmole of Trolox equivalent/g.References: X. Wu et al, J Agri Food Chem, 52, 4026-37,2004; A.G. Schauss et al, J Agri food Chem, 54(22), 8604-10, 2006.

H-ORAC value for Capros® was determined by Brunswick Laboratories, based on in-vitro testing.

ORAC (Oxygen Radical Absorbance Capacity) measures

the scavenging capacity of an antioxidant compound against

free radicals.

Fruit Extracts H-ORAC*

1770

Acai 997

Pomegranate 105

Cranberry 93

Plum 63

Blueberry 62

GSH

CytokinesHeart Health

MDA

SUPPORTS REGULATES

Antioxidants & Micronutrients

HealthyAging

Cellular Health

Cytokines

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. 4

Capros® Amla is standardized to potent polyphenols, including hydrolysable tannins, emblicanin A, emblicanin B, punigluconin and pedunculagin. Polyphenols are powerful antioxidants found in a variety of plant extracts, that have been shown to support cognitive health, digestion, heart health and a healthy immune response. These polyphenols have been shown to support the immune system by modulating ROS and lipid peroxidation.(35, 37-39) Tannins, found in Capros®, have been shown to impact ROS, MDA, antioxidant GSH and cytokine production.(33-39)

Polyphenol bioavailability, including tannins, is typically very low due to limited absorption, extensive metabolism and rapid excretion. Capros’® unique aqueous extract preserves the polyphenols and at 500 mg (250 mg twice a day) ensures cardio benefits indirectly supporting a healthy immune response.(33-37, 40)

In addition to heart health, Capros® further supports the body’s natural balance by protecting the body against oxidative stress(41) and supports a healthy immune response(35, 40) without being a pro-oxidant.

Figure 2: ORAC Values

PrimaVie® is one of the most clinically studied shilajit supplement available and contains one of the highest concentrations of bioactives, including ≥ 50% fulvic acid, >10% of free plus conjugated urolithin A and urolithin B, with more than 40 naturally occurring microminerals. Fulvic acid has been studied to have potent antioxidant effects.(42-44)

Fulvic acid has been shown to impact the production of ROS(45, 46) as well as the release of mediators.(47) Fulvic acid independently protects mitochondrial membranes from oxidative stress,(48) allowing for healthy mitochondrial function. Lastly, fulvic acid has also been shown to act as a biocarrier for minerals and the other bioactives like antioxidants that further contribute to the immune benefit properties of shilajit.

Another bioactive found in PrimaVie®, urolithin A is a unique indirect immune health supporter. Urolithin A is not known to be in any food source but is the result of the transformation of ellagic acids and ellagitannins by the gut microflora.(49) Recent research has shown that urolithins support the gut by having antioxidant effects and supports a healthy immunological response.(50)

In addition to the immune health effects of these potent bioactives found in shilajit, PrimaVie® has many indirect benefits to cellular health, energy and healthy aging. In two human clinical trials, 500 mg of PrimaVie® shows significant improvements in male vitality and sexual health,(51, 52) supporting both healthy aging and rejuvenation. PrimaVie® has been shown repeatedly to improve energy, fitness and sports performance.(53, 54)

Recently completed clinical studies have also shown 500 mg of PrimaVie® improves skin health and skin permeability and significantly supports bone mineral density in healthy aging women.(55)

The mechanisms of action for these benefits have not been fully elucidated in clinical studies, PrimaVie® has shown significant upregulation of collagen and other extra-cellular matrix protein genes related to the development, maintenance and growth of skin, skeletal muscles and bones.(53, 55) These health benefits are unique to PrimaVie® and the bioactive standardization found only in PrimaVie®. Indirectly, PrimaVie® supports a variety of healthy aging benefits which support a healthy immune system and healthy cellular function.

Shilajit has been used in traditional Ayurveda for centuries and offers a variety of health benefits. Shilajit is considered to be one of the most promising energizers or rejuvenators and helps reduce everyday fatigue by supporting energy production. Similar to ashwagandha and amla, shilajit has been shown to be an immunomodulator.(42-44) The mechanism of action for these benefits have not been fully elucidated but it appears fulvic acid is a potent bioactive modulating cytokine production.(43, 44)

Primavie® ShilajitBMD

Vitality

Minerals

Testosterone

Free Radicals

Cytokines

SUPPORTS REGULATES

Antioxidants & Micronutrients

HealthyAging

Cellular Health

Cytokines

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. 5

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. 6

About NatreonNatreon is a leader in nutritional ingredient innovation, quality and research. Trusted by manufacturers for over 20 years, Natreon’s patented ingredients are derived from nature and founded on evidence-based Ayurveda.

Committed to quality, its extracts are purified and standardized using proprietary process technology and controls that result in optimal levels of bioactive constituents. Natreon’s ingredients have been tested in multiple clinical and safety studies to ensure safety, efficacy and authenticity.

Natreon brings storied knowledge and expertise in botanical cultivation and extraction, and its ingredients are sourced through an integrated supply chain to ensure quality and potency.

Natreon has its global headquarters in New Jersey and a state-of-the-art R&D facility in Kolkata, India. For more information, visit: www.natreoninc.com

Natreon’s unique adaptogens provide a variety of health benefits including:

Which all directly or indirectly support the healthy immune system properties of Sensoril® Ashwagandha, Capros® Amla and PrimaVie® Shilajit.

Summary

PerformanceSleep Everyday Stress Healthy Aging

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. 7

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This whitepaper is intended to provide scientific and educational information only and should not be considered medical advice. Brand manufacturers should consult with their counsel as to whether claims are properly substantiated and for appropriate structure function claims.