Nanotechnology and Integrated Bioengineering Centre

(NIBEC)

Healthcare Sensors Systems

H2020 Funding

The Healthcare Sensor Systems Group

Dr David Steel Research Associate

Global Drivers

FDA approves edible electronic pills

that sense when you take your

medication

http://www.digitaltrends.com/home/f

da-approves-edible-electronic-

pills/#ixzz2v87CKxZW

Pillcam

Proteus

Biomedical

PH Pill

Personalised Sensors

Flexible Thin Sensors

Wearables

Multi-disciplinary research centre applying nanotechnology and bioengineering to the following thrusts:

The Connected Health Innovation Centre

(CHIC) is focused on business led research

in the area of connected health.

The Multidisciplinary Assessment of

Technology Centre for Healthcare

(MATCH) is a well-established research

collaboration between four leading UK

universities (Birmingham, Brunel,

Nottingham & Ulster) and a cohort of

industrial partners

CACR

Key current research topics in Connected Health

AF sensing/pattern

recognition

Sleep Apnoea early warning

Smart MEWS based multi-

sensing Algorithms

Novel Wearable Electrode

Systems

De-hydration Sensing

NIBP systems and Pulse

Wave Velocity

Perfusion and CO sensing

systems

SpO2 chest sensing

Integrated VS/Blood/unrine

Cardiac Mapping

Remote Foetal monitoring

Hypo- detection in Diabetics

Non-Invasive Glucose Monitoring (IR)

Point of Care Diagnostics – Microfluidic Systems

Integrated Photonic-CCD Systems

Wi-FI Hospital integration to an FDA standard

Point of Care – Biomarker analytics

Multiple data analysis – MVA, Big Data analytics

PCR Platforms

Healthcare Sensors

Systems Group : NIBEC

3-Lead ECG

Respiration Motion

(3-axis accelerometer)

Automatic

Arrhythmia Detection

Wi-Fi Vital Signs – Point of Care Systems/Devices

Connected Health Devices – functional code

Algorithms derived from Big Data sets for Smart Sensing

Over 30 years experience of driving higher sensitivities,

higher specificities and lower false positives for improved

predictivity (MEWS)

Prof. Jim McLaughlin

Prof Omar Escalona

Dr Dewar Finlay

Smart: ECG Pattern Recognition (FDA Approved)

Bradyarrhythmia

Ventricular Tachycardia

Supra Ventricular Tachycardia

Self-terminating Ventricular Fibrillation

Asystole

Atrial Flutter

Atrial Fibrillation

1st Degree Heart Block

2nd Degree Heart Block

3rd Degree Heart Block

•Congenital

heart defects

•Congestive

heart failure

•Heart muscle

disease

•Heart valve

disorders

•Other

diseases, such

as lung

conditions

•External

forces such as

electric shock

or severe chest

injury Fall Detection

Multiparameter analysis

Sensitivity are all greater than 90%

Specificity are all greater than 90%

False Positives lower than 1 per 10 patients per data

Alarm

Total No.

True

Positives

Total No.

False

Positives

False

Positive

Rate

(#FPs/pati

ent/day)

False

Positive

Rate 24

Bed

System/da

y

Sustained

Low

Respiratio

n Rate

149 5 0.05 1.20

Sustained

High

Respiratio

n Rate

817 2 0.02 0.48

Total 966 7 0.07 1.68

False alarm rates for aingeal arrhythmia algorithms (Ulster hospital and Ulster clinic)

Re(Z) ≡ Z’ = Z cos(θ) and Im(Z) ≡ Z” = Z sin(θ)

Z(ω) = |Z| exp( jθ),

θ=tan-1(Z”/Z’) , Z =[(Z”)2 +(Z’)2] 1/2

(θ: Phase angle , Z: Impedance magnitude. )

Arrays of Biomarkers (with Vital Signs Input)

High Resolution micro-dotting, integrated optics/IDE for high sensitivity

Higher levels of predictively following on-board statistically derived algorithms

Higher levels of stratified decision making approaches following clinically marked-up data as produced from smart-sensing systems with control.

0 250 500 750 1000 125085000

90000

95000

100000

105000

Time (Sec)

|Z| (

Ohm

)

Anti-rabbit R100 vs time.z

0 250 500 750 1000 1250

-66

-65

-64

-63

-62

Time (Sec)

thet

a

NIBEC WiFi Impedimetric Point of Care Blood

Diagnostic System

Commercialisation – Spin-outs

Cardiac Mapping

PRIME ECG Mapping

• Cardiac Mapping –led by Professor Jennifer Adgey and Professor John Anderson

• Electrodes – JMcL and EMcA

• Numerous MD programmes

• Led to large volume of high quality published / patented output

• Commercialised as PRIME-Meridian- Heartscape – Verathon and now Roper.

The first HeartSine

defibrillator was the AED –

The Automated External

Defibrillator- Launched in

2008

HeartSine samaritan® PAD

.

The Defibrillator in every

building is still the vision.

FDA cleared AED’s in 44

countries

Key algorithms to assist

CPR – using ICG

The body-worn

wireless patch

based ecg,

respiration rate,

temperature and

activity with on

board smart

algorithms

designed for the

hospital and

home (Zensor)

CHIC Industry led R&D

Projects.

ECHA (Collaborative Networks,

Large industry, Government and Academic European

Partnership)

NI

CH ECO System

R&D and Innovation --- Business Led --- ECO System of Users

Manchester ECO Oulu ECO Catalonia ECO New York E Health

Collaborative

CH NI Task and Finish Group, CHAP, NIMAC, CHIP

NI ECO

System

Innovation, Economic and Health Benefits via Collaboration

ERI: Industry Interactions and Routes to Impact

Keys Initiatives CHIC (industry led Competence Centre) –

Connected Health at Ulster and the NI CH Eco System (With ECHA)

NIACE and NIACCE (industry led Competence Centre)

Mass Customisation Facility Innovation – McColgan Innovation Award, ERI

Timeline of Innovation and the ERI Impact Hall of Innovation

Keys Initiatives ERI Lecture Series (weekly) Engineering Advisory Panel NISP, W5 and Ulster Museum Exhibitions All Party Science Forum, MATRIX Board Roles STEM Forum Industry Advisory Group Impact Strategic Forum Interdisciplinary Research

HORIZON 2020

Sensors: (2001-2013): Warthe (Marie-Curie-H2020) PhD studentships

CEC-MEST-CT-2005-021024, Neural stimulation (CEC-FPV-N IHP) and

Neuropro, Microtrans, Microcard, DiAdvisor (FP7) projects;

Photocatalysis Materials: solar disinfection of water in developing

countries Sodiswater-CEC-FP-6-INCO-DEV), solar energy conversion

and surface sterilisation e.g. medical devices. (CEC-FP5-Env.-PEBCAT)

or for water splitting CEC-FP5-COCON.

Plasma processing: COLAPE-CEC-FPV-R

Nanomaterials: NMP4-CT-2004-505626-DesynIT

Previous EU projects

Brand New Connected Health H2020 (last six months)

H2020 Pathway – 550k Euros (Connected Health)

H2020 CHESS – 550k (Connected Health)

2 Marie Currie H2020 (Connected Health) (£500k – Prof Escalona and Dr McEneaney)

2 Cost Action – CH and General

PATHway (euro 4.9M, 44 months and 8 EU Pratners

Individualized rehabilitation programs - socially inclusive

exercise sessions - a personalized comprehensive

lifestyle intervention program (exercise/physical activity

(PA), smoking, diet, stress management, alcohol use,

medication compliance)

to enable patients to both better understand and deal with

their own condition and to lead a healthier lifestyle in

general.

by the provision of a home based internet-enabled sensor-

based home exercise platform that allows remote participation in CR exercise programs

PATHway

PATHway

Title: PATHway – Technology enabled behavioural

change as a pathway towards better self-

management of CVD

Programme: Horizon 2020 – Programme under Research and

Innovation action

Instrument: PHC-26-2014: Self management of health and

disease: citizen engagement and mHealth

Total Cost: 4,899,080.00€

EC Contribution: 100%

Duration: 44 months – February 2015 until September

2018

Coordinator: Dublin City University (DCU), Ireland

Consortium: 8 partners from 7 countries

PATHway

PATHway

CHESS

Call: H2020-MSCA-ITN-2015

Topic: MSCA-ITN-2015-ETN Action: MSCA-ITN-ETN

Partners

•Caregiver Control University College Dublin, Ireland

•Clinician Education, University College Dublin, Ireland

•Go-to-market strategies, University College Dublin, Ireland

•Orthopaedic rehabilitation, Beacon Hospital, Ireland

•Gamification for Health Coaching, Salumedia, Spain

•Clinical Trials, Grenoble Ecole de Management, France

•Multi-sided Markets, Grenoble Ecole de Management, France

•Well-being, Grenoble Ecole de Management, France

•Patient Responsibility, Aristotle University of Thessaloniki, Greece

•Visualizations, University of Oulu, Finland

•Health Data Ownership, University of Oulu, Finland

•Inverting value creation, University of Oulu, Finland

•BP Monitoring, University of Ulster, N. Ireland

•AF Detection, University of Ulster, N. Ireland

•Information Needs in Connected Health (INCH), Philips Electronics, Netherlands

CHESS (Connected Health

Early Stage Researcher

Support System) has been

funded to the tune of €3.9

million under the Horizon2020

People Programme.

It is Europe’s first networked

Connected Health PhD training

programme.

What is CHESS?

Connected health puts the correct information in the correct hands at

the correct time allowing patients, clinicians, and planners to make

better decisions.

CHESS will develop connected health scientists and champions who

can understand multiple domains, communicate in an interdisciplinary

world and operate across the education, industry, health and policy

sectors.

It will include intersectoral secondments and a programme of

interrelated research projects in health economics, use of big data,

personal sensing, business modelling, navigating markets and

ecosystems, change management and user-led design.

Work Package 3: Data Lead beneficiary: UU,

Partners involved: INT, CAH, VTT, LOC, AUTH, UO, Philips.

This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 676201

www.chessitn.eu

Objective

• To investigate, develop, and evaluate new algorithms and models to support the acquisition to exploitation lifecycle for “data” in CH applications.

• Involves:

– Data acquisition

– Processing

– Utilisation

www.chessitn.eu

ESR8 (Ulster)

• Title: – Cuff-less Non-Invasive Blood Pressure Monitoring

• Objectives: – To explore a suitable method for continuous BP monitoring that does not

require a cuff

• Expected Results: – Methods and techniques to acquire challenging signal-capture – Algorithms for high quality signal processing, with high ROC curve UTC values

and low false alarms, and for correction of inter/intra individual variability in captured signals

– ESR with experience in signal capture and processing in challenging health environments.

• Planned secondment(s): – Intelesens Device Build and Test Lab and Electrode Fabrication Facility

(Industry Partner),10 months (M 12-21) to develop methods/techniques to acquire challenging signal-capture

www.chessitn.eu

ESR9 (Ulster)

• Title: – Development of Advanced Algorithms for AF Detection in the Wearable Device

Setting

• Objectives: – To develop an improved model for the detection of atrial fibrillation

• Expected Results: – Investigation of new AF analytical techniques, knowledge pooling of clinical

experts and mining of large AF datasets – Improved data analytic algorithms, including wearable device development for

algorithm support – Early stage technical training process at CAH – ESR with experience in analytical techniques and wearable device

development.

• Planned secondment(s): – Craigavon Area Hospital (Clinical Partner), 6 months (M 20-25) in the

cardiovascular research unit to gain an understanding of the hospital’s capability to integrate key data

www.chessitn.eu

ESR10 (UO)

• Title: – MyData as an Enabler for Personalised Health Services

• Objectives: – To explore the effect of data changes in making healthcare services more

personalised and human centred

• Expected Results: – Identification of key factors for wider adoption of MyData in health and well-

being services – Validation of MyData impact in designing and delivering health and well-being

services – Theoretical models of successful value co-creation with MyData in health

domain – An ESR with experience in health data management and health policy.

• Planned secondment(s): – LocalTapiola (SME), 3 months (M12-14) to determine the ethical challenges

facing companies using digital data in health services.

www.chessitn.eu

ESR11 (PHIL)

• Title: – Paving the Way from Personal Health to Public Health Policies

• Objectives: – To improve coordinated care and telehealth by developing integrated

procedures and methods for the management, analysis, visualisation, and study of widespread data in key health related performance areas

• Expected Results: – Unified framework of health related KPIs that can be applied at

different scales – Visual exploration and quantitative analysis procedures and scenarios – An ESR with experience in co-ordinated care – analysis and policy.

• Planned secondment(s): – Secondment 1: AUTH (Academic Partner), 6 months M13-18 & 4

months M22-25

www.chessitn.eu

EU Funding at Ulster in the area of Connected Health (over £5M since 2005)

Title Start Date Amount

CARDIWORKBENCH: Drug design for cardiovascular diseases:

Integration of in silico and in vitro analysis 1/12/05 £187,345

PHIME: Public health impact of long-term, low level mixed element

exposure in susceptible population strata 25/2/06 £517,740

Advanced methods and technologies for bioinformatics. 2/4/06 £5,520

COG-KNOW - Helping People with mild dementia navigate their day. 1/9/06 £262,551

Wide Area Research Training in Health Engineering: WARTHE 1/9/06 £303,185

CREATE 1/1/07 £13,591

NETWELL 1/2/07 £30,607

LIPGENE EXT: Diet, genomics and the metabolic syndrome nutrition,

agro-food, social and economic analysis 5/6/07 £10,698

MyHealth@Age - Improved Health and Safety for Elderly People living

in Northern Periphery regions: Preparatory Project 1/7/07 £1,040

DESYGN IT: Design synthesis and growth of nanotubes for industrial

technology - extension 1/9/07 £8,921

EUROCAT: Surveillance of congenital anomalies in Europe 2006103 1/9/07 £426,865

Neuros; Neuropro; Tuluzit etc 2011 £500,000

Myhealth @ Age 1/1/08 £196,702

Electronic's Production and Innovation Technology Centre (EPI Centre) 1/1/08 £186,164

BRAIN - BCI'S with Rapid Automated Interfaces for Non-experts 1/9/08 £306,226

Science and the treatment of autism: A multimedia package for parents

and professionals: STAMPPP 1/10/08 £128,526

World Mental Health Survey 1/2/09 £13,055

Innovation for Competitive Enterprises (ICE) 1/4/09 £486,861

SAFE- COMMS 1/4/09 £140,380

Pro-fit: Fieldlab sport innovation & stimulation 25/9/09 £187,333

MaPEeR: Making Progress and Economic Enhancement a Recalling for

SMEs 1/11/09 £120,714

STAR: Skills Training and Re-Skilling for Carers of People with Dementia 1/12/10 £37,900

Eurocat: European surveillance of congenital anomalies 1/1/11 £949,738

MICHELANGELO: Patient-centric Model for Remote Management,

Treatment and Rehabilitation of Autistic Children 1/10/11 £202,058

BESECURE - Best practices for enhancing security policy in urban zones. 1/4/12 £450,000

SULA: Sustainable Living Assistance 1/12/12 £124,811

EU Funding at Ulster in the area of Connected Health

Excellent Science

European Research Council (ERC)

Future and Emerging Technologies (FET)

Marie Skłodowska-Curie Actions (MSCA)

Research Inf rastructures

Industrial Leadership

Leadership in Enabling and Industrial

Technologies (LEIT) -ICT, KETs, Space

Access to Risk Finance

Innovation in SMEs

Societal Challenges

Health and Wellbeing

Food security

Transport

Energy

Climate action

Societies

Security

Widening Participation; Science with and for Society

European Institute of

Innovation and Technology

(EIT)

Joint Research Centre

(JRC)EURATOM

Thank You !

Acknowledgements to

all within CHIC and my

Research Group-

Healthcare Sensor

Systems at UU

Acknowledgements to all

funders: EPSRC, DEL, INI,

US-IRL (NSF); Wellcome

Trust; British Council, TSB

and FP&/H2020 EU