Presentation Name

Name Surname

Date

What will we

build and what

will it look like?

Claus Svendsen

Kickoff Meeting Barcelona 27-29th Oct 2015

NanoF

ASE

The NanoFASE

Exposure Assessment Framework

Kickoff Meeting Barcelona

27-29th Oct 2015

Deliver better models and methods for ENM fate in the

environment:

Where, in what form and for how long?

London (UK)

Thames (UK)catchment

3) Object-oriented multimedia fate modelsdynamically connecting “Environmental cells”

Air

W

ate

r

SMPPhase

Freephase

Sedimentphase

SolidPhase

Soil

Pore waterPhase

X

Y

2) Environmental„cell“reactors

1) ENM enabledProduct value chains& release pathways

ENM Synthesis

ENM Prod. Manu.

Distribution

Use phase

Waste mgt.

GIS layers providing “cell” specific:• Human population & Industry• Elevation & river network• Vegetation, soil type & landuse• Environmental chemistryRecycling

Conceptual workflow for a framework to deliver dynamic multimedia fate prediction both in a generalised model environment and GIS enabled mode.

Focus on the “real product” and “environmentally realistic/relevant forms.

NanoF

ASE

The Scope and limitations:• Focused on Release to and Fate in the environment

• Generation of Exposure Assessment Framework

• Models and Methods for parameterising these

• Environmental Fate includes transfer to Biota

• EXCLUDED are measures of EFFECT/Hazard

• Human exposure only through the environment

• EXCLUDED are Worker and consumer exposure

NanoFASE – Scope and limitations:

Kickoff Meeting Barcelona

27-29th Oct 2015

NanoF

ASE

NanoFASE the connections:

Kickoff Meeting Barcelona

27-29th Oct 2015

NanoF

ASE

NanoFASE the connections:

Kickoff Meeting Barcelona

27-29th Oct 2015

London (UK)

Thames (UK)catchment

3) Object-oriented multimedia fate modelsdynamically connecting “Environmental cells”

Air

W

ate

r

SMPPhase

Freephase

Sedimentphase

SolidPhase

Soil

Pore waterPhase

X

Y

2) Environmental„cell“reactors

1) ENM enabledProduct value chains& release pathways

ENM Synthesis

ENM Prod. Manu.

Distribution

Use phase

Waste mgt.

GIS layers providing “cell” specific:• Human population & Industry• Elevation & river network• Vegetation, soil type & landuse• Environmental chemistryRecycling

Conceptual workflow for a framework to deliver dynamic multimedia fate prediction both in a generalised model environment and GIS enabled mode.

Focus on the “real product” and “environmentally realistic/relevant forms.

WP4

WP5

WP6

WP7

WP8

WP9

WP2

NanoF

ASE

NanoFASE – Cross cutting delivery:

Kickoff Meeting Barcelona

27-29th Oct 2015

London (UK)

Thames (UK)catchment

3) Object-oriented multimedia fate modelsdynamically connecting “Environmental cells”

Air

W

ate

r

SMPPhase

Freephase

Sedimentphase

SolidPhase

Soil

Pore waterPhase

X

Y

2) Environmental„cell“reactors

1) ENM enabledProduct value chains& release pathways

ENM Synthesis

ENM Prod. Manu.

Distribution

Use phase

Waste mgt.

GIS layers providing “cell” specific:• Human population & Industry• Elevation & river network• Vegetation, soil type & landuse• Environmental chemistryRecycling

Conceptual workflow for a framework to deliver dynamic multimedia fate prediction both in a generalised model environment and GIS enabled mode.

Focus on the “real product” and “environmentally realistic/relevant forms.

WP1:Exposure Assessment Framework for ENMsFrom here comes the “EAF” and the “FFG”

WP2:Integrated Multimedia Fate ModelFrom here comes the “Model Catalogue”

WP3:ENM Supply, characterisation, & TransformationFrom here comes the “Method Catalogue”• Exposure preparation and media• “Pristine” &“Exposure relevant” ENMs• Analytics & Characterisation• “Functional fate assays”

NanoF

ASE

NanoFASE – What will the EAF look like:

Kickoff Meeting Barcelona

27-29th Oct 2015

London (UK)

Thames (UK)catchment

3) Object-oriented multimedia fate modelsdynamically connecting “Environmental cells”

Air

W

ate

r

SMPPhase

Freephase

Sedimentphase

SolidPhase

Soil

Pore waterPhase

X

Y

2) Environmental„cell“reactors

1) ENM enabledProduct value chains& release pathways

ENM Synthesis

ENM Prod. Manu.

Distribution

Use phase

Waste mgt.

GIS layers providing “cell” specific:• Human population & Industry• Elevation & river network• Vegetation, soil type & landuse• Environmental chemistryRecycling

Conceptual workflow for a framework to deliver dynamic multimedia fate prediction both in a generalised model environment and GIS enabled mode.

Focus on the “real product” and “environmentally realistic/relevant forms.

[Fe3+L]

FeOx NP

Fe2+aqu

AsO43-

AsO43-

AsO43-

PO43-

PO43-

PO43-

NOMNOM

NOM

aggr

egat

ion

de-

aggr

egat

ion

diffusion limitedDf < ~2

reaction limitedDf > ~2

FeOx NPs emitted into waste waterfrom use in cancer therapy

Fig. 2 Likely transformations of FeOx NPs in water reactors

Methods and protocolsSummaryEnvironmentalFateNan

oFASE

NanoFASE – What will the FFGs look like:

Kickoff Meeting Barcelona

27-29th Oct 2015

London (UK)

Thames (UK)catchment

3) Object-oriented multimedia fate modelsdynamically connecting “Environmental cells”

Air

W

ate

r

SMPPhase

Freephase

Sedimentphase

SolidPhase

Soil

Pore waterPhase

X

Y

2) Environmental„cell“reactors

1) ENM enabledProduct value chains& release pathways

ENM Synthesis

ENM Prod. Manu.

Distribution

Use phase

Waste mgt.

GIS layers providing “cell” specific:• Human population & Industry• Elevation & river network• Vegetation, soil type & landuse• Environmental chemistryRecycling

Conceptual workflow for a framework to deliver dynamic multimedia fate prediction both in a generalised model environment and GIS enabled mode.

Focus on the “real product” and “environmentally realistic/relevant forms.

WWTP & Incineration Processes

The Functional Fate Groups:• Reducing complexity• Focusing on the main flows

e.g. Where 80% of the mass goese.g. Where the most reactive forms go

NanoF

ASE

How will people find all that we do?

We have to tell them, show them, and give it to

them.

We have to select the right formats

We will use the Advisory Board to guide us

They will provide direct feedback and collaboration to

the project AND the WPs

Making the work have IMPACT

Kickoff Meeting Barcelona

27-29th Oct 2015

NanoF

ASE

The Stake holder part of the AB:

Making the work have IMPACT

Kickoff Meeting Barcelona

27-29th Oct 2015

NanoF

ASE

The Academic part of the AB:

Making the work have IMPACT

Kickoff Meeting Barcelona

27-29th Oct 2015

The “Experts” will:• Link directly with selected WPs through collaboration where possible.• Advise on upcoming events where NanoFASE should be present.Nan

oFASE

Feedback from the 1st AB:

Need to create “acceptance” for a set of models to begin

populating as a community

Need spatially resolved models

Need to include chemistry in the models

Need to consider integration of models, e.g. particle number basis

or mass basis.

Need bio-uptake models

Need “groupings” for NMs and determine how we define

transformations

Need general models and assays for “screening” fate

Making the work have IMPACT

Kickoff Meeting Barcelona

27-29th Oct 2015

NanoF

ASE

NanoF

ASE