NANOCURE Research | University of Wisconsin-Platteville
Process for RESEARCH pages
MEET THE RESEARCHERS
Provide the following faculty, department affiliation, with
photo and student major affiliation, with photo.
TITLE Research (WEB PAGE TEMPLATE)
Main Photo
Summary
Provide a short summary, elevator speech description of
research.
Description of Research
Provide a full abstract style description of research.
One of the goals of biology is to understand how cells work.
This goal requires various approaches for measurements on a single
cell maintaining its structural integrity. Microfluidics can
provide a solution for cell isolation and analysis. Microfluidic
devices have emerged as distinct new structures that can precisely
control the transport of fluids through channels at the micro and
nano scale, and therefore have the ability to control and study
small particles over time. This research uses microfluidic
technology to manipulate movement of human colorectal carcinoma
cells and entrap single cells.
Previous research at UW-Platteville demonstrated that cesium
treatment eliminated colorectal tumors in mice without noticeable
adverse effects. Complementary alternative medicine therapies based
on the use of cesium chloride preparations for the treatment of
cancer and radiation poisoning, have generated therapeutic
interest; but oral or intravenous administration of cesium chloride
(CsCl) to cancer patients as an alternative mode of cancer therapy
have not been approved by the US Food and Drug Administration
(FDA). Our project investigates cesiums suppressive effect human
colorectal carcinoma cells in vitro.
The biochemical output of cancer cells is vastly different from
normal cells, and in particular, cancer cells are highly acidic. A
biocompatible microfluidic device capable of measuring the
extracellular pH of human colorectal carcinoma cells was developed.
The sensors electrodes consist of a silver chloride reference
electrode and an iridium oxide-working electrode that provides real
time voltage output in the mV range. Calibration was performed via
linear regression of induced voltage as a function of pH, and the
slope, or Nernstian value, provided relationship of 53mV/pH of the
device. Current studies are being conducted to incorporate the pH
sensor into a microfluidic device that isolates single cells. In
addition, future research include Raman spectroscopy to provide
quantitative information of the biochemical output of cells. Raman
spectroscopy will be used to verify changes in biochemical
composition that correspond to cellular pH changes with cesium
treatment.
Academic Areas of Focus
Provide a list of program areas and associated fundamentals.
BiologyThis project is related to biology because it involves
the use of microfluidics technology to study cell biology.
Microfluidic devices enables studies of cell behavior from single-
to multi-cellular organisms.
Nanotechnology ("nanotech")This project operates in the design,
fabrication and testing of micro- or nano-scale fluidic platforms.
Some microfluidic devices rely on photolithography, a
nanotechnology process, for fabrication.
EngineeringThis project requires the understanding of the
fundamentals of fluid mechanics for applications in the biomedical
and engineering areas. For example, it is important to understand
the different driving forces for controlling fluid flows in smaller
scales to isolate single cells.
Senior Design a "Capstone Design Experience"Senior Design is
about students, working in small teams and tackling design
challenges. Part of the success of the NANOCURE research is due to
the work of several senior design teams.
Spring 2017 Mechanical senior design, designed and fabricated a
microscope X-Y stage with precision motion to locate cancer cells
in a microfluidics device.The team members: Jeremy Borg, Matt
Dittmer, Adam Gagliardi, Tyler Huttenlocher, and Dan Wright.
Fall 2016 Mechanical senior design, designed and fabricated a
microfluidic chip holder that allows one to control the temperature
of the chip and provide electrical connections to the chip.The team
members: Adriana Hernandez-Berrios, Austin Gaspar, Derek Thieme,
Jacob Ahrenholtz, and Nicholas Devroy.
Spring 2016 Mechanical senior design, designed and fabricated a
Raman Spectroscope to analyze cancer cells by obtaining vibrational
information of molecules like chemical bonds.The team members:
Bradley A Devroy, Victoria J Dittmann, Patrick T Meicher, Kevin M
Norris, and Brian E Weiss.
Events
List conferences, symposiums or activities.
Wisconsin Science & Technology Symposium (WSTS
2017)http://www.wisys.org/events/wsts
Pioneer Academic Center for Community Engagement (PACCE) Poster
Day (2017) https://www.uwplatt.edu/pacce
UW System Undergraduate Research Symposium
(2017)https://www.uwsp.edu/oscar/Pages/symposium/default.aspx
Research in the Rotunda
(2017)https://www.wisconsin.edu/research-in-the-rotunda/
Application and Career Opportunities
List the various careers and research opportunities.
There are many career opportunities for students with experience
in microfluidics-based medical devices.
Microfluidics
companies:http://fluidicmems.com/list-of-microfluidics-lab-on-a-chip-and-biomems-companies/
Join our research group...
Provide information on the current need for more students and
the how to apply to join.
We are always looking for highly motivated students. If you are
interested in a more in-depth research experience such as
independent study credit, please contact Dr. Jorge Camacho if you
are majoring in engineering (We welcome all engineering majors.)
and you think that NANOCURE is the right project for you. Please
contact Dr. Miranda Bader if you are majoring in biology and you
think that NANOCURE is the right project for you.
Provide photos for the photo gallery with short title
descriptions.
TITLE Research Group (WEB PAGE TEMPLATE)Faculty Photo is
needed.
Faculty NamePrinciple InvestigatorDepartment
[email protected]
Research Interests: Short description needed.
Students Photo is needed.
Student NameLead Student Researcher
Major: Program AffiliationMinor: Program AffiliationResearch
Interests: Short description needed.
Collect the information into a WORD document
Reference Template below and collect the information needed
using the highlighted yellow text.
Email drafted WORD document and photos to Web Publisher
email: [email protected]
email subject: RESEARCH PAGE
Web Publisher will create the new research pages.
Any questions or more information needed will be coordinated by
email.
Faculty lead researcher will review to approve final web page
version.
