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Int J Food Sci Nutr. 2005 Sep;56(6):399-414 .  P!nt "ood# in t$e %!n!&e%ent o" di!'ete# %eitu#: #pice# !# 'ene"ici! !ntidi!'etic "ood !dunct#. Srini!#!n *. +ep!rt%ent o" ,ioc$e%i#tr Nutrition/ entr! Food ec$noo&ic! e#e!rc$ In#titute/ #ore-50013/ Indi!.  +iet $!# 'een reco&nied !# ! corner #tone in t$e %!n!&e%ent o" di!'ete# %eitu#. Spice# !re t$e co%%on diet!r !dunct# t$!t contri'ute to t$e t!#te !nd "!our o" "ood#. ,e#ide#/ #pice# !re !#o no7n to e8ert #eer! 'ene"ici!  p$#ioo& ic! e""ect# incudin& t$e !ntidi!'etic in"uence. $i# reie7 con#ider# ! t$e !!i!' e in"or%!tion "ro% !ni%! e8peri%ent!tion !# 7e !# cinic! tri!# 7$ere #pice#/ t$eir e8tr!ct# or t$eir !ctie principe# 7ere e8! %ined "or tre!t%ent o" di!'ete#. %on& t$e #pice#/ "enu&ree #eed# (ri&one! "oenu%&r!ecu%)/ &!ric (iu% #!tiu%)/ onion (iu% cep!)/ !nd tur%eric (urcu%! on&!) $!e 'een e8peri%ent! docu%ented to po##e## !ntidi!'etic potenti!. In ! i%ited nu%'er o" #tudie#/ cu%in #eed# (u%inu% c%inu%)/ &in&er (in&i'er o""icin!e)/ %u#t!rd (,r!##ic! ni&r!)/ curr e!e# (urr!! oeni&ii) !nd cori!nder (ori!ndru% #!tiu%) $!e 'een reported to 'e $po&c!e%ic.  Pu'ic!tion pe#:  eie7 PI+: 1636111 <Pu'ed - inde8ed "or =+>IN=?  J Nutr Sci @it!%ino (oo). 2003 pr;49(2):-93.  Protectie e""ect# o" %u#t!rd e!" (,r!##ic! unce!) !&!in#t di!'etic o8id!tie #tre##. Aoo!7! / *i% BA/ $o =J/ A!%!'i N/ $oi JS.  In#titute o" N!tur! edicine/ o!%! edic! !nd P$!r%!ceutic! Cnier#it/ Su&it!ni/  o!%! 930-0194/ J!p!n. oo!7!D%#.to !%!-%pu.!c.p  E" "our "r!ction# (B22/ =tEc/ ,uEB !nd B2E) "ro% %u#t!rd e!" (,r!##ic! unce!)/ t$e =tEc "r!ction #$o7ed t$e #tron&e#t in$i'itor e""ect#/ 7$ic$ 7ere concentr!tion-dependent/ on t$e "or%!tion o" !d!nced &c!tion end  product# !nd "ree r!dic!-%edi !ted protein d!%!&e in !n in it ro ##te%/ indic!tin& t$! t t$i# "r!ction $!# ! potent i!  protectie roe !&!in#t d i!'ete# !ndor it# co%pic! tion#. ,!#ed on t$e#e re#u t#/ 7e c!rried out !n in io #tu d to deter%ine 7$et$er t$e =tEc "r!ction protected !&!in#t di!'etic o8id!tie #tre## induced ' #treptootocin. Er! !d%ini#tr!tion o" t$e =tEc "r!ction !t do#e# o" 50 !nd 200 %&& 'od 7ei&$td "or 10 d reduced t$e #eru% ee# o" &uco#e !nd &co#!ted protein/ i%pin& t$!t t$e i%p!ired &uco#e %et!'oi#% due to di!'ete# $!d 'een !%eior!ted. In !ddition/ t$e =tEc "r!ction #i&ni"ic!nt reduced t$e t$io'!r'ituric !cid-re!ctie #u'#t!nce ee# o" #eru% !nd $ep!tic !nd ren! %itoc$ondri!. Furt$er%ore/ t$e ee!ted ee# o" #upero8ide !nd nitritenitr!te 7ere reduced in ! do#e-dependent %!nner ' or! !d%ini#tr!tion o" t$e =tEc "r!ction. $e#e "indin&# #u&&e#t t$!t t$e =tEc "r!ction

Mustard and Diabetes

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• Int J Food Sci Nutr. 2005 Sep;56(6):399-414.

P !nt "ood# in t$e %!n!&e%ent o" di!'ete# %e itu#: #pice# !# 'ene"ici! !ntidi!'etic "ood !d unct#.

Srini !#!n *.

+ep!rt%ent o" ,ioc$e%i#tr Nutrition/ entr! Food ec$no o&ic! e#e!rc$ In#titute/

#ore-5 0013/ Indi!.

+iet $!# 'een reco&ni ed !# ! corner #tone in t$e %!n!&e%ent o" di!'ete# %e itu#. Spice# !re t$e co%%on diet!r!d unct# t$!t contri'ute to t$e t!#te !nd " ! our o" "ood#. ,e#ide#/ #pice# !re ! #o no7n to e8ert #e er! 'ene"ici!

p$ #io o&ic! e""ect# inc udin& t$e !ntidi!'etic in" uence. $i# re ie7 con#ider# ! t$e ! !i !' e in"or%!tion "ro%!ni%! e8peri%ent!tion !# 7e !# c inic! tri! # 7$ere #pice#/ t$eir e8tr!ct# or t$eir !cti e princip e# 7ere e8!%ined "ortre!t%ent o" di!'ete#. %on& t$e #pice#/ "enu&ree #eed# ( ri&one ! "oenu%&r!ecu%)/ &!r ic ( iu% #!ti u%)/ onion( iu% cep!)/ !nd tur%eric ( urcu%! on&!) $! e 'een e8peri%ent! docu%ented to po##e## !ntidi!'etic potenti! .In ! i%ited nu%'er o" #tudie#/ cu%in #eed# ( u%inu% c %inu%)/ &in&er ( in&i'er o""icin! e)/ %u#t!rd (,r!##ic!ni&r!)/ curr e! e# ( urr! ! oeni&ii) !nd cori!nder ( ori!ndru% #!ti u%) $! e 'een reported to 'e $ po& c!e%ic.

Pu' ic!tion pe#:

e ie7

P I+: 163611 1 <Pu' ed - inde8ed "or =+>IN=?

• J Nutr Sci @it!%ino ( o o). 2003 pr;49(2): -93.

Protecti e e""ect# o" %u#t!rd e!" (,r!##ic! unce!) !&!in#t di!'etic o8id!ti e #tre##.

Ao o !7! / *i% BA/ $o =J/ A!%!'i N/ $oi JS.

In#titute o" N!tur! edicine/ o !%! edic! !nd P$!r%!ceutic! Cni er#it / Su&it!ni/

o !%! 930-0194/ J!p!n. o o !7!D%#.to !%!-%pu.!c. p

E" "our "r!ction# ( B2 2/ =tE c/ ,uEB !nd B2E) "ro% %u#t!rd e!" (,r!##ic! unce!)/ t$e =tE c "r!ction #$o7edt$e #tron&e#t in$i'itor e""ect#/ 7$ic$ 7ere concentr!tion-dependent/ on t$e "or%!tion o" !d !nced & c!tion end

product# !nd "ree r!dic! -%edi!ted protein d!%!&e in !n in itro # #te%/ indic!tin& t$!t t$i# "r!ction $!# ! potenti! protecti e ro e !&!in#t di!'ete# !nd or it# co%p ic!tion#. ,!#ed on t$e#e re#u t#/ 7e c!rried out !n in i o #tud todeter%ine 7$et$er t$e =tE c "r!ction protected !&!in#t di!'etic o8id!ti e #tre## induced ' #trepto otocin. Er!!d%ini#tr!tion o" t$e =tE c "r!ction !t do#e# o" 50 !nd 200 %& & 'od 7ei&$t d "or 10 d reduced t$e #eru% e e # o"& uco#e !nd & co# !ted protein/ i%p in& t$!t t$e i%p!ired & uco#e %et!'o i#% due to di!'ete# $!d 'een !%e ior!ted.In !ddition/ t$e =tE c "r!ction #i&ni"ic!nt reduced t$e t$io'!r'ituric !cid-re!cti e #u'#t!nce e e # o" #eru% !nd$ep!tic !nd ren! %itoc$ondri!. Furt$er%ore/ t$e e e !ted e e # o" #upero8ide !nd nitrite nitr!te 7ere reduced in !do#e-dependent %!nner ' or! !d%ini#tr!tion o" t$e =tE c "r!ction. $e#e "indin&# #u&&e#t t$!t t$e =tE c "r!ction

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"ro% %u#t!rd e!" %i&$t 'e 'ene"ici! in !ttenu!tin& t$e d!%!&e c!u#ed ' o8id!ti e #tre## in o ed in di!'ete# !nd it#co%p ic!tion#.

Pu' ic!tion pe#:

In @itro

P I+: 12 153 <Pu' ed - inde8ed "or =+>IN=?

• J =t$nop$!r%!co . 2004 Ju ;93(1):113-6.

,r!##ic! unce! ( !i) #i&ni"ic!nt pre ented t$e de e op%ent o" in#u in re#i#t!nce in r!t# "ed "ructo#e-enric$ed diet.

A!d! SP/ @!t# @/ %%ini / Gro er J*.

+ep!rt%ent o" P$!r%!co o& / Indi! In#titute o" edic! Science#/ n#!ri

N!&!r/ Ne7 +e $i 110049/ Indi!.

,r!##ic! unce! (,J; Bindi n!%e: !i) #eed# !nd urr! ! oeni&ii ( *; =n& i#$ n!%e#: urr e! e#) e! e#/ u#ed !#"ood in&redient# !nd ! #o ' di!'etic# in Indi!/ 7ere !##e##ed in ! "ructo#e-%edi!ted non-&enetic %ode o" in#u inre#i#t!nce. Feedin& o" "ructo#e ric$ diet "or 30 d! # re#u ted in ri#e in ' ood & uco#e ' 29.4H/ in#u in ' 101.2H !nd

c$o e#tero ' 26. H indic!tin& de e op%ent o" in#u in re#i#t!nce. Bo7e er/ "eedin& o" ! "ructo#e diet cont!inin& 10H,r!##ic! unce! #eed# po7der "or 30 d! # #i&ni"ic!nt decre!#ed "!#tin& #eru% & uco#e/ in#u in !nd c$o e#tero e e # 'ut did not nor%! i e t$e%. En t$e ot$er $!nd/ ! diet cont!inin& 15H urr! ! oeni&ii e! e# po7der "!i ed to e8ert!n e""ect on t$e#e p!r!%eter#. e#u t# o" t$e pre#ent #tud #u&&e#t# t$!t ,J c!n p ! ! ro e in %!n!&e%ent o" pre-di!'etic #t!te o" in#u in re#i#t!nce !nd #$ou d 'e pro%oted "or u#e in p!tient# prone to di!'ete#.

Pu' ic!tion pe#:

o%p!r!ti e Stud

P I+: 151 2915 <Pu' ed - inde8ed "or =+>IN=?

• J =t$nop$!r%!co . 2002 Jun; 1(1): 1-100.

edicin! p !nt# o" Indi! 7it$ !nti-di!'etic potenti! .

Gro er J*/ A!d! S/ @!t# @.

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+ep!rt%ent o" P$!r%!co o& / Indi! In#titute o" edic! Science#/ n#!ri

N!&!r/ Ne7 +e $i-110049/ Indi!. &ro erD$ot%!i .co%

Since !ncient ti%e#/ p !nt# $! e 'een !n e8e%p !r #ource o" %edicine. ur ed! !nd ot$er Indi!n iter!ture %entiont$e u#e o" p !nt# in tre!t%ent o" !riou# $u%!n !i %ent#. Indi! $!# !'out 45000 p !nt #pecie# !nd !%on& t$e%/ #e er!t$ou#!nd# $! e 'een c !i%ed to po##e## %edicin! propertie#. e#e!rc$ conducted in !#t "e7 dec!de# on p !nt#%entioned in !ncient iter!ture or u#ed tr!dition! "or di!'ete# $! e #$o7n !nti-di!'etic propert . $e pre#ent p!perre ie7# 45 #uc$ p !nt# !nd t$eir product# (!cti e/ n!tur! princip e# !nd crude e8tr!ct#) t$!t $! e 'een %entioned u#edin t$e Indi!n tr!dition! # #te% o" %edicine !nd $! e #$o7n e8peri%ent! or c inic! !nti-di!'etic !cti it . Indi!n

p !nt# 7$ic$ !re %o#t e""ecti e !nd t$e %o#t co%%on #tudied in re !tion to di!'ete# !nd t$eir co%p ic!tion# !re:iu% cep!/ iu% #!ti u%/ oe er!/ ! !nu# c! !n/ occini! indic!/ !e#! pini! 'onduce !/ Ficu# 'en&! ene#i#/

G %ne%! # e#tre/ o%ordic! c$!r!nti!/ Eci%u% #!nctu%/ Pteroc!rpu# %!r#upiu%/ S7erti! c$ir! it!/ S i&iu%cu%ini/ ino#por! cordi"o i! !nd ri&one ! "oenu% &r!ecu%. %on& t$e#e 7e $! e e ! u!ted . c$!r!nti!/ =u&eni!

!%'o !n!/ ucun! prurien#/ . cordi"o i!/ . "oenu% &r!ecu%/ E. #!nctu%/ P. %!r#upiu%/ urr! ! oein&ii !nd,r!##ic! unce!. p !nt# $! e #$o7n !r in& de&ree o" $ po& ce%ic !nd !nti-$ per& ce%ic !cti it .

Pu' ic!tion pe#:

e ie7

P I+: 12020931 <Pu' ed - inde8ed "or =+>IN=?

• Indi!n J ,ioc$e% ,iop$ #. 1995 pr;32(2):106- .

B po& ce%ic !ction o" urr! ! oeni&ii (curr e!") !nd ,r!##ic! unce! (%u#t!rd): %ec$!ni#% o" !ction.

*$!n , / 'r!$!% / >ee !%%! S.

+ep!rt%ent o" ,ioc$e%i#tr / Cni er#it o" *er! !/ *!ri! !tto%/ ri !ndru%.

=""ect o" urr! ! oeni&ii !nd ,r!##ic! unce! on c!r'o$ dr!te %et!'o i#% $!# 'een #tudied u#in& r!t# !#e8peri%ent! !ni%! #. ,ot$ #$o7ed #i&ni"ic!nt $ po& ce%ic !ction. $ere 7!# incre!#e in t$e concentr!tion o"$ep!tic & co&en !nd & co&ene#i#/ !# e ident "ro% t$e incre!#ed !cti it o" & co&en # nt$et!#e/ !nd decre!#e in& co&eno #i# !nd & uconeo&ene#i# !# e ident "ro% t$e decre!#ed !cti it o" & co&en p$o#p$or !#e !nd& uconeo&enic en %e#.

P I+: 642200 <Pu' ed - inde8ed "or =+>IN=?

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