Ethylene Oxide

001081

Synthetic/Analytical chemistry.

4/19/2012.

Material Safety Data Sheet

Product name

AIRGAS INC., on behalf of its subsidiaries259 North Radnor-Chester RoadSuite 100Radnor, PA 19087-52831-610-687-5253

Product use

MSDS #

Date ofPreparation/Revision

In case of emergency

Section 1. Chemical product and company identification

Ethylene Oxide

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Supplier

1-866-734-3438

Synonym : Oxirane; Dihydrooxirene; Dimethylene oxide; Epoxyethane; Ethene oxide; ETO;Oxacyclopropane; Oxane; Oxidoethane; Oxirene, Dihydro-; Oxyfume; Oxyfume 12; T-Gas; 1,2-Epoxyethane; Aethylenoxid; Amprolene; Anprolene; Anproline; ENT-26263;E.O.; 1,2-Epoxyaethan; Ethox; Ethyleenoxide; Etylenu tlenek; FEMA No. 2433; Merpol;NCI-C50088; α,β-Oxidoethane; Oxiraan; Oxiran; Rcra waste number U115; Sterilizinggas ethylene oxide 100%; UN 1040; C2H4O; Qazi-ketcham

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Inhalation Dermal Eyes

Emergency overview

Section 2. Hazards identification

Routes of entry

Potential acute health effects

Toxic by inhalation.

Severely irritating to eyes. Risk of serious damage to eyes. Contact with rapidlyexpanding gas may cause burns or frostbite.

Ingestion is not a normal route of exposure for gases

Severely irritating to the skin. Contact with rapidly expanding gas may cause burns orfrostbite.

Eyes

Skin

Inhalation

Ingestion

Physical state Gas. [COLORLESS GAS AT ROOM TEMP. MOBILE LIQUID BELOW BOILING POINT.HAS A SWEET ODOR]

WARNING!

FLAMMABLE GAS.MAY CAUSE FLASH FIRE.HARMFUL IF INHALED OR SWALLOWED.MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL DATA.CANCER HAZARD - CAN CAUSE CANCER.CAUSES SEVERE SKIN IRRITATION.CAUSES SEVERE EYE IRRITATION.CONTENTS UNDER PRESSURE.

Keep away from heat, sparks and flame. Do not puncture or incinerate container. Donot ingest. Avoid breathing gas. Avoid contact with eyes, skin and clothing. May causetarget organ damage, based on animal data. Risk of cancer depends on duration andlevel of exposure. Use only with adequate ventilation. Wash thoroughly after handling.Keep container closed.

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Contact with rapidly expanding gases can cause frostbite.

Target organs : May cause damage to the following organs: blood, kidneys, lungs, the reproductivesystem, liver, upper respiratory tract, skin, eyes, central nervous system (CNS).

Potential chronic health effects

Carcinogenicity : Can cause cancer. Risk of cancer depends on duration and level of exposure.

Target organs : May cause damage to the following organs: blood, kidneys, lungs, the reproductivesystem, liver, upper respiratory tract, skin, eyes, central nervous system (CNS).

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Ethylene Oxide

See toxicological information (Section 11)

Medical conditionsaggravated by over-exposure

Pre-existing disorders involving any target organs mentioned in this MSDS as being atrisk may be aggravated by over-exposure to this product.

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Ethylene Oxide 75-21-8 100 ACGIH TLV (United States, 1/2009).TWA: 1.8 mg/m³ 8 hour(s).

TWA: 1 ppm 8 hour(s).NIOSH REL (United States, 6/2009).

CEIL: 9 mg/m³ 10 minute(s). CEIL: 5 ppm TWA: 0.18 mg/m³ 10 hour(s). TWA: 0.1 ppm 10 hour(s).OSHA PEL (United States, 11/2006).

STEL: 5 ppm 15 minute(s). TWA: 1 ppm 8 hour(s).OSHA PEL 1989 (United States, 3/1989).

STEL: 5 ppm 15 minute(s). TWA: 1 ppm 8 hour(s).

Section 3. Composition, Information on IngredientsName % Volume Exposure limitsCAS number

As this product is a gas, refer to the inhalation section.

Check for and remove any contact lenses. Immediately flush eyes with plenty of waterfor at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medicalattention immediately.

In case of contact, immediately flush skin with plenty of water for at least 15 minuteswhile removing contaminated clothing and shoes. To avoid the risk of static dischargesand gas ignition, soak contaminated clothing thoroughly with water before removing it.Wash clothing before reuse. Clean shoes thoroughly before reuse. Get medicalattention immediately.

Move exposed person to fresh air. If not breathing, if breathing is irregular or ifrespiratory arrest occurs, provide artificial respiration or oxygen by trained personnel.Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attentionimmediately.

Section 4. First aid measures

Eye contact

Skin contact

Inhalation

Ingestion

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No action shall be taken involving any personal risk or without suitable training.If it is suspected that fumes are still present,the rescuer should wear an appropriate mask or self-contained breathing apparatus.It may be dangerous to the personproviding aid to give mouth-to-mouth resuscitation.

Frostbite : Try to warm up the frozen tissues and seek medical attention.

428.88°C (804°F)

Flammable.

Decomposition products may include the following materials:carbon dioxidecarbon monoxide

Open cup: -29.15°C (-20.5°F).

Lower: 3% Upper: 100%

In case of fire, use water spray (fog), foam or dry chemical.

Section 5. Fire-fighting measuresFlammability of the product

Auto-ignition temperature

Flash point

Flammable limits

Products of combustion

Fire-fighting media andinstructions

In case of fire, allow gas to burn if flow cannot be shut off immediately. Apply water froma safe distance to cool container and protect surrounding area. If involved in fire, shutoff flow immediately if it can be done without risk.

Contains gas under pressure. Flammable gas. In a fire or if heated, a pressureincrease will occur and the container may burst, with the risk of a subsequent explosion.

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Ethylene Oxide

Special protectiveequipment for fire-fighters

Fire-fighters should wear appropriate protective equipment and self-contained breathingapparatus (SCBA) with a full face-piece operated in positive pressure mode.

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Immediately contact emergency personnel. Keep unnecessary personnel away. Usesuitable protective equipment (section 8). Shut off gas supply if this can be done safely.Isolate area until gas has dispersed.

Immediately contact emergency personnel. Stop leak if without risk. Use spark-prooftools and explosion-proof equipment. Note: see section 1 for emergency contactinformation and section 13 for waste disposal.

Environmental precautions

Section 6. Accidental release measures

: Avoid dispersal of spilled material and runoff and contact with soil, waterways, drainsand sewers.

Personal precautions :

Methods for cleaning up :

Keep container in a cool, well-ventilated area. Keep container tightly closed and sealeduntil ready for use. Avoid all possible sources of ignition (spark or flame). Segregatefrom oxidizing materials. Cylinders should be stored upright, with valve protection cap inplace, and firmly secured to prevent falling or being knocked over. Cylinder temperaturesshould not exceed 52 °C (125 °F).

Use only with adequate ventilation. Use explosion-proof electrical (ventilating, lightingand material handling) equipment. Wash thoroughly after handling. High pressure gas.Do not puncture or incinerate container. Use equipment rated for cylinder pressure.Close valve after each use and when empty. Do not ingest. Keep container closed. Avoidcontact with skin and clothing. Avoid contact with eyes. Keep away from heat, sparksand flame. To avoid fire, eliminate ignition sources. Protect cylinders from physicaldamage; do not drag, roll, slide, or drop. Use a suitable hand truck for cylindermovement.

Section 7. Handling and storageHandling

Storage

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Use only with adequate ventilation. Use process enclosures, local exhaust ventilation orother engineering controls to keep worker exposure to airborne contaminants below anyrecommended or statutory limits. The engineering controls also need to keep gas, vaporor dust concentrations below any lower explosive limits. Use explosion-proof ventilationequipment.

Section 8. Exposure controls/personal protectionEngineering controls

Product name

Use a properly fitted, air-purifying or air-fed respirator complying with an approvedstandard if a risk assessment indicates this is necessary. Respirator selection must bebased on known or anticipated exposure levels, the hazards of the product and the safeworking limits of the selected respirator.

Safety eyewear complying with an approved standard should be used when a riskassessment indicates this is necessary to avoid exposure to liquid splashes, mists ordusts.

Personal protective equipment for the body should be selected based on the task beingperformed and the risks involved and should be approved by a specialist before handlingthis product.

Personal protection

Eyes

Skin

Respiratory

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Personal protection in caseof a large spill

: Self-contained breathing apparatus (SCBA) should be used to avoid inhalation of theproduct. Full chemical-resistant suit and self-contained breathing apparatus should beworn only by trained and authorized persons.

Chemical-resistant, impervious gloves complying with an approved standard should beworn at all times when handling chemical products if a risk assessment indicates this isnecessary.

Hands :

The applicable standards are (US) 29 CFR 1910.134 and (Canada) Z94.4-93

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Ethylene Oxide

ethylene oxide ACGIH TLV (United States, 1/2009).TWA: 1.8 mg/m³ 8 hour(s).

TWA: 1 ppm 8 hour(s).NIOSH REL (United States, 6/2009).

CEIL: 9 mg/m³ 10 minute(s). CEIL: 5 ppm TWA: 0.18 mg/m³ 10 hour(s). TWA: 0.1 ppm 10 hour(s).OSHA PEL (United States, 11/2006).

STEL: 5 ppm 15 minute(s). TWA: 1 ppm 8 hour(s).OSHA PEL 1989 (United States, 3/1989).

STEL: 5 ppm 15 minute(s). TWA: 1 ppm 8 hour(s).

Consult local authorities for acceptable exposure limits.

10.7°C (51.3°F)

-112.8°C (-171°F)

1.52 (Air = 1)

22 (psia)

195.9°C (384.6°F)

44.06 g/mole

Boiling/condensation point

Melting/freezing point

Section 9. Physical and chemical propertiesMolecular weight

Critical temperature

Vapor pressure

Vapor density

C2-H4-OMolecular formula

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Specific Volume (ft 3/lb) : 8.7719

Gas Density (lb/ft 3) : 0.114

The product is stable.

Extremely reactive or incompatible with the following materials: oxidizing materials.

Under normal conditions of storage and use, hazardous polymerization will not occur.

Under normal conditions of storage and use, hazardous decomposition products shouldnot be produced.

Section 10. Stability and reactivityStability and reactivity

Incompatibility with varioussubstances

Hazardous decompositionproducts

Hazardous polymerization

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Section 11. Toxicological informationToxicity data

IDLH : 800 ppm

ethylene oxide LD50 Oral Rat 72 mg/kg -LD50 Subcutaneous Rat 187 mg/kg -LDLo Unreported Rat 200 mg/kg -LC50 InhalationGas.

Rat 1460 ppm 4 hours

LC50 InhalationGas.

Mouse 836 ppm 4 hours

LC50 InhalationGas.

Rat 800 ppm 4 hours

LC50 InhalationGas.

Rat 800 ppm 4 hours

Product/ingredient name Result Species Dose Exposure

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Ethylene Oxide

Specific effects

Carcinogenic effects Can cause cancer. Risk of cancer depends on duration and level of exposure.

Mutagenic effects No known significant effects or critical hazards.

Reproduction toxicity No known significant effects or critical hazards.

Hazardous by the following route of exposure: of skin contact (irritant), of eye contact(irritant), of inhalation (lung irritant).

CARCINOGENIC EFFECTS: Classified 1 (Proven for humans.) by IARC, 1 (Known tobe human carcinogens.) by NTP, + (Proven.) by OSHA, + (Proven.) by NIOSH.Classified A2 (Suspected for humans.) by ACGIH, 2 (Suspected for humans.) byEuropean Union.MUTAGENIC EFFECTS: Classified 2 by European Union.May cause damage to the following organs: blood, kidneys, lungs, the reproductivesystem, liver, upper respiratory tract, skin, eyes, central nervous system (CNS).

Chronic effects on humans

Other toxic effects onhumans

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Section 12. Ecological information

Environmental fate : Not available.

Environmental hazards : No known significant effects or critical hazards.

Toxicity to the environment : Not available.

Aquatic ecotoxicity

Product/ingredient name Test SpeciesResult Exposureethylene oxide - Acute LC50 1000000

ug/L Marine waterCrustaceans -Brine shrimp -Artemia sp.

48 hours

- Acute LC50 >500000ug/L Marine water

Crustaceans -Brine shrimp -Artemia sp.

48 hours

- Acute LC50 490000 ug/LMarine water

Crustaceans -Brine shrimp -Artemia sp.

48 hours

- Acute LC50 300000 ug/LFresh water

Daphnia - Waterflea - Daphniamagna

48 hours

- Acute LC50 200000 to243000 ug/L Fresh water

Daphnia - Waterflea - Daphniamagna

48 hours

- Acute LC50 137000 to179000 ug/L Fresh water

Daphnia - Waterflea - Daphniamagna

48 hours

- Acute LC50 84000 to96000 ug/L Fresh water

Fish - Fatheadminnow -Pimephalespromelas

96 hours

:Products of degradation

Section 13. Disposal considerationsProduct removed from the cylinder must be disposed of in accordance with appropriate Federal, State, localregulation.Return cylinders with residual product to Airgas, Inc.Do not dispose of locally.

Section 14. Transport informationRegulatoryinformation

UN number Proper shippingname

Class Packing group Label Additionalinformation

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Ethylene Oxide

2.3 Reportablequantity10 lbs.(4.54 kg)

DOT Classification

TDG Classification 2.3

Ethylene Oxide

UN1040 Ethylene Oxide

UN1040

ExplosiveLimit andLimitedQuantityIndex0

ERAP Index500

PassengerCarrying ShipIndexForbidden

PassengerCarryingRoad or RailIndexForbidden

MexicoClassification

UN1040 Ethylene Oxide 2.3 -

Not applicable (gas).

Not applicable (gas).

Not applicable (gas).

“Refer to CFR 49 (or authority having jurisdiction) to determine the information required for shipment of theproduct.”

Section 15. Regulatory information

U.S. Federal regulations United States inventory (TSCA 8b): This material is listed or exempted.

Clean Water Act (CWA) 307: No products were found.

Clean Water Act (CWA) 311: No products were found.

Clean Air Act (CAA) 112 regulated flammable substances: No products were found.

Clean Air Act (CAA) 112 regulated toxic substances: ethylene oxide

SARA 302/304/311/312 extremely hazardous substances: ethylene oxideSARA 302/304 emergency planning and notification: ethylene oxideSARA 302/304/311/312 hazardous chemicals: ethylene oxideSARA 311/312 MSDS distribution - chemical inventory - hazard identification:ethylene oxide: Fire hazard, reactive, Sudden release of pressure, Immediate (acute)health hazard, Delayed (chronic) health hazard

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SARA 313

Form R - Reportingrequirements

Ethylene Oxide 75-21-8 100:

United States

Product name CAS number Concentration

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Connecticut Carcinogen Reporting: This material is not listed.Connecticut Hazardous Material Survey: This material is not listed.Florida substances: This material is not listed.Illinois Chemical Safety Act: This material is not listed.Illinois Toxic Substances Disclosure to Employee Act: This material is not listed.Louisiana Reporting: This material is not listed.Louisiana Spill: This material is not listed.Massachusetts Spill: This material is not listed.Massachusetts Substances: This material is listed.Michigan Critical Material: This material is not listed.Minnesota Hazardous Substances: This material is not listed.New Jersey Hazardous Substances: This material is listed.New Jersey Spill: This material is not listed.New Jersey Toxic Catastrophe Prevention Act: This material is listed.New York Acutely Hazardous Substances: This material is listed.New York Toxic Chemical Release Reporting: This material is not listed.Pennsylvania RTK Hazardous Substances: This material is listed.Rhode Island Hazardous Substances: This material is not listed.

WARNING: This product contains a chemical known to the State of California to causecancer and birth defects or other reproductive harm.

State regulations

CEPA Toxic substances: This material is listed.Canadian ARET: This material is not listed.Canadian NPRI: This material is listed.Alberta Designated Substances: This material is not listed.Ontario Designated Substances: This material is not listed.Quebec Designated Substances: This material is not listed.

WHMIS (Canada) Class A: Compressed gas.Class B-1: Flammable gas.Class D-1A: Material causing immediate and serious toxic effects (Very toxic).Class D-2A: Material causing other toxic effects (Very toxic).Class E: Corrosive materialClass F: Dangerously reactive material.

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Ethylene Oxide 75-21-8 100Supplier notification :

Canada

SARA 313 notifications must not be detached from the MSDS and any copying and redistribution of the MSDS shallinclude copying and redistribution of the notice attached to copies of the MSDS subsequently redistributed.

Ethylene Oxide Yes. Yes. Yes. Yes.

Ingredient name Cancer Reproductive No significant risklevel

Maximumacceptable dosagelevel

California Prop. 65 :

Section 16. Other information

FLAMMABLE GAS.MAY CAUSE FLASH FIRE.HARMFUL IF INHALED OR SWALLOWED.MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL DATA.CANCER HAZARD - CAN CAUSE CANCER.CAUSES SEVERE SKIN IRRITATION.CAUSES SEVERE EYE IRRITATION.CONTENTS UNDER PRESSURE.

Label requirements :

Label requirements : Class A: Compressed gas.Class B-1: Flammable gas.Class D-1A: Material causing immediate and serious toxic effects (Very toxic).Class D-2A: Material causing other toxic effects (Very toxic).Class E: Corrosive materialClass F: Dangerously reactive material.

United States

Canada

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Ethylene Oxide

Notice to reader

To the best of our knowledge, the information contained herein is accurate. However, neither the above-namedsupplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of theinformation contained herein.Final determination of suitability of any material is the sole responsibility of the user. All materials may presentunknown hazards and should be used with caution. Although certain hazards are described herein, we cannotguarantee that these are the only hazards that exist.

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National Fire ProtectionAssociation (U.S.A.)

Health

Special

Instability

Flammability:

Hazardous MaterialInformation System (U.S.A.)

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Flammability

Physical hazards

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