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Inpharma 1365 - 23 Nov 2002
■ Morphine-6-glucuronide* prevents postoperativepain as effectively as morphine, according to recentlyannounced results of a phase II clinical trial. 68patients undergoing hip replacement surgery receiveda single IV dose of either morphine-6-glucuronide 20mg/70kg at the induction of general anaesthesia (n =24), morphine-6-glucuronide 30 mg/70kg at the end ofsurgery (n = 20), or morphine 10 mg/70kg at the endof surgery. There were no significant between-groupdifferences in postoperative pain, as assessed by thepatient for 24 hours after the operation. Treatmentwith morphine-6-glucuronide, especially the higherdose, was associated with decreases in postoperativemorphine consumption, nausea and retching/vomiting,compared with morphine.* CeNeS Pharmaceuticals; phase II for postoperative pain
CeNeS Pharmaceuticals plc. CeNeS Announces Further Positive Results of itsPhase II Clinical Trials of Morphine-6-glucuronide (M6G). Media Release : 15Nov 2002. Available from: URL: http://www.cenes.co.uk 809015243
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Inpharma 23 Nov 2002 No. 13651173-8324/10/1365-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved