Monthly Healthcare Review August 2016 - BioEnterprise€¦ · orphan indications for fast to market regulatory strategy. 30.00 Cowen and Company, Jefferies, RBC Capital Markets The

Monthly Healthcare Review

August 2016

Company NameLast Financing

DateHQ Location Description

Last

Financing

Size

(Millions)

Lead Manager

Protagonist

Therapeutics (PTGX)

11-Aug-2016 Milpitas, CA Developer of peptide and peptidomimetic therapeutics. The company develops oral drugs

that offer a targeted therapy treatment paradigm in gastrointestinal diseases.

90.00 Barclays Capital,

BMO Capital

Markets, Leerink

Partners

Gemphire Therapeutics

(GEMP)

05-Aug-2016 Northville, MI Developer of novel drugs for the treatment of dyslipidemia. The company treats the unmet

need of patients with high cardiovascular and pancreatitis risk who are unable to reach

optimal LDL cholesterol or triglyceride levels with current therapies - initially targeting

orphan indications for fast to market regulatory strategy.

30.00 Cowen and

Company, Jefferies,

RBC Capital

Markets

The following table includes the medical devices, biotechnology, pharmaceuticals, and healthcare IPO pricings, filings and withdrawals announced over the previous month.

IPOs

Compiled by: Morgan Reape

Source: Pitchbook 1


August 2016

Company Name

Last

Financing

Date

HQ Location Round Description

Last

Financing

Size

(Millions)

Lead Investor(s)

Cernostics 31-Aug-16 Pittsburgh, PA Later Stage VC Developer of technologies for cancer diagnosis. The company utilizes a

proprietary technology platform for deep interrogation of tissue biopsies,

quantitatively evaluating molecular and cellular changes that precede

structural changes within tissues.

1.30 Undisclosed

Zillion Group 30-Aug-16 Norwalk, CT Later Stage VC Operator of a health technology platform. The company provides weight

loss and related disease prevention programs online.

28.14 TwinFocus Capital

Partners

SHYFT Analytics 30-Aug-16 Waltham, MA Later Stage VC Provider of cloud-based data, analytics and mobile services for the global

life sciences industry. The company offers analytical insights in order to

provide new ways to commercialize drugs and measure patient outcomes.

12.50 McKesson

Ventures, Medidata

Solutions

Renovion 30-Aug-16 Chapel Hill, NC Angel Developer of a therapy for patients that have received a bilateral lung

transplant and suffer from chronic inflammatory airway diseases.

0.47 Undisclosed

Relievant Medsystems 30-Aug-16 Redwood City, CA Later Stage VC Developer of percutaneous radiofrequency procedure for the treatment of

axial low back pain. The company develops an invasive technology that

uses radiofrequency energy delivered through a small access tube into the

vertebral body to ablate basivertebral nerve.

22.16 Undisclosed

Bio2 Medical 30-Aug-16 San Antonio, TX Later Stage VC Developer of a catheter-based inferior vena cava filter for the prevention

of pulmonary embolism in critical care patients.

20.00 Oxford Finance,

other undisclosed

CBT Pharmaceuticals 29-Aug-16 Santa Clara, CA Early Stage VC Developer and provider of oncology therapeutics targeting the growth and

proliferation of cancer cells.

9.75 OrbiMed Advisors

Branchpoint

Technologies

29-Aug-16 Irvine, CA Early Stage VC The company focuses on improving neurological treatment through access

to intracranial pressure measurements using platforms employing precision

semiconductor gauges.

1.50 Undisclosed

Arcus Biosciences 29-Aug-16 Hayward, CA Early Stage VC The company is building a portfolio of immune-focused cancer therapies

that target one or more therapeutic nodes and discover drugs that block

tumors' ability to highjack the immune system.

70.00 GV

Mitra Biotech 28-Aug-16 Woburn, MA Later Stage VC The company focuses on personalized cancer care and rational drug

development and enables physicians to make an informed treatment

decision for a cancer patient by determining an optimal drug combination.

27.40 Sequoia India, Sands

Capital Ventures

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced

over the previous month.


Source: Pitchbook 2


August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



WinProbe 26-Aug-16 Palm Beach

Gardens, FL

Angel Designer and manufacturer of medical diagnostic ultrasound systems for

clinical applications and research.

0.32 Undisclosed

VytronUS 26-Aug-16 Sunnyvale, CA Later Stage VC Manufacturer of a device used to treat cardiac arrhythmia using both

imaging capabilities and ultrasound energy.

59.00 Apple Tree

Swift Health Systems 26-Aug-16 Riverside, CA Angel Developer of a orthodontic device combining the effectiveness of

conventional braces, the aesthetics of lingual braces and the comfort and

ease of invisalign all in a single appliance.

5.60 Undisclosed

Pinteon Therapeutics 26-Aug-16 Concord, MA Early Stage VC Developer of cancer therapeutics targeting a cis-trans isomerase. The

company is focused on the discovery and development of therapeutics

targeting Pin1 and related targets. Pin1 acts as a central regulator in cancer

development and growth as well as a number of other disease areas,

including CNS and autoimmune disease.

3.94 Morningside

Technology

Ventures

Nexgenia 26-Aug-16 Seattle, WA Early Stage VC Developer of polymer-based nanotechnology for diagnostics and life

science applications. The company develops and validates nanoparticles

and co-aggregates them for cell separation for use in cancer

immunotherapies and other medical applications.

2.00 W Fund

Inscopix 26-Aug-16 Palo Alto, CA Early Stage VC Provider of cellular imaging technologies. The company caters to the

healthcare industry and offers miniature fluorescence microscopes to

understand the brain and its diseases.

10.00 Playground Global

Thorasys 25-Aug-16 Montreal, Canada Angel Provider and developer of pulmonary function test equipment for the

diagnosis and monitoring of lung diseases, such as asthma and chronic

obstructive pulmonary disease, using the forced oscillation technique.

1.30 Anges Québec

Sanoculis 25-Aug-16 Ono, Israel Early Stage VC Developer and provider of a minimally invasive micro sclerostomy

technique for the treatment of glaucoma.

Undisclosed Undisclosed

Mint Solutions 25-Aug-16 Amsterdam,

Netherlands

Later Stage VC Developer of a technology for medication and patient safety in hospitals

and other healthcare institutions. The company's primary product helps

nurses verify and document all medication for patients to ensure that

patients receive the right medication in the proper dose and time.

5.62 BOM Capital, Life

Sciences Partners,

Seventure Partners


Source: Pitchbook 3


August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Harborside Health

Center

25-Aug-16 Oakland, CA Angel Provider of medical cannabis dispensary services. Undisclosed Anthos Ventures

Gobiquity 25-Aug-16 Scottsdale, AZ Later Stage VC Provider of a mobile application for the early detection and tracking of eye

diseases. It enables users to perform tests at home or in primary care

settings using mobile computing platforms.

6.00 InterWest Partners

Four Eyes Insight 25-Aug-16 London, United

Kingdom

PE Growth/

Expansion

Provider of clinical consulting services. The company helps healthcare

providers with medical workforce plans, business opportunity

development plans, market modeling and workflow management

techniques.

Undisclosed Livingbridge

DoseMe 25-Aug-16 Brisbane, Australia Angel Provider of a prevision dosing software that allows clinicians to dose a

specific amount of a drug based upon that patient's individual ability to

absorb, process and clear it.

2.60 Greg Spurgin, Gary

Cunningham

Safe N' Simple 24-Aug-16 Clarkston, MI Angel Developer and marketer of medical product accessories for the ostomy

care market, such as alcohol free adhesive removers, silver alginate

dressings kits and ostomy deodorant.

1.40 Undisclosed

Rivanna Medical 24-Aug-16 Charlottesville, VA Early Stage VC Developer of a medical imaging device based on medical ultrasound. The

company has developed Accuro, an imaging product for spinal anesthesia

guidance and diagnostic imaging of the cardiac and abdominal anatomies.

3.00 Undisclosed

MBio Diagnostics 24-Aug-16 Boulder, CO Later Stage VC The company provides testing systems that enable diagnosis of multiple

diseases and develops analyzers and disposable cartridges for clinical and

analytical testing applications.

0.56 Undisclosed

Eyenovia 24-Aug-16 Tampa, FL Early Stage VC Provider of an ophthalmic microdrops technology. The company offers

eye-care formulations for glaucoma, allergic eye disease, dry eye and other

eye diseases.

4.04 Undisclosed

Elemeno Health 24-Aug-16 Alameda, CA Accelerator/

Incubator

Provider of a healthcare information platform that engages frontline

healthcare staff in generating, learning and adhering to healthcare and

medical practices.

0.12 Y Combinator


Source: Pitchbook 4


August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



ClearCare 24-Aug-16 San Francisco, CA Later Stage VC Provider of a Web and mobile platform for administration of home-care

agencies. The company provides a front-end and back-end system for the

management of home-care agencies, including scheduling, integrated

telephony, two-way caregiver messaging and marketing.

60.00 Battery Ventures

ArunA 24-Aug-16 Athens, GA Later Stage VC Provider of a cell-based bio-sensor platform for the treatment of neural

diseases. The company develops stem cell research products and services

to support scientists engaged in drug discovery and development.

1.16 Undisclosed

Theraworx 23-Aug-16 Asheville, NC Later Stage VC Provider of therapeutic skin care products. The company manufactures

products that include specialty care packs for peri-care prior to foley

catheter insertion and on-going foley maintenance.

21.21 Undisclosed

Recombinetics 23-Aug-16 St. Paul, MN Later Stage VC Developer of gene editing technologies. The company manipulates the

DNA sample to add and activate genes to solve problems in biomedical

research, livestock productivity and animal-derived biomaterials for use in

medical applications.

6.29 Undisclosed

PatientBank 23-Aug-16 New Haven, CT Accelerator/

Incubator

Developer of an online medical platform. The company's software allows

users and patients to share medical records with hospitals, doctors and

family members for the purpose of heath checkups.

0.12 Y Combinator

MOM Incubators 23-Aug-16 London, United

Kingdom

Seed Round Manufacturer of an electronically controlled, inflatable incubator for

babies. The company offers portable inflatable incubators to decrease the

number of premature child deaths in developing countries.

0.90 MaSa Partners

InDemand Interpreting 23-Aug-16 Wenatchee, WA PE

Growth/Expa

nsion

Provider of video remote interpreting for limited English proficient and

deaf patients through WiFi, mobile broadband or LAN channels that can

be delivered to the patient bedside. It provides the translations with its

staff of certified interpreters.

5.85 Undisclosed

HIL Applied Medical 23-Aug-16 Jerusalem, Israel Later Stage VC Developer of a new class of ultra-compact cancer proton therapy systems

using a patented approach, combining nanotechnology with high-intensity

lasers and ultra-fast magnets.

Undisclosed Ion Beam

Applications,

OurCrowd


Source: Pitchbook 5


August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Health2Sync 23-Aug-16 Taipei, Taiwan Early Stage VC Provider of a comprehensive health management platform. The company

develops systems that transform smartphones into legacy medical devices

and smart health monitoring machines, enabling patients to connect with

family, friends and health providers who want to care for them.

3.00 WI Harper Group

Clear Guide Medical 23-Aug-16 Baltimore, MD Later Stage VC Provider of ultrasound-guided medical devices and disposables. The

company's approach to interventional image guidance reduces the

footprint, simplifies the workflow and reduces the cost of ultrasound-

guided interventions.

1.18 Undisclosed

Affinity Biosensors 23-Aug-16 Santa Barbara, CA Angel Developer of particle metrology systems. The company develops analytical

instruments for use in research, manufacturing and life sciences based on

the company's Resonant Mass Measurement device.

7.08 Undisclosed

Vyome 22-Aug-16 Delhi, India Later Stage VC Developer of novel drugs for antibiotics-resistant acne, pathogens and

antifungal agents in dermatology through a unique pipeline of antibiotics

that retard resistance development.

14.00 Perceptive Advisors,

Romulus Capital

Singlera Genomics 22-Aug-16 La Jolla, CA Early Stage VC Provider of a non-invasive genetic testing for tumor diagnosis. It also

provides a non-invasive prenatal diagnosis, pre-implantation genetic

screening and other genetic disease diagnosis.

20.00 Lilly Asia Ventures

Klara Technologies 22-Aug-16 New York, NY Early Stage VC Provider of a HIPAA-compliant medical messaging platform that allows

practices to centralize medical communication.

3.04 Project A Ventures

Amylyx Pharmaceuticals 22-Aug-16 Cambridge, MA Early Stage VC Developer of therapeutics for Amyotrophic Lateral Sclerosis (ALS) and

other neurodegenerative diseases. The company is developing disease-

modifying therapeutics for neuro-degenerative diseases that target the

neuro-inflammation and nerve cell death that characterize these disorders.

5.00 Morningside

Ventures


Source: Pitchbook 6


August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Allied-Bristol Life

Sciences

22-Aug-16 Boston, MA PE

Growth/Expa

nsion

The company works with university partners to develop novel therapeutic

treatments. It provides access to a fully integrated drug discovery center,

financial backing and project management. Its therapeutic areas of interest

include cardiovascular diseases, fibrosis, genetically defined diseases,

immunology and oncology.

15.00 Allied Minds, Bristol-

Myers Squibb,

Woodford

Investment

Management,

Invesco

Vesselon 19-Aug-16 Norwalk, CT Angel Developer of a medical device that works as an automated external

defibrillator during a stroke.

0.33 Undisclosed

Element Science 19-Aug-16 San Francisco, CA Early Stage VC Developer of wearable medical devices for sudden cardiac death treatment

and other life-saving therapies.

25.00 Undisclosed

Aridis Pharmaceuticals 19-Aug-16 San Jose, CA Angel Developer of drugs to treat infectious diseases and pneumonia. 15.22 Undisclosed

Nutrinia 18-Aug-16 Ramat-Gan, Israel Later Stage VC Developer of a proprietary oral formulation of insulin for the treatment of

intestinal failure and gastrointestinal diseases in infants.

30.00 TPG Biotech

HemoSonics 18-Aug-16 Charlottesville, VA Angel Developer of a point-of-care diagnostic platform. The company's platform

offers actionable information to guide the management of critical bleeding

and clotting.

7.63 Undisclosed

Avelas Biosciences 18-Aug-16 La Jolla, CA Later Stage VC Developer of fluorescent technologies for cancer surgery. The company's

technology allows real time diagnosis of metastatic nodes using proprietary

platform technology of activatable cell-penetrating peptides.

20.00 Pharmstandard

Webbhälsa 17-Aug-16 Stockholm, Sweden Seed Round Provider of digital medical care services. The company operates a medical

center and employs medical professionals to provide consultations.

6.86 Index Ventures,

Creandum

Wasatch Microfluidics 17-Aug-16 Salt Lake City, UT Later Stage VC Provider of a label free biomolecular interaction analysis platform. The

company develops and commercializes novel microarray deposition

technologies that enables multiplexing on planar array surfaces and offers

the Continuous Flow Microspotter, which includes an array printing

instrument and a microfluidic print head.

10.30 Undisclosed

VUV Analytics 17-Aug-16 Cedar Park, TX Later Stage VC Developer of vacuum ultraviolet spectroscopy instruments for use in

various industries, including pharmaceuticals.

6.50 New Science

Ventures


Source: Pitchbook 7


August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Strong Arm

Technologies

17-Aug-16 Brooklyn, NY Early Stage VC Manufacturer of a lift assist device for nurses and caregivers

who perform patient lift assistance.

4.20 3M, Newark

Venture Partners

Standard Bariatrics 17-Aug-16 Cincinnati, OH Seed Round Manufacturer of surgical devices and instruments for weight loss

procedures. The company has developed a reusable device to help

surgeons standardize sleeve gastrectomy.

Undisclosed Queen City Angels

INRange Systems 17-Aug-16 Altoona, PA Later Stage VC Developer of remote medication management systems. The company

offers EMMA, a telehealth medical device for documented and

professional medication administration to outpatients.

1.43 Undisclosed

Enable Injections 17-Aug-16 Cincinnati, OH Later Stage VC Developer, designer and seller of disposable body-worn devices that allows

patients self-administration of viscosity drugs in development for the

treatment of cancer, autoimmune diseases, genetic and rare diseases.

5.25 CincyTech USA,

Cincinnati

Children's Hospital

Medical Center,

other undisclosed

Concentric Analgesics 17-Aug-16 San Francisco, CA Angel Developer of therapeutics for the management of postoperative pain. The

company focuses on developing novel small molecules that provide pain

relief after a single administration during surgery.

5.98 Undisclosed

Tioma Therapeutics 16-Aug-16 Brisbane, CA Later Stage VC Developer of therapeutic antibodies. The company is developing a

portfolio of anti-CD47ies for the treatment of cancer and pulmonary

hypertension, the prevention of certain complications of solid organ

transplantation and other important medical applications.

86.00 RiverVest Venture

Partners, Novo

Ventures, Roche

Venture Fund, SR

One

ProteoMediX 16-Aug-16 Schlieren,

Switzerland

Later Stage VC Developer of diagnostic biomarkers in order to early detect and define the

stage of the cancer. The company engages in the delivery of prognostic

tools for the discrimination of aggressive and indolent cancers. It enables

personalized medicine by developing stratification biomarkers to match

patients with therapies that are more likely to be safe and effective.

5.16 Altos Venture


Source: Pitchbook 8


August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Progenity 16-Aug-16 San Diego, CA Early Stage VC Provider of genetic carrier screening and prenatal diagnostic services. The

company provides molecular testing services for cystic fibrosis, spinal

muscular atrophy, fragile X syndrome and genetic carrier screening.

12.00 Undisclosed

Millipede 16-Aug-16 Santa Rosa, CA Early Stage VC Developer of a percutaneous device used for mitral valve repairs in the

heart.

6.21 Undisclosed

Confluent Medical

Technologies

16-Aug-16 Fremont, CA PE Growth/

Expansion

Manufacturer of Nitinol-based components, balloon components and

balloon catheters.

55.74 Undisclosed

Brain Shake 16-Aug-16 Finland Early Stage VC Provider of a blood testing device which can be used to detect metabolic

biomarkers for chronic diseases.

3.93 Nordea Fonder,

Finnvera, Cor

Group

Live Better With 15-Aug-16 London, United

Kingdom

Seed Round Provider of an online platform for healthcare products. The company

operates a marketplace for healthcare, home aid and wellness products and

technologies for patients with long-term conditions.

2.00 Find Invest Grow

Breethe 15-Aug-16 Baltimore, MD Seed Round Developer of wearable artificial lungs that help in respiratory conditions

and fitness management.

2.17 Undisclosed

Bloom Technologies 15-Aug-16 San Francisco, CA Seed Round Developer of a wearable device for expectant mothers to track

contractions. The company's device acts as a personalized pregnancy coach

that measures frequency, duration and intensity of contractions.

4.00 Marc Benioff,

Efficient Capacity

Aseptium 15-Aug-16 Essex, United

Kingdom

Angel Provider of infection control technologies for decontamination of surgical

instruments. The company develops equipment, processes and systems for

cleaning, disinfection and sterilization of surgical instruments and other

medical equipment.

0.81 Seedrs

Metabolon 12-Aug-16 Durham, NC Later Stage VC Developer of metabolics-based diagnostic testing and research services.

The company is the developer of a biochemical biomarker discovery and

profiling platform with a pipeline of laboratory-developed tests for obesity-

related conditions and cancer.

15.00 Essex Woodlands

ILiAD Biotechnologies 12-Aug-16 New York, NY Angel Provider of a technology to prevent bordetella pertussis. The company is

focused on the eradication of whooping cough by developing an improved

pertussis vaccine.

1.50 Undisclosed


Source: Pitchbook 9


August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



CTMG 12-Aug-16 Greenville, NC Later Stage VC Provider of clinical trial management services for private practice

physicians. The company specializes in assisting in investigative site

performance across a wide range of therapeutic areas while conducting

clinical trials.

2.37 Undisclosed

Zurex Pharma 11-Aug-16 Middleton, WI Later Stage VC Developer of anti-microbial products to reduce the risks associated with

surgical site infections and catheter-related bloodstream infections.

6.24 Undisclosed

OrthoSensor 11-Aug-16 Dania Beach, FL Later Stage VC Developer of orthopedic implants and sensor-assisted surgery systems.

The company offers a disposable sensor-assisted knee arthroplasty

instrument which can detect and monitor various functions in the

musculoskeletal system.

0.97 Undisclosed

Oculis Pharma 11-Aug-16 Reykjavik, Iceland Later Stage VC Provider of ophthalmic drugs and novel drug delivery to facilitate drug

absorption to both anterior and posterior parts of the eye for treatment of

diabetic macular edema.


JenaValve Technology 11-Aug-16 Munich, Germany Later Stage VC Manufacturer of second generation transcatheter aortic valve implantation

systems for transapical and transfemoral implantation.

10.00 Undisclosed

Biosceptre International 11-Aug-16 Cambridge, United

Kingdom

Angel Developer of antibody technologies to address applications in the

diagnosis and treatment of cancer.

1.66 Undisclosed

Atomo Diagnostics 11-Aug-16 Sydney, Australia Later Stage VC Manufacturer of medical devices used for early detection and ongoing

treatment of infectious and chronic diseases.

3.33 Global Health

Investment Fund,

Allan Moss, other

undisclosed

WiserCare 10-Aug-16 Los Angeles, CA Early Stage VC Provider of a healthcare decision making platform. The company provides

personalized reports that include evidence-based treatment options,

medical records, personal values, preferences regarding patients' treatment

options and details to patients about the success rates of each treatment

and its associated side effects.

2.66 Vidinovo, other

undisclosed


Source: Pitchbook 10


August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Moderna 10-Aug-16 Cambridge, MA Later Stage VC Developer of messenger RNA therapies. The company is developing an in

vivo drug modality platform that produces human proteins or antibodies

inside patient cells, which are in turn secreted or active intracellularly. The

platform is designed to address currently undruggable targets and to offer

an alternative to existing drug modalities for inherited genetic disorders,

hemophilic and blood factors and oncology.

451.37 AstraZeneca, other

undisclosed

Koniku 10-Aug-16 Newark, CA Angel Developer of an organic neurocomputation platform. The company helps

to improve clinical trial success rates for new drug therapies by delivering

organ-on-chip and brain-on-chip preclinical testing services.

1.40 Undisclosed

IngagePatient 10-Aug-16 Gainesville, FL Later Stage VC Provider of cloud-based tools that allow patients to schedule and register

for their doctor's appointment online. The company offers online patient

registration, insurance verification, email, text and voice appointment

reminders and electronic patient referrals. It also offers a patient portal

with patient-to-provider messaging, online appointment requests and

prescription refill requests.

3.67 Undisclosed

Femasys 10-Aug-16 Suwanee, GA Later Stage VC Developer of medical devices for cancer diagnosis, infertility and

permanent contraception in women.

3.30 Undisclosed

Cytocentrics 10-Aug-16 San Antonio, TX Later Stage VC Developer of an automated patch clamp technology platform. The

company develops technology that allows the study of single or multiple

ion channels in cells, automated patch clamp systems, ion channel cell

lines, patch clamp reagents and in-house patch clamp screening services.

15.82 Undisclosed

Cornovus

Pharmaceuticals

10-Aug-16 Farmington, CT Early Stage VC Developer of methods to treat cardiac hypertrophy and heart failure. The

company develops a technology that helps to delay the onset of heart

failure after a heart attack or injury.

0.98 Undisclosed




August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Teckro 9-Aug-16 Limerick, Ireland Early Stage VC Developer of a software platform to streamline the process of clinical

trials. The company partners with pharmaceutical companies and research

institutions to simplify the clinical development process by using

information retrieval and machine learning technologies to improve the

speed and accuracy of trial conduct.

6.00 Founders Fund

Sonavex 9-Aug-16 Baltimore, MD Early Stage VC Developer of imaging technology to visualize and quantify critical data to

detect anastomotic blood clots. The company develops patent pending

primary technology that enables clinicians to measure critical intravascular

flow metrics to detect post-operative clots prior to morbid and expensive

surgical failures.

2.50 Grey Sky Venture

Partners, other

undisclosed

Iconic Therapeutics 9-Aug-16 South San

Francisco, CA

Later Stage VC Developer of immunoconjugate proteins for the treatment of retinal

diseases and cancer. The company develops proprietary I-cons, proteins

that trigger the immune system to target and destroy unwanted cells in the

body.

48.50 Xeraya Capital,

HBM Healthcare

Investments,

Cormorant Asset

Management

EyeKor 9-Aug-16 Madison, WI Angel Developer of a software for managing clinical trials of therapeutics for

ocular diseases. The company's software specializes in clinical trials

imaging expertise, reading centers with expertise across a range of ocular

testing, consultants in clinical trial design, ophthalmic data reading and

interpretation, as well as site-training, certification and monitoring.

0.60 Undisclosed

C-SATS 9-Aug-16 Seattle, WA Early Stage VC Developer of a performance management system in the field of healthcare. 3.20 SpringRock

Ventures, other

undisclosed

CoNextions Medical 9-Aug-16 Sandy, UT Angel Producer of medical devices to improve tendon repair outcomes. The

company's devices allow for faster rehabilitation, fewer complications, and

lower long-term costs.

2.70 Undisclosed

CareSkore 9-Aug-16 Mountain View, CA Seed Round Developer of a platform that offers patient management services, cost

optimization services, workflow management and automated patient

outreach services.

4.30 Cota Capital, Storm

Ventures, Rising

Tide Fund




August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



AVM Biotechnology 9-Aug-16 Seattle, WA Later Stage VC Developer of stem cell-enabling technologies for unmet medical needs in

regenerative medicine, G-CSF induced stem cell mobilization, GvHD,

germinal center lymphomas, and iPS cell lines fully human biologics,

including patient-specific biologics for personalized medicine in orphan

diseases.

2.84 Undisclosed

Auris Surgical Robotics 9-Aug-16 San Carlos, CA Later Stage VC Developer of surgical robotics and visualization technology for surgical

applications that require very fine movements.

49.03 Undisclosed

Alafair Biosciences 9-Aug-16 Austin, TX Early Stage VC Developer of anti-adhesive bio-materials for wound healing. 2.00 ATP Fund

Accolade 9-Aug-16 Plymouth Meeting,

PA

Later Stage VC Provider of consumer healthcare information services. The company

operates a healthcare engagement and influence platform for large self-

insured employers and payment organizations. Its goal is to assist

consumers in determining healthcare benefits and to find healthcare

providers.

70.00 Andreessen

Horowitz

PreViser 8-Aug-16 Mt. Vernon, WA Later Stage VC Provider of web enabled diagnostic and treatment planning decision

support software for dental clinicians. The company's software is used by

dentists, hygienists, periodontists, orthodontists and academic institutions

for the care of patients with oral disease.

2.00 Undisclosed

Fe3 Medical 8-Aug-16 San Antonio, TX Later Stage VC Developer of a novel transdermal patch for the treatment of anemia. The

company focuses on drug-delivery technologies enabling non-toxic

transport of iron across the skin.

14.50 Jianmin

Pharmaceuticals,

HG Capital, PingAn

Ventures

BioCurity 8-Aug-16 New Smyrna Beach,

FL

Angel Developer of a nanoparticle drug candidate to treat radiation-related

xerostomia and dermatitis.

0.31 Undisclosed

Appistry 8-Aug-16 St. Louis, MO Later Stage VC Provider of bioinformatics tools for the analysis of genomics data. The

company's platform provides performance computing and cloud

computing architectures to help clinical labs, research institutions and

hospitals to practice genomically enhanced medicine.

4.13 Undisclosed




August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Aligned TeleHealth 8-Aug-16 Agoura Hills, CA Later Stage VC Provider of telemedicine and healthcare management services. The

company offers full, end-to-end telemedicine services, including

psychiatric specialty physician consultations to acute-care hospitals,

emergency rooms, skilled nursing facilities, and correctional institutions via

telecommunication.

12.00 SV Life Sciences

Advisers

Miramar Labs 5-Aug-16 Santa Clara, CA Later Stage VC Manufacturer of electromechanical devices for cosmetic surgeries. 43.15 Aisling Capital,

other undisclosed

Forerun 5-Aug-16 Waltham, MA Later Stage VC Provider of clinical documentation services. The company develops a

digital platform that offers electronic charting services for the hospital

emergency department.

4.57 Undisclosed

CVRx 5-Aug-16 Minneapolis, MN Later Stage VC Developer of an implantable technology designed to trigger the body's

natural blood-flow regulation system for the treatment of high blood

pressure and heart failure.

113.00 Johnson & Johnson

Innovation, Oxford

Finance

Complion 5-Aug-16 Cleveland, OH Early Stage VC Provider of a Web application for managing regulatory documents of

physician sponsored clinical trials.

1.58 Undisclosed

Baker 5-Aug-16 Denver, CO Seed Round Provider of an engagement platform for cannabis dispensaries and brands.

The company has developed a customer engagement platform that

integrates personalized messaging and online shopping.

1.60 Michael Lazerow

Alodokter 5-Aug-16 Jakarta, Indonesia Early Stage VC Provider of an online health portal for content related to various viruses,

diseases and drugs.

2.50 Golden Gate

Ventures

Woundtech 4-Aug-16 Hollywood, FL Early Stage VC Provider of a telehealth based platform that offers wound management

technology that reduces and prevents diabetic foot ulcers.

40.00 Aldrich Capital

Partners

Tricog Health 4-Aug-16 Bangalore, India Later Stage VC Manufacturer of a cloud-connected device for heart diagnosis. The

company provides a real-time reporting of electrocardiography results

which enables users to detect heart attack.

2.08 Blume Ventures

Advisors, Inventus

Capital Partners,

other undisclosed




August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



ElationHealth 4-Aug-16 San Francisco, CA Later Stage VC Developer of an electronic health record system for physicians. The

company's patient care platform allows physicians to manage their practice

operations and administrative tasks.

15.00 Draper Fisher

Jurvetson

Dance Biopharm 4-Aug-16 Brisbane, CA PE Growth/

Expansion

Developer of inhaled insulin products. The company's product, Dance-

501, is a pocket-sized inhaler device and insulin container that is designed

to be used together to control prandial blood sugar in adults with diabetes

without the need for injections.

0.63 Aegis Capital

Group, other

undisclosed

Cellarian Health 4-Aug-16 The Woodlands,

TX

Angel Developer of a prescription analysis software. The company's software

enables visualization and analyzing of prescription drug data which helps

physicians and pharmacists in detecting and preventing drug abuse.

0.79 Undisclosed

Ambrx 4-Aug-16 La Jolla, CA PE Growth/

Expansion

Developer of protein-based drugs. The company has developed a platform

that combines site specific conjugation with proprietary linkers, payloads

and pharmacokinetic extenders to create a single molecular species.

45.00 Shanghai Fosun

Pharmaceutical

Company, Hopu

Investment

Management, China

Everbright,

Northeast Securities,

Apricot Capital,

Sinopharm Capital,

Humanwell

Healthcare Group

viihealth 3-Aug-16 Bethlehem, PA Angel Provider of tools and services that enable users to access personal health

information. The company designs online and mobile tools for people who

want simple, secure, and easily accessible solutions for managing their

health.

0.34 Undisclosed

Sequence Bio 3-Aug-16 St. John's, Canada Seed Round Provider of data and analytics services for drug discovery and patient care.

The company provides a platform with genomic and phenotypic data that

allows for therapeutic discovery and development.

3.00 Data Collective




August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Ornim 3-Aug-16 Foxboro, MA Later Stage VC Developer of medical devices for patient monitoring. The company

focuses on the development of non-invasive monitoring tools designed to

aid in cerebral oxygen-saturation assessment.

20.00 LongTec HongTao

China Ventures

Indigo Biosciences 3-Aug-16 State College, PA Later Stage VC Provider of preclinical contract research services for pharmaceutical

research and development, biotechnology and related sectors, along with

screening services for drug discovery and active ingredient determination.

0.50 Life Sciences

Greenhouse of

Central

Pennsylvania, Allied

Sciences

Greenhouse of

Central

Pennsylvania

Florence Healthcare 3-Aug-16 Atlanta, GA Seed Round Provider of workflow automation software for clinical trial sites. The

company provides a software that connects home healthcare data from

outside the clinic with the healthcare community.

1.70 Bee Partners

First Light Biosciences 3-Aug-16 Bedford, MA Early Stage VC Developer of diagnostic devices for DNA-based detection of infections

using digital imaging to detect and count fluorescent targets without using

magnification.

0.81 Undisclosed

EPIC Research &

Diagnostics

3-Aug-16 Scottsdale, AZ Angel Developer of a non-invasive electro-physiological assessment device to

analyze and recommend treatment for conditions and functions associated

with a general state of health.

0.22 Undisclosed

Tetra Discovery

Partners

2-Aug-16 Grand Rapids, MI Later Stage VC Developer of drugs for depression and other neurological conditions. The

company designs allosteric inhibitors of phosphodiesterase 4, an enzyme in

the brain that controls the biochemical process of memory research. It also

focuses on developing treatments for depression, mild cognitive

impairment and traumatic brain injury.

5.28 Grand Angels

Optikira 2-Aug-16 Cleveland, OH PE Growth/

Expansion

Developer of therapeutics to prevent blindness. Undisclosed Arix Bioscience,

other undisclosed




August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



OpenTempo 2-Aug-16 Williston, VT Angel Provider of a medical staff scheduling software. The company offers a

workforce management system that features real-time access to call, shift

and daily case schedules from any browser or mobile device.

1.25 Undisclosed

MedMinder Systems 2-Aug-16 Needham, MA Later Stage VC Provider of an automated wireless pill dispenser system to improve

medication adherence by reminding users of the time to take their

medication through flashes, beeps, text messages and phone calls.

0.50 Undisclosed

Kalytera Therapeutics 2-Aug-16 Manhattan Beach,

CA

Angel Developer of a portfolio of non-psychoactive cannabinoid and

cannabinoid-modulating medicines.

0.25 Undisclosed

iBeat 2-Aug-16 San Francisco, CA Seed Round Developer of a heart monitoring device. The company develops a

smartwatch which monitors heart rate activity and alerts the user, their

family and emergency responders upon detection of a life-threatening

condition.

1.50 Maveron,

Subtraction Capital,

Correlation

Ventures

Avrobio 2-Aug-16 Cambridge, MA Early Stage VC Developer of transformative and life-changing gene therapies for rare

diseases and cancer.

25.00 Atlas Venture,

Clarus Ventures, SV

Life Sciences

Siren (care) 1-Aug-16 Kongens Lyngby,

Denmark

Accelerator/

Incubator

Developer of textiles and apparel products to treat health diseases. The

company develops textiles with user-centric software to help them make

decisions about health, such as a sensor embedded sock that helps prevent

diabetic foot ulcers.

0.13 500 Startups

Rediscovery Life

Sciences

1-Aug-16 Charleston, SC Seed Round Developer of drugs to treat acute kidney diseases and other medical

conditions using repurposing innovation technology.

0.75 Undisclosed

PrimeGen Biotech 1-Aug-16 Santa Ana, CA Angel Provider of stem cell research services. The company engages in research

and therapeutic applications of adult stem cells for individualized patient

therapies and various other diseases and injuries including Alzheimer's

disease, cardiac disease, diabetes, lupus, multiple sclerosis, leukemia,

muscular dystrophy, Parkinson's disease and rheumatoid arthritis.

2.06 Undisclosed




August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Nonnatech 1-Aug-16 New York, NY Accelerator/

Incubator

Provider of remote monitoring services for continuous monitoring of

patients. The company's technology helps users in early detection of

physiological changes by utilizing its unobtrusive connected sensors,

predictive analytics and machine learning.

0.13 500 Startups

Nodthera 1-Aug-16 Edinburgh, United

Kingdom

Early Stage VC Developer of inhibitors for complex proteins. The company designs and

develops small molecule modulators of the NLRP3 inflammasome

complex for their clientele.

Undisclosed Epidarex Capital

Level Therapy 1-Aug-16 San Francisco, CA Accelerator/

Incubator

Developer of a medical application that provides patients with treatment

tools and access to behavioral health professionals.

0.13 500 Startups

G-Therapeutics 1-Aug-16 Ecublens,

Switzerland

Early Stage VC Developer of an implantable neuro-stimulation system to rehabilitate

patients suffering from neurological disorders, such as spinal cord injury.

40.47 Life Sciences

Partners, INKEF

Capital, Gimv,

Wellington Partners,

Rijksdienst voor

Ondernemend

Nederland

Deltalab 1-Aug-16 Rubí, Spain PE Growth/

Expansion

Producer of plastic and disposable laboratory products. The company

engages in the manufacture and distribution of labware products for use by

clinical, chemical and industrial laboratories as well as universities and

research centers.

Undisclosed Espiga Capital,

Talde Gestion

CancerIQ 1-Aug-16 Chicago, IL Seed Round Provider of a Web-based digital application for researchers and clinicians.

The company develops a big data application which helps patients and

physicians to identify risk factors caused due to cancer, genetics and other

oncological problems.


Bioniz 1-Aug-16 Irvine, CA Later Stage VC Developer of drugs for the treatment of autoimmune diseases and some

forms of cancer.

13.00 KGC Capital,

Takeda Ventures,

David Pyott




August 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Adient Medical 1-Aug-16 Pearland, TX Early Stage VC Developer of implantable, absorbable medical devices. The company is

developing the first absorbable IVC filter for the prevention of pulmonary

embolism.

1.80 Houston Health

Ventures, Texas

Halo Fund, Green

Park & Golf

Ventures




August 2016

Acquirer Target HQ Location Date DescriptionTransaction

Value (Millions)

OPKO Transition

Therapeutics

Toronto, Canada 31-Aug-16 Developer of therapeutics for the treatment of Alzheimer's disease and diabetes. 60.00

Debiopharm

Diagnostics

GenePOC Québec, Canada 30-Aug-16 Developer of a molecular diagnostics platform. The company develops a portable

instrument for the prevention and early detection of infectious diseases based on a

unique centripetal technology platform.

Undisclosed

athenahealth Patient IO Austin, TX 29-Aug-16 Developer of a care coordination platform for enterprise healthcare. The company

helps health systems and hospitals transition into value-based care by connecting

them with patients between visits.

Undisclosed

Nichi-iko

Pharmaceutical

Sagent

Pharmaceuticals

Schaumburg, IL 28-Aug-16 Manufacturer of injectable pharmaceutical products in the therapeutic areas of

cardiovascular, anti-infective/antibacterial, antineoplastic agent and antiemetic.

750.00

Ascendis Health Remedica Limassol, Cyprus 25-Aug-16 Manufacturer of pharmaceutical products for the treatment of diseases, such as

malaria.

392.35

Denali Therapeutics Incro

Pharmaceuticals

San Diego, CA 25-Aug-16 Developer of bio-pharmaceutical products. The company is focused on the

control of programmed necrosis for the treatment of degenerative and

inflammatory diseases.

Undisclosed

Earth Science Tech BEO STIs Charlesbourg,

Canada

24-Aug-16 Developer of non-invasive diagnostic products. The company offers diagnostic

kits for specimen collection and pathogen diagnosis related to sexually transmitted

diseases.

0.62

Investx Capital Norman Precision Stonehouse, United

Kingdom

23-Aug-16 Provider of precision engineering services to different industries, including

medical. Its services include design, prototyping, assembly, distribution services

and overall supply chain consolidation.

Undisclosed

Santen Pharmaceuticals InnFocus Miami, FL 19-Aug-16 Operator of an ophthalmic medical device company. The company develops and

provides next generation products for glaucoma surgery.

225.00

IMS Health Quintiles Durham, NC 17-Aug-16 Provider of biopharmaceutical services. The company offers clinical data

management, clinical trial execution services, pharmaceuticals, drug development,

financial partnering and commercialization expertise to companies in the

biotechnology, pharmaceutical and healthcare sectors.

8900.00

SASMAR Aquatrove

BioSciences

Chicago, IL 17-Aug-16 Provider of biotechnology services with its focus on human reproductive health to

address issues relating to human fertility and contraception.

Undisclosed

Mergers and AcquisitionsThe following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous

month.




August 2016


Value (Millions)


month.

Lifetree Biotechnology

Company

TrimGen Sparks, MD 16-Aug-16 Manufacturer and distributor of genetic testing products to assist biomedical

professionals in clinical research and early disease detection.

Undisclosed

Leidos Lockheed Martin

(Information

Systems & Global

Solutions Business)

Bethesda, MD 16-Aug-16 Provider of information systems and technology services, including government

healthcare information technology.

5000.00

Merz North America ON Light Sciences Dublin, CA 15-Aug-16 Developer of technologies to enhance laser-based dermatological procedures. The

company engages in the development of laser equipment for tattoo removal,

dermatological treatment and other related services.

Undisclosed

Cannabis Sativa iBudtender Danville, CA 15-Aug-16 Provider of medical data analytical services. The company provides patients with a

comprehensive medical cannabis resource database where they can find cannabis

medication based on their needs and preferences and medicate themselves safely.

0.40

Zimmer Biomet

Holdings

CD Diagnostics Claymont, DE 15-Aug-16 Developer of diagnostic tools for joint disease. The company is an integrated

diagnostics enterprise specializing in immunoassay development and biomarker

testing to address diagnostic determinations in joint health and therapeutic

outcomes.

Undisclosed

Global Medical

Solutions

Lantheus (Radio

Pharmacy Servicing

Business)

Melbourne,

Australia

11-Aug-16 Manufacturer and supplier of individual, patient-ready doses of single photon

emission computed tomography-based radiopharmaceuticals, which are sold by

the radiopharmacies to healthcare providers for administration to patients.

1.48

Mesa Canada Rapid Aid (CC

Gels)

Mississauga, Canada 10-Aug-16 Manufacturer of cold chain packaging products. The business unit produces cold

packaging gels used by pharmaceutical and life science industries to manage and

maintain temperature of products.

Undisclosed

OmniGuide Holdings Domain Surgical Salt Lake City, UT 10-Aug-16 Developer of thermal surgical technology. The company has developed the FMX

Ferromagnetic Surgical System, an intelligent surgical platform that uses

ferromagnetic technology to precisely cut, coagulate and seal tissue without

passing electrical current through the patient.

Undisclosed




August 2016


Value (Millions)


month.

Arterium Marifarm,

proizvodnja in

storitve

Maribor, Slovenia 9-Aug-16 Manufacturer of pharmaceutical products. 7.64

Confluent Medical Biomedical

Structures

Warwick, RI 9-Aug-16 Designer, developer and manufacturer of biomedical textiles for device

manufacturers in the orthopedic, cardiovascular, general surgery and tissue

engineering and regenerative medicine markets.

Undisclosed

Medtronic Smith & Nephew

(Gynaecology Unit)

London, United

Kingdom

8-Aug-16 Manufacturer of a medical system for uterine surgery. It also offers gynecology

and other related medical services.

350.00

Echo Morrisey Associates Chicago, IL 8-Aug-16 Developer of healthcare management software that helps health systems and

hospitals streamline the entire credentialing process from onboarding through

reappointment by eliminating paper-based and manual administrative tasks.

48.00

Charme Capital

Partners, Amadeus

Capital Partners, Aleph

Capital, Graham

Snudden

Igenomix Paterna, Spain 8-Aug-16 Provider of genetic testing services for reproductive health clinics. The company

also creates and develops tools for the reproductive medicine field.

Undisclosed

Mylan Meda Solna, Sweden 5-Aug-16 Developer of pharmaceutical products. The company primarily develops nasal

sprays and skin care products.

4500.00

M3 Health Impetus Mumbai, India 4-Aug-16 Provider of patient therapy compliance services. The company provides integrated

disease management and electronic health records management services.

4.16

Velocity Fund Partners InClinica Wayne, PA 3-Aug-16 Provider of clinical trial services for biotechnology and pharmaceutical companies.

The company provides contract research organization services and conducts

clinical trials in the areas of oncology, infectious diseases, metabolism, diabetes,

cardiovascular, neuropsychiatry, pain and rheumatology, women's health,

ophthalmology and medical devices.

Undisclosed

RoundTable Healthcare

Partners

Goodier Cosmetics Dallas, TX 3-Aug-16 Manufacturer of skin care products. The company provides acne treatment,

sunscreen, anti-aging and daily use skin care products.

Undisclosed




August 2016


Value (Millions)


month.

Avara Norman

Pharmaceutical Services

Astellas Pharma

Technologies

Norman, OK 3-Aug-16 Manufacturer of pharmaceutical products. Undisclosed

Sony Europe eSATURNUS Leuven, Belgium 2-Aug-16 Developer of imaging technologies for operating rooms and hospitals. The

company offers a digital operating room that assists clinicians during surgery and

also provides live surgery broadcasting services.

Undisclosed

Teva Pharmaceutical

Industries

Allergan (Global

Generics Business)

Dublin, Ireland 2-Aug-16 Producer of a large portfolio of generic medicines and applications. 40500.00

Mazzetti Gene Burton &

Associates

Franklin, TN 1-Aug-16 Provider of healthcare technology consulting services. The company offers

technology integration management, medical equipment planning, system design,

project management and operational implementation services.

Undisclosed

BTC Network BTC of New

Bedford

New Bedford, MA 1-Aug-16 Provider of clinical research services. The company provides phase II to phase IV

clinical trial services to the biopharmaceutical and medical device industries. It

conducts the clinical research protocol and collects the data necessary to support

the safety and efficacy of the drug company's product to the FDA.

Undisclosed

Biolabo BPC BioSed Castelnuovo di

Porto, Italy

1-Aug-16 Manufacturer and seller of automatic analyzers. Undisclosed

Pfizer BIND Therapeutics Cambridge, MA 1-Aug-16 Developer of clinical stage nanomedicine. The company develops therapeutics for

the treatment of cancer, and its pharmaceutical properties intend to target tumors

at tissue, cellular and molecular levels.

40.00

Pfizer Bamboo

Therapeutics

Chapel Hill, NC 1-Aug-16 Developer of gene therapies to diagnose diseases related to central nervous system

and neuromuscular conditions.

645.00

Bio- Techne Advanced Cell

Diagnostics

Newark, CA 1-Aug-16 Developer of cell- and tissue-based diagnostic tests for personalized medicine,

including tests for breast cancer, circulating tumor cells and cervical cancer.

325.00

Cantel Medical Accutron Phoenix, AZ 1-Aug-16 Manufacturer of nitrous oxide delivery systems. The company is engaged in the

production of nasal masks, oral surgery products, conscious sedation equipment

and accessories for dental practitioners.

52.50



Documents

Monthly Healthcare Review August 2016 - BioEnterprise€¦ · orphan indications for fast to market regulatory strategy. 30.00 Cowen and Company, Jefferies, RBC Capital Markets The