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Molecules of Life – Biomolecules

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Molecules of Life – Biomolecules. http://www.dnareplication.info/images/dnadoublehelix2.jpg. What Do These Pictures Have in Common?. gov.mb.ca. k8science.org. nuclearfamilywarhead.com. gsbs.utmb.edu. Brain Tissue. learn.genetics.utah.edu. - PowerPoint PPT Presentation

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Page 1: Molecules of Life –  Biomolecules

Molecules of Life – Biomolecules

http://www.dnareplication.info/images/dnadoublehelix2.jpg

Page 2: Molecules of Life –  Biomolecules

What Do These Pictures Have in Common?

gov.mb.ca

k8science.org

gsbs.utmb.edunuclearfamilywarhead.com

Page 3: Molecules of Life –  Biomolecules

Brain Tissue

learn.genetics.utah.edu

Page 4: Molecules of Life –  Biomolecules

Protein Structure –

the correct protein

structure is important for

normal function

new-science-press.com

Page 5: Molecules of Life –  Biomolecules

Prions

stanford.edu

Dr. Stanley Prusiner.cmu.edu

Page 6: Molecules of Life –  Biomolecules

Why Is Carbon So Important?Organic/Inorganic Molecules

• Organic vs. Inorganic in Chemistry– Organic refers to molecules containing a

carbon skeleton– Inorganic refers to carbon dioxide and all

molecules without carbon

Page 7: Molecules of Life –  Biomolecules

Carbon’s Versatility

• Carbon atoms are versatile and can form up to four bonds (single, double, or triple) and rings

• Functional Groups in organic molecules confer chemical reactivity and other characteristics– Determines how that molecule will function

(For ex. whether it is polar [charged] or nonpolar [uncharged])

Page 8: Molecules of Life –  Biomolecules

Common Elements Found in Living Organisms

• Carbon (C)• Hydrogen (H)• Nitrogen (N)• Oxygen (O)• Phosphorous (P)

Page 9: Molecules of Life –  Biomolecules
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Organic Molecule Synthesis

• Biomolecules are polymers (chains) of subunits called monomers

Page 16: Molecules of Life –  Biomolecules

Dehydration Synthesis

• Monomers are joined together through dehydration synthesis– An H and an OH are removed, resulting in the

loss of a water molecule (H2O)

Page 17: Molecules of Life –  Biomolecules

Hyrolysis

• Polymers are broken apart through hydrolysis (“water cutting”)– Water is broken into H and OH and used to

break the bond between monomers

Page 18: Molecules of Life –  Biomolecules

Biological Molecules

• All biological molecules fall into one of four categories– Carbohydrates– Lipids– Proteins– Nucleic Acids

Page 19: Molecules of Life –  Biomolecules

1. Carbohydrates

• Carbohydrate composition– Made of C, H, and O in the ratio of 1:2:1

• Construction– Simple or single sugars are

monosaccharides– Two linked monosaccharides are

disaccharides– Long chains of monosaccharides are

polysaccharides

Page 20: Molecules of Life –  Biomolecules

Carbohydrates

• Carbohydrates are important energy sources for most organisms

Page 21: Molecules of Life –  Biomolecules

Monosaccharides

• Basic monosaccharide structure– Backbone of 3-7 carbon atoms– Many –OH and –H functional groups– Usually found in a ring form in cells

• Example monosaccharides– Glucose (C6H12O6): the most common

Page 22: Molecules of Life –  Biomolecules
Page 23: Molecules of Life –  Biomolecules

Monosaccharides

• Fate of monosaccharides inside a cell– Some broken down to free their chemical

energy– Some are linked together by dehydration

synthesis for storage

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Page 25: Molecules of Life –  Biomolecules

Disaccharides

• Disaccharides are two-part sugars– Sucrose (table sugar) = glucose + fructose– Lactose (milk sugar) = glucose + galactose– Maltose (malt sugar)= glucose + glucose

Page 26: Molecules of Life –  Biomolecules

Polysaccharides Used For Energy Storage

• Monosaccharides are linked together to form chains (polysaccharides)

• Storage polysaccharides– Starch (polymer of glucose)

• Formed in roots and seeds as a form of glucose storage

– Glycogen (polymer of glucose)• Found in liver and muscles

Page 27: Molecules of Life –  Biomolecules
Page 28: Molecules of Life –  Biomolecules

Polysaccharides Used For Structural Support

• Structural polysaccharides– Cellulose (polymer of glucose)– Found in the cell walls of plants

• Indigestible for most animals due to orientation of bonds between glucoses

nsf.gov

Page 29: Molecules of Life –  Biomolecules
Page 30: Molecules of Life –  Biomolecules

Polysaccharides Used For Structural Support

• Structural polysaccharides continued– Chitin (polymer of modified glucose units)

• Found in the outer coverings of insects, crabs, and spiders

• Found in the cell walls of many fungi

Page 31: Molecules of Life –  Biomolecules

2. Lipids

• All lipids contain large chains of nonpolar hydrocarbons (a chain of carbon atoms w/hydrogen atoms attached)

• Most lipids are hydrophobic (don’t like water) and water insoluble (don’t dissolve in water)

• Lipids are diverse in structure and serve in a variety of functions– Energy storage– Waterproofing– Membranes in cells– Hormones

Page 32: Molecules of Life –  Biomolecules

3 Groups of Lipids• 1. Oils, fats, and waxes• 2. Phospholipids• 3. Steroids

Page 33: Molecules of Life –  Biomolecules

Oils, Fats, and Waxes

• Made of only C, H, and O

• Made of one or more fatty acid subunits– Long chains of C and H with a carboxylic acid

group (-COOH) at one end

• Fats and oils – Formed by dehydration synthesis

Page 34: Molecules of Life –  Biomolecules
Page 35: Molecules of Life –  Biomolecules

Oils and Fats

• Fats and oils used for long-term energy storage– Fats and oils possess a high density of stored

chemical energy

Page 36: Molecules of Life –  Biomolecules

Oils and Fats

• Fat solidity is due to single or double carbon bonds– Fats that are solid at room temperature are

saturated (carbon chain has as many hydrogen atoms as possible, and mostly or all C-C single bonds), e.g. beef fat

Page 37: Molecules of Life –  Biomolecules

Oils and Fats• Fat solidity is due to single or double carbon

bonds (continued)– Fats that are liquid at room temperature are

unsaturated (fewer hydrogen atoms, many C=C double bonds), e.g. corn oil

Page 38: Molecules of Life –  Biomolecules

Waxes

• Composed of long hydrocarbon chains and are strongly hydrophobic

• Highly saturated and solid at room temperature

• Form waterproof coatings

• Used to build honeycomb structures

Page 39: Molecules of Life –  Biomolecules

Phospholipids• Form plasma membranes around all cells • Phospholipids have hydrophobic and

hydrophilic portions– Polar functional groups are water soluble– Nonpolar fatty acid “tails” are water insoluble

Page 40: Molecules of Life –  Biomolecules

Steroids

• Steroids are composed of four carbon rings fused together

• Examples of steroids– Cholesterol

• Found in membranes of animal cells– Male and female sex hormones

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Page 42: Molecules of Life –  Biomolecules

3. Proteins

• Proteins have a variety of functions– Enzymes catalyze (speed up) reactions– Structural proteins (e.g. collagen) provide

support

Page 43: Molecules of Life –  Biomolecules

Amino Acids

• Proteins are formed from chains of amino acids (monomers)

– There are 20 amino acids that make up proteins of living things.

Page 44: Molecules of Life –  Biomolecules

Amino Acids

• All amino acids have similar structure– Central carbon atom bonded to four different

functional groups• 1. An amino group (-NH2) • 2. A carboxylic acid group (-COOH)• 3. A hydrogen (H)• 4. All have a variable “R” group

– Some R groups are hydrophobic– Some are hydrophilic– Cysteine R groups can form disulfide bridges

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Page 46: Molecules of Life –  Biomolecules
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Amino Acids

• The sequence of amino acids in a protein dictates its function

Page 48: Molecules of Life –  Biomolecules

Dehydration Synthesis

• Amino acids are joined to form chains by dehydration synthesis– An amino group reacts with a carboxyl group,

and water is lost

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Dehydration Synthesis

• Resultant covalent bond is a peptide bond

• A chain of two amino acids or a short amino acid chain is called a peptide

• Long chains of amino acids are known as polypeptides or just proteins

Page 50: Molecules of Life –  Biomolecules

Three Dimensional Structures

• The type, position, and number of amino acids determine the structure and function of a protein

– Precise positioning of amino acid R groups leads to bonds that determine structure

– Disruption of these bonds leads to denatured proteins and loss of function• For ex. If you expose a protein to high temperatures,

it will cause the protein to unfold, in other words, to denature.

Page 51: Molecules of Life –  Biomolecules

4.Nucleic Acids

• Nucleotides are the monomers of nucleic acid chains

• All nucleotides are made of three parts– Phosphate group – Five-carbon sugar– Nitrogen-containing base

Page 52: Molecules of Life –  Biomolecules
Page 53: Molecules of Life –  Biomolecules

Molecules of Heredity• Two types of nucleotides

– Ribonucleotides (A, G, C, and U) found in RNA• A = adenine• G = guanine• C = cytosine• U = uracil

– Deoxyribonucleotides (A, G, C, and T) found in DNA• A = adenine• G = guanine• C = cytosine• T = thymine

Page 54: Molecules of Life –  Biomolecules

Molecules of Heredity

• Two types of polymers (chains) of nucleic acids

– DNA (deoxyribonucleic acid) found in chromosomes • Carries genetic information needed for protein

construction

– RNA (ribonucleic acid) • Copies of DNA used directly in protein construction

Page 55: Molecules of Life –  Biomolecules

One nucleotide

Page 56: Molecules of Life –  Biomolecules

Molecules of Heredity

• Each DNA molecule consists of two chains of nucleotides that form a double helix

• The nucleotides on opposing strands form hydrogen bonds, linking the two strands

• RNA is copied from DNA in the nucleus– That information is used to synthesize proteins

in the cell’s cytoplasm

Page 57: Molecules of Life –  Biomolecules
Page 58: Molecules of Life –  Biomolecules

The End