Francis TienAcademic WritingGCP 1218 March 2015
Molecular interactions of the CcdB poison with its bacterial
target, the DNA gyrase
BackgroundThe Ccd (control of cell death) toxin/antidote system
generates the CcdB, a toxin that targets the DNA gyrase, and the
CcdA, that can neutralize the CcdB toxin. CcdB causes the negative
supercoiling of the DNA. This system programs cell death for
defected organisms or for the control of the bacteria. CcdB makes
the whole population more flexible under different situations. The
mazEF system is activated under conditions of starvation.
MethodThis paper gathered information from multiple researches
and put together all the data and pathways of the Ccd system. The
author put together a chart on what systems are located in where to
produce what toxins to affect which parts of the cell and are
countered by what antidotes. Review and analyze research data from
other institutions.
ResultsDifferent systems and pathways are responsible different
types of cell control. One interesting point is that a high level
of CcdB leads to cell death, but with a lower level it can prevent
replication or transcription of the cell.
ConclusionThe need for antibacterial drugs has increased
throughout the globe. But as more drugs are used, multi-drug
resistance bacteria are also emerging. The control and study of
CcdB, along with other multiple drugs can help to improve the
research and production of antibacterial agents.
ReferencesMelderen, L. (2002). Molecular interactions of the
CcdB poison with its bacterial target, the DNA gyrase (Medicine).
Institut de Biologie et Mdecine Molculaires, Universit Libre de
Bruxelles, Gosselies, Belgium. Retrieved from
http://www.urbanfischer.de/journals/ijmm
