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Molecular imaging using contrast-enhanced ultrasound: evaluation of angiogenesis and cell therapy
by Howard Leong-Poi
Cardiovasc ResVolume 84(2):190-200
November 1, 2009
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].
(A) Fluorescent microscopic images of the normal cremasteric microcirculation after intravenous injection of FITC–dextran to highlight the microvessels (left panel).
Howard Leong-Poi Cardiovasc Res 2009;84:190-200
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].
Background-subtracted colour-coded CEU images reflecting signal from microbubbles retained in Matrigel plugs 15 min after intravenous injection of microbubbles targeted to angiogenesis.
Howard Leong-Poi Cardiovasc Res 2009;84:190-200
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].
Background-subtracted colour-coded CEU images reflecting retention fraction of αVβ3-targeted microbubbles in ischaemic proximal hindlimb adductor muscles from control untreated and FGF-
2-treated rats immediately after ligation (day 0) and at day 4 post-iliac artery ligation.
Howard Leong-Poi Cardiovasc Res 2009;84:190-200
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].
CEU molecular imaging data for microbubbles targeted to activated neutrophils (A), α5-integrin (B), and VCAM-1 (C) at various time points after femoral artery ligation in mice.
Howard Leong-Poi Cardiovasc Res 2009;84:190-200
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].
(A) Normalized microvascular blood flow in the ischaemic muscle for untreated (filled circles) and FGF-2-treated (open circles) animals.
Howard Leong-Poi Cardiovasc Res 2009;84:190-200
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].
Schematic diagram of potential strategies for CEU-targeted imaging of stem/progenitor cells, such as EPCs. One strategy involves manipulation/transfection of EPCs to express a specific
marker protein on their surface.
Howard Leong-Poi Cardiovasc Res 2009;84:190-200
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].
