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Meet your Biotech Meet your Biotech Partners at GenopolePartners at Genopole®®
Agence d’Evry Entreprises25, cours Blaise Pascal - 91000 EVRY
Responsable du Pôle Entreprises Evry Juvisy Hervé MONNERIE Tél. : 01 60 90 57 02
Chargé de clientèle Ludovic BOURSCHEIDT
Tél. : 01 60 90 57 44
Fax : 01 60 90 57 37
HSBC de Baecque Beau3, rue des Mathurins - 75009 PARIS
Responsables du secteur Santé : Jacques-André GOURION Tél. : 01 44 94 43 70 / 06 87 73 61 56
Anne MARNATTél. : 01 44 94 46 33 / 06 87 71 67 59
Fax : 01 44 94 43 65
They support our biotech companies
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Thierry Mandon, President of Genopole®,
First Vice-president of the General Council
of the Essonne Department
Pierre Tambourin, Chief Executive of Genopole®
Genopole®’s objective is to foster therapeutic innovation by providing optimal
growth conditions for life science research and biotech companies. With a portfolio
of over 60 companies (over half of which are located on its Evry campus), Genopole®
represents more than a quarter of France’s biotech start-ups. Taking into account
the staff working in the campus’s 23 academic labs, Genopole® accounts directly
for about 2,000 jobs. Around 140 million euros in equity funding have been raised
since 1999, with one or two initial public offerings expected by 2010. Fifteen drug
candidates are in the preclinical regulatory and clinical development phases and are
due for market launch by 2008. These treatments developed in Evry (together with
the expected creation of a clinical research unit within the new Evry-Corbeil medical
center and a Biomanufacturing Center for recombinant proteins and monoclonal
antibodies) will further boost the potential of one of France’s benchmark biomedical
research locations.
This guide will equally show you that Genopole® is a life science park where over
25 companies are now commercializing innovative biotech products and services.
The brochure will help you discover how these enterprises can put their skills and
expertise at your disposal. Of the wide range of services offered here, you will be able
to select those that will accelerate the development of your organization and raise its
performance levels.
Meet your Biotech Partners at Genopole®
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CLINICAL TOOLS
ClinicalTesting Kits
MedicalDevices
MedicalServices
ConsultingResearch
InformaticsR&D
Services
Acriter ●
Atragene ●
Biomanufacturing Center
BioSystems International ●
Biofords
Cellvax ●
Centaure Metrix ●
CERFE ●
DrugAbilis ● ●
Flowgene
GeneCust ●
Genewave
GenOptics
GenoSafe ●
IntegraGen ● ●
MilleGen ●
Nokad ●
Open Biochip Center ●
PartnerChip ●
Serial Genetics ●
Sigma Aldrich ●
Stalife ●
Surface Functionalization Services ●
TcLand ●
Tech Innovation ●
Texcell ●
WatchFrog
XenTech ●
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R&D TOOLS BIOSAFETY SERVICES
AnimalModels
BiomarkersLab
InstrumentationBiochips Biomanufacturing Health
Environment /AgriFood
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R&D Tools
AcriterDo you need to add value to your R&D activities, improving quality and productivity?
Acriter provides consulting services, training support and customized solutions for enabling drug discovery-oriented organizations to overcome the constraints of the drug discovery cycle.
Acriter’s expertise■ Drug discovery & development processes■ A process-oriented approach, multi-project and knowledge management■ IT tool design and development
Acriter’s experience■ Extensive pharmaceutical industry experience■ A focus on medicinal chemistry, pharmacology and pharmaceutical sciences
A responsive and fl exible organizational structure to meet your needs
Learning-focused methods ensuring greater uptake and use of the custom Acriter solution
References
> LEEM (the French Pharmaceutical Manufacturers Association - Training Section)
> Novagali> Euroscreen> Medicen Paris Region> Xenon Pharmaceuticals> University Paris XI> Fournier laboratories
7› Drug discovery and development process - Training supportResearch Projet management - IT tool
Consulting
Consulting activityA process-oriented approach
■ Process diagnostics ■ Design and implementation of customized
action plans■ Organizational optimization via an iterative
process and starting from the current status
Project management■ Research project management processes
using PM ProDitTM, proprietary software from Acriter that underlines process weaknesses and strengths, reveals opportunities for improvement and generates performance indicators and communication tools
■ Project portfolio management■ Optimization of early drug discovery project
planning in order to reduce late-stage attrition, mainly focusing on chemistry, pharmacology (activity & safety), formulation (drug delivery systems development), pharmacokinetics and metabolism
■ Project stakeholder support and coaching (project teams, group leaders, steering committees)
Knowledge management■ Development of corporate information sharing
systems■ Application support and design of in-house
software solutions
ACRITERLe Magellan7 rue MontespanF-91024 EVRY, FRANCE
Phone: +33 (0)1 69 47 60 45Fax: +33 (0)1 69 47 60 70
www.acriter-consulting.com
List of services
Training sessions
Drug discovery processIntensive overview of the global R&D process, from the scientifi c or medical idea to market launch.
Research project managementProject management expertise with tools and methods adapted to the specifi cities of research activity.
Development of research-dedicatedinformation systemsIT tool design and development projects, communication tools in order to analyze and optimize corporate information systems.
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R&D Tools
AtrageneATRAGENE supports R&D processes in pharmaceutical, biotechnology and chemistry companies by providing professional services, IT solutions and R&D informatics tools.
You need ■ Integration and visualization of heterogeneous data
■ Information capture, sharing and management
■ Data integrity and storage
■ Data analysis workfl ow optimization
Solution descriptionAfter in-depth interviews with your end users and your management team, Atragene will custom-design an optimized IT solution.
Atragene’s expertise allows you to:
■ design and implement IT solutions to integrate, share, visualize and mine heterogeneous biological and chemical information
■ design and implement powerful informatics infrastructures for capturing, managing and storing large amounts of data at the enterprise level (Biointegration®)
■ develop tailor-made software to meet particular technology and business requirements
References
> Air Liquide Group
> Genoplante Valor
> Nautilus Biotech
> Nokad Technology
> Statlife
9› Professional services - Workfl ow analysis - Data management -R&D automation and traceability
Research Informatics
List of services
Atragene’s range of services can be itemized as follows:
■ Data integration in biology and chemistry
■ Database design and implementation
■ Application development and integration
■ Analysis workfl ow design and implementation
■ Collaborative platform & web portal development
Technology features Atragene’s policy is based on a partnership-oriented relationship. Besides its consulting skills, Atragene has solid know-how in the use of:
■ Project management: UML, MS Project, Gantt Project, etc.
■ Programming languages: PHP, Java, .Net, Python, etc.
■ Databases: MySQL, Oracle, SQL Server, etc.■ Operating systems: BSD, Linux, Solaris,
Windows
Benefi ts By placing your trust in Atragene’s total solutions, you will benefi t from:
■ Better data and information management■ R&D process automation■ Improvements in laboratory data collection and
workfl ow■ Global information sharing■ Capitalization of the enterprise’s knowledge base■ R&D process traceability■ Information integrity and security
ATRAGENE10 allée des Champs ElyséesF-91042 EVRY CEDEX, FRANCE
Phone: +33 (0)1 60 78 34 11Fax: +33 (0)1 60 78 34 11
www.atragene.com
PartnersiSoftETL & Workfl ow software (Amadea)
Klee GroupELN software (Kalabie)
ServiwareHardware infrastructure (Storage, HPC, etc.)
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R&D Tools
GenopoleBiomanufacturing Center
A Genopole®-MAbgene joint venture
■ By founding the Genopole® Biomanufacturing Center, Genopole and MAbgène have opened up new horizons in service provision.
■ GMP custom biomolecule production:- recombinant proteins- monoclonal antibodies
■ By late 2007, the Center will be capable of producing preclinical & clinical batches for Phase I, II and III trials (orphan diseases) with fast turnaround times, at competitive prices and in strict compliance with GMP guidelines.
Equipment and resources that match your ambitions
■ The center boasts 1300 square meters of fl oor space, most of which is devoted to production activities
■ The technical choices correspond to today's most demanding pharmaceutical requirements
■ Use of a range of animal cell culture processes (CHO and NSO cell lines, etc.)
■ Two USP fermentation zones enabling the simultaneous production of 2 different biomolecules under GMP conditions
■ A production capacity of between 8 and 10 batches per year
■ Use of 20-liter, 250-liter and 1700-liter bioreactors
■ Two DSP purifi cation zones, with the product delivered as a purifi ed fi nal bulk
■ A team of 15 highly-qualifi ed staff
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Biomanufacturing
MAbgène - Impasse des Chênes RougesF-30319 ALÈS CEDEX, FRANCE
Contact: Patrick Henno - President of the BoardPhone: +33 (0)4 66 56 40 80
www.mabgene.com
Genopole® - 2 rue Gaston Crémieux, CP 5723F-91057 EVRY CEDEX, FRANCE
Contact: Alain Métayer - Biomanufacturing ManagerPhone: +33 (0)1 60 91 32 87 / +33 (0)6 88 63 83 32
www.genopole.fr
A comprehensive service offering■ Selection of high-yield cell lines■ Cell line optimization and creation of master cell banks and working cell banks■ Process optimization (culture & purifi cation conditions)■ Production of pre-GMP pilot batches■ Scale-up and protocol validation operations■ GMP production of purifi ed protein/antibody batches of up to 100g■ Discontinuous, semi-continuous, continuous and perfused cell culture modes■ Multi-step chromatographic purifi cation before or after viral inactivation and nanofi ltration
By pooling their respective skills within the Genopole Biomanufacturing Center, Genopole and MAbgène now offer custom production capacities that are unmatched in France.
For any technical or commercial enquiries, please contact:
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R&D ToolsClinical tools
BioSystems InternationalYou need■ To improve the productivity of your drug discovery & development efforts
e.g. deliver safer and more effective drugs faster and at a lower cost■ Disease management tools■ Biomarker candidates for feeding your development pipeline
Who are we ?BioSystems International merges pharmaceutical and diagnostics industry experience with leading scientifi c and technology expertise and know-how in bioanalysis, proteomics, genome sciences and immunology.
What do we deliver?BioSystems International delivers biomarker discovery and validation services in the fi elds of chronic diseases and cancer.BSI discovers, rapidly validates and qualifi es biomarkers via alliances with pharma and biotech companies, as well as through its focused in-house programs.
The advantage of BSI’s approachBSI’s discovery technology and unique development methods combine high-throughput monoclonal antibody technology, mass spectrometry and genome analysis techniques.
Technology features■ A proprietary, monoclonal antibody-based biomarker discovery and expression profi ling
platform: HTS of up to 10,000 hybridomas in a single project■ Proprietary plasma proteome normalization technology■ Combined single-step discovery and fi rst-level validation (one year)■ Protein ID using nanovolume integrated mass spectrometry (NVIMS)■ Biomarkers (proteins) and reagents (mAb) available in one step
These features enable BSI to:■ achieve targeted, quantitative analysis of virtually all the proteins in a patient’s bodily fl uids■ monitor subjects with ELISA-standard sensitivity and precision.
BSI builds a streamlined strategy for identifying, validating and qualifying the most promising biomarkers via a process that includes confi rmation of clinical relevance on BSI’s own patient cohorts or clinical material from our clients’ large Phase II and Phase III clinical trials.
13› Biomarker discovery, validation and development - Biomarker-related diagnostic kits for chronic diseases and cancer
Biomarker research servicesClinical testing kits
BIOSYSTEMS INTERNATIONAL4 rue Pierre FontaineF-91058 EVRY CEDEX, FRANCE
Contact: François LiebaertPhone: +33 (0)1 60 87 89 75Fax: +33 (0)1 60 78 71 49
www.biosys-intl.com
BioSystems International service applicationsPharma & biotech solutionsBiomarker discovery and validation programs (from clinical collections to assays for clinical trials) via collaboration contracts.Goals: ■ Shorten development times■ Reduce development costs■ Select patients for clinical trials■ Distinguish responders from non-responders
Diagnostics solutionsDevelopment of innovative diagnostics and disease management tools: validated biomarker candidates for developing diagnostic kits and disease management systems for chronic diseases and cancer.
Goal: Feed research pipelines with novel, innovative biomarkers
Partner benefi ts■ Expertise and know-how in the form of data,
information and knowledge generated when identifying, validating and qualifying biomarkers
■ Tools (e.g. monoclonal antibodies, clinical assays) to enable partners to quantify biomarker presence and/or activity in patients participating in clinical trials
References
> AstraZeneca (UK): Biomarker discovery and validation program in osteoarthritis
> Euroscreen (B): Biomarker discovery and validation program for a chronic disease
> Pfi zer (UK): technology platform proof of concept
PartnersNortheastern University Boston (USA)Exclusive license agreement for mAb biomarker technology
University of Debrecen (Hungary)Patient collection, biobanking
Curie Institute and Gustave Roussy Institute (France)Clinical expertise and joint discovery projects in cancer
NCI (USA)Preliminary research project
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Biosafety Services
BiofordsAlong with AGDIA (its exclusive partner in the US), BIOFORDS develops and supplies diagnostic tools & solutions for detecting diseases, waterborne toxins and GMOs in the agricultural and environmental sectors.
Thanks to its quality control tools for all steps in the production process from crop sites (fi elds, greenhouses, etc.) to end consumers, BIOFORDS enables its customers to produce quality crops whilst respecting the environment.
BIOFORDS also provides technology transfer and innovation consulting services for managing new biotechnological breakthroughs and results in the agricultural sector.
References
> Syngenta (UEE) > Monsanto (USA) > Seminis (UEE) > RAGT (FR) > PAU-EURALIS (FR) > Bayer Crop Science (B) > Nunhems (NL) > Ministry of Agriculture (FR) > LNPV > SNPV > INRA (FR) > CNRS (FR) > Evialis > Feed Industrial (FR) > CSL (UK) > De Ruiter (NL)
Collaborations
BIOFORDS is looking for other partnerships to access new antibody sources (monoclonal or polyclonal) and any technologies which can be linked to rapid diagnostic tools (immunological or DNA/RNA technologies) in order to develop new kits.
You need■ Plant screening for disease resistance and
early disease detection■ Reduced risks of disease and prevention of
disease onset■ Checks on plant health before shipping and
testing incoming plantlets before producing fi nal plants
■ Monitoring diseases as part of a scouting program for protecting healthy plants from infection
■ Determination of waterborne toxins, such as microcystins and nodularins
■ Checks for the presence or absence of transgenic proteins (GMOs) in plants, oil-cakes, seeds, etc.
Technologies used■ Immunology / ELISA / monoclonal and
polyclonal antibodies■ DNA & RNA probes and hybridization
membranes■ PCR kits■ Rapid diagnostic tools like Flashkits (LFD,
Lateral Flow Devices)
15› Biological testing kits - Plant diagnostics - GMO detection - Waterborne toxins - Lateral fl ow devices
Environment / Agri-Food
Distributors> LINARIS (Germany) > Cultek (Spain) > Peramed (Turkey) > Florilab (Italy) > ABC Biokits Maghreb.
Biofords is looking for sales agents or distributors for covering its large territory (Europe, Africa and Middle East)
BIOFORDS solutionsFlashkits■ Plant pathogen detection kits (viruses, bacteria,
fungi, phytoplasms and viroids)■ GMO detection kits
Applications■ Greenhouses: checking the health of incoming
plants, protecting healthy plants from infection, ensuring plant health quality before plants are shipped
■ Research: varietal resistance development, plant hormone measurements, tests for more than 200 viruses, qualitative and quantitative GMO detection kits, etc.
■ Diagnostic Labs and Plant Quarantine & Inspection Authorities: Rapid diagnostics with reliable products for diseases (over 200 viruses, 30 bacteria, etc.), GMO and water toxin detection tools
■ Growers’ fi elds: preventing disease onset, checking GMO varieties and GMO pollutions, etc.
Benefi tsBIOFORDS’ extensive range of products offers:> quality > reliability > cost-effectiveness> fast delivery > ease of use
ReliabilityAll our rapid detection kits have been validated by the appropriate USDA departments:■ plant pathogen detection kits, validated by APHIS
and/or ISTA ‘s labs■ GMO kits are validated by seed companies and
GIPSA (a USDA department) and are recommended by European National GMO laboratories.
QualityBIOFORDS and AGDIA are implementing certifi cation programs for their R&D programs and their kit production units in collaboration with the NAK (Dutch Offi cial Plant Certifi cation Agency).
BIOFORDS5 allée du Grand Saint BernardSILIC 1413 CourcouronnesF-91019 EVRY CEDEX, FRANCE
Phone: +33 (0)1 60 78 81 64Fax: +33 (0)1 69 13 08 65
www.biofords.comwww.agdia.com
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R&D Tools
CellvaxCellvax is a service company offering full in vitro and in vivo validation studies for the preclinical regulatory phase in oncology.
Our expertise enables you to:■ speed up development of your drug candidates■ add value to your drug portfolio by evaluating a drug’s potential and selecting disease targets■ decrease your drug development costs
Cellvax R&D services are designed for biotech fi rms, pharmaceutical companies and public-sector research laboratories which focus on anti-cancer drug discovery and development.
You need■ Early-stage drug screening with a novel anti-tumor test■ Comprehensive toxicity studies in animals■ A wide range of tests with relevant cancer models in animals■ Angiogenesis models (in vitro and in vivo)■ In vivo imaging■ In vivo biodistribution and pharmacokinetics (PK) studies■ Histological analysis■ Complementary analysis
Cellvax helps you to identify and defi ne ways to enhance your oncology research:■ choosing the most relevant animal and tumor models■ drawing up the most relevant experimental protocols
Cellvax carries out customized studies in animal models (including a positive control) and provides you with a comprehensive fi nal GLP expertise and report .
PartnersMAT Biopharma (FR)Immunology expertise
Other partnership under confi dentiality
17› Oncology - Anticancer drug validation - Preclinical studies - Preclinical regulatory phase - CRO - Expertise
R&D ServicesAnimal Models
CELLVAXPépinière Genopole® Entreprises4 rue Pierre FontaineF-91058 EVRY CEDEX, FRANCE
Contact: Ming Wei, PhDMobile: +33 (0)6 71 43 47 51Phone: +33 (0)1 60 87 89 57Fax: +33 (0)1 60 87 89 99
www.cellvax-pharma.com
Cellvax technology■ Animal tumor models: orthotopic and/or
subcutaneous xenografts - Up to 150 mice in one study
■ “Nodules” in a 3D system: an original anti-tumor test based on a 3D cell culture system for early-stage drug screening
■ In vitro validation studies (Up to a ten-compound test capacity)
■ In vivo imaging in live small animals■ Ascites production in mice■ Histological analysis■ Flow cytometry,...
Cellvax services (non-exhaustive)
■ Anti-tumor tests for early-stage drug screening■ Tests on primary tumor cells isolated from human
biopsies■ Comprehensive toxicity studies in animal models■ Both subcutaneous and/or orthotopic tumor
models in small animals■ In vitro and in vivo angiogenesis tests (angiogenesis
models)■ Anti-metastasis tests■ In vitro and in vivo drug-resistant tumor models■ In vivo studies of biodistribution and
pharmacokinetics (PK)
Benefi ts ■ The expertise of our management and operational
teams■ Complementary and extensive biological tests■ Continuously optimized and competitive tests■ Responsive, effi cient service provision■ GLP procedures■ Confi dentiality■ State-of-the-art animal facilities■ Access to a network of private- and public-sector
laboratories■ A comprehensive fi nal GLP report including study
scope, materials & methods, results (raw data) and analysis conclusions
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Clinical Tools
Centaure MetrixDo you need tools to facilitate your clinical patient follow-up?Helping you: ■ to medically assess gait disorders■ with medical diagnosis and prognosis■ to monitor a patient’s treatment
Centaure Metrix provides the medical profession with a tool based on the measurement of gait disorders.
Applications
RheumatologyDoes your patient suffer from hip or knee osteoarthritis? Do you want to evaluate the level of disability?■ Locometrix enables you to measure excessive
joint loading■ Rapid evaluation …for a great prognosis
RehabilitationLocometrix enables you: ■ to perform functional monitoring of patient
motricity throughout a rehabilitation program■ to boost patient motivation
GeriatricsDoes your patient suffer from instability at rest or when walking? Do you want to evaluate the risk of falls?■ Locometrix enables you to determine early-onset
deteriorations in gait, characterized by a decreasein stride frequency and regularity
NeurologyDoes your patient suffer from Parkinson’s disease?Do you want to rate the effi ciency of treatment?■ Locometrix enables you to rate the loss of gait
regularity, correlated to the motor score (UPDRSscale) and the extent of bradykinesia
Does your patient suffer from fi bromyalgia?■ Locometrix enables you to evaluate the level of
clinical severity for disease stage clustering
EndocrinologyLocometrix enables you to assess obesity and monitor the corresponding activity program, in order to stimulate energy expenditure.
Sport medicineLocometrix enables you:■ to detect early-stage joint, tendon or muscle
trauma■ to evaluate running performance:
- stride quality and defects- running effi ciency- monitoring training after an injury by determining
the speed limit beyond which the lesion is aggravated
19› Medical check up - Joint osteoarthrosis - Clinical trial -Treatment evaluation
Medical services
Locometrix solution
ProductApparatus enabling the measurement of acceleration next to the center of gravity
Product features:■ Tri-axial accelerometer■ Long recording time - 7 hours and 45min■ USB computer connection
Parameters measured:■ Patient profi le (age, activity, medical/sporting
history)■ Stride pattern (frequency, length)■ Stride coordination (left & right symmetry and
regularity index)■ Mediolateral instability■ Gait constraints: shock analysis■ Mechanical power and energy expenditure whilst
walking
SoftwareInnovative software for generating very informative gait variables, validated by scientifi c, clinical studies.
Computer integration:■ Data saving, storage and analysis■ Calculation of biomechanical gait parameters■ Database for comparative analysis of the patient
against references grouped by age and gender
Clinical servicesServices for clinical trials (Phase III)
Custom experimental studies for clinical trial follow-up:■ Experimental protocol defi nition■ Patient identifi cation and selection■ Centralized data for standardized analysis■ Complementary patient examinations■ Results directly usable by clinicians■ Counseling for interpretation of clinical trial data
After sales services■ Installation assistance■ Training■ Hotline■ Maintenance
CENTAURE METRIXPépinière Genopole® Entreprises4 rue Pierre FontaineF-91058 EVRY CEDEX, FRANCE
Contacts: Dr Bernard Auvinet,Dr Eric Barrey
Phone: +33 (0)1 60 87 89 71Fax: +33 (0)1 60 87 89 99
www.centaure-metrix.com
PartnersFor distribution in the BeneluxEnraf-Nonius, Phone: +32 34 5072 44
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R&D Tools
Service description
Small animal housing (rodents and lagomorphs) and breeding (rodents) in optimal conditions■ SPF and SOPF environment■ L1/A1 and L2/A2 standards■ Production of genetic models■ Access to Charles River Laboratories services■ Capacity: 15,000 mice, 1,000 rats and 60 rabbits
Access to 14 fully-equipped laboratories for■ In vivo evaluations and preclinical studies:
cell culture, surgery, hematology/histology, physiological behavior, motricity studies, etc.
■ Functional exploration and phenotyping
Experiments performed by Charles River technicians■ Total study management■ Minor in situ manipulations on animals:
- Assistance for applications:tranquilization, anesthesia, joinings, post-surgery care or euthanasia
- User support for in situ exploration of the animals - Administration of substances, minor invasive
surgery: tissue sampling, injections (IV, IM, IP, ID, SC, etc.)
- Clinical follow-up - Weighing
Consulting on animal experimentation■ Protocol design■ Technical, scientifi c, ethical & veterinary support
by CERFE and Charles River experts
CERFECenter for Exploration and
Experimental Functional Research
CERFE is an integrated research platform established in April 2005 by Genopole as shared-access infrastructure for both companies and academic organizations.
CERFE is an animal facility (rodents and lagomorphs) offering a broad range of contract services:■ Animal housing and breeding■ Access to laboratories equipped for animal experimentation and functional exploration■ Performance of experiments and total study management■ Animal experimentation consulting
Facility management is performed by Charles River Laboratories.CERFE is a not-for-profi t organization managed as a business unit within Genopole.
21› Animal facilities - Research platform - Experimentation support -Functional exploration - Phenotyping - In vivo evaluation - Preclinical studies
Animal Models R&D Services
CERFE / GENOPOLE®
2 rue Gaston CrémieuxF-91057 EVRY CEDEX, FRANCE
Contact: Naceur TounektiPhone: +33 (0)1 60 91 32 80Fax: +33 (0)1 60 91 32 92
www.genopole.fr
Host Organization
Benefi ts
■ Privileged access to the services and technologies of Charles River Laboratories
■ Cost and time savings, fl exible organization, responsiveness, know-how and experience, competitive prices
■ Optimum conditions for animal experimentation: high sanitary status, a panel of laboratories equipped for functional exploration, a team of experienced Charles River technicians
■ Broad and fl exible service offering for in vivo evaluation studies: from help with protocol design to the performance of complete studies
■ The benefi ts of synergies and collaborations with other organizations (e.g. CROs which are members of CERFE) and several Genopole platforms (e.g. the Genethon in vivo evaluation and imaging facilities)
Partners
Charles River LaboratoriesAnimal facility management
GenethonImaging and preclinical evaluation platform (tools and expertise for molecular exploration, from the single cell to the whole organism level)
22
R&D Tools
DrugAbilis
List of services
■ Characterization and selection of druggable compounds
■ Characterization and selection of delivery systems
■ Physical characterization of drug substance bulks
■ Formulation for in vivo experiments:
- any animal model (effi cacy, PK, safety)
- any administration route and at any stage of the research project
■ Emerging activity:rational formulation of biologicals (proteins, peptides, DNA, etc.)
■ Consultancy and due diligence work
References
> Cytomics Systems
> Trophos
> etc.
DrugAbilis is a research specialist in early formulation design and the physicochemical characterization of research compounds.
DrugAbilis provides users with:
■ rationalization of the drug candidate selection process during the research phase
■ preclinical development support (animal study design) and preparation of phase I
Solution description
DrugAbilis provides:
■ customized solutions combining consulting expertise and the performance of experimental studies in early formulation design
■ operational services in research and preclinical physicochemical profi ling
23› Drug Research - Preclinical development - Early formulation -Customized solutions - Consulting and operational services
ConsultingR&D Services
Technical expertise fi elds
Consulting services and experimental studies are performed on a proprietary platform:
Physical characterization platform:Optical microscopy, submicron granulometry, hot-stage microscopy, thermal analysis (TGA/IR, DSC), Raman microscopy, IR, UV, water sorption measurements (DVS), powder X-ray diffraction
Physicochemical analysis:HPLC-UV, pH-metry, osmometry, LC-MS
Benefi ts
DrugAbilis is the fi rst CRO to specialize in pharmaceutical physicochemical characterization and formulation applied to the early selection of new drug candidates and the characterization of preclinical compounds.
With DrugAbilis, you benefi t from: ■ Experimental support and consulting services■ Service provision throughout the early-stage
process■ Experience of the drug candidate selection process■ Chemical and physical experimental capabilities
enabling: - a comprehensive approach to mastering a compound’s properties- and thus its in vivo behavior
■ A responsive team
DRUGABILIS5 rue Jean-Baptiste ClémentF-92290 CHATENAY-MALABRY, FRANCE
Phone: +33 (0)1 46 61 28 50Fax: +33 (0)1 46 61 28 50
www.drugabilis.com
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R&D Tools
FlowgeneFlowgene supplies scientifi c instrumentation with a particular focus on innovative detection systems for use in analytical chemistry (high pressure liquid chromatography and capillary electrophoresis).
Do you need easy-to-use instruments for identifying and quantifying very low analyte concentrations in liquid samples?Are you seeking a highly sensitive detector technology that provides the same low detection limit whilst avoiding the need to use tedious labeling procedures?
Flowgene has developed a proprietary, laser-induced fl uorescence detection (LIFD) technology that integrates a new generation of low-cost 224 nm lasers.Given that most biomolecules (proteins, peptides, neuropeptides, etc.) fl uoresce at this wavelength, Flowgene’s detector eliminates the need to label them.
HPLC 224 nm LINF Detector A 224 nm integrated laser-induced fl uorescence detector, designed for use with HPLC, µ-HPLC or capillary electrophoresis.
Product features■ Native fl uorescence detection■ Performance: 1000 times more sensitive than a
lamp-based fl uorescence detector■ Stand-alone unit
Benefi ts■ Ability to study proteins containing aromatic
amino acids■ Avoidance of polluting labeling steps and
functional protein modifi cations
Examples of applications■ Diagnostics:
low-concentration biomarker identifi cation■ Therapeutics:
- Drug purifi cation (ibuprofen, etc.)- Purifi cation of neuropeptides (serotonin, etc.)
25› Scientifi c Instrumentation - Detection systems - Analytical Chemistry - High Pressure Liquid Chromatography (HPLC) - Capillary Electrophoresis
Lab instrumentation
Coming soon
224 nm Raman Emission Detector
Analytical chemistry application
■ Potentially able to replace mass spectrometry techniques
■ A non-destructive technique■ Easy to use
FLOWGENERond Point du BiopoleF-63360 SAINT BEAUZIRE, FRANCE
Contact: Bruno de VandièrePhone: +33 (0)4 73 64 43 69Fax: +33 (0)4 73 64 43 44
b.de.vandiere@fl owgene.com
Web site under construction
Flowgene
References
> School of Pharmacy, Chatenay Malabry, France
> School of Medicine, Boston College, Boston, USA
26
R&D Tools
GeneCustGenecust provides custom services and products in molecular biology, protein expression and virology.
You need Time and resource savings:
■ a single service contact■ choice of the most appropriate services in a highly competitive fi eld■ low prices - even for small orders
Solution description■ a wide selection of products and services at competitive prices■ help in defi ning the most appropriate service for each customer■ management of after-sales services
ProductsProduct list available at www.genecust.com
Product range Products
DNA SynthesisDistribution of several hundred references from the leader Chemgenes
Peptide Synthesis Products
Reagents: ■ amino acids and derivatives■ FMOC-amino acids and derivatives■ amino alcohols■ amino acids coupled to Wang resin (aminoacyl resin)■ resin and derivatives
OthersBiochemicals, molecular biology kits, RNA- & DNA-modifying enzymes, markers, media, labware
27› Custom services - Molecular biology - Peptide synthesis - Virology
R&D Services
List of services■ Recombinant Adenovirus and Gene
Silencing: gene expression in adenoviral systems, amplifi cation and purifi cation of adenoviruses, plaque purifi cation, adenovirus titer determination, assays.
■ Baculovirus Expression: production of recombinant baculoviruses and titer determination, expression optimization, large-scale expression, purifi cation of recombinant proteins.
■ Gene Silencing: siRNA synthesis, RNAi-Mate transfection reagent, siRNA package.
■ Peptide Synthesis: every single custom peptide is analyzed by mass spectrometry and HPLC.
■ Custom Polyclonal and Monoclonal Antibodies: includes antigen design, peptide synthesis, polyclonal antibody and monoclonal antibody production. Rat monoclonal or polyclonal antibodies for the study of gene expression and proteomics in mice (including mouse models of human diseases).
■ Gene Synthesis: artifi cial gene synthesis up to 10 kb, codon optimization for free if required and double strand DNA sequencing on the end product; mutation associated service.
■ Cloning and Subcloning
■ Mutagenesis
■ Oligonucleotide Synthesis and RNA
■ DNA Sequencing
■ Laboratory instruments and service support: refurbished instruments for DNA & protein analysis and, for many of the instrument systems we sell, preventative maintenance, system refurbishment, comprehensive annual repair contracts, service call-outs with hourly rates.
ServicesBenefi ts■ Expertise and know-how in molecular biology,
protein expression and virology
■ A broad range of products: a single order for all your laboratory needs
■ Selection of the best products from different providers, suited to your needs
■ Fully customizable and scalable services
■ One contact for all your needs
■ Management of after-sales services
■ Competitive prices: price list available on ourwebsite: www.genecust.com
GENECUSTPépinière Genopole® Entreprises4 rue Pierre FontaineF-91058 EVRY CEDEX, FRANCE
Phone: +33 (0)1 60 87 89 23Fax: +33 (0)1 60 87 89 99
www.genecust.com
28
R&D Tools
GenewaveGenewave provides microarray instruments & consumables for DNA, RNA, protein & cell biochips and surface functionalization services.
Do you need tools for applications based on fl uorescence biochips (DNA, RNA, proteins, cells) with high sensitivity, specifi city, portability, real time results and automation features at affordable prices?
Genewave provides ■ High-sensitivity refl ective microarray substrates ■ Easily affordable, versatile microarray readers ■ Low-cost, high-quality glass microarray substrates ■ Real-time hybridization imagers and systems■ Surface functionalization services (see p. 50)
- Standard slide dimensions (75x25x1mm)- Chemistries: aminosilane, epoxysilane (coming soon) or custom - Barcode- Packaging: 5 or 25 slides; vacuum sealed
AmpliSlideTM
High-sensitivity Refl ective Microarray Slides
■ Signifi cant improvements in microarray sensitivity
■ Reliable detection of low-expressed genesor low-abundance proteins
■ Lower amounts of sample required (in biopsies, for example)
■ Reduction in the number of cell passaging steps
■ Savings on costly reagents such as dye labelingamplifi cation kits
■ Faster microarray imaging
- Standard slide dimensions (75x25x1mm)- Chemistries: aminosilane, epoxysilane (coming soon)- Dye compatibility: 570 and 670 nm- Packaging: 5 or 25 slides; vacuum sealed
■ Cost-effective microarray substrates
■ Low fl uorescence background
■ Highly uniform functional coating
■ High binding effi ciency
■ Long shelf life
BrioSlideTM
Low-cost, High-quality Glass Microarray Slides
29› Microarray instruments & consumablesSurface funtionalization services
Lab InstrumentationBiochips
GENEWAVE Bat.404 (XTEC),Ecole Polytechnique CampusF-91128 PALAISEAU CEDEX FRANCE
Contact: Constantin NelepPhone: +33 (0)1 69 33 35 93Fax: +33 (0)1 69 33 30 44
[email protected]@genewave.com
www.genewave.com
- Compatible fl uorophores: Cy™5, Alexa®647, DY®-648 and analogs - Detector: High quantum effi ciency cooled CCD - Imaged area: 1 cm2
- Resolution: 10 µm - Frame rate: 3 images per minute - Image depth: 16 bits - Number of washing solutions: 4 - Temperature control: +/- 0.1 °C - Temperature range: from RT to 70 °C
- Excitation: 640 & 532 nm (customizable)- Dye compatibility: Cy™3 & Cy™5 and analogs- Detector: High quantum effi ciency cooled CCD - Sample format: standard microscope slides- Acquisition time: 3 min per full slide
HybLiveTM
Integrated Hybridization Station and Real-time Biochip Reader
■ Easily affordable double-color microarray reader
■ Extra-small footprint: 26x35 cm
■ High dynamic range■ Novel large-fi eld optical architecture
■ No stitching artifacts
■ Adjustable exposure time enables a range of applications - from rapid diagnostics to gene expression studies
■ Powerful and intuitive control & analysis software for increased workfl ow
■ Single-color CCD-based biochip reader
■ Full-featured hybridization & wash station
■ Highly effi cient mixing
■ Accurate temperature control
■ Time-resolved analysis
■ "Walk-away" computer-controlled operation
■ User-printable cartridges based on AmpliSlide™ technology
AmpliReaderTM
Compact Microarray Reader
HybLive™ development was partially funded by DGA / SPNUuM.
30
R&D Tools
GenOpticsGenOptics provides lab instrumentation solutions focused on the development of high-performance systems with advanced optical imaging based on the company’s proprietary “Surface Plasmon Resonance imaging” (SPRi) technology.
GenOptics SPRi-systems enable label-free, real-time monitoring and quantifi cation of DNA-DNA, DNA-protein, protein-protein, peptide-protein and carbohydrate-protein interactions in microarray formats.
Instruments■ SPRi-Spot: a manual spotter designed for
immobilizing probes on a SPRi-BiochipTM, supplied with a proprietary spotting head for electro-copolymerization.
■ SPRi-Arrayer: an automated and programmable spotter enabling immobilization of up to 400 probes on a SPRi-biochipTM, supplied with a proprietary spotting head for electro-copolymerisation.
References
> CEA, INSERM and IPBS (Grenoble, FR)
> McGill University (Quebec, Canada)
> CGM CNRS (Gif sur Yvette, FR)
> CNRS (Evry, FR)
> CEB (Vert-le-Petit, France) Joint Research Centre (Ispra, Italy)
■ SPRi readers: enabling parallel and simultaneous detection of up to 400 spots
- SPRi PlexTM: for automation of large-scale screening operations
An automated system including:- a piston pump- an automated injection valve- an optional auto-injection system
- SPRi LabTM: an open confi guration for lab experiments
Manual system- pumping system not included- supplied complete with computer and software
31
Entreprise
› Drug discovery - Diagnostics - Proteomics - Interaction analysis
Lab instrumentation
ConsumablesSPRi-BiochipTM
> high-index glass prism coated with a thin gold fi lm> can be re-used more than 30 times (depending on the biomolecular
model employed)> up to 400 immobilized molecules can be spotted> dimensions: 25 mm x 12.5 mm.
GENOPTICS Centre Scientifi que, Plateau du Moulon Bât. 503F-91403 ORSAY, FRANCE
Contact: Philippe KerourédanPhone: +33 (0)1 69 35 87 86Fax: +33 (0)1 69 35 88 36
www.genoptics-spr.com
Benefi tsLabel-free: no labelling - no fl uorochromeReal-time imaging: from start to fi nish, the entire run is fi lmed at a rate of 1 frame per second by a highly sensitive CCD camera
Multiplexed: ■ Advanced optical capabilities enable the detection
of multiple targets on the same biochip at the same time
■ Between 1 and 400 probes can be immobilized at any concentration and at any position on the biochip
■ Molecules can be related or from completely different families
Collaborations The French Military Procurement Directorate (DGA, Paris, France) for biosecurity applicationsLAMBE - Academic research laboratory (Evry, FR) Jeanine Tortajada, Scientifi c director Institute of Optics - LCFIO laboratory (Orsay, FR)
ApplicationsDrug discovery, tumour marker monitoring (for early diagnosis and patient monitoring), biosecurity (bioterrorism).■ Measurement of the strength of antibody-epitope
interactions■ Binding of: IgE to allergens, P53 protein to DNA
probes, chemokines to various sugar probes■ Detection of circulating anti-HCV antibodies directly
in patient serum■ Measurement of polymer fi lm thickness (in surface
treatment QC, for example)
Our SPRi readers are supplied complete with a PC, our proprietary SPRi-ViewTM user interface software and the SPRi-1000TM data analysis program.
32
R&D ToolsBiosafety Services
GenoSafeGenoSafe - a subsidiary of Genethon - is a contract services company dedicated to evaluating the safety and effi cacy of biotherapeutic products (viral and non-viral vectors, vaccines, recombinant proteins, monoclonal antibodies, cellular products, etc.).
From the research stage to the market, we provide customized studies and analytical testing in order to move along the product development chain effi ciently, successfully and in accordance with regulatory requirements.
On request, we can operate under Good Laboratory Practice (GLP) conditions. Our quality assurance (QA) system guarantees the high levels of quality and traceability required by the regulatory authorities.
Genosafe servicesOur services are targeted at users
■ working in vaccination and the gene/cell therapy fi elds■ developing products to fi ght cancer and infectious,
metabolic & genetic diseases
Because each project is unique, Genosafe designs fully customized studies to meet its customers’ specifi c needs.
Our main services include:■ Expert advice, design and completion of in vitro and in vivo studies■ Preclinical biodistribution studies of gene-based therapeutics■ Characterization of the immune response induced by biotherapeutic products■ Quality control of viral vector batches for preclinical or clinical use■ Genotypic and phenotypic characterization/derivation of stem cells■ Adaptation of preclinical tests to the clinical
phases for patient selection & monitoring
Technical expertise■ Molecular biology (PCR, real-time Q-PCR,
real-time RT Q-PCR, etc.)■ Cell biology■ Immunology, immunochemistry■ Virology■ In vivo testing
References> Pasteur Institute (FR)> INSERM (French National Institute for Health
and Medical Research)> CEA (French Atomic Energy Commission)> Genethon (FR)> King’s College London (GB)> University of Geneva (CH)> MDS Pharma (FR)
33› Contract services company - Safety & effi cacy evaluation /Biotherapeutic products
R&D ServicesHealth
List of services
In vitro and in vivo studies for the assessment of safety and effi cacy
■ Expert advice and study design & management■ Biodistribution studies: assessments of vector
distribution, traffi cking and persistence in a relevant animal model.
■ Gene expression profi ling■ Assessment of immune responses■ Detection of replication-competent viruses
(RCVs) for viral-based gene therapy■ Evaluation of insertional mutagenesis
.Clinical safety evaluations
We take care of all the specifi c patient eligibility tests for treatment and follow-up. In many instances, these services will benefi t from thetechniques previously developed and implemented during preclinical studies.■ Vector distribution and shedding■ Transgene expression■ Immunomonitoring■ RCV testing
Q.C. on viral vector batches
Quality control tests on batches of viral vectors (AAV, LV, Ad, MLV) for preclinical or clinical use: titration, RCV detection, evaluation of the risk of insertional mutagenesis and detection of specifi c DNA sequences.
Q.C. on stem cells
Genotypic and phenotypic characterization/derivation of stem cell lines
Benefi ts Know-how and expertise
You will be able to profi t from our in-house know-how plus advice from our regulatory experts. Together, we defi ne the tests required for the successful development of your product.
A personalized approach
Because your project is unique, we will supply you with personalized solutions by designing and performing studies that specifi cally meet your needs.
One-to-one support
A single contact person will provide you with support throughout the lifetime of your project. We provide you with the expertise, dialogue and fl exibility that are essential for driving your project forward.
Quality
GenoSafe’s clients benefi t from our quality assurance policy. Our services are performed in compliance with Good Laboratory Practice.
A reliable long-term partner
GenoSafe is funded by Genethon and the AFM, making it a fi nancially stable company capable of providing you with long-term project support.
GENOSAFE1 rue Pierre FontaineF-91058 EVRY CEDEX, FRANCE
Contact: Vincent ZulianiPhone: +33 (0)1 69 36 07 57Fax: +33 (0)1 60 78 66 20
www.genosafe.com
34
Clinical Tools R&D Tools
IntegraGenIntegraGen is a pioneer in the fi eld of personalized healthcare, identifying genes causally associated with complex diseases, developing and commercializing molecular diagnostic tests for individualized diagnosis, prevention and treatment.
By leveraging internal expertise, IntegraGen offers customized genotyping and BAC chips to support the research community.
■ IntegraGen’s unique genomic analysis technology (GenomeHIP™) provides the foundation for discovery and validation of genetic markers.
■ Compared to today’s other technologies (e.g. SNPs, microsatellites), GenomeHIP™ is the most powerful technology available for identifying genes causally associated with complex diseases within standard-sized patient cohorts.
■ IntegraGen’s discovery activity is currently focused on obesity, diabetes and autism.
■ IntegraGen’s fi rst gene-based test is in clinical trials and will be launched in 2007. Commercial operations and a service-oriented, ISO-accredited lab in Germany (focused on molecular testing in diabetes) have been operational since 2005.
35› Genetic research and diagnostics - Discovery and validation ofgenetic markers -Personalized healthcare - Predictive diagnostictests – Complex diseases – Gene-based tests
Genetic ServicesR&D Services Biochips
Genotyping ServicesBy customizing its offer to meet a wide spectrum of research needs, IntegraGen provides time-sensitive, high-quality SNP genotyping services on the following platforms:
■ Taqman®
■ SNPlex®
■ Illumina®
This enables the company to tackle all project sizes, from gene-based association studies to pharmacogenomics.On request, the genotyping service can include project counselling and data analysis.
BAC ArraysServices include customized manufacturing, high-density microarrays (4898 BAC clones developed for the French Cancer League’s CIT program) and cytogenetics services.
Founded for and dedicated to discovering and commercializing gene-based diagnostics, IntegraGen’s proprietary GenomeHIP™ technology, bioinformatics capabilities and genotyping & BAC array services are available to researchers worldwide.
INTEGRAGENGenopole® Campus 1 - Bât. G85 rue Henri DesbruèresF-91030 EVRY CEDEX, FRANCE
Contact: PD Dr Jean Mous (CEO)Phone: +33 (0)1 60 91 09 00Fax: +33 (0)1 60 91 09 22
www.integragen.com
SERVICES supporting the research community include:
36
R&D Tools
MilleGenMilleGen’s innovative platform combines random mutagenesis with a high throughput screening process and a bioinformatic analysis to improve proteins in the fi elds of human antibodies for therapeutic and diagnostic use, as well as industrial enzymes.
You need■ Antibody affi nity maturation■ Improvement of protein stability or activity■ Development of research and diagnostic tools
MilleGen solution■ Antibody generation: fully human antibody libraries■ Antibody optimization: recombinant antibody engineering and cell screening technologies■ Antibody expression and conversion (the entire IgG molecule)■ Recombinant protein engineering■ Discovery and selection of antibodies against targets of interest
■ Research toolsA catalogue of recombinant proteins and polyclonal & monoclonal antibodies
■ A large range of productsOver 4,000 antibody references to support user research
References> Pharmaceutical and biotech companies
> INSERM, CNRS, INRA, CEA, IFREMER (France)
> French and European universities
> Pasteur Institute (France)
ProductsMilleGen provides
37› Innovative platform - Human therapeutic antibodies -Recombinant protein engineering
R&D Services
MILLEGENBâtiment Prologue BiotechRue Pierre et Marie CurieBP 28262, F-31682 LABEGE CEDEX, FRANCE
Contact: Aurore FalcozPhone: +33 (0)5 61 28 70 10Fax: +33 (0)5 61 28 70 11
www.millegen.com
List of services (Non-exhaustive) ■ High-throughput DNA sequencing: 28 Mbp (HTS)
and 7 Mbp custom sequencing per month
■ Large-scale sequencing (microbial genomes, BACs, etc.)
■ Exon sequencing / mutation detection
■ Cloning, vector construction
■ Directed and random mutagenesis
■ Peptide synthesis (5 to 100 AAs)
■ Bioinformatics analysis: database integration and development; data-mining; customized genomic and proteomic analysis (SNP discovery, annotation and validation)
Benefi ts■ Fast (24hr turnaround) and high-quality
automated DNA analysis
■ A completely automated robotic biosystem
■ Experience: MilleGen is involved in several high throughput sequencing projects with private-sector companies and academic laboratories
■ Bioinformatics know-how, fl exibility and customized solutions
■ Extensive knowledge and experience in the fi eld of custom peptide synthesis
■ Quality and speed of delivery
■ Very competitive prices
■ Hotline
Services
38
R&D Tools
Nokad
PartnersAtrageneBio-informatics platform implementationCERFE (Genopole Evry)Small animal housing (mice and rats)National Veterinary School (Nantes)Large animal housing (from rat to primate)Gene Therapy Laboratory (Nantes, Vector Core Production)Viral vector constructionOncodesignPhenotyping (imaging and laboratory tests)
References> Ongoing contracts with pharmaceutical
companies under confi dentiality agreements
> Academic collaborations
You need■ Fast functional characterization of secreted proteins and membrane receptors.■ Functional inactivation:
- in different animal strains- in different mammalian species- in pre-existing models (transgenic models, disease models, etc.)- when genetic KO induces embryonic lethality- at different animal ages- of proteins formed by alternative splicing or different sections of enzymatically-cleaved
proteins
Solution description NOKAD, the pioneer in Functional Knock-out generation in all mammals, offers you its proprietary technology to accelerate your functional characterization.
NOKAD is the fi rst company in the world to have developed and marketed the functional inactivation of endogenous proteins in all mammals (mouse, rat, rabbit, primate, etc), through direct in vivo induction of a specifi c immune response.
NOKAD allows you to increase cost-effi ciency and discovery performance, providing dedicated research tools for effi cient and strategic research management.
39› Functional genomics - In vivo protein models - Functional KO - Protein function - Target & drug discovery
Animal ModelsR&D Services
Technology features■ In vivo protein inactivation is based on controlled, cross-reactive antibody induction of a specifi c immune response
■ Fast functional knock-out:- in 6 months for the fi rst animals- and 2 months for subsequent ones
■ Functional KO models in all mammals
■ Easy switching:- from one strain to another (a 1-2 months
operation)- from one species to another (1-6 months)
■ Functional KO directly in adult animals or at different animal ages
■ Selective inactivation of proteins:- from alternative splicing- from gene clusters- from enzymatic cleavage
■ Long-term stable phenotypes
■ Inactivation kinetics
■ Possibility of phenotype reversion
Benefi ts■ Inactivation on the protein level
■ Ability to work directly on the most relevant species for functional studies
■ Generation of a functional KO in the specifi c animal model or strain for target validation
■ Functional characterization of endogenous secreted proteins and receptors is enabled in a variety of physiological or pathological situations
■ Possibility of kinetic studies
■ Quality control: design of dedicated validation tests
■ Rapid and serial analysis of a broad range of target proteins
■ Time and cost savings:- starting in vivo and in vitro tests at the same
time- yields more predictive information thanks to
use of the most relevant model
List of services:
NOKAD™ models: Functional KO generation in all mammals.Mouse and rat models are available for worldwide distribution, other species are available only in France.
NOKAD™ Plus: Phenotyping Services.
NOKADPépinière Genopole® Entreprises 4 rue Pierre FontaineF-91058 EVRY CEDEX, FRANCE
Phone: +33 (0)1 60 87 89 90Fax: +33 (0)1 60 87 89 99
www.nokad-technology.com
40
R&D Tools
Open Biochip CenterR&D platform service ■ Simplifi ed, effi cient access to up-to-date biochip fabrication equipment which matches your needs.■ The technology platform of the Open Biochip Center is open to campus researchers and bio-entrepreneurs.■ The facility is operated by Serial Genetics. The facility’s equipment has been set up in partnership with
Genopole an the DRIRE*.
* French Regional Direction of Industry, Research and Environment - Paris Region
Key advantages
■ Access to cutting-edge equipment for the design, fabrication and analysis of low-density biochips on a single site
■ Attractively-priced access
■ Quality: benefi t from Serial Genetics’ expertise in producing biochips for diagnostics, genetic susceptibility tests and series identifi cation
■ Special access conditions for start-ups
■ Organization of hands-on training courses in the fi eld of array-based genetic diagnostics - Patient group visits for discovery days (“DNA School”).
41
R&D ServicesBiochips
› Up-to date biochip production - Self service access to equipment - Practical training course
SERIAL GENETICS2 rue Gaston Crémieux, F-91000 EVRY, FRANCE
Phone: +33 (0)1 60 87 35 09 Fax: +33 (0)1 60 78 76 23
www.serialgenetics.com
Molecular biology ■ Agilent 2100 Bioanalyzer■ Eppendorf robot pipette ■ 96- and 384-well PCR
machines
Spotting & hybridization■ Affymetrix 417 spotter■ Lucidea SlidePro workstation ■ Hybridization oven
Image and data analysis ■ Axon 4000B Scanner,
Genepix 5.0 analysis software, server
■ 2 workstations
Available equipment 3 types of activity
Platform managed by :
42
R&D Tools
PartnerChipPartnerChip provides state-of-the-art gene expression tools and services:■ Design and supply of dedicated/custom biochips■ Laboratory operations and consulting■ Bioinformatics data analysis
You need■ Transcriptome (gene expression) studies monitoring large-scale genomes in order to:
- provide signatures and profi les- identify novel transcriptional elements- understand complex biological mechanisms or gene transfers
■ Genotyping and associated studies in order to:- conduct whole-genome association studies- measure linkage disequilibrium
Benefi ts ■ As an Affymetrix Offi cial Service Provider (AOSP), PartnerChip is committed to meet several requirements:
- quality- compliance with deadlines- performance
■ Choosing PartnerChip means:- time savings- a total solution: full information with more
thoroughly analyzed data- fl exibility & versatility: co-development of
dedicated biochips
Technology features■ A powerful system: very high density arrays
- up to 500,000 SNPs for genotyping- and 45,000 transcripts for gene expression
■ Rapid provision of fully-analyzed data
Industrial collaborations for total solutionsAffymetrix: DNA chip provider
Invitrogen: Protein chip provider
Stratagene: Data analysis software
References (non-exhaustive)
> French hospitals: the Lariboisiere Hospital (Paris), Angers Hospital (FR)
> Luxury cosmetics companies
> AFM – Genethon
> European research programs: the Medicen Biotype and EuroIron projects.
43› CRO - Consulting - Bioinformatics - Genotyping -Transcriptome studies
R&D ServicesBiochips
PARTNERCHIPBat.G2, 2 rue Gaston CrémieuxF-91057 EVRY CEDEX FRANCE
Contact: Pascal SoularuePhone: +33 (0)1 60 87 34 62Fax: +33 (0)1 60 87 34 98
[email protected]@partnerchip.fr
www.partnerchip.fr
List of services■ Experimental design■ Provision of data analyses including
- normalization (validation tests)- identifi cation of metabolic pathways involved
■ Performance of all the following steps
- cDNA and cRNA synthesis- target QC- hybridization on GeneChip arrays- array processing and scanning- raw data production
Applications■ Disease classifi cation, clinical follow-up■ Pharmacogenomic analysis (predictive and
preventive medicine)■ Identifi cation of contaminants■ Hygiene and safety tools for hospital environments■ Quality control processes in the food & beverage
and cosmetics industries
44
Clinical ToolsR&D Tools
Biosafety Services
Serial GeneticsSerial Genetics designs and manufactures DNA chips for genetic testing kits. Based on the company’s proprietary HairLoopTM technology, our DNA chip kits are powerful devices for organism identifi cation, pharmacogenetics and medical diagnostics.
DNA HairLoopTM kits are simple, robust and cost-effective solutions for the analysis of all kinds of mutations or allele sets for applications in research, medical diagnostics and the pharmaceutical & agrifood industries.
Benefi ts ■ Simplicity: easy to use (at room temperature…) - unambiguous yes/no results, easy to interpret
■ Rapidity: your results in just 4 hours after DNA purifi cation; minimal hands-on time
■ Specifi city: - HairLoop’s™ thermodynamics confers higher specifi city on the DNA probes relative to conventional
linear probes- High specifi city in mutation analysis, even in highly homologous species
■ Effi ciency: - In one single assay, HairLoop™ kits detect a broad
range of allele variations (SNPs, large deletions and/or insertions, microsatellite allelic imbalance)
- A valuable alternative to PCR-based technologies
■ Economy: - No specifi c equipment required (just
an off-the-shelf thermocycler, a low-cost scanner)- On-demand custom kits rapidly developed
■ Quality: CE-marked clinical in vitro diagnostic kits
References
> Sanofi -Aventis Genetics Center - Bayer> CNRS - INSERM - Cornell University (NY, USA)> French hospitals: the American Hospital in Paris,
University Hospitals in Limoges and Strasbourg> Danone, Limagrain, INRA, US Department of
Agriculture> Vilmorin Clause Téziers> Syngenta – Keygene
45› DNA chips - Medical diagnostics - Drug discovery and development - Biomarkers
Clinical testing kitsBiochipsAgrifood
ProductsMedical/Clinical Diagnostic kits (in vitro) for genetic testing assays■ Launched in 2006: Diagnostic kits for the
genetic analysis of 4 hereditary diseases- Cystic fi brosis (CFTR)- Charcot-Marie-Tooth disease- Beta thalassemia- Hemochromatosis
■ Coming soon, in 2007: 2 other diagnostic kits- Bladder cancer: early onset diagnosis - Coagulation disorders
■ All genetic testing kits include- HairLoopTM microarrays- Amplifi cation reagents- An application-dedicated
software module for analysis of the results
■ Diagnostic kits features- Include 5 internal controls and 2 negative controls- Are available in 2, 10 and 96 assay formats- Will be sold as CE-marked kits by late 2006
Services
Development of customized testing kits for on-demand industrial applicationsSerial Genetics designs on-demand, fl exible kits that meet customer requirements. Kits can be reconfi gured at any moment, by adding or removing
mutations.■ Pharmaceutical R&D and CROs
Rapidly developed GLP pharmacogenetics assays, simple to use, fl exible and ready for CE labeling as a drug companion test.
■ The agrifood industry and biotechSpecies identifi cation kits (bacteria, mammals, insects):- Lactic bacteria species identifi cation.
- 15-species termite identifi cation kit.
SERIAL GENETICS2 rue Gaston CrémieuxF-91000 EVRY, FRANCE
Phone: +33 (0)1 60 87 35 09Fax: +33 (0)1 60 78 76 23
www.serialgenetics.com
PartnersGreiner Bio-One GmbH (Germany)“Check Report” interpretation software and “Check Scan” fl uorescent scanner
Innopsys SAS (France)Innoscan 700 low-cost fl uorescent scanner
Genewave SAS (France)Low-cost scanner and Amplislide real- time instrumentation reader
46
R&D Tools
Sigma AldrichOur biochemical and organic chemical products and kits are used in scientifi c and genomic research, biotechnology, pharmaceutical development, the diagnosis of diseases and as key components in pharmaceutical and other high technology manufacturing.
Solution description■ Molecular biology: DNA & RNA oligonucleotide synthesis, dual-labeled DNA probe detection,
PCR & qPCR, nucleic acid purifi cation, transfection, cloning & expression.
■ Functional genomics: shRNA, siRNA.
■ Proteomics: custom peptide synthesis, polyclonal antibody production, protein extraction /purifi cation / expression, profi ling arrays, mass spectrometry, expression profi ling, antibody and protein arrays.
■ Cell biology: antibodies, cell signaling and neuroscience kits & assays.
Products and custom
services Technical features Customer benefi ts Applications
Synthetic siRNA
Rosetta design, custom synthesis and validated panels
- Broad range- Expertise: design,
R&D, productionRNA interference
TCR Mission shRNA Libraries
- Target sets, individual clones, gene families
- Glycerol, plasmid or lentivirusformat
- 15 000 genes (human, mice)
- Widest choice in the market,
- Long term knockdown
Long term RNA interference
WGA (Whole Genome Amplifi cation)
Representative amplifi cation of genomic DNA from trace amounts of sample
- Rapidity- Use as little as 10 ng
of tissu
qPCR, cCGH microarray, SNP analysis
PanoramaTM Ab or Protein Arrays
Complete kit for rapid screening of several hundred validated antibodies or functional proteins
- Sensibility and specifi city
- Easy and fast protocol- Wide range of
products targeting key cellular proteins
Multiplexed protein analysis
47› Custom services - Molecular biology - Functional genomics -Proteomics - Cell biology & culture
R&D ServicesBiomanufacturing
SIGMA ALDRICH FRANCE - 80 rue de Luzais, BP 701F-38297 SAINT QUENTIN FALLAVIER, FRANCEPhone: +33 (0)800 21 14 08 Fax: +33 (0)800 03 10 52
SIGMA ALDRICH / SIGMA PROLIGO - Genopole Campus 15 rue Henri Desbruères, F-91030 EVRY CEDEX, FRANCEPhone: +33 (0)810 40 09 82 Fax: +33 (0)4 74 99 10 12
www.sigmaaldrich.com
Accelerating Customer’s Success through Leadership in Life Science, High Technology and Service
Products and custom
services Technical features Customer benefi ts Applications
ProteoPrep® 20
Depletion kit for the elimination of 97% of the most abundant human proteins from serum and plasma by immunoaffi nity
Detection of rare proteins
Electrophoresis and mass spectrometry analysis
Sigma Proligo platform
- DNA and RNA oligos synthesis, labeling of nucleic acid
- siRNA and LNA analogs production
- Development of new protocols and methods for the synthesis and the labeling of nucleic acid
- High expertise: design, production and R&D made in home
- HTS platform
PCR, qPCR, arrays…
SAFC Global
Products and services for pharmaceuticals, biopharmaceuticals, IVD diagnostics manufacturers and fl avors & fragrances
- Worldwide manufacturing base (including cGMP facilities)
- Regulatory expertise
Biochemical production and manufacturing of complex, multi-step organic synthesis of APIs and key intermediates
48
Clinical Tools
StatlifeStatlife provides informatics solutions for predictive and preventive medicine applications, enabling:
■ the delineation and enlargement of the target population who could benefi t from a treatment
■ better use of medicines
Statlife’s solutionOn-demand development of custom, exclusive software for quantifying:
■ an individual’s risk of developing major diseases (breast, ovary & colon cancer, etc.; Alzheimer’s disease, osteoporosis, infarct, etc.), according to lifestyle, treatments taken, biological data, family and personal medical history, etc.
■ the prescription’s impact on the patient’s risk profi le
Key features■ Access to unique academic databases and prospective cohorts, especially suited to European
populations
■ Close collaboration with INSERM (the French National Institute for Health and Medical Research)
■ Know-how for designing modern risk scores
■ A successful collaboration for HRT (Hormone Replacement Therapy) prescription (software now being fi nalized)
Partners
INSERM: database development coordinator
Software houses: user interface development and co-validation of the entire evaluation system.
49› Prescription support tool - Healthcare programs
Medical Services
Therapeutic area-oriented services■ Statlife’s fi rst software solution was developed in order to quantify HRT-associated risks
■ Statlife provides co-development services for other therapeutic fi elds: prevalent cancers, cardiology, Alzheimer’s disease, osteoporosis, etc.
A 2-level service:
■ A 2-year-program for designing validated risk scores
■ A 3-month software development phase
Benefi ts■ Flexibility for an appropriate marketing strategy
■ Exclusivity
■ Customized solutions
■ A patient focus
STALIFE22 rue DurocF-75007 PARIS, FRANCE
Contact: Stéphane RagusaPhone: +33 (0)1 60 84 83 85
www.statlife.com
50
R&D Tools
Surface Functionalization Services
The facility is operated by Genewave. The facility’s equipment has been set up in partnership with Genopole and the DRIRE*.
Custom Surface Functionalization
List of services■ R&D studies in surface chemistry and corresponding
biological buffers and protocols
■ Proof of concept
■ Feasibility studies
■ Industrialization
■ Production
■ Expertise and supply of substrates and packaging
■ Standard or custom barcode labeling
■ Quality control
Technology features■ State-of-the-art cleaning and chemistry deposition
equipment
■ Contamination-free technology
■ Clean room environment (substrates are manipulated in Class 10 area)
■ An extensive range of characterization equipment: - contact angle goniometer- microarray arrayer, hybridization
station & fl uorescence scanners- microscope slide washing station- ellipsometer- UV-VIS-NIR spectrometer
* French Regional Direction of Industry, Research and Environment - Paris Region.
51
R&D ServicesBiochips
› Custom surface chemistries - High reproducibility and uniformity
Benefi ts■ Increased reliability and robustness of custom surface chemistry
■ Excellent coating uniformity and reproducibility
■ Fluorescence background control ready-to-use/ready-to-sell packaging and labeling solutions
Reference partners
DNA combing chipsGenomic Vision / Pasteur Institute, France
Innovative surface coatings for DNA biochips “Macromolecules and Microsystems in Biology and Medicine” Group, Curie Institute, Research Division, France. Tested by GODMAP (Gif-Orsay DNA Microarray Platform), France
GENEWAVE Bât. 404 (XTEC)Ecole Polytechnique Campus,F-91128 PALAISEAU CEDEX, FRANCE
Phone: +33 (0)1 69 33 35 93 +33 (0)1 69 33 28 53
Fax: +33 (0)1 69 33 30 44
www.genewave.com
52
R&D Tools
TcLandIf you need a reliable partner to …
■ Identify the T and B cell populations selectively mobilized in complex situations■ Analyze a complex immune response to unknown antigens■ Monitor the effect of a treatment on the immune system■ Determine a disease’s “immune signature”■ Identify/evaluate new therapeutic strategies■ Perform quantitative PCR
…then contact us! We can meet your needs.
The TcLand biotechnology company was founded in 2002. At TcLand, we perform innovative immunological analyses focused on T and B cell immune responses. Our customers around the world (pharma and biotech companies, leading academic centers) are already using these techniques as immunomonitoring solutions for a range of therapeutic applications, such as cancer1, infectious diseases2 (AIDS, hepatitis, etc.) and auto-immune diseases3 (Multiple Sclerosis, Rheumatoid Arthritis, Crohn’s disease, etc.).
1- N. Degauque et al. 2004. Int J Cancer. 110:721; 2 - M. Guillet et al. 2006. AIDS research and human retroviruses. 22:648 ; 3 - D. Laplaud et al. 2004. Brain. 127:981, D. Laplaud. 2006. J. Neuroimmunol. 177:151
Technology featuresTcLandscape®:■ A breakthrough technology with strong patent protection■ A comprehensive, precise overview of T cell immune responses
References
> Pharmaceutical & biotech companies such as GlaxoSmithKline, Biogen and Fresenius.
> Renowned academic institutions such as the Weizmann Institute of Science (Israel), the University of Queensland (Australia), Baylor Healthcare System (USA), Oxford University (UK), INSERM research units and Clinical Investigation Centers (France).
53› Repertoire Analysis, Immunomonitoring, Clonal responses, T cells, B cells, Epitopes, Immunoscope/Spectratyping, Quantitative PCR, Immunotherapy, Immune signatures
R&D Services Biomarkers
Sample preparation cells, RNA, cDNA
Cell Sorting (CD8, CD4, CD25…)
TcLandscape
Appropriate StatisticsAppropriate Statistics
Cell sorting- J Analysis- qPCR- cloning- other …
TCR surface analysis
T&B CELLS ANALYSEST&B CELLS ANALYSES
Immunoscope BcLandscape
Real time qPCR
IgD IgE
IgM IgG
Services - DescriptionAll analyses are performed in our own laboratories
TCLANDCentre d’Affaires Genopole Campus 15 rue Henri DesbruèresF-91030 EVRY CEDEX, FRANCE
Contact: Marina Guillet, PhDPhone: +33 (0)2 40 41 28 34Fax: +33 (0)2 40 41 11 01
www.tcland-biotech.com
Benefi ts ■ Patented and validated technologies (12 peer-reviewed scientifi c publications in collaboration with well-known scientists such as JP Soulillou, JG Guillet, S. Khoury, M. Maeurer, etc.).
■ Quality assurance.
■ Appropriate statistical analysis, performed by a team of specialists.
■ A standardized process based on a reliable, dedicated data management and validation system.
■ Additional services are available, giving you a total solution for repertoire analysis
This breakthrough technology for analyzing the complex immune responses allows new applications
■ Monitoring: Immune Response - Treatment impact - Epitope spreading
■ Identifi cation: Mobilized T Cell populations - Patient groups, «immune signature»
■ Discovery: Therapeutic targets - Immune mechanisms
PartnersAcademic laboratoriesApplication of the technologies in animal models (rats, mice and primates) for research purposes
Clinical Investigation CentersValidation of the technologies as predictive biomarkers in Rheumatoid Arthritis, Multiple Sclerosis, transplantation, etc.
European NetworkValidation of the technologies as a diagnostic tool
54
Clinical Tools
Tech InnovationTech Innovation is a medical device company specializing in the design and development of innovative upper-limb orthopedic products.
Do you need a high-quality prosthesis for a specifi c use?(e.g. a prosthesis for a specifi c sports activity)
Tech Innovation’s R&D services are dedicated to facilitating everyday activity for handicapped people.
Tech Innovation offers effi cient, easy-to-use prosthetic systems at competitive prices, with made-to-measure prostheses for particular needs.
Technology features■ Hi-tech manufacturing system based on 3D modeling tools, enabling:
- made-to-measure prosthesis design- production of all types of device shapes and styles
■ R&D on composite materials (resins, etc.) for the development of prostheses which are:- light in weight- strong and hard-wearing
Benefi ts■ Comfortable, easy-to-use and effi cient prosthetic systems
■ Affordable, high-quality prostheses
■ Ability to perform sporting activities under optimal conditions, despite disability
■ Specifi cally designed, made-to-measure prostheses
Examples of products
The T102 myoelectric elbow Technology featuresElectronic control system enabling easy prosthesis controlBenefi ts■ Mechanical/myoelectric clutching system■ Comfort, ease of use and effi ciency■ Speedier patient adaptation for daily prosthesis use
55› Medical devices - Orthopedics – R&D services - Consulting
Medical devices
Collaborations
AFM (the French Muscular Dystrophy Association)Finding solutions for people suffering from muscle disorders
Prosthetists:Tech Innovation collaborates closely with prosthetists for custom product development.
TECH INNOVATION40 rue du PelvouxCE 1455F-91020 EVRY COURCOURONNES, FRANCE
Phone: +33 (0)1 69 47 75 88Fax: +33 (0)1 69 47 75 77
www.techinnovation.fr
The TIS sports elbow Prosthesis designed for mountain bikingTechnical featuresShock absorber system at the elbow or wrist
The MMC06 motocross hand Prosthesis designed for motocross practiceBenefi ts■ 5-fi nger system for good handlebar grip■ A “quick-release thumb”:
- enabling easy hand positioning on the handlebar- automatic opening in the event of a fall for maximum safety
The SJ 05 joystick support Accessories for positioning a joy stick on a bed or a wheelchair
The SSDB 06 bottle opener sphere Accessories for opening a bottle of water or soda, rolling up a tube of tooth-paste, etc.
56
Biosafety ServicesClinical Tools
Texcell... Viral Safety and Immunology GLP services...
Texcell is a world-renowned company (a Pasteur Institute spin-off) providing GLP and GMP services in viral safety and immunology.
Are you from a biotech or biopharma company ?■ Texcell assists you during the pre-clinical and clinical development phases of your new therapeutics.
■ With 19 years of experience in testing biotech products, our team of virologists and immunologists provides you with protocols, tools and expertise to complete your regulatory fi lings for new therapeutics such as: - recombinant proteins
- monoclonal antibodies- vaccines- viral vectors for gene therapy- cell therapy products- medical devices- blood-derived products- products of animal origin
■ We have tested and validated products now licensed by the FDA and the EMEA.
■ Texcell means a guaranteed GLP- and GMP-compliant service, certifi ed by the French regulatory bodies (AFSSAPS).Based on our extensive knowledge of regulatory guidelines worldwide (EMEA, FDA, WHO, MHW), we are able to offer product-specifi c safety testing strategies.
57› Viral safety testing & validation - Immuno-profi lingGLP/GMP services
HealthMedical Services
Viral Safety TestingA comprehensive service offering for cell bank characterization and derived product testing (batch release).Our catalogue includes more than 70 GLP-validated protocols that follow worldwide guidelines, such as:■ isoenzyme analysis■ mycoplasma detection by culture■ adventitious virus detection via in vitro assays
(10 different cell types available)■ adventitious virus detection via in vivo assays
(embryonated eggs, mice, guinea pigs)■ replication-competent virus detection by culture■ fl uorescent PERT assay■ quantitative PCR for specifi c virus detection
(25 virus species available)■ electron microscopy analysis■ bioassays■ biodistribution studies■ etc.
Virus Validation and Prion StudiesEvaluation of manufacturing process in terms of their capacity to eliminate and inactivate viruses/prions:■ virus-spiking experiments using more than
30 model viruses■ prion studies with Western blots or in vivo titrations
ImmunoProfi lingDevelopment and validation of methods for monitoring the humoral and cell-based immune response during clinical trials:■ immunogenicity■ PBMC isolation and freezing (Ficoll)■ custom cytometry using a 4-color cytometer■ GLP custom ELISA testing■ custom bioassays for potency evaluation of biotech
products■ seroneutralization assays for vaccines■ hemagglutination inhibition assays for infl uenza
vaccines
TEXCELLGenavenir 51 rue Pierre FontaineF-91058 EVRY CEDEX, FRANCE
Phone: +33 (0)1 60 91 33 10Fax: +33 (0)1 60 91 33 29
www.texcell.fr
3 service areas
58
R&D ToolsBiosafety Services
WatchFrogWatchfrog delivers R&D tools and services which are particularly focused on industrial fi elds concerned by environmental regulations and alternative models.
User needs■ Incorporate in vivo signifi cance into the early in vitro stages of drug discovery
■ Integrate biotech tools for accelerating environmental risk assessments
■ Exploit synthetic biological applications
Solution descriptionFluorescent-based screening in translucent amphibian models:The new generation of WatchFrog tests “light up” to provide biological answers.
“Rainbow Larvae Assays”: different colors for reading multiple parameters at the same time.
Product features■ Genetically engineered larvae for
detecting the early steps in physiopathological processes
■ Naturally translucent amphibian larvae - ideal for fl uorescent-based screening
■ Small model organisms which are closer to human physiology than fi sh or invertebrates
■ Development of organs similar to those in mammals within 48 hours
■ Compatibility with standard lab equipment for screening a large number of samples
■ Dedicated devices for real-time monitoring of biological effects
■ Increased sensitivity compared to in vitro techniques
■ More reliably predictive tools than cell cultures and DNA chips
ApplicationsEnvironment
■ Eco-toxicological screening of chemicals for risk assessment
■ Identifi cation of endocrine-disrupting chemicals in line with future OECD regulations
■ Real-time monitoring of the presence of pollutants in industrial waste
■ Overall water diagnostics for various industrial water-treatment activities
59› Amphibian models - In vitro tools - In vivo information -Drug discovery - Environmental risk assessments
Animal ModelsHealth
Pharmaceutical industry
■ Target validation and drug evaluation
■ Design of new pathological models based on “synthetic biology”
■ Mid-/high-throughput screening
■ Monitoring primary and secondary undesirable biological effects
■ Endocrine regulation, neurotoxicity, disruption, neurodevelopmental impairment, cardiotoxicity, teratogenicity, immunomodulation, malformation
Benefi tsIn vivo information…
■ Integrated approach taking into account the complete metabolism of the compound
■ Amphibian model with main organ systems similar to those in mammals/humans
■ Particular similarities for the endocrine, angiogenic, immune and neurogenic systems
■ Simultaneous detection of multiple biological markers
…from in vitro tools
■ Simplifi ed drug administration or handling of liquid samples via direct contact with the larvae
■ Only small quantities of active substance needed (microwell assay formats)
■ High statistical validity: each set of eggs enables approx. 2,000 individual assays
■ Rapidity of screening: fl uorescence is detectable after a few hours
■ Easy-to-read results by measuring fl uorescence via transparency
■ Ease of quantifi cation
■ Minimization of ethical issues by using amphibian larvae
■ Low cost of amphibian maintenance and
production
WATCHFROG7 rue CuvierF-75005 PARIS, FRANCE
Contact: Gregory LemkinePhone: +33 (0)6 16 39 81 91Fax: +33 (0)1 40 79 36 18
www.watchfrog.fr
Partners
CNRS UMR5166 (French academic research unit)Head: Prof. Barbara DemeneixFundamental research on endocrine disruptors funded by the French Ministry of the Environment
SoftRay Inc. CEO: Prof. Paul JohnsonDesign of industrial devices
60
R&D Tools
XenTechDo you need clinically relevant animal models to test your oncology compounds?
Xentech is developing a pertinent pre-clinical oncology platform based on panels of human tumors directly xenografted onto nude mice.
XenTech enables:■ proof-of-concept and target validation studies■ predictive determination of compound anti-tumor activity prior to lead compound clinical
development■ studies of action mechanism ■ identifi cation of responsive cancer sub-types■ identifi cation of biomarkers associated with a therapeutic response
Technology featuresHuman cancer animal models are generated by performing direct patient tumor xenografts in immunodefi cient mice.
XenTech provides:■ Validated, highly predictive tumor models - Orthotopic implantation on demand
■ Large panels of specifi c cancer subtypes (breast, lung, colon, etc.) covering today’s clinical diversity
■ Extensive molecular characterization of tumors (Affymetrix, signaling pathways, etc.)
PartnersPartnerChip (FR)Genome and transcriptome analyses
CERFE (FR)Animal facilities
Clinical & Research Institutions (Curie, Pasteur, HEGP, INSERM, CNRS) (FR)Histology, immunohistochemistry, tumor repositoriesHuman tumor surgical samples
Scientifi c collaboration with M.F. Poupon MD, PhD, INSERM U612 Scientifi c
61› Preclinical oncology platform - Human tumor xenografts - Experimental pharmacology - Biomarkers - Theranostics
R&D ServicesAnimal Models
Working with XenTech...Benefi ts■ Large panels of tumor xenografts from various
histological subtypes (representative of clinical populations):
- over 120 characterized tumors from a range of histological subtypes (lung, brain, prostate, colon, etc.)
- the world’s largest human breast cancer collection
- one of the world’s only two human prostate models (the hormonal escape model)
■ A large, state-of-the-art animal facility:
- 1,500-mouse housing capacity
- operated by Charles River Laboratories
■ High-content molecular database for target and response marker identifi cation (transcriptome and proteome data).
■ Expertise in preclinical and clinical cancer drug development:
Scientifi c consultant - Marie France Poupon MD, PhD, INSERM U612 Scientifi c Director
■ Optimal follow-up via frequent data reporting and consulting with our project managers
■ Cost saving by late attrition risk reduction and rational indication targeting
Applications■ High-throughput in vitro anti-tumor assays:
proliferation, apoptosis and clonogenic assays
■ Predictive in vivo anti-tumor effi cacy studies
■ Consulting in preclinical experimental oncology and clinical drug development
■ Identifi cation of tumor sensitivity/resistance biomarkers
XENTECHPépinière Genopole® Entreprises4 rue Pierre FontaineF-91058 EVRY CEDEX, FRANCE
Phone: +33 (0)1 60 87 89 05
www.xentech-biotechnology.com
2, rue Gaston Crémieux - CP 5723 - 91057 Evry Cedex, FranceTel: +33 1 60 87 83 00 - Fax: +33 1 60 87 83 01 - www.genopole.fr
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Welcome to Genopole®
Véronique DufeyExecutive Manager, Genopole® EntreprisesTel: +33 1 60 87 44 [email protected]
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