Ministry of Science, Technology and

Productive Innovation

Cooperation with the European Union

AMR Activities

Institutional

Coordination Secretary

Policy and Planning

Secretary

Ministry of Science,

Technology and

Productive Innovation

(MINCYT)

CONICET CONAE

SEGEMAR

CNEA

INA

INPRES

M. of Industry

INTI

INTA

INIDEP

M. of Education

Public and Private

Universities

Provinces CITEDEF

I+D Provincial

Promoting

Agencies

I+D Provincial

Institutions

ANPCYT

M. of Agriculture

Livestock and Fishing

National Directorate of

International Relations

M. of Foreign Affairs

M. of Planning

M. of Defense

M. of Health

ANLIS

IGN

IAA

Nonprofit

Organizations

Companies

National System of Science & Technology

Argentina- European Union Cooperation in STI

Cooperation Agreement in Science and Technology (1999)

Argentinean Liaison Office for Enhancing Cooperation with the European

Union in Science, Technology and Innovation (ABEST A-EU 2005- ABEST

II 2009- ABEST III 2012) Argentinean Boureau enhancing Science and

Technology

ABEST III operates within the Ministry of Science, Technology and

Productive Innovation (MINCyT), through its National Directorate of

International Relations.

Objective: to set in Argentina a platform to enhance and expand technical

cooperation activities in science, technology and innovation with both the

EU and the member countries.

AR-EU Liaison Office in STI

Platform created to expand STI cooperation activities among European

and Argentine researchers, organizations and SMEs

information Dissemination

(newsletter, Web, mailing)

Matching of institutions,

researchers and SMEs

Monitoring (calls participations

results)

Facilities to promote

consortia-building

Awareness raising activities

(info days, workshops, etc.)

Customized Advice (Help- Desk, NIPs,

NCPs)

Training for institutional

representatives

• ALCUE NET INCONET

• ERANet-LAC ERANET

• ABEST III BILAT

• ENSOCIO-LA

• ALCUE-KBBE

• LEADERSHIP Thematic Projects

• NET for MOBILITY

• INCONTACT 2020

• IDEALIST 2018 Others

• EU-LAC HEALTH

• NMP DeLA

Other ongoing MINCYT- DG RELEX projects (Programme for Strengthening

the Competitiveness of SMEs and Employment Creation in Argentina,

Plataform BIOTECSUR II)

Co – Fund activities experiences

• MINCYT Budget: €150,000

• Area: Sustainable Renewable Energy in the frame of CC and Nano with emphasis on human health

• Funded projects: 5

EULANEST

• MINCYT Budget: €480.000

• Area: Bioeconomy, Health, Biodiversity (inc CC), Energy

• 90 proposals (Under evaluation)

ERA NET LAC

(1st call)

• MINCYT Budget: €300,000 (by call)

• Area: Sustainable Supply of Raw Materials

• Open call

ERA MIN

(2nd & 3rd Call)

//abest.mincyt.gob.ar

AMR ACTIVITIES

1. Surveillance: Deepening monitoring antimicrobial resistance with national reach. Identifying the magnitude of the problem at the local, regional and national levels to develope action adjusted to the reality of each level. Develop systems for monitoring resistance in the area of veterinary and food production. Establish strategies for the use of information surveillance resistance to the development of control actions.

2. Treatment: Progress in the optimization of clinical diagnosis at the national level through the implementation of rapid methods of detection of resistance mechanisms with high impact on morbidity and mortality of patients. Apply concept of pharmacokinetics and pharmacodynamics to clinical diagnosis for the optimization of the report to get better use of it by the medical staff.

OUR PROPOSAL TO ENTER JPIAMR (2014)

3. Research: establish national research priorities aimed at the characterization of

the existing or emerging resistance mechanisms to drug most widely used in

clinical practice as well as resistance genetic platforms containing them. This will

identify the current and potential mechanisms for disseminating them, contributing

to the control. Establish national and international collaborations to search for

synergistic joint actions in the investigation of antimicrobial resistance.

4. Technology Incorporation: Incorporation into the clinic, reference and research setting of

new technologies such as total genome sequencing, mass spectrometry for identification and antimicrobial susceptibility, etc. to optimize clinical diagnosis, characterization of resistance mechanisms gene and platforms containing this, epidemiological monitoring of microorganisms dissemination, etc.

5. Human Resources Training: Establish a comprehensive training program for health professionals, especially physicians, veterinarians, microbiologists and pharmacists oriented to understanding of the problem and existing control strategies.

6. Use of antimicrobials: Working in compliance with existing law in Argentina for selling antibiotics by prescription that is not met at present.

AMR ACTIVITIES: WHAT WE DID IN

SURVEILLANCE

1. Surveillance: Deepening monitoring antimicrobial resistance with national reach. Identifying the magnitude of the problem at the local, regional and national levels to develope action adjusted to the reality of each level. Develop systems for monitoring resistance in the area of veterinary and food production. Establish strategies for the use of information surveillance resistance to the development of control actions.

Antimicrobial Resistance

Surveillance – Red WHONET-

Argentina

XV Workshop

WHONET-Argentina

Network Córdoba Capital, 16th and 17th

August 2014

Participants: 140 Clinical Microbiologist and

Physicians belonging to 96 Hospitals from

the 24 Provinces of Argentina

Financed by the participants and Ministry of

Health.

WHONET – Argentina

Network 2015

96 laboratories

20

11

2 3

2

8

2

3

2

2

2

2

2 4

3

4

2

2

2

2

7

3

2

4

OBJECTIVES 1) discusion and implementation of the international news about clinical

diagnostic of antimicrobial resistance CLSI/EUCAST

2) Update working protocol. Incorporation of automated testing (25% of

hospitals and 50% of the data)

3) Integration of surveillance and outbreak detection of food transmited

pathogens and antimicrobial resistance (MIDAS)

4) Current situation of WHONET-Argentina Network and next steps

5) Improve analysis and communication of ARM at participants level

6) disseminate national initiative of integrated approach to addressing

antimicrobial resistance from Ministry of Health

7) Incorporation of the concepts of pharmacokinetics and pharmacodynamics

as a fundamental tool for optimizing the diagnosis and treatment of

infectious diseases

8) Review the fields: clinical diagnosis, underlying disease and risk factor to

improve the clinical use of the antimicrobial resistance data

9) International and national frame of antimicrobial resistance. New

opportunities for the Network

AMR ACTIVITIES: OTHER NATIONAL

ACTIVITIES 1. Surveillance:

Organization of Provincial Networks for AMR Surveillance.

I. Workshop WHONET-Chaco Network for AMR Surveillance.

Resistencia, Chaco 15th November 2014

I. Workshop WHONET-San Juan Network for AMR Surveillance.

San Juan, 19th November 2014

I. Workshop WHONET-Chubut Network for AMR Surveillance.

Puerto Madryn, 12th to 13th December 2014

II. Workshop WHONET-Santa Fe Network for AMR Surveillance.

Santa Fe 18th December and Rosario, Santa Fe 19th December

2014

Funded by National and Provincials Ministry of Health

I

IV

IIIII

I

IV

IIIII

AMR ACTIVITIES: REGIONAL LEVEL

1. Surveillance:

A. Develop a new WHONET database that can include data from HUMANS,

ANIMALS, FOOD, FEED and ENVIROMENTAL samples. Joint activity with PAHO,

GFN, AGISAR and RELAVRA.

B. Argentina is collaborating with Harvard University in the development of a new web

bases real time version of WHONET Software for AMR surveillance

AMR ACTIVITIES-TREATMENT NATIONAL

AND REGIONAL LEVEL 2. Treatment: Progress in the optimization of clinical diagnosis at the national level through

the implementation of rapid methods of detection of resistance mechanisms with high impact on morbidity and mortality of patients. Apply concept of pharmacokinetics and pharmacodynamics to clinical diagnosis for the optimization of the report to get better use of it by the medical staff.

1. In the program of all Workshop and training courses we conduct this year, we

include the PK/PD topic and the application of this concepts to the diagnostic and

report of antimicrobial resistance. Also the related concept "susceptibility dose

dependent"

2. We include in the national work protocol for antimicrobial susceptibility test the

blue carba method for rapid detection of carbapenemases in GNB.

3. We developed and transferred to the industry a kit for phenotipic confirmation of

the different carbapenemases in all GNB

3. Research: establish national research priorities aimed at the characterization of

the existing or emerging resistance mechanisms to drug most widely used in

clinical practice as well as resistance genetic platforms containing them. This will

identify the current and potential mechanisms for disseminating them, contributing

to the control. Establish national and international collaborations to search for

synergistic joint actions in the investigation of antimicrobial resistance.

AMR ACTIVITIES - RESEARCH NATIONAL

AND REGIONAL LEVEL

A. Regional project for characterization of resistance mechanism to fluorquinolones

and macrolides in Salmonella. All Latin-American Countries and Canada

involved. 360 isolates with reduced susceptibility to CIP. Ongoing

B. Characterization of SAU with resistance to ceftaroline in Argentina.

C. During 2014 were characterized 38 outbreak from Argentina. 445 MDR strains

D. Also were received 884 strains for characterization the resistance mechanism.

E. Ìn the last 3 years NRL from Argentina received 232 strains (98 in 2014) from 14

different countries of Latin America for full characterization of R mechanism

(most of them Carbapenemases: KPC, NDM and OXA type)

4. Technology Incorporation: Incorporation into the clinic, reference and research setting of new technologies such as whole genome sequencing, mass spectrometry for identification and antimicrobial susceptibility, etc. to optimize clinical diagnosis, characterization of resistance mechanisms gene and platforms containing this, epidemiological monitoring of microorganisms dissemination, etc.

A. During 2014 National Reference Lab incorporate a Mass Spectrometer. Also

nine clinical laboratories incorporate the technology in Argentina. We are

working with these to improve the use of the tool.

B. At the end 2014 and through FDA-USA we receive a WGS equipment In the

frame of a pilot project of epidemiology of food borne transmitted Infection

(WHO-PAHO-SANGER-FDA-Argentina)

C. Though National Ministry of Health we provided PCR and PCR-Real Time to the

Provinces to transfer molecular diagnostic of infectious diseases to the Clinical

Labs

AMR ACTIVITIES - TECHNOLOGY

5. Human Resources Training

AMR ACTIVITIES - TRAINING NATIONAL

AND REGIONAL LEVEL

National courses 2014:

I. Course of Updating on Antimicrobial Resistance. Buenos Aires, May 19th to 23rd

II. XI Course of Molecular Epidemiology applied to Surveillance of Bacterial

Infections. Bs As, 5th to 9th Nov. 19 participants from Argentina and LatinAmerica.

III. International Simposium of Antimicrobial Resistance. Chaco, 12th to 13th Nov

2014 for Chaco, Corrientes, Formosa, Santa Fe, Misiones. 155 participants

IV. “II Conference of Bacterial Resistance”, San Juan 27th to 28th Nov 2014. For San

Juan, Mendoza, San Luis, La Rioja. 160 participants

V. “Provincial Conference of clinical microbiology and antimicrobial resistance”.

Puerto Madryn, Chubut. 12th to 13th de Dec de 2014. 65 participants

VI. Training Course “Antimicrobial Resistance” for Food and Drugs.National

Administration (ANMAT). Buenos Aires, 25th November and 1st Dec 2014

PARTICIPANTS (105)PARTICIPANTS (105)

Colombia (1)Colombia (1)Colombia (1)Colombia (1)

Ecuador (1)Ecuador (1)Ecuador (1)Ecuador (1)

Peru (3)Peru (3)Peru (3)Peru (3)

Uruguay (6)Uruguay (6)Uruguay (6)Uruguay (6)

Venezuela (4)Venezuela (4)Venezuela (4)Venezuela (4)

Argentina (85)Argentina (85)Argentina (85)Argentina (85)

Bolivia (1Bolivia (1))Bolivia (1Bolivia (1))

Panama (1)Panama (1)Panama (1)Panama (1)

Chile (1Chile (1))Chile (1Chile (1))

Cuba (2)Cuba (2)Cuba (2)Cuba (2)

PARTICIPANTS (85)

Buenos Aires (33)

Capital Federal (13)

Chaco (2)

Chubut (1)

Córdoba (9)

Corrientes (1)

Entre Ríos (2)

Neuquén (2)

Rio Negro (3)

San Juan (2)

San Luis (1)

Santa Fe (5)

Tucuman (2)

Mendoza (3)

Salta (1)

Catamarca (2)

La Pampa (1)

La Rioja (2)

AMR ACTIVITIES - TRAINING NATIONAL

AND REGIONAL LEVEL Regional training activities 2014:

I. III International Course of Bacterial Resistance and XXX LatinAmerican Course of

Actualization in Antimicrobial Agents. Lima, Peru, 10th to 12th Jun 2014

II. Workshop: Antimicrobial Resistance La Havana, Cuba 14th October 2014. 40

participants

III. “Course of Bacterial Resistance. Panamá City, Panamá. 28th October 2014. 55

participants.

IV. Multidisciplinary Workshop: Diagnostic, Report of antimicrobial resistance and the

use for infection treatment. Two Hospitals of Panamá City (Hospital del Nino and

Hospital San Jorge). 27th and 29th October 2014, 60 Physician, Pharmacists,

Microbiologists and Nurses.

V. Workshop of strengthening of Laboratory Antimicrobial Resistance Surveillance.

Bogotá, Colombia, 10th to 11th November 2014

VI. “International Course: Bacterial Resistance to Antibiotic , Present, Past and

Future”. Antofagasta, Chile, 5th to 8th January 2015

Coordination: Secretary of Promotion and Sanitary Programs. Ministry of Health

Participants

1. Ministry of Health

ANLIS National Administration of Laboratories and Health Institutes

ANMAT National Administration of Drugs, Food and Medical Technology

REMEDIAR Program.

2. Ministry of Agriculture, Livestock and Fisheries

INTA National Agriculture Technology Institute

SENASA National Service of Health and Agro-Food Quality

3. SADI Argentina Society of Infectious Diseases

4. SATI Argentina Intensive Care Society

5. National Universities of La Plata and the Center of the Province of Buenos Aires

6. OIE American representative of World Animal Health Organization

AMR ACTIVITIES – ARGENTINEAN

STRATEGY FOR ANTIMICROBIAL

RESISTANCE CONTROL

1. Antimicrobial Resistance Surveillance in Human Health

2. Antimicrobial Resistance Surveillance in Animal Health and food production

3. Surveillance of Antibiotic Use

4. Regulation of Use of Antibiotics in Human Health

5. Regulation of Use of Antibiotics in Anmal Health and Food Production

6. Rational Use of Antibiotics in Human Health

7. Rational Use of Antibiotics in Animal Health and Food Production

8. Control and Prevention of infections in Human Health Care

9. Control and Prevention of infections in Animal Health and Food Production

AMR ACTIVITIES – ARGENTINEAN

STRATEGY FOR ANTIMICROBIAL

RESISTANCE CONTROL

CH

AP

TE

RS

Argentinean Liaison Office for Enhancing Cooperation with the European Union

National Directorate of International Relations

abest@mincyt.gob.ar +54011 4899-5000

www.abest.mincyt.gob.ar