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Flexible Efficient Compatible MiniBlock and MiniBlock XT Maximize Productivity with Parallel Synthesis

MiniBlock and MiniBlock XT - Mettler Toledo · Heat Dispersion Adapter for IKA 1 1 IKA Feedback Control Kit 1 1 Stir Bars * * Reaction Vessels * * * Applicable Reaction Vessels and

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Flexible

Efficient

Compatible

MiniBlock™ and MiniBlock™ XT Maximize Productivity with Parallel Synthesis

MiniBlock™ and MiniBlock™ XT for Parallel Synthesis

Find out how METTLER TOLEDO MiniBlock™ can maximize productivity in your

� Modular RacksReadily interchangeable reaction vessel racks

Automation friendly microtiter formats

Simple conversion between 6, 12, 24 or 48 reaction arrays

� Efficient RefluxingSingle reflux jacket cools all vessels

No need for individual condensers

Quick and easy connections

Tap water or chiller/recirculator

Minimal solvent loss (Example: DCM Reflux Loss, 20 HR: 6%)

� Inert Atmosphere CapabilityContinuous inert gas flow enables air/moisture sensitive reactions

Easily add reagents through septum layer

� Evaporation CapabilityDirects gas flow into vessel

� Easy Reaction Set-upAll vessels sealed with one layer

Single septum layer seals vessels and allows easy access to reactions

� Efficient Magnetic Stirring – Easily VisibleExample: 40 mL slurry, 20% solids

� Precise Temperature ControlController displays temperature and regulatesheating

Working temperature range: -70°C to +160°C

� Low Temperature BathMaintains dry ice/acetone for 4 hours

� Uniform HeatingInsulated design ensures efficient heat transfer

Fast to temperature

Temperature uniformity

� XT Plus allows heating & cooling via recirculator

M i n i B l o c k ™ X T

MiniBlock™ – the only compact parallel synthesizer that allows synthesis via solid or solution p

7 – 10 mLWorking Volume24 Vessels

20 – 25 mLWorking Volume12 Vessels

40 – 50 mLWorking Volume6 Vessels

Flexible One platform: 4 volumes

Improve your throughput with the METTLER TOLEDO MiniBlock™

Efficient More synthesized compounds per unit of time

Compact space-saving design

Compatible Works with existing equipment in your lab

2 – 3 mLWorkingVolume48 Vessels

XT Plus

“Since using MiniBlocks, our labs report a 400% increase in new drugcandidates and a 40% reduction indevelopment time. MiniBlocks areso widely accepted by our medicinalchemists that 70% of all currentprograms now use high–throughputchemistry.”Dr. Harold Weller, Research Fellow, Bristol Myers Squibb,Pharmaceutical Research Institute

� Collection RacksVast range of racks and containers available, all with microtiter plate footprints

Compatible with all major parallel evaporators and liquid handlers

� Volume FlexibilityChoose reaction vessels from 4 mL to 40mL

288 reactions can be carried out in parallel, within a standard fume hood

Large volume formats available

� Inert Atmosphere CapabilityPurges each reaction vessel, eliminating air and moisture

Allows the addition of liquids under inert conditions by septum piercing

� Unique Built-in ValveAllows rapid bottom filtration

No need to invert or disassemble reactor

Saves time and prevents cross-contamination

� Vacuum Collection BaseAccommodates industry standard microplate format racks

� AgitationCustomized 2 and 6 position shakers allow precision vortex mixing of reactions

Built-in washing capability allows rapid processing of solid phase reactions

� Heating and CoolingPrecision heating to 120˚C and cooling to –20˚C are achieved using modular heat Transfer Jackets

Temperature uniformity and reproducibility is within 1˚C at 80˚C

“MiniBlock’s performance has beenoutstanding even under the moststringent reaction conditions. Manyof these require completely inert andanhydrous conditions at tempera-tures as low as –70˚C.”Prof. Dieter Enders, Head of the Institute of Organic Chemistry,Aachen University of Technology (RWTH),Germany

lab!

Just turn the key!to collect productsfrom MiniBlocks cleanly and efficiently

M i n i B l o c k ™

phase, and purification – all carried out in the same platform!

1.0

0.5

1.0

0.5

1.0

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product family

On the web at www.mtautochem.com or email [email protected].

Red and BlueMiniBlock combine to produce 96 compounds

5 – 7 mLWorking Volume24 Vessels

10 – 12 mLWorking Volume12 Vessels

25 – 30 mLWorking Volume6 Vessels

Flexible One platform: 4 volumes

Efficient Increases productivity up to 96x

Compatible Use manually or with automated workstations.

2 – 3 mLWorking Volume48 Vessels

A

B

1 2 3

1 2 3 4 5 6

A

B

C

D

1 2 3 4 5 6 7 8 9 10 11 12

A

B

C

D

E

F

G

H

B

A

C

D

E

F

G

H

1 2 3 4 5 6 7 8 9 10 11 12 2 – 3 mLWorking Volume48 Vessels

MB/MBXT Combo 11/04/ QTYCopyright ©2004 Mettler-Toledo AutoChem, Inc.

USA Mettler-Toledo AutoChem, Inc. 7075 Samuel Morse DriveColumbia, MD 21046 USATel: +1 410 910 8100Fax: +1 410 910 8101Toll Free 866 333 MTAC

Australia Mettler-Toledo Ltd.220 Turner StreetPort Melbourne, Victoria 3207Tel: +61 39 644 5700Fax: +61 39 645 3935

Belgium N.V. Mettler-Toledo S.A.Leuvensesteenweg 384Zaventum B-1932Tel: +32 (02) 334 02 11Fax: +32 (02) 334 03 34

Denmark Mettler-Toledo A/SNaverland 82600 GlostrupTel: +45 (43) 27 08 00Fax: +45 (43) 27 08 28

France Mettler-Toledo S.A.18-20 Av de la PepiniereViroflay Cedex 78220Tel: +33 (01) 309 717 17Fax: +33 (01) 309 716 16

Germany Mettler-Toledo GmbHOckerweg 3Giessen 35353Tel: +49 (0641) 50 70Fax: +49 (0641) 507 128

Italy Mettler-Toledo S.p.A.Via Vialba 42Novate Milanese 20026Tel: +39 (02) 333 321Fax: +39 (02) 356 29 73

Japan Mettler-Toledo K.K. 5F Tokyo Ryutsu Center Annex 6-1-1 Heiwajima, Ohta-ku, Tokyo 143-0006 Japan Tel: +81 (35) 67 20 743Fax: +81 (35) 67 20 758

Korea Mettler-Toledo (Korea) Ltd. Yeil Bld. 1&2F, 124-5, Yang-Je-Dong, SeCho-Ku, Seoul 137-130 Korea Tel: +82 (2) 3498 3500Fax: +82 (2) 3498 3556

Netherlands Mettler-Toledo B.V.Franklinstraat 5, Postbus 6006Tiel 4004 HATel: +31 (0344) 638 363Fax: +31 (0344) 638 390

Singapore Mettler-Toledo (S) Pte LtdBlk 28 Ayer Rajah Crescent, #05-01Singapore 139959Tel: +65 890 00 11Fax: +65 890 00 13

Spain Mettler-Toledo S.A.E.Miguel Hernandez 69-71 08908 L'Hospitalet de Llobregat Tel: +34 932 237600Fax: +34 932 237601

Sweden Mettler-Toledo ABBesoksadress Virkesvagen 10S-12008 StockholmTel: +46 (08) 702 50 00Fax: +46 (08) 642 45 62

Switzerland Mettler-Toledo (Schweiz) AG,CH-8606 GreifenseeTel: +41 (01) 944 45 45Fax: +41 (01) 944 46 60

UK Mettler-Toledo Ltd.64 Boston Road, Beaumont Leys,Leicester, LE4 1AWTel: +44 (0) 116 235 7070Fax: +44 (0) 116 236 6399

Other Mettler-Toledo AutoChem, Inc.Countries 7075 Samuel Morse Drive

Columbia, MD 21046 USATel: +1 410 910 8100Fax +1 410 910 8101

www.mtautochem.com METTLER TOLEDO

Proven Chemistry Examples

Configure Your METTLER TOLEDO MiniBlock™

to Suit Your Needs!

R E A G E N T S

Acid ChloridesAlkyl HalidesAminesBoranesBorohydridesCl3SiH Grignard Reagents

R E A C T I O N S

AcylationAlkylationBiaryl CouplingStille ReactionEnolate FormationGrignard ReactionHeck ReactionHeterocycle Formation

MiniBlock™ MiniBlock Set MiniBlock PackageItem Quantity Quantity

MiniBlock Synthesizer 2 6Shaking and Washing Station 1 Compact 1 High Capacity Heat Transfer Block 2 2Vacuum Collection Base 1 2Tall Tube Extender 2 4Recirculator Manifold 1 (2-position) 1 (6-position)Counterweight for Shaking Station 1 4Air Push Assist Device 1 1Inerting/Purging Manifold - 2Transfer Adapter - 2SPE Manifolds - 2Resin Dispenser - 1Multi-Channel Electronic Pipettor - 1Consumables Kit Small Large

MiniBlock™XT MBXT Set MBXT PackageItem Quantity Quantity

Inerting/Purging Manifold 1 2Reactor Frame 1 2Removeable Vessel Rack 1 4Refluxing Layer 1 2Vessel Rack Removal Tool 1 2Sealing Gaskets 5 10Inner/Piercing Septa 5 10Top Plate 1 2Multi-Layer Septa, Pre-scored for Top Plate 5 10IKA Hot Plate Stirrer,115V/60Hz or 230V/50Hz 1 1Heat Dispersion Adapter for IKA 1 1IKA Feedback Control Kit 1 1Stir Bars * *Reaction Vessels * *

* Applicable Reaction Vessels and Stir Bars included.

MetallationReductionReductiveAminationSaponificationSulfonylationSnArSuzuki Coupling

HydroxidesIsocyanatesLDA LiAlH4

MercaptansnBuliTFA

Rapid Purification for MiniBlocksGain speed and efficiency with selected SPE sorbents pre-loaded into MiniBlock reaction vessels. Available on disposablecartridges or in loose tubes. Sorbents available are SCX, SAX,Silica Gel, C18, and Diatomaceous Earth. Other sorbents available upon request.