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Milli-Q Advantage A10Water Puriication SystemsUser-adapted ultrapure water


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GIVING YOU THE ADVANTAGE

As a scientist today, you ace many challenges. Youre responsible or deliveringhigh quality technical resultsbut now at an even aster pace. You also have tocomply with a growing number o quality and regulatory standards, while workingin a laboratory where space may be limited. Resulting rom on-going dialogueswith scientists like you, Merck Millipore continues to develop water systems thatimprove your work environment.

The Milli-Q Advantage system has been designed especially or you. Thissystem delivers high quality water adapted to todays lab environment.

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A NEW APPROACH

Advanced technology meets total exibility.

The Milli-Q Advantage system simplifes your daily lie in the lab by utilizing two

distinct components:

The Milli-Q production unit is a compact system that can be placed either on thebench, under the bench or on a wallwherever it best suits you.

The Q-POD (Quality-Point-o-Delivery) unit provides fnal polishing at the point-o-use, delivering ultrapure water adapted to your specifc needs.

The revolutionary Q-POD technology empowers you with convenient and exibledispensing options. Up to three Q-POD units can be used with each Milli-QAdvantage system at dierent locations within the same laboratory.

Can you envision a laboratory environment

where the ultrapure water source is exible

enough to support a variety o daily activities?

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IMPROVING THE WAY

...YOU PURIFY

Appropriate water quality

Depending on your application, specifc contaminantscan aect your results.The Milli-Q Advantage system oers a unique rangeo fnal purifers or complete peace o mind.

...YOU CONTROL

Required inormation

The Milli-Q Advantage system provides relevant dataabout the water quality and system status.

The Q-POD units multicolor graphic displayallows easy interaction with the system and providesinormation about water quantity and quality.

The primary graphic screen on the Milli-Qproduction unit details the systems operation andperormance or managing routine maintenance andtroubleshooting procedures.

...YOU OPERATE

Flexible water delivery

Working both intuitively and precisely, the Q-POD unit

is always within your reach. Select a very precise volumethrough the autofll key or manually press the plunger.

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DESIRED WATER QUALITY

You just choose the appropriate media that remove

the specic contaminants which may aect your

results depending on the application.

For example, the Millipak flter with the MilliporeExpress membrane (0.22 m) produces particulate-and bacteria-ree ultrapure water or analyticalapplications such as spectrophotometry, spectroscopyand chromatography. The BioPak ultraflter, while

removing particulates and bacteria, producespyrogen- and nucleaseree ultrapure water orbiochemical applications.

PRACTICALITY CONVENIENT DELIVERY

Daily perormance is acilitated by having ultrapure

water and inormation conveniently delivered at the

point-o-use.

EASY DATA ACCESS

Following your own workfow, relevant data is ac-

cessible conveniently.

See essential inormation on the Q-POD unit screenat any time.All critical inormation, including water quality,system status and warnings, is summarized on themulticolor graphic display. The water quality statusalso can be printed directly rom the Q-POD unit.

Control system use and maintenance on the waterproduction unit screen.The main graphic screen on the production unit displays

details o the systems operation and perormance.Graphics assist the user in perorming specifc tasks,including maintenance procedures.

Protect access to critical inormation.An ID code and password ensure that only thedesignated user can access felds containing criticalinormation, such as water quality set points.

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ENHANCED FLEXIBILITY

Your work is enhanced through convenient and

adaptable dispensing.

Adjust the Q-POD unit arm (rotation and height)or all commonly-used laboratory glassware andplasticware.

Set the optimized water quality beore delivery bypressing the water recirculation button on the base othe Q-POD unit.

Select the desired volume by simply using the + and keys and then pressing the central key. The lastdelivered volume is recorded to acilitate re-use.

Move the Q-POD dispenser rom the arm or varyingwater delivery:

low-ow

medium-ow

high-ow (up to 2 l/min)

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QUALITY

OPTIMIZED PURIFICATION

The most reliable ultrapure water quality depends onbuilding an optimized purifcation sequence.

REQUIRED PURIFICATION STEPS...

You need a exible system that can match thediversity o your applications. This is possible with avariety o purifcation media!

Pure water, ideally rom an Elix purifcation system,enters the Q-Gard pretreatment pack (1) which ischosen based on the eed water source.

Pretreated water then passes into a dual wavelengthUV lamp (2), which ensures organic molecule oxidationand bacteria destruction.

Next, the Quantum polishing cartridge (3) removesionic and organic contaminants below trace levels tomatch the water quality required or your application.

...UP TO THE POINT OF DELIVERY

The ultrapure water produced by the system recirculatesthrough a loop up to the Q-POD unit, where the fnalpurifcation step required or your particular applicationoccurs

UNDER CONTROL

The measurement o both organic and ionic qualityo produced water occurs at the outlet o the system,

through the appropriate calibrated meters:

Accurate Total Oxidizable Carbon (TOC) monitor (4)

High-sensitivity resistivity cell (5)

Both the Q-Gard and Quantum cartridges enable ull traceability.

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4

31

2

5

TOC

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ALLOWING SENSITIVE IONIC DETECTION

Milli-Q Advantage systems high precision resistivity meters have specic

eatures to ensure that the value displayed on the screen is meaningul:

Patented cell design with coaxial electrodes to warrant cell constant stabilityFlow-through design to make sure that the measure is representative o the actualionic concentration in waterLow cell constant (0.01 cm-1) to ensure optimum measurement accuracy o lowionic contamination as required by ASTM norm D 1125-95 (1999)Temperature measurement with a 0.1 C resolution or proper report o temperature-compensated resistivity, as recommended in ASTM norm D 1125-95 (1999)Automatic warning messages i the resistivity measure is compromised by a deectDesign allows TOC suitability test to be perormed as required by USP ( 645).

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TOTAL CONTROL

Double monitoring allows control over both ionic andorganic contaminants that can impact your results.

PREVENTING ORGANIC BREAKTHROUGH

The proper measurement o TOC levels is key or

confrming that the systems organic removal processis operating within specifcations.

The integrated TOC meter accurately monitors rom 1to 999 ppb. The design takes into account USP suitability requirements.

TOC measurements are perormed automatically on acontinuous basis during production and intermittentlyduring periods o non-use. This lets you check theorganic content o the water regularly, while avoidingthe risk o your work being compromised by anundetected organic breakthrough.

The TOC monitor uses a 0.5 ml quartz cell to captureultrapure water.

When the A10 UV lamp is on, photocatalyticoxidation o organic compounds occurs.

The end product o organic oxidation is carbon dioxide,which dissolves in water and causes conductivity toincrease. This change in conductivity (temperature-compensated to 25 C) is monitored continually by thetitanium electrodes in the TOC monitor.

A set o algorithms confrms complete oxidationand calculates the carbon level associated with thisconductivity change.

Zeit

conductivity

valve

lamp

time

fll

initial measure

o conductivityoxidation & fnal

conductivity measure

purge

open

on o

closed

on

open

solenoid valve

thermistor

quartz cell

0,5 ml

titanium electrodes

185/254 nm

UV lamp

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ADVANCED TECHNICAL

SUPPORTMerck Millipore application specialists provideinormation about system use and application insightsas well as how to select the best services related toyour particular situation.

COMPREHENSIVE SERVICE PROGRAM

Choose the services you need rom Merck Milliporescomprehensive service program.

InstallationTechnical and scientifc assistancePreventive maintenance visitsTroubleshooting visitsCustomized user trainingVerifcation and/or calibration o monitoring devicesPharmacopeia suitability testsValidation supportMaintenance plans

QUALIFICATION EXPERTISE

Merck Millipores Qualifcation Program acilitates

laboratory validation procedures.

Validation support is provided by trained MerckMillipore Field Service Support Engineers usingcalibrated equipment and Qualifcation Workbooks.

With more than 10 years experience in water systemqualifcation services, Merck Millipore can assist youin complying with regulatory standards applicable toyour industry.

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PRODUCT SPECIFICATIONS

Product specifcations Milli-Q Advantage A10 System

Product Water Specifcations

Parameter Value

Resistivity 18.2 M.cm at 25 C

TOC 5 ppb

Particulates* (> 0.22 m/ml) < 1 particulate/ml

Bacteria* < 0.1 cu/ml

Pyrogens (endotoxins)* < 0,001 EU/ml

RNases* < 0,01 ng/ml

DNases* < 4 pg/

Flow Rate up to 2 l/min

*Test conditions with the appropriate Q-POD fnal polisher. These values are typical and may vary

depending on the nature and concentration o contaminants in the eed water.

Milli-Q Advantage A10 System Specifcations

Parameter Value

Production unit dimensions (H x W x D)497 x 332 x 360 mm(19.5 x 13 x 14.2 in)

Q-POD delivery unit dimensions (H x D)579 x 230 mm(22.8 x 9 in)

Production unit weight 15 kg (33 lb)

Production unit operating weight 19 kg (41.9 lb)

Q-POD delivery unit weight 5 kg (11 lb)

Q-POD delivery unit operating weight 5.5 kg (12.1 lb)

Distance rom production unit to Q-POD 2.9 m (9.5 t)

Dispenser tubing length 80 cm (31.5 in)

Electric power cable length 2.9 m (9.5 t)

Electric power supply voltage 100 230 V +/- 10 %

Electric power supply requency 50 60 Hz

Feed water connector: GazMilli-Q Advantage A10 main unit data connection: Ethernet (RJ45)Q-POD data connection: Parallel port (25-pin D-Sub)

ALL-INCLUSIVE SYSTEM CERTIFICATES

To assist you in ollowing industry requirements, Milli-Q Advantage systems aredelivered with specifc Certifcates o Quality and Calibration or temperature,resistivity and TOC meters. Merck Millipores manuacturing site is ISO 9001v.2000 and ISO 14001 certifed.

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Lit. No. PB0001EN00 01/12. Copyright 2012, EMD Millipore, Billerica, MA, U.S.A. Merck Millipore, A10, Milli-Q, Q-POD, BioPak,

Quantum, Millipak, Merck Millipore Express, Elix and Q-Gard are registered trademarks o Merck KGaA, Darmstadt, Germany. The M

mark and Merck Millipore are tr ademark o Merck KGaA. USP is a registered trademark o the United States Pharmacopeial Convention.

ISO is a registered trademark o the International Organization or Standardization. All rights reserved. Photographs: BHL Production.

Design: Sysaxe.

ORDERING INFORMATION

To order a Milli-Q Advantage A10 system and associated consumables, pleasecontact your local Merck Millipore subsidiary, or visit our dedicated web page at:www.millipore.com/advantage

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