6
This year we turn the alumni spotlight on Dr. Elizabeth Hussa. Elizabeth received her Ph.D. in 2008 under the men- torship of Dr. Visick. Her dis- sertation investigated the role of two-component response regu- lators in symbiotic colonization and in particular, SypG. After she graduated from Loyola she was a post-doctoral fellow at the University of Wisconsin- Madison for five years in the Department of Bacteriology under the mentorship of Dr. Heidi Goodrich-Blair. Then for the 2013-2014 academic year she worked as a visiting professor at her alma mater Illinois Wes- leyan University where she taught Introductory Biology and Microbi- ology. She eventually grew tired of the cold and decided it was time to move south. In July of this year she moved to Mississippi where she was appointed to Assistant Professor at Millsaps College – a college known for its strong dedication to providing research experi- ence to its students. At Millsaps College she teaches Introduction to Cell Biology and Genetics and in the future she will be teaching Microbiology. In July she was also awarded an MS-INBRE grant, which is awarded to professors who perform biomedical research with undergraduate students. Dr. Hussa’s current research focuses on the way bacteria interact with other organisms. One bacterium in particular that interests Dr. Hussa is Xenorhabdus nematophila, which is beneficial to nema- todes but is parasitic to caterpillars. As she describes it is like “the Jekyll and Hyde of bacteria”. She likes the idea that the bacteria could be both a mutualist and pathogenic. For instance, this bacte- ria is sold commercially to farmers to protect their crops for infesta- tion of harmful insects. However, working with this particular bacte- rium has been challenging as the bacteria is very fussy. It is light- sensitive and it prefers highly purified water. Despite its challenges, she has found the system to be extremely useful in her teaching of research to undergraduate students. Because of its unique charac- teristics, the students are able to see the complexities of bacteria without having to use human pathogens. She often thinks back about her time at Loyola and how it prepared her for her long term goal in teaching. She reflects back on the 1st year Journal Club and how the course forced her to confront her less than stellar skills and how to fine tune those skills in order to become an effective speaker. The department’s dedication to teaching also inspired her to have the same level of commitment to her students. She enjoys watching her students’ eyes light up when they come back with their research findings or when they under- stand a concept that they did not know before. She loves to teach, and one of her greatest rewards is knowing that she helped spark an interest in science and research in her students. MIIM Summer 2014 Microbiology & Immunology News This year I celebrate my 25th an- niversary as serving as chair of the department. Thank you to eve- ryone who has contributed to the many years of doing it together. The department would not be where it is today without the sup- port and commitment of the de- partment members. I am pleased to share with you the many of ac- complishments from this last year. Our graduate students and pro- gram continue to succeed. Domenick Kennedy was awarded an F31 from the NIH and two students, Anna Mielech and Va- lerie Ray, were awarded the Schmitt Fellowship for the 2013 - 2014 academic year. This year we matriculated our largest group of nine students into the Ph.D. program and our NIH Immunology Training Grant has been renewed for another 5 years. The department welcomes Assistant Professor, Dr. Francis Alonzo to the department. Dr. Alonzo is a microbiologist and studies bacterial pathogenesis focusing on a single organism Staphylococcus aureus. Find out more about Dr. Alonzo and his research on page 2. We also welcome our newest joint appointee, Dr. Katherine Radek from the department of Surgery. One of our virologists, Dr. Edward Campbell, was promoted to Associate Professor with tenure. The department says farewell to one of our faculty, Dr. John Clancy who retired from the university in August. Dr. Clancy has been an invaluable member of our department and the institution and we wish Dr. Clancy all the best in his future endeavors. To learn about his tenure at Loyola go to page 4. We are always pleased to hear about our students’ successes and it is a pleasure to feature Eliabeth Hussa in our alumni spotlight this year and to read about her many accomplish- ments. We thoroughly enjoy hear- ing from all of you and I encour- age you to stay in touch. Sincerely, Katherine L. Knight, Ph.D. Professor and Chair Inside… Spotlight on Faculty ...... 2 Meetings Attended ........ 2 Spotlight on Students .... 3 Alumni News ................ 4 SURP update ................ 4 In Memoriam................ 4 Recent Graduates ......... 5 Publications .................. 5 Dr. Knight’s Message Spotlight on Alumni—Elizabeth Hussa

MIIM Microbiology & Immunology News · PDF fileJames Mahon—Le Poole Lab ... sessions discussed training in the Microbiology/Immunology track, preliminary exam preparation,

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This year we turn the alumni spotlight on Dr. Elizabeth Hussa. Elizabeth received her Ph.D. in 2008 under the men-torship of Dr. Visick. Her dis-sertation investigated the role of two-component response regu-lators in symbiotic colonization and in particular, SypG. After she graduated from Loyola she was a post-doctoral fellow at the University of Wisconsin-Madison for five years in the Department of Bacteriology under the mentorship of Dr. Heidi Goodrich-Blair. Then for the 2013-2014 academic year she worked as a visiting professor at her alma mater Illinois Wes-leyan University where she taught Introductory Biology and Microbi-ology. She eventually grew tired of the cold and decided it was time to move south. In July of this year she moved to Mississippi where she was appointed to Assistant Professor at Millsaps College – a college known for its strong dedication to providing research experi-ence to its students. At Millsaps College she teaches Introduction to Cell Biology and Genetics and in the future she will be teaching Microbiology. In July she was also awarded an MS-INBRE grant, which is awarded to professors who perform biomedical research with undergraduate students. Dr. Hussa’s current research focuses on the way bacteria interact with other organisms. One bacterium in particular that interests Dr. Hussa is Xenorhabdus nematophila, which is beneficial to nema-todes but is parasitic to caterpillars. As she describes it is like “the Jekyll and Hyde of bacteria”. She likes the idea that the bacteria could be both a mutualist and pathogenic. For instance, this bacte-ria is sold commercially to farmers to protect their crops for infesta-tion of harmful insects. However, working with this particular bacte-rium has been challenging as the bacteria is very fussy. It is light-sensitive and it prefers highly purified water. Despite its challenges, she has found the system to be extremely useful in her teaching of research to undergraduate students. Because of its unique charac-teristics, the students are able to see the complexities of bacteria without having to use human pathogens. She often thinks back about her time at Loyola and how it prepared her for her long term goal in teaching. She reflects back on the 1st year Journal Club and how the course forced her to confront her less than stellar skills and how to fine tune those skills in order to become an effective speaker. The department’s dedication to teaching also inspired her to have the same level of commitment to her students. She enjoys watching her students’ eyes light up when they come back with their research findings or when they under-stand a concept that they did not know before. She loves to teach, and one of her greatest rewards is knowing that she helped spark an interest in science and research in her students.

MIIM

Summer 2014

Microbiology & Immunology News

This year I celebrate my 25th an-niversary as serving as chair of the department. Thank you to eve-ryone who has contributed to the many years of doing it together. The department would not be where it is today without the sup-port and commitment of the de-partment members. I am pleased to share with you the many of ac-complishments from this last year. Our graduate students and pro-

gram continue to succeed. Domenick Kennedy was awarded an F31 from the NIH and two students, Anna Mielech and Va-lerie Ray, were awarded the Schmitt Fellowship for the 2013 - 2014 academic year. This year we matriculated our largest group of nine students into the Ph.D. program and our NIH Immunology Training Grant has been renewed for another 5 years. The department welcomes Assistant Professor, Dr. Francis Alonzo to the department. Dr. Alonzo is a microbiologist and studies bacterial pathogenesis focusing on a single organism Staphylococcus aureus. Find out more about Dr. Alonzo and his research on page 2. We also welcome our newest joint appointee, Dr. Katherine Radek from the department of Surgery.

One of our virologists, Dr. Edward Campbell, was promoted to Associate Professor with tenure.

The department says farewell to one of our faculty, Dr. John Clancy who retired from the university in August. Dr. Clancy has been an invaluable member of our department and the institution and we wish Dr. Clancy all the best in his future endeavors. To learn about his tenure at Loyola go to page 4. We are always pleased to hear about our students’ successes and it is a pleasure to feature Eliabeth Hussa in our alumni

spotlight this year and to read about her many accomplish-ments. We thoroughly enjoy hear-ing from all of you and I encour-age you to stay in touch.

Sincerely,

Katherine L. Knight, Ph.D. Professor and Chair

Inside… Spotlight on Faculty ...... 2

Meetings Attended ........ 2

Spotlight on Students .... 3

Alumni News ................ 4

SURP update ................ 4

In Memoriam ................ 4

Recent Graduates ......... 5

Publications .................. 5

Dr. Knight’s Message Spotlight on Alumni—Elizabeth Hussa

The Microbiology and Immunology department is pleased to announce the appointment of Dr. Francis Alonzo to the department. Dr. Alonzo received his PhD from University of Illinois at Chicago and com-pleted his postdoctoral fellowship at New York University School of Medicine. Dr. Alonzo is a microbiol-ogist and studies bacterial pathogenesis focusing on a single organism Staphylococcus aureus. His lab is interested in how S. aureus evades the host defense in order to cause disease, and from this knowledge to determine how to prevent the many infections caused by the bacterium. His lab uses a multi-disciplinary approach, incorporating immunology, cell biology, and bacteriology to understand the disease process at the host-pathogen interface. When commenting on the transition from Post-doctoral fellow to Assistant Professor Dr. Alonzo men-tioned there have been a few surprises along the way, but overall he has been enjoying the experience. He has been appreciating the level of research independence and having the time to develop his own ideas and concepts. He finds the open door environment in the department beneficial to his research in that he can simply walk to a neighboring lab to discuss any questions or concerns or “talk shop”. He also finds the department to be very communicative which has been extremely help-ful in getting things started in his lab. When asked why he chose Loyola, he stated that he was attracted to our department and its commitment to training and develop-ing all those that enter the department. From the volunteers to the senior post-docs, Dr. Alonzo witnessed how the department is committed to the success of each individual. When searching for a department to join, he looked for a department that placed a strong emphasis on teaching and mentoring and he thinks he has found a good fit. Dr. Alonzo joined the department in July and has already hired a Research Technician and submitted two grant applications.

Spotlight on Faculty—Dr. Francis Alonzo

Page 2 Microbiology & Immunology News MIIMMIIM

Awards Domenick Kennedy, NIH F31 AG047817 “Decline of B lymphopoiesis with Age: Adipocytes and Myeloid Suppressor Cells”, May 2014 Domenick Kennedy, 2014 AAI Trainee Abstract Award, American Association of Immunologists Immunology Conference, 2014 Anna Mielech, Arthur J. Schmitt Dissertation Fellowship, 2013– 2014 Anna Mielech, 2nd Place - Oral Presentation, St. Albert's Day, 2013 Mallory Paynich, AAI Young Investigator Award, Autumn Immunology Conference, November 2013 Valerie Ray, Arthur J. Schmitt Dissertation Fellowship, 2013 –2014 Valerie Ray, The Spirit of Dr. Martin Luther King Jr. Award (for the Biomedical Sciences Division), January 2014

Presentations James Earnest, “Tetraspanins aid coronavirus entry”, 32nd Annual Meeting of the American Society for Virology, University Park,

PA, July 2013 James Earnest, “Tetraspanins aid coronavirus entry” American Society for Virology, Colorado State University, June 2014 Domenick Kennedy, “Adipocytes and the Decline of B lymphopoiesis with Age”, Abstract, Oral and Poster Presentations: Autumn

Immunology Conference, Chicago, November 2013 Domenick Kennedy, “Inhibition of B lymphopoiesis by myeloid-derived suppressor cells (HEM2P.262)”. Abstract, Oral Presenta-

tion and Poster Presentation. American Association of Immunologists Immunology Conference, Pittsburgh, May 2014 Anna Mielech, “Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis”, Oral

Presentation at Chicago Area Virology Association Meeting, Chicago 2014 Michael Misale, “Psychosocial Dysregulation of NK cells: A Role for Global H4K8ac”, IMTAC Interactive Summer School in Tu-

mor Immunology at the Karolinska Institute, Stockholm, Sweden, August 2013. Michael Misale, “Psychosocial Dysregulation of NK cells: A role for global H4K8ac” , Loyola Cancer Center Retreat, July 2013 Mallory Paynich, “Mechanism by which commensal exopolysaccharides limit inflammation”. Autumn Immunology Conference,

Chicago, November 2013 Mallory Paynich, “Mechanism by which commensal exopolysaccharides limit inflammation”. AAI Annual Meeting, Pittsburgh, Penn-

sylvania, May 2014 Krystal Thomas-White, “Accuracy of RDP Classifier via the Qiime Pipeline on Sequences from the female Urinary Microbiome-

Project” 20th Annual Midwest Microbial Pathogenesis Conference, Columbus, OH, August 2013

Graduate Students’ Awards, and Presentations

Ph.D. Students David Christensen—Wolfe Lab Karina Durso—Uprichard Lab Iris Figueroa—Cook Lab Erica Fleming—Knight Lab Michael Hantak—Gallagher Lab

Laura Johnsen—Campbell Lab Natalie Nidetz—Wiethoff Lab An Nguyen—Qiao Lab Kristin Pupa—Uprichard Lab Lucasz Sewara—Wiethoff Lab

M.S. Students Abigail Cannon—Choudhry Lab Kendra Foley—Nishimura Lab James Mahon—Le Poole Lab Travis Price—Wolfe Lab

Welcome New Students!

The department annual retreat was held at the Klarcheck Information Commons on the beautiful Lake Shore Campus. The retreat provided an opportunity for faculty and students to share their current research findings and to engage in scientific dialogue. The approximately 65 attendees benefited from the lab presentations, large group activities, and special talks. Small group sessions discussed training in the Microbiology/Immunology track, preliminary exam preparation, and post-doc and workforce oppor-tunities. And a total of 20 posters were presented between the two poster sessions by students and post-docs.

Krystal first became interested in science at an early age. From “take your daughter to work day” she learned what DNA was at the age of five and she would play with pipet-ters while working with her mother at Genentech. The exposure to sci-ence at the young age inspired her to pursue science as a career. She studied microbiology as an under-graduate at California Polytechnic

State University and worked internships at Genentech. After graduation, she worked for a year at the University of California, San Fransciso with Dr. Kwok in the human genomics lab where she first learned sequencing techniques. All these experiences lead her to pursue a graduate degree in Microbiology. In decid-ing on a program she looked for places outside of California and as a starting point, where her professors went for their graduate degrees. One of her professors was Dr. Candace Winstead, an alum of the Knight lab, which brought Krystal to Loyola. She knew she wanted to continue to work in microbiology and rotat-ed in every microbiology lab, and ultimately choose to work in the Wolfe lab.

In the beginning Krystal’s research focused on Dr. Wolfe’s acet-ylation work, but Krystal became more interested in the many different urinary microbiome projects and choose one that piqued her interest. It is known that post-menopausal women have an increased number of UTIs and estrogen is often pre-scribed to decrease recurrent infection. Krystal wanted to un-derstand if estrogen is affecting the urinary microbiome and how any changes compare to the vaginal microbiome. Her research is focusing on understanding the relationship between the bac-teria in the urinary tract and vaginal tract and whether there are correlative changes in each area.

Krystal has been grateful for the Microbiology & Immunology program. She finds that the interactive and collaborative nature of the department has been extremely beneficial to her growth as a scientist. She enjoys the ability to talk to anyone in the de-partment about a question or concern and being able to ask for their expert opinion. Even though at times it has been a chal-lenge to juggle the many demands of a graduate student, she truly appreciates the program’s dedication to her learning and being immersed in a multi-disciplinary scientific environment. Because of the program and being exposed to many different science disciplines, she is able to challenge herself as a scien-tist and be able to speak intelligently about different areas of sciences, including her own.

Spotlight on Graduate Student— Krystal Thomas-White

MIIMMIIM Page 3 Microbiology & Immunology News

Bioinformatics: Erasing the Line Between Biology and Hacking Krystal and her husband, Patrick, together are trying to bridge the gap between their two fields. Krystal working with bio-informatics and Patrick a professional computer hacker. Over long talks at the dinner table when talking about their respective fields, Krystal and Patrick discovered their fields had deep and meaningful similarities. Both genetic code and computer code are simple languages that produce incredibly complex systems, and it turns out that many of the same techniques work for ana-lyzing them both. Biology researchers today are spending count-less hours trying to understand these complex systems, without realizing that tools already exist within the computer science com-munity. What if these two sides could find a way to communicate in a way that both parties could understand and create new soft-ware programs to help the research community? Krystal and Pat-rick are laying down the tracks and starting that conversation. They presented at an information security conference, BSides Chicago, back in April with their presentation titled “Bioinformatics: Erasing the Line Between Biology and Hacking” . Their thoughts were well received by the audience, and after the conference they were invited to be a guest on the podcast Secur-aBit and to present at a conference in California this upcoming January. Relations between these fields are only in the beginning

stages but they are excited to see where it will go. One of their immedi-ate goals is to create ways for the biological sciences community to get access to the computer science side and to create a platform for scientists to learn from and ask for help from software experts in order to advance their research.

Department Retreat—SEPTEMBER 2013

This Week in Virology, a netcast about viruses - the kind that make you sick, visited the department back in January to record an episode to discuss coronaviruses with Drs. Susan Baker and Tom Gallagher.

The netcast is available online:

(http://www.twiv.tv/2014/03/16/twiv-276-ramblers-go-viral/)

Host: Vincent Raciello

In March all faculty, students and staff were converted to Outlook and all e-mail addresses have changed to @luc.edu (versus @lumc.edu). Please update your address books accordingly.

TWiV 276: Ramblers go viral

E-mail Update

This summer we said farewell to Professor John Clancy. Dr. Clancy joined Loyola in 1986 as Professor and Chair of the former Anatomy Department and in 1990 the department was re-named Cell Biology, Neurobiology, and Anatomy for which Dr. Clancy continued to chair for a total of 23 years. Through-out his tenure he has been an active teacher and mentor to graduate and medical students. He received the Basic Science Teacher of the Year 15 Award times, served on over 50 PhD Dissertation Committees and over 20 Thesis committees. His research studied transplantation immunobiology, the role of heat shock pro-teins in the immune response, and neuroimmunology which led to numerous article publications and abstracts, two patents, and the publication of one book.

In 2009, the department of Micro/Immuno was pleased to welcome him to the department and he has been a valuable teacher and mentor to both Micro and InDIRI graduate students. For several years he has been the coordinator for the Immunology Journal Club and IDIM 400: Infections and Immunology.

In July, CBNA and Micro, hosted a joint celebration recognizing Dr. Clancy’s many years of service to the institute. At the celebration, former faculty and students spoke about his dedication to teaching and his commitment to their develop-ment as an independent researcher. Many stated that they would not be where they are today without his leadership, guidance and support.

Dr. Clancy will continue to serve the department as Professor Emeritus, but in the colder months he will be with his wife in sunny California playing tennis. We wish him all the best in his retirement!

MIIMMIIM Page 4 Microbiology & Immunology News

Yougang Zhai, PhD, Research Associate 5 years Ed Campbell, PhD, Associate Professor 5 years Sara Jones, PhD, Research Associate 5 years Karen Visick, PhD, Professor 15 years Liang Qiao, MD, Professor 20 years Pi Chen Yam, Research Specialist 25 years Mae Kingzette, Lab Director 25 years Periannan Sethupathi, MD, Research Associate 25 years Katherine Knight, PhD, Professor and Chair 25 years

Clive Clandis, PhD, a former graduate student, published a thesis writing e-book in fall of 2013 titled “Getting Over the Thesis Barrier”. The e-book is an essential writing guide aimed squarely at stu-dents suffering various stages of writer’s block. Students will learn the tricks of the trade - applica-ble to any thesis, whether in the humanities or the sciences - to conquer writer's block and sail through the thesis writing process, overcoming hurdles faced by generations of students before and generations to come, but starting with the obvious question: where to start? And if there is one piece of advice to take home from this book it is this: DO NOT START AT THE BEGINNING! The e-book can be purchased on amazon.com for $5.99. Dr. Landis is currently chair of Cardiovascular Research at the Chronic Disease Research Centre at the University of West Indies

Celebrating Many Years of Service

Microbiology/Immunology Alum Publishes e-Book

In Memoriam

Professor Emeritus, Charles Lange, passed away in October 2013. Dr. Lange was a professor in the department from 1970-1995 and in 1996 he was granted the title of Pro-fessor Emeritus. In honor of his memory the department provided a donation to the Charles Lange Memorial Scholarship fund to the Chicago Public Schools Student Sci-ence Fair. We received a note from the Lange family that they had the honor to pre-sent the scholarship to the first recipient at the CPS Student Science Fair in May.

The Summer Undergraduate Research Program entered its 15th year this summer and it continues to grow and attract great stu-dents. The program, headed by Drs. Lanning and Schlutz, provides “hands on” research experience for students who are considering a graduate degree. On average the department receives over 175 applications per year for approximately 6 slots. Participants in the program develop a research project, attend weekly journal clubs and Friday meetings, and receive a stipend. Each summer, the pro-gram invites outside speakers to talk about careers in science and research ethics and new this year current PhD and MD/PhD stu-dents spoke to the participants about their different degree paths. At the end of the program all participants present their summer research at Friday meeting. The program has been successful and many students who have participated have pursued careers in science.

To find out more about the Undergraduate Summer Research Program, please visit: www.stritch.luc.edu/microimmunogrp.

Summer Undergraduate Research Program Update

Retirement of Dr. John Clancy

Sucha Nand, Kevin Barton, Richard Schultz, Mary Klein, and Ameet Kini, Heckathorn's Disease Revisted, Blood 123:1429-1431 (2014).

Kilianski, Andy, Anna Mielech, Xufang Deng and Susan C. Baker. 2013. Assessing Activity and Inhibition of MERS-CoV Papain-like and 3C-like Proteases Using Luciferase-based Biosensors. J. Virol. 87: 11955-11962.

Mielech, Anna M, Andy Kilianski, Yahira M. Baez-Santos, Andrew D. Mesecar and Susan C. Baker. 2014. MERS-CoV Papain-like Protease has deISGylating and deubiquitinating activities. Virology 450: 64-70

Ratia K, Kilianski A, Baez-Santos YM, Baker SC, Mesecar A (2014) Structural Basis for the Ubiquitin-Linkage Specificity and deIS-Gylating Activity of SARSCoV Papain-Like Protease. PLoS Pathog 10(5): e1004113. doi:10.1371/journal.ppat.1004113

Qin H, Driks A. Phylogenomic insights into the evolution of the Bacillus spore coat. BMC Evol. Biol. 2013; 13: 261-273. Sahin O, Driks A. Generation of electricity by harnessing water evaporation. Nat. Nanotechnol. 2014 Jan. 26 epub ahead of print. Semenyuk, E.G., Laning, M.L., Foley, J., Johnston, P.F., Knight, K.L., Gerding, D.N., Driks, A. Spore Formation and Toxin Pro-

duction in Clostridium difficile Biofilms. PLoS ONE 2014; 9: e87757. Bai, Y., Wang, Y., Goulian, M., Driks, A. and Dmochowski, I. J.. Bacterial spore detection and analysis using hyperpolarized

129Xe chemical exchange saturation transfer (Hyper-CEST) NMR. Chem. Sci. 2014; advanced publication. Barlan A1, Zhao J, Sarkar MK, Li K, McCray PB Jr, Perlman S, Gallagher T., Receptor variation and susceptibility to Middle East

respiratory syndrome coronavirus infection, J Virol. 2014 May;88(9):4953-61. doi: 10.1128/JVI.00161-14. Epub 2014 Feb 19., PMC3993797

Zhao J1, Li K, Wohlford-Lenane C, Agnihothram SS, Fett C, Zhao J, Gale MJ Jr, Baric RS, Enjuanes L, Gallagher T, McCray PB Jr, Perlman S., Rapid generation of a mouse model for Middle East respiratory syndrome, Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4970-5. doi: 10.1073/pnas.1323279111. Epub 2014 Mar 5. PMC3977243

Jones SE, Paynich ML, Kearns DB, Knight KL, Protection from intestinal inflammation by bacterial exopolysaccharides, J Immu-nol. 2014 May 15;192(10):4813-20. doi: 10.4049/jimmunol.1303369. Epub 2014 Apr 16.

Yam PC, Knight KL, Generation of rabbit monoclonal antibodies, Methods Mol Biol. 2014;1131:71-9. Johnston PF1, Gerding DN, Knight KL, Protection from Clostridium difficile infection in CD4 T Cell- and polymeric immunoglobulin

receptor-deficient mice, Infect Immun. 2014 Feb;82(2):522-31 Epub 2013 Nov 11. Eddy JL, Krukowski K, Janusek L, Mathews HL, Glucocorticoids regulate natural killer cell function epigenetically, Cell Immunol.

2014 Jun 18;290(1):120-130. doi: 10.1016/j.cellimm.2014.05.013. [Epub ahead of print] Bu P, Vin A, Sethupathi P, Ambrecht L, Zhai YG, Nikolic N, Qiao L, Bouchard C. Effects of Activated Omental Cells on Rat Limbal

Corneal Alkali Injury. Exp Eye Res, 2014; 121:143-146. PMID: 24582890 Lyer, S.S., H. Qiong, J.R. Janczy, E.I. Elliot, Z. Zhong, A.K. Olivier, J.J. Sadler, V. Knepper-Adrian, R. Han, L. Qiao, S.C. Eisen-

barth, W.M. Nauseef, S.L. Cassel, and F.S. Sutterwala. Mitochondrial cardiolipin regulates Nlrp3 inflammasome activation. Im-munity. 2013 Aug 22;39(2):311-23. doi: 10.1016/j.immuni.2013.08.001. Epub 2013 Aug 15. PMID: 23954133.

Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche. 2013. Zook EC, Zhang S, Ger-stein RM, Witte PL, and Le PT. J Immunol. 191:5583-9320. PMCID:4081451

Ray, V. A., J. L. Eddy, E. A. Hussa, M. Misale, and K. L. Visick. 2013. The syp enhancer sequence plays a key role in transcrip-tional activation by the σ54-dependent response regulator SypG and in biofilm formation and host colonization by Vibrio fischeri. J. Bacteriol.

Ray, V. A., J. L. Eddy, E. A. Hussa, M. Misale, and K. L. Visick. 2013. The syp enhancer sequence plays a key role in transcrip-tional activation by the σ54-dependent response regulator SypG and in biofilm formation and host colonization by Vibrio fischeri. J. Bacteriol.

Norsworthy, A. N. and K. L. Visick. 2013. Gimme shelter: how Vibrio fischeri successfully navigates an animal’s multiple environ-ments. Frontiers in Aquatic Microbiology 4:356

Recent Publications

Microbiology & Immunology News MIIMMIIM Page 5

MIIMMIIM

Defenses: Linda Hu, Ph.D. (Mentor: Dr. Wolfe) “Understanding posttranslational regulation of the response regulator RCSB and the novel

acetyl donor acetyl phosphate in Escherichia coli” Current Position: Postdoctoral Fellow, Univ. of WI—Madison Nick Huang, Ph.D. (Mentor: Dr. Iwashima) “Modulation of Th17 responses by Omental Cells” .

Current Position: Returned to Stritch School of Medicine to complete MD portion of his MD/PhD degree Andrew Kilianski, Ph.D. (Mentor: Dr. Baker) “Coronavirus Proteases as Therapeutic Targets: Development of Biosensors to De-

tect Inhibition of Protease Activity and Dissecting the Multifunctionality of SARS-CoV PLpro ”, Current Position: National Research Council Postdoctoral Fellow, Edgewood Chemical and Biological Center on Aberdeen Prov-ing Ground in Edgewood, MD

Anna Mielech, Ph.D. (Mentor: Dr. Baker) “Multifunctional Coronavirus Papain-Like Proteases as Targets for Antiviral Therapeutics and Vaccines”. Current Position: Postdoctoral Fellow, Loyola University Chicago

Kathleen McGuire Ph.D. (Mentor: Dr. Wiethoff) “Adenovirus Vectores As Potent Adjuvants in Vaccine Development.” Current Position: Postdoctoral Fellow, Harvard University Medical School

Valerie Ray, Ph.D. (Mentor: Dr. Visick) “Identifiying novel factors involved in biofilm formation by Vibrio fischeri.” Current Position: Postdoctoral Fellow, Ohio State University

Graduate Student Defenses

Sastri J, Johnsen L, Smolin N, Imam S, Mukherjee S, Lukic Z, Brandariz-Nuñez A, Robia SL, Diaz-Griffero F, Wiethoff C, Camp-bell EM. (2014) Restriction of HIV-1 by rhesus TRIM5α is governed by alpha-helices in the Linker2 region. Journal of Virology. (In Press)

Pearce, M. M., Hilt, E. E, Rosenfeld, A. B., Zilliox, M. J., Thomas-White, K., Fok, C., Kliethermes, S., Schreckenberger, P. C., Bru-baker, L., Gai, X., Wolfe, A. J.. 2014. The Female Urinary Microbiome: A Comparison of Women With and Without Urgency Uri-nary Incontinence. mBio. In press.

Kuhn, M. L., Zemaitaitis, B., Hu, L. I., Sahu, A., Sorensen, D., Minasov, G., Lima, B. P., Scholle, M., Mrksich, M., Anderson, W. F., Gibson, B. W., Schilling, B., and Wolfe, A. J. 2014. Structural, kinetic and global mass spectrometric characterization of acetyl phosphate-dependent bacterial protein acetylation. PLoS One. Apr 22;9(4):e94816. doi: 10.1371/journal.pone.0094816. eCollec-tion 2014.PMID:24756028

Primary Faculty Francis Alonzo, PhD Susan Baker, PhD Edward Campbell, PhD John Clancy, PhD Adam Driks, PhD Thomas Gallagher, PhD Makio Iwashima, PhD Katherine Knight, PhD

Dennis Lanning, PhD Phong Le, PhD Herbert Mathews, PhD Liang Qiao, MD Richard Schultz, PhD Karen Visick, PhD Christopher Wiethoff, PhD Pamela Witte, PhD Alan Wolfe, PhD

Joint Faculty Mashkoor Choudry, PhD Manuel Diaz, PhD Andrew Dingwall, PhD Kimberly Foreman, PhD David Hecht, MD Gail Hecht, MD Elizabeth Kovacs, PhD Caroline Le Poole, PhD

J. Paul O’Keefe, MD Clodia Osipo, PhD Katherine Radek, PhD John Robinson, MD Susan Uprichard, MD

Stephanie Watkins, PhD

Recent Publications—continued

Microbiology & Immunology News MIIMMIIM Page 6

MIIMMIIM

Your input: If you know someone whom you would like to see featured in the Alumni Spotlight section, or have ideas about things you would like to see in future newsletters, please send an email to Deborah Hammer at [email protected]. Department Website: www.lumc.edu/microimmuno Respectfully prepared by Ashley Glodowski September 2014

Current Faculty

Want to Donate to the Katherine L. Knight Fund for Mentoring? http://www.luc.edu/giving/ Be sure to select the ‘other’ box under area of support and in the comment box type “Katherine L. Knight Mentoring Fund– AU 210973.”